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Cell-type-specific RNA polymerase II activity maps in intact tissues provide a gateway to mammalian gene regulatory mechanisms in vivo

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  DOI: 10.1016/j.devcel.2025.09.017
  
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sciencedirect.com/science/article/pii/S1534580725006021
Aug 2025
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A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation

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  DOI: 10.1016/j.molcel.2025.08.001
  
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sciencedirect.com/science/article/pii/S1097276525006513
Jul 2025
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The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci

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1. scibot 23 Jul 2025
  
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  DOI: 10.7554/eLife.41444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6447362/
Jul 2024
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An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.molcel.2024.06.006
  
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sciencedirect.com/science/article/pii/S1097276524004842
Mar 2024
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The winged helix domain of MORF binds CpG islands and the TAZ2 domain of p300

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1. scibot 22 Mar 2024
  
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  DOI: 10.1016/j.isci.2024.109367
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10946326/
Nov 2023
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Selective inhibition of CDK9 in triple negative breast cancer

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1. scibot 25 Nov 2023
  
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  DOI: 10.1038/s41388-023-02892-3
  
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nature.com/articles/s41388-023-02892-3
Jul 2023
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Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER

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1. scibot 05 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112700
  
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sciencedirect.com/science/article/pii/S2211124723007118
May 2023
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Functional interplay between Mediator and RSC chromatin remodeling complex controls nucleosome-depleted region maintenance at promoters

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  DOI: 10.1016/j.celrep.2023.112465
  
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sciencedirect.com/science/article/pii/S221112472300476X
Apr 2023
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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities

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  DOI: 10.1016/j.xcrm.2023.101007
  
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sciencedirect.com/science/article/pii/S2666379123001179
Jan 2023
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C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1

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1. scibot 27 Jan 2023
  
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  DOI: 10.15252/embj.2022111895
  
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embopress.org/doi/10.15252/embj.2022111895
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MDC1 maintains active elongation complexes of RNA polymerase II

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1. scibot 19 Jan 2023
  
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  DOI: 10.1016/j.celrep.2022.111979
  
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sciencedirect.com/science/article/pii/S2211124722018836
Oct 2022
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Topoisomerases I and II facilitate condensin DC translocation to organize and repress X chromosomes in C. elegans

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1. scibot 27 Oct 2022
  
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  DOI: 10.1016/j.molcel.2022.10.002
  
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sciencedirect.com/science/article/pii/S1097276522009595
Aug 2022
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The BASP1 transcriptional corepressor modifies chromatin through lipid-dependent and lipid-independent mechanisms

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1. scibot 17 Aug 2022
  
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  DOI: 10.1016/j.isci.2022.104796
  
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sciencedirect.com/science/article/pii/S2589004222010689
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A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth

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1. scibot 04 Aug 2022
  
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  DOI: 10.1016/j.chom.2022.07.001
  
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sciencedirect.com/science/article/pii/S1931312822003171
Feb 2022
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The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation

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1. scibot 23 Feb 2022
  
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  DOI: 10.1016/j.molcel.2022.01.024
  
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sciencedirect.com/science/article/pii/S1097276522001009
Nov 2021
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Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage

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1. scibot 03 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.109938
  
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sciencedirect.com/science/article/pii/S221112472101411X
Sep 2021
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HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

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1. scibot 04 Sep 2021
  
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  DOI: 10.7554/eLife.65872
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8387021/
Aug 2021
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Untitled document

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1. scibot 10 Aug 2021
  
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  DOI: 10.1016/j.devcel.2018.11.046
  
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sciencedirect.com/science/article/pii/S153458071831030X
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Untitled document

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1. scibot 04 Aug 2021
  
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  DOI: 10.1016/j.molcel.2019.01.033
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6482433/
Jul 2021
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Establishment, maintenance, and recall of inflammatory memory

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1. scibot 30 Jul 2021
  
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  DOI: 10.1016/j.stem.2021.07.001
  
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sciencedirect.com/science/article/pii/S1934590921002861
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The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output

