214 Matching Annotations
  1. Dec 2024
  2. www.cell.com www.cell.com
    EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling
    1
    1. scibot 12 Dec 2024
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      DOI: 10.1016/j.devcel.2024.11.014

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    cell.com/developmental-cell/fulltext/S1534-5807(24)00696-8
  3. Sep 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Smyd3-mediated immuno-modulation in HPV-negative head and neck squamous cell carcinoma mouse models
    1
    1. scibot 17 Sep 2024
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      DOI: 10.1016/j.isci.2024.110854

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    sciencedirect.com/science/article/pii/S2589004224020790
  5. Aug 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Artificially inserted strong promoter containing multiple G-quadruplexes induces long-range chromatin modification
    1
    1. scibot 23 Aug 2024
      RRID:AB_306847

      DOI: 10.7554/eLife.96216

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    ncbi.nlm.nih.gov/pmc/articles/PMC11333042/
  7. Jul 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A CPF-like phosphatase module links transcription termination to chromatin silencing
    1
    1. scibot 26 Jul 2024
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      DOI: 10.1016/j.molcel.2024.05.016

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    ncbi.nlm.nih.gov/pmc/articles/PMC7616277/
  9. www.cell.com www.cell.com
    YY1-mediated enhancer-promoter communication in the immunoglobulin μ locus is regulated by MSL/MOF recruitment
    1
    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114456

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    cell.com/cell-reports/abstract/S2211-1247(24)00785-X
  10. Jun 2024
  11. www.sciencedirect.com www.sciencedirect.com
    Proximal termination generates a transcriptional state that determines the rate of establishment of Polycomb silencing
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.molcel.2024.05.014

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    sciencedirect.com/science/article/pii/S1097276524004374
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex
    1
    1. scibot 13 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114227

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    ncbi.nlm.nih.gov/pmc/articles/PMC11163479/
  13. May 2024
  14. www.sciencedirect.com www.sciencedirect.com
    A chromatin code for limb segment identity in axolotl limb regeneration
    1
    1. scibot 24 May 2024
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      DOI: 10.1016/j.devcel.2024.05.002

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    sciencedirect.com/science/article/pii/S1534580724003009
  15. www.sciencedirect.com www.sciencedirect.com
    A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification
    1
    1. scibot 02 May 2024
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      DOI: 10.1016/j.immuni.2024.04.007

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    sciencedirect.com/science/article/pii/S1074761324002127
  16. Apr 2024
  17. www.sciencedirect.com www.sciencedirect.com
    The Drosophila Hippo pathway transcription factor Scalloped and its co-factors alter each other’s chromatin binding dynamics and transcription in vivo
    1
    1. scibot 26 Apr 2024
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      DOI: 10.1016/j.devcel.2024.04.006

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    sciencedirect.com/science/article/pii/S1534580724002314
  18. pubs.acs.org pubs.acs.org
    Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region
    2
    1. scibot 18 Apr 2024
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      DOI: 10.1021/acs.jmedchem.3c01549

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    2. scibot 18 Apr 2024
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      DOI: 10.1021/acs.jmedchem.3c01549

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    pubs.acs.org/doi/10.1021/acs.jmedchem.3c01549
  19. www.sciencedirect.com www.sciencedirect.com
    Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction
    1
    1. scibot 16 Apr 2024
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      DOI: 10.1016/j.immuni.2024.03.018

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    sciencedirect.com/science/article/pii/S1074761324001390
  20. www.sciencedirect.com www.sciencedirect.com
    H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation
    1
    1. scibot 11 Apr 2024
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      DOI: 10.1016/j.molcel.2024.02.030

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    sciencedirect.com/science/article/pii/S1097276524001710
  21. www.sciencedirect.com www.sciencedirect.com
    SAFB restricts contact domain boundaries associated with L1 chimeric transcription
    1
    1. scibot 11 Apr 2024
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      DOI: 10.1016/j.molcel.2024.03.021

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    sciencedirect.com/science/article/pii/S1097276524002314
  22. Mar 2024
  23. www.sciencedirect.com www.sciencedirect.com
    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
    2
    1. scibot 29 Mar 2024
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      DOI: 10.1016/j.xcrm.2024.101468

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      DOI: 10.1016/j.xcrm.2024.101468

