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    Implications of noncoding regulatory functions in the development of insulinomas
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  3. Jul 2024
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    Cell-type-specific loops linked to RNA polymerase II elongation in human neural differentiation
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  5. Jun 2024
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    A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis
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  7. May 2024
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    Reciprocal conversion between annual and polycarpic perennial flowering behavior in the Brassicaceae
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    Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration
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  10. Mar 2024
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    Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency
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    Alternative splicing decouples local from global PRC2 activity
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  13. Feb 2024
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    A SUMO E3 ligase promotes long non-coding RNA transcription to regulate small RNA-directed DNA elimination
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  15. Jan 2024
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    Optimizing rice grain size by attenuating phosphorylation-triggered functional impairment of a chromatin modifier ternary complex
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    Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate
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    XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells
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  19. Nov 2023
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    Lineage-specific 3D genome organization is assembled at multiple scales by IKAROS
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  21. Oct 2023
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    Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells
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    Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritis
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    ZEB2 and MEIS1 independently contribute to hematopoiesis via early hematopoietic enhancer activation
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  25. Aug 2023
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    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    Histone variants shape chromatin states in Arabidopsis
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  28. Jul 2023
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    Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis
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    The default and directed pathways of hepatoblast differentiation involve distinct epigenomic mechanisms
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    Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease
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    TONSOKU is required for the maintenance of repressive chromatin modifications in Arabidopsis
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  33. Jun 2023
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    Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing
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    An EZH2-NF-κB Regulatory Axis Drives Expression of Pro-Oncogenic Gene Signatures in Triple Negative Breast Cancer
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    sciencedirect.com/science/article/pii/S2589004223011926
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    Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis
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  37. May 2023
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    Epigenetic reprogramming of imprinting at meiosis
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    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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  40. Apr 2023
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    Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures
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    MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer
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    sciencedirect.com/science/article/pii/S2666379123001167
  43. Mar 2023
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    ATXN3 controls DNA replication and transcription by regulating chromatin structure
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad212/7086677
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    Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1
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    europepmc.org/article/med/36924502
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    A pair of readers of bivalent chromatin mediate formation of Polycomb-based “memory of cold” in plants
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    JMJ28 guides sequence-specific targeting of ATX1/2-containing COMPASS-like complex in Arabidopsis
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    sciencedirect.com/science/article/pii/S2211124723001742
  48. Feb 2023
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    Efficient generation of marmoset primordial germ cell-like cells using induced pluripotent stem cells
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      DOI: 10.7554/eLife.82263

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    ncbi.nlm.nih.gov/pmc/articles/PMC9937652/
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    PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9388591/
  51. Jan 2023
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    Loss of epigenetic information as a cause of mammalian aging
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    sciencedirect.com/science/article/pii/S0092867422015707
  53. Dec 2022
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    Hypoxia induces transgenerational epigenetic inheritance of small RNAs
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    sciencedirect.com/science/article/pii/S2211124722016886
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    Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis and promotes breast cancer
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      DOI: 10.1158/2159-8290.CD-21-0865

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    aacrjournals.org/cancerdiscovery/article/12/12/2930/711188/Loss-of-Epigenetic-Regulation-Disrupts-Lineage
  56. Nov 2022
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    The target antigen determines the mechanism of acquired resistance to T cell-based therapies
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    Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor
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    Polycomb-mediated repression of paternal chromosomes maintains haploid dosage in diploid embryos of Marchantia
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    Transcription factors TCF-1 and GATA3 are key factors for the epigenetic priming of early innate lymphoid progenitors toward distinct cell fates
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    Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
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    Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells
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    Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration
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    SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity
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    Coordinated maintenance of H3K36/K27 methylation by histone demethylases preserves germ cell identity and immortality
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    Identification of the sex-determining factor in the liverwort Marchantia polymorpha reveals unique evolution of sex chromosomes in a haploid system
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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
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    Discrete cis-acting element regulates developmentally timed gene-lamina relocation and neural progenitor competence in vivo
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    Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
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    Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules
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    SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States
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    Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas
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    A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus
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    Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
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  127. Jun 2021
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  130. May 2021
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    Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome
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    Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
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    Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation
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    Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation
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    Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas
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    H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model
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  151. Feb 2021
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    Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use
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    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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    Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive Heterochromatin
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  155. Jan 2021
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    Deleting Mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice
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    Regulatory Elements Inserted into AAVs Confer Preferential Activity in Cortical Interneurons
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  158. Dec 2020
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    Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency
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  160. Nov 2020
  161. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors
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  162. Sep 2020
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    The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators
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    Silencing Trisomy 21 with XIST in Neural Stem Cells Promotes Neuronal Differentiation
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    Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer
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    Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive Heterochromatin
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    Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells
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    A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells
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    PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells
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    Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits
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    Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development
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    PRC2 Acts as a Critical Timer That Drives Oligodendrocyte Fate over Astrocyte Identity by Repressing the Notch Pathway
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    Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity
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    Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas
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    Gallic acid attenuates blood-spinal cord barrier disruption by inhibiting Jmjd3 expression and activation after spinal cord injury
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    Chromatin Immunoprecipitation of Low Number of FACS-Purified Epidermal Cells
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    Superresolution imaging of chromatin fibers to visualize epigenetic information on replicative DNA
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    LINE-1 specific nuclear organization in mice olfactory sensory neurons
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    Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters
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    Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development
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  181. Jan 2020
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    Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy
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    H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis
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    Quantitative Multiplexed ChIP Reveals Global Alterations that Shape Promoter Bivalency in Ground State Embryonic Stem Cells
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    Nucleome Dynamics during Retinal Development
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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    Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells
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    CoBATCH for High-Throughput Single-Cell Epigenomic Profiling
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    Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung
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    Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression
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    ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures
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    Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms
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    PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression
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    Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
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    HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice
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    The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability
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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation
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    The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression
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    Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf
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    Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG
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    DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns
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    Cooperation of PU.1 With IRF8 and NFATc1 Defines Chromatin Landscapes During RANKL‐Induced Osteoclastogenesis
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    Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques
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    Global epigenetic analysis of BDNF Val66Met mice hippocampus reveals changes in dendrite and spine remodeling genes
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    MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis
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    Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells
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    Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses
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    Architectural Proteins and Pluripotency Factors Cooperate to Orchestrate the Transcriptional Response of hESCs to Temperature Stress
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    Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia
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    A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities
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    RNA-Dependent Epigenetic Silencing Directs Transcriptional Downregulation Caused by Intronic Repeat Expansions
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    Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development
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    Cross Talk between One-Carbon Metabolism, Eph Signaling, and Histone Methylation Promotes Neural Stem Cell Differentiation
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    Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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    Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males
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    Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors
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    Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells
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    PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification
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