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1. scibot 30 Jul 2021
  
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  DOI: 10.1016/j.stem.2018.02.004
  
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sciencedirect.com/science/article/pii/S1934590918300663
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Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

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1. scibot 30 Jul 2021
  
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  DOI: 10.1016/j.cell.2018.09.051
  
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sciencedirect.com/science/article/pii/S0092867418312637
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A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers

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1. scibot 29 Jul 2021
  
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  DOI: 10.1016/j.cell.2019.07.011
  
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sciencedirect.com/science/article/pii/S0092867419307767
academic.oup.com academic.oup.com

GADD45a Promotes Active DNA Demethylation of the MMP-9 Promoter via Base Excision Repair Pathway in AGEs-Treated Keratinocytes and in Diabetic Male Rat Skin

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1. scibot 29 Jul 2021
  
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  DOI: 10.1210/en.2017-00686
  
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2. scibot 29 Jul 2021
  
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  DOI: 10.1210/en.2017-00686
  
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academic.oup.com/endo/article/159/2/1172/4736306
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Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation

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1. scibot 14 Jul 2021
  
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  DOI: 10.1016/j.celrep.2021.109357
  
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sciencedirect.com/science/article/pii/S2211124721007555
May 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ZC3H4 restricts non-coding transcription in human cells

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1. scibot 26 May 2021
  
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  DOI: 10.7554/eLife.67305
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8137146/
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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

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1. scibot 18 May 2021
  
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  DOI: 10.1016/j.cell.2021.04.022
  
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sciencedirect.com/science/article/pii/S009286742100502X
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Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.molcel.2021.03.008
  
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sciencedirect.com/science/article/pii/S1097276521001763
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Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.molcel.2021.01.010
  
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sciencedirect.com/science/article/pii/S1097276521000101
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A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.molcel.2020.11.010
  
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sciencedirect.com/science/article/pii/S1097276520307887
Apr 2021
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Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma

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1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.celrep.2021.109013
  
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sciencedirect.com/science/article/pii/S2211124721003272
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation

1
1. scibot 26 Feb 2021
  
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  DOI: 10.7554/eLife.59994
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7462607/
Jan 2021
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MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends

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1. scibot 08 Jan 2021
  
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  DOI: 10.1016/j.celrep.2020.108565
  
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sciencedirect.com/science/article/pii/S2211124720315540
Dec 2020
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RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions

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1. scibot 23 Dec 2020
  
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  DOI: 10.1016/j.celrep.2020.108546
  
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sciencedirect.com/science/article/pii/S2211124720315357
Nov 2020
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Formation of the CenH3-Deficient Holocentromere in Lepidoptera Avoids Active Chromatin

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1. scibot 20 Nov 2020
  
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  DOI: 10.1016/j.cub.2020.09.078
  
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cell.com/current-biology/abstract/S0960-9822(20)31448-2
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G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program

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1. scibot 12 Nov 2020
  
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  DOI: 10.1016/j.celrep.2020.108341
  
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sciencedirect.com/science/article/pii/S2211124720313309
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Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia

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1. scibot 30 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108200
  
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Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS

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  DOI: 10.1016/j.cell.2020.03.002
  
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Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells

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  DOI: 10.1016/j.celrep.2020.107715
  
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Enhancer RNAs Mediate Estrogen-Induced Decommissioning of Selective Enhancers by Recruiting ERα and Its Cofactor

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1. scibot 13 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107803
  
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Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb

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1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.48725
  
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.40806
  
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.01.033
  
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Nov 2018
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Arabidopsis ARGONAUTE 1 Binds Chromatin to Promote Gene Transcription in Response to Hormones and Stresses

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Different Neuronal Activity Patterns Induce Different Gene Expression Programs

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1. scibot 05 Nov 2018
  
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Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States

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Nov 2017
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Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate

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1. scibot 08 Nov 2017
  
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Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle

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1. scibot 08 Nov 2017
  
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BTBD18 Regulates a Subset of piRNA-Generating Loci through Transcription Elongation in Mice

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1. scibot 08 Nov 2017
  
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s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways

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1. scibot 08 Nov 2017
  
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