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    sciencedirect.com/science/article/pii/S2666379124001149
  24. pubs.acs.org pubs.acs.org
    Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region
    2
    1. scibot 15 Mar 2024
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      DOI: 10.1021/acs.jmedchem.3c01549

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    2. scibot 15 Mar 2024
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      DOI: 10.1021/acs.jmedchem.3c01549

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    pubs.acs.org/doi/10.1021/acs.jmedchem.3c01549
  25. www.sciencedirect.com www.sciencedirect.com
    The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA
    2
    1. scibot 14 Mar 2024
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      DOI: 10.1016/j.devcel.2024.02.008

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    2. scibot 14 Mar 2024
      RRID:AB_306847

      DOI: 10.1016/j.devcel.2024.02.008

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    sciencedirect.com/science/article/pii/S1534580724001072
  26. Feb 2024
  27. 52.53.155.43 52.53.155.43
    bvae029-html.html
    1
    1. scibot 15 Feb 2024
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      DOI: 10.1210/jendso/bvae029

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    52.53.155.43/91f4741c570f637c33beb2463bb95c19a65c82ea/bvae029-html.html
  28. www.sciencedirect.com www.sciencedirect.com
    FOXA1 forms biomolecular condensates that unpack condensed chromatin to function as a pioneer factor
    1
    1. scibot 09 Feb 2024
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      DOI: 10.1016/j.molcel.2023.11.020

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    sciencedirect.com/science/article/abs/pii/S1097276523009656
  29. Jan 2024
  30. www.sciencedirect.com www.sciencedirect.com
    PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression
    1
    1. scibot 19 Jan 2024
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      DOI: 10.1016/j.devcel.2023.12.015

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    sciencedirect.com/science/article/pii/S1534580723006962
  31. www.sciencedirect.com www.sciencedirect.com
    XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells
    1
    1. scibot 05 Jan 2024
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      DOI: 10.1016/j.cell.2023.11.033

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    sciencedirect.com/science/article/pii/S0092867423013193
  32. Dec 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Crosstalk between chromatin and Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1016/j.isci.2023.108624

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    sciencedirect.com/science/article/pii/S2589004223027013
  34. www.sciencedirect.com www.sciencedirect.com
    Super-enhancers include classical enhancers and facilitators to fully activate gene expression
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.cell.2023.11.030

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    sciencedirect.com/science/article/pii/S0092867423013168
  35. Nov 2023
  36. dx.doi.org dx.doi.org
    Reactivation of the G1 enhancer landscape underlies core circuitry addiction to SWI/SNF
    1
    1. scibot 26 Nov 2023
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      DOI: 10.1093/nar/gkad1081

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    dx.doi.org/10.1093/nar/gkad1081
  37. www.sciencedirect.com www.sciencedirect.com
    RNA polymerase II dynamics and mRNA stability feedback scale mRNA amounts with cell size
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.cell.2023.10.012

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    sciencedirect.com/science/article/pii/S0092867423011285
  38. Oct 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
    1
    1. scibot 28 Oct 2023
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      DOI: 10.1016/j.stem.2023.09.007

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    sciencedirect.com/science/article/pii/S1934590923003284
  40. www.sciencedirect.com www.sciencedirect.com
    PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly
    1
    1. scibot 28 Oct 2023
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      DOI: 10.1016/j.molcel.2023.09.028

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    sciencedirect.com/science/article/pii/S1097276523007554
  41. www.sciencedirect.com www.sciencedirect.com
    Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.xgen.2023.100424

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    sciencedirect.com/science/article/pii/S2666979X23002501
  42. Sep 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Perturbations in 3D genome organization can promote acquired drug resistance
    1
    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113124

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    sciencedirect.com/science/article/pii/S2211124723011361
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear miR-150 enhances hepatic lipid accumulation by targeting RNA transcripts overlapping the PLIN2 promoter
    1
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      DOI: 10.1016/j.isci.2023.107837

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    ncbi.nlm.nih.gov/pmc/articles/PMC10509351/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution
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      DOI: 10.1016/j.isci.2023.107796

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    ncbi.nlm.nih.gov/pmc/articles/PMC10502414/
  46. link.springer.com link.springer.com
    SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin
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      DOI: 10.1007/s00018-023-04883-9

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    link.springer.com/article/10.1007/s00018-023-04883-9
  47. Aug 2023
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Srd5a1 is Differentially Regulated and Methylated During Prepubertal Development in the Ovary and Hypothalamus
    1
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      DOI: 10.1210/jendso/bvad108

