415 Matching Annotations
  1. Aug 2021
  2. www.sciencedirect.com www.sciencedirect.com
    BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication
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    1. scibot 09 Aug 2021
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    sciencedirect.com/science/article/pii/S2211124718316838
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    1. scibot 08 Aug 2021
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    sciencedirect.com/science/article/pii/S2211124718314062
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    Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration
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    1. scibot 08 Aug 2021
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      DOI: 10.1016/j.chom.2018.08.002

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    sciencedirect.com/science/article/pii/S193131281830430X
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 07 Aug 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC6039718/
  6. www.embopress.org www.embopress.org
    Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway
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    1. scibot 06 Aug 2021
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      DOI: 10.15252/embj.2020107413

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    embopress.org/doi/abs/10.15252/embj.2020107413
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 05 Aug 2021
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      DOI: 10.1016/j.stem.2018.05.003

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    ncbi.nlm.nih.gov/pmc/articles/PMC5988582/
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.neuron.2018.09.044

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    ncbi.nlm.nih.gov/pmc/articles/PMC6277851/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6286383/
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.molcel.2018.11.001

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    ncbi.nlm.nih.gov/pmc/articles/PMC6344341/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 03 Aug 2021
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      DOI: 10.1016/j.stem.2019.02.019

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    ncbi.nlm.nih.gov/pmc/articles/PMC6458988/
  12. europepmc.org europepmc.org
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    1. scibot 03 Aug 2021
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      DOI: 10.7554/eLife.38771

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    europepmc.org/articles/PMC6037479/
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    Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2
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    1. scibot 02 Aug 2021
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      DOI: 10.1016/j.molcel.2018.05.018

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    sciencedirect.com/science/article/pii/S1097276518303927
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    Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer
    1
    1. scibot 01 Aug 2021
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      DOI: 10.1016/j.molcel.2018.04.023

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    sciencedirect.com/science/article/pii/S1097276518303459
  15. Jul 2021
  16. www.sciencedirect.com www.sciencedirect.com
    The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis
    1
    1. scibot 31 Jul 2021
      Mouse Anti-phospho Histone H2A.X (Ser139) conjugated with Alexa Fluor 647

      DOI: 10.1016/j.cub.2019.11.064

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    sciencedirect.com/science/article/pii/S0960982219315660
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning
    1
    1. scibot 31 Jul 2021
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      DOI: 10.7554/eLife.39304

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    ncbi.nlm.nih.gov/pmc/articles/PMC6345566/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 30 Jul 2021
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      DOI: 10.1016/j.molcel.2018.08.042

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    ncbi.nlm.nih.gov/pmc/articles/PMC6242708/
  19. www.sciencedirect.com www.sciencedirect.com
    ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links
    1
    1. scibot 28 Jul 2021
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      DOI: 10.1016/j.celrep.2018.08.019

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    sciencedirect.com/science/article/pii/S2211124718312737
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    An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion
    1
    1. scibot 28 Jul 2021
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      DOI: 10.1016/j.stem.2018.05.003

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    sciencedirect.com/science/article/pii/S1934590918302212
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    A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals
    1
    1. scibot 28 Jul 2021
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      DOI: 10.1016/j.molcel.2018.08.007

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    sciencedirect.com/science/article/pii/S1097276518306415
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages
    2
    1. scibot 28 Jul 2021
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      DOI: 10.7554/eLife.24655

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    2. scibot 28 Jul 2021
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      DOI: 10.7554/eLife.24655

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    ncbi.nlm.nih.gov/pmc/articles/PMC5409825/
  23. www.sciencedirect.com www.sciencedirect.com
    Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING
    1
    1. scibot 23 Jul 2021
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      DOI: 10.1016/j.celrep.2021.109412

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    sciencedirect.com/science/article/pii/S2211124721008251
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Perturbed DNA methylation by Gadd45b induces chromatin disorganization, DNA strand breaks and dopaminergic neuron death
    1
    1. scibot 21 Jul 2021
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      DOI: 10.1016/j.isci.2021.102756

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    ncbi.nlm.nih.gov/pmc/articles/PMC8264156/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor
    1
    1. scibot 14 Jul 2021
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      DOI: 10.7554/eLife.69454

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    ncbi.nlm.nih.gov/pmc/articles/PMC8260222/
  26. www.sciencedirect.com www.sciencedirect.com
    Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action
    1
    1. scibot 14 Jul 2021
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      DOI: 10.1016/j.celrep.2021.109383

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    sciencedirect.com/science/article/pii/S2211124721007816
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    FANCI functions as a repair/apoptosis switch in response to DNA crosslinks
    1
    1. scibot 13 Jul 2021
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      DOI: 10.1016/j.devcel.2021.06.010

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    sciencedirect.com/science/article/pii/S1534580721005177
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    Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
    1
    1. scibot 09 Jul 2021
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      DOI: 10.1016/j.molcel.2021.06.016

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    sciencedirect.com/science/article/pii/S1097276521004962
  29. www.sciencedirect.com www.sciencedirect.com
    EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart
    1
    1. scibot 03 Jul 2021
      05-636

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    sciencedirect.com/science/article/pii/S1097276521004202
  30. www.cell.com www.cell.com
    Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
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    1. scibot 03 Jul 2021
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      DOI: 10.1016/j.molcel.2021.06.011

