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    Characterising replisome disassembly in human cells
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    TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends
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  4. Jun 2024
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    Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule
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    TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends
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    The ribotoxic stress response drives UV-mediated cell death
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    2024.05.31.596483v1.full-html.html
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  9. May 2024
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    Chloroquine-induced DNA damage synergizes with DNA repair inhibitors causing cancer cell death
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    PKCð regulates chromatin remodeling and DNA repair through SIRT6
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      Catalog no. 05–636, RRID:AB_309864, Millipore

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    aacrjournals.org/mcr/article/22/2/181/733696/PKC-Regulates-Chromatin-Remodeling-and-DNA-Repair
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    Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1
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    TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
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    Deregulation of multiple mechanisms shapes the onset of LAMA2-congenital muscular dystrophy
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    NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors
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  16. Apr 2024
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    Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
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    DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response
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    Principles of chromosome organization for meiotic recombination
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    AXL/WRNIP1 mediates replication stress response and promotes therapy resistance and metachronous metastasis in HER2+ breast cancer
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    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
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    PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
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    DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage
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    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
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    GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break repair and determining cancer radiosensitivity
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    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
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    BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks
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  28. Mar 2024
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    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
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  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation
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    Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer
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    The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    AurkA/TPX2 co-overexpression in nontransformed cells promotes genome instability through induction of chromosome mis-segregation and attenuation of the p53 signalling pathway
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  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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  36. Feb 2024
  37. 52.53.155.43 52.53.155.43
    delete 6-html.html
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    A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis
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    The proteomic landscape of genotoxic stress-induced micronuclei
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    A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
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    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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    Specialized replication mechanisms maintain genome stability at human centromeres
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    PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends
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    RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
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    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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    BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells
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    The male pachynema-specific protein MAPS drives phase separation in vitro and regulates sex body formation and chromatin behaviors in vivo
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    The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export
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    Metabolic regulation of homologous recombination repair by MRE11 lactylation
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    Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells
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    PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition
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    Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality
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    Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells
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    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
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    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
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    Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring
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    Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells
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    Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction
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    Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor
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    Genetic dissection of crossover mutants defines discrete intermediates in mouse meiosis
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    Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression
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    ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis
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  84. Jul 2023
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    CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper sperm movement
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    Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition
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    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
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    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
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    Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma
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    Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells
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  91. Jun 2023
  92. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    A DNA damage response-like phenotype defines a third of colon cancers at onset
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    Relaxed targeting rules help PIWI proteins silence transposons
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    Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability
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  95. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Characterizing microglial senescence: Tau as a key player
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  96. www.nature.com www.nature.com
    Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling
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    Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency
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  98. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Endonuclease VIII-like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's disease
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  99. www.biorxiv.org www.biorxiv.org
    PKCδ regulates chromatin remodeling and DNA repair through SIRT6
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    Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging
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  101. May 2023
  102. www.sciencedirect.com www.sciencedirect.com
    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
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    Replication stress impairs chromosome segregation and preimplantation development in human embryos
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repurposing ceritinib induces DNA damage and enhances PARP inhibitor responses in high-grade serous ovarian carcinoma
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  105. Apr 2023
  106. www.sciencedirect.com www.sciencedirect.com
    Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling
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    A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
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  109. www.science.org www.science.org
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
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  110. www.sciencedirect.com www.sciencedirect.com
    TERRA stability is regulated by RALY and polyadenylation in a telomere-specific manner
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    SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology
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    ERCC6L2 mitigates replication stress and promotes centromere stability
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  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells
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  114. Mar 2023
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    TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells
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    DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation
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    Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy
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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug–gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition
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    m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis
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    HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression
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  121. Feb 2023
  122. www.biorxiv.org www.biorxiv.org
    YTHDC2 serves a distinct late role in spermatocytes during germ cell differentiation
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  123. Jan 2023
  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human metastatic cholangiocarcinoma patient-derived xenografts and tumoroids for preclinical drug evaluation
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  125. www.sciencedirect.com www.sciencedirect.com
    SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses
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    Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia
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  127. www.sciencedirect.com www.sciencedirect.com
    Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication
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  128. www.mdpi.com www.mdpi.com
    Remarkable Synergy When Combining EZH2 Inhibitors with YM155 Is H3K27me3-Independent
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  129. www.sciencedirect.com www.sciencedirect.com
    ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen
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  130. Dec 2022
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    The ADP-ribose hydrolase NUDT5 is important for DNA repair
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    p53/p21 pathway activation contributes to the ependymal fate decision downstream of GemC1
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    NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
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    NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
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  135. Nov 2022
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    Autophagy promotes cell survival by maintaining NAD levels
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    POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps
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    Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors
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    Enhanced DNA repair through droplet formation and p53 oscillations
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    The phenotypic landscape of essential human genes
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    Metabolic regulation by p53 prevents R-loop-associated genomic instability
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    Is microglial dystrophy a form of cellular senescence? An analysis of senescence markers in the aged human brain
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    DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation
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    Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF
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    A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1
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    C9orf72 functions in the nucleus to regulate DNA damage repair
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    Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen
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    Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks
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    Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization
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    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
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    Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage
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    Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner
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    CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS
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    Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop
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    RAD51 protects human cells from transcription-replication conflicts
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    A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
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  160. Jul 2022
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    Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer
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    Guiding ATR and PARP inhibitor combinationswith chemogenomic screens
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    Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes
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    Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy
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  165. Jun 2022
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    Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
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    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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    Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts
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    Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTD
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    Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators
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  172. May 2022
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    AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma
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    Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging
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    A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    Nde1 is required for heterochromatin compaction and stability in neocortical neurons
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  178. Apr 2022
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    Sister chromatid–sensitive Hi-C to map the conformation of replicated genomes
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    H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
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    CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair
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    Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors
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    Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks
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    MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells
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    The roles of RNA helicases in DNA damage repair and tumorigenesis reveal precision therapeutic strategies
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  186. Mar 2022
  187. www.embopress.org www.embopress.org
    K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
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    ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression
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    Force-generating apoptotic cells orchestrate avian neural tube bending
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    Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner
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    Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation
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    Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity
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    Sesquiterpene Lactones Potentiate Olaparib-Induced DNA Damage in p53 Wildtype Cancer Cells
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    Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis
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    RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair
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    WASH interacts with Ku to regulate DNA double-stranded break repair
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    Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  201. Dec 2021
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    Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining
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    Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage
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    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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    Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
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    Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1
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    Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
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    RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair
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    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
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    Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability
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    Prediction and identification of synergistic compound combinations against pancreatic cancer cells
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    The 3′-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching
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