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    ncbi.nlm.nih.gov/pmc/articles/PMC10461783/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO
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      DOI: 10.1016/j.isci.2023.107319

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    ncbi.nlm.nih.gov/pmc/articles/PMC10393733/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone variants shape chromatin states in Arabidopsis
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      DOI: 10.7554/eLife.87714

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    ncbi.nlm.nih.gov/pmc/articles/PMC10393023/
  51. Jul 2023
  52. www.sciencedirect.com www.sciencedirect.com
    The default and directed pathways of hepatoblast differentiation involve distinct epigenomic mechanisms
    1
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      DOI: 10.1016/j.devcel.2023.07.002

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    sciencedirect.com/science/article/abs/pii/S1534580723003325
  53. Jun 2023
  54. www.sciencedirect.com www.sciencedirect.com
    SETD7 promotes lateral plate mesoderm formation by modulating the Wnt/β-catenin signaling pathway
    1
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      DOI: 10.1016/j.isci.2023.106917

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    sciencedirect.com/science/article/pii/S258900422300994X
  55. May 2023
  56. www.sciencedirect.com www.sciencedirect.com
    Chemical-induced epigenome resetting for regeneration program activation in human cells
    1
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      DOI: 10.1016/j.celrep.2023.112547

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    Mechanical pressure-induced dedifferentiation of myofibroblasts inhibits scarring via SMYD3/ITGBL1 signaling
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    SMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with Myocardin
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  59. Apr 2023
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    NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons
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    Restraint of IFN-γ expression through a distal silencer CNS–28 for tissue homeostasis
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    NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons
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    Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas
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    Regulation of human trophoblast gene expression by endogenous retroviruses
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  65. Mar 2023
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    Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation
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    Aryl hydrocarbon receptor activity downstream of IL-10 signaling is required to promote regulatory functions in human dendritic cells
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  68. Dec 2022
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    Hypoxia induces transgenerational epigenetic inheritance of small RNAs
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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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    SENP7 deSUMOylase-governed transcriptional program coordinates sarcomere assembly and is targeted in muscle atrophy
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    Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia
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    Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes promotes chromatin compaction at promoters
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  75. Sep 2022
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    Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner
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  77. Aug 2022
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    Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression
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    Smarca4 inactivation promotes lineage-specific transformation and early metastatic features in the lung
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  80. Jul 2022
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    Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes
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  82. May 2022
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    Binary outcomes of enhancer activity underlie stable random monoallelic expression
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    Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging
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  85. Apr 2022
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    H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
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    MUC1-C Dictates JUN and BAF-mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells
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  88. Mar 2022
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    MLL5 is involved in retinal photoreceptor maturation through facilitating CRX-mediated photoreceptor gene transactivation
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    A cell-sorting-based protocol for cell cycle small-scale ChIP sequencing
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    Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit
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  92. Feb 2022
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    EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells
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    Histone marks regulate the epithelial-to-mesenchymal transition via alternative splicing
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    Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells
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    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
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  97. Jan 2022
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    SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers
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    Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos
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  100. Dec 2021
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    TRACE generates fluorescent human reporter cell lines to characterize epigenetic pathways
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    KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma
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    SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity
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  104. Nov 2021
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    Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine
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  106. Oct 2021
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    Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma
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    Collective regulation of chromatin modifications predicts replication timing during cell cycle
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  109. Sep 2021
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    MLL3 is a de novo cause of endocrine therapy resistance
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    KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2
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    Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
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    Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms
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    Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
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    A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire
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    Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
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    Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG
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    MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis
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    Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming
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    The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain
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    Combinatorial CRISPR/Cas9 Approach to Elucidate a Far-Upstream Enhancer Complex for Tissue-Specific Sox9 Expression
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    Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses
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    Architectural Proteins and Pluripotency Factors Cooperate to Orchestrate the Transcriptional Response of hESCs to Temperature Stress
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    Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19
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    GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency
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    LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
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    Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2
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    Cross Talk between One-Carbon Metabolism, Eph Signaling, and Histone Methylation Promotes Neural Stem Cell Differentiation
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    MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes
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    BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome
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    Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis
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    A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response
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    BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
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    IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure
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    Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance
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    CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression
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    Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate
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    Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis
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    A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription
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    Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation
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    The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis
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