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    cell.com/molecular-cell/fulltext/S1097-2765(21)00458-5
  31. Jun 2021
  32. www.sciencedirect.com www.sciencedirect.com
    The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair
    1
    1. scibot 30 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109306

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    sciencedirect.com/science/article/pii/S2211124721006823
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    Translation stress and collided ribosomes are co-activators of cGAS
    1
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    sciencedirect.com/science/article/pii/S1097276521004020
  34. www.nature.com www.nature.com
    The SUN1-SPDYA interaction plays an essential role in meiosis prophase I
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      DOI: 10.1038/s41467-021-23550-w

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    nature.com/articles/s41467-021-23550-w
  35. May 2021
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC8170441/
  37. link.springer.com link.springer.com
    In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration
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      DOI: 10.1186/s40478-021-01200-y

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    link.springer.com/article/10.1186/s40478-021-01200-y
  38. www.sciencedirect.com www.sciencedirect.com
    Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy
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    1. scibot 20 May 2021
      mouse monoclonal anti-phospho-H2A.X (Ser139)

      DOI: 10.1016/j.dnarep.2021.103136

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    sciencedirect.com/science/article/pii/S1568786421000926
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    Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development
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      DOI: 10.1016/j.stem.2021.04.030

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    sciencedirect.com/science/article/pii/S193459092100206X
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    Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis
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      DOI: 10.1016/j.chom.2021.04.006

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    sciencedirect.com/science/article/pii/S1931312821001827
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    Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin
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      DOI: 10.1016/j.stem.2020.10.012

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    sciencedirect.com/science/article/pii/S1934590920305063
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    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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    sciencedirect.com/science/article/pii/S1097276521001684
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    Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response
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    sciencedirect.com/science/article/pii/S109727652030647X
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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging
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    Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
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    DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation
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    TMPRSS11a is a novel age‐altered, tissue specific regulator of migration and wound healing
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  49. Apr 2021
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    p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)
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    Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells
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    A Genetic Map of the Response to DNA Damage in Human Cells
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      Mouse monoclonal anti-γH2AX

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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors
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    Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
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    Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
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    Influence of the microenvironment on modulation of the host response by typhoid toxin
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    SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
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  58. Mar 2021
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    DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1
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    TRPS1 drives heterochromatic origin refiring and cancer genome evolution
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    Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decisions
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    The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks
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    A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
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    ER-directed TREX1 limits cGAS activation at micronuclei
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    MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
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  66. Feb 2021
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    A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia
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    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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    Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double strand break repair
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    Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51
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  71. Jan 2021
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    A FOXO-dependent replication checkpoint restricts proliferation of damaged cells
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    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
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    The Essential Function of SETDB1 in Homologous Chromosome Pairing and Synapsis during Meiosis
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    MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
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    DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks
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  77. Dec 2020
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    RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions
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    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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    WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin
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    Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics
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  82. Nov 2020
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    Release from cell cycle arrest with Cdk4/6 inhibitors generates highly synchronized cell cycle progression in human cell culture
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    PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage
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    The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells
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      Anti-γH2AX

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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment
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      DOI: 10.7554/eLife.57117

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  87. Oct 2020
  88. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest
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  89. Sep 2020
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    The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells
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    Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase
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    Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner
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    Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes
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    Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity
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    Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice
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    L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis
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    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
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    Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication
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    PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
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    Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
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    Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles
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    CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma
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    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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    Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability
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    FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function
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    Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment
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    Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via Its Interaction with TDRD12
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    MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis
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      mouse anti-phospho-Histone H2A.X

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    Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne
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    Zygotic Nuclear F-Actin Safeguards Embryonic Development
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      anti-γH2AX mouse monoclonal

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    Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase
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    Parvovirus Minute Virus of Mice Interacts with Sites of Cellular DNA Damage to Establish and Amplify its Lytic Infection
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    Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability
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    Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage
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  120. Jan 2020
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    CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons
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  122. www.eneuro.org www.eneuro.org
    Homeoprotein Neuroprotection of Embryonic Neuronal Cells
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    The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
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    SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing
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    Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
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    Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
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    Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition
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    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
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    TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
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    PCNA Unloading Is Negatively Regulated by BET Proteins
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    Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations
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    LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL
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    Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks
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    Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21
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    The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis
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    DNA Damage Activates TGF-β Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TβRII
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    A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
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    Quiescent Cells Actively Replenish CENP-A Nucleosomes to Maintain Centromere Identity and Proliferative Potential
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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    Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection
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    DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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    TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency
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    MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network
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    Viral vector‐mediated Cre recombinase expression in substantia nigra induces lesions of the nigrostriatal pathway associated with perturbations of dopamine‐related behaviors and hallmarks of programmed cell death
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    High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells
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    Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence
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    Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks
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    The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage
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    Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts
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    Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration
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      (Millipore Cat# 05-636, RRID:AB_309864)

      SciCrunch record: RRID:AB_309864

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_309864 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S0092867417305901
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    TERRA RNA Antagonizes ATRX and Protects Telomeres
    1
    1. scibot 08 Nov 2017
      Mouse monoclonal anti-phospho-Histone H2A.X (Ser139)EMD MilliporeCat#05-636

      Curator: @Jmenke

      Resource used:

      (Millipore Cat# 05-636, RRID:AB_309864)

      SciCrunch record: RRID:AB_309864

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_309864 RRIDCUR:Missing
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    URL

    sciencedirect.com/science/article/pii/S0092867417307006