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NicheSphere reveals an Spp1-centered multicellular niche in myeloproliferative neoplasm-associated fibrosis

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1. scibot 16 Oct 2026
  
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  DOI: 10.1016/j.cpblue.2026.100146
  
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sciencedirect.com/science/article/pii/S3051383926001441
Sep 2026
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P2X7R+CD8αβ+ T cells exacerbate postoperative ileus by inducing the loss of enterochromaffin cells

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1. scibot 19 Sep 2026
  
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sciencedirect.com/science/article/pii/S2589004226028701
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Endothelial PERK restricts lymphoid regeneration by reducing DLL4-NOTCH3 signaling at the Pre-B niche

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1. scibot 11 Sep 2026
  
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  DOI: 10.1016/j.celrep.2026.117953
  
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sciencedirect.com/science/article/pii/S2211124726010314
Aug 2026
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

d-Sorbose Promotes Regulatory T-Cell Differentiation and Ameliorates Autoimmune and Allergic Diseases via Hexosamine Biosynthetic Pathway Inhibition

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1. scibot 30 Aug 2026
  
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  DOI: 10.1096/fj.202601110R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202601110R
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Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune-stromal interactions as a therapeutic target

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1. scibot 28 Aug 2026
  
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  DOI: 10.1016/j.stem.2026.07.012
  
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sciencedirect.com/science/article/pii/S1934590926002729
Jun 2026
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De novo pyrimidine synthesis controls germinal center B cell and plasma cell fates and systemic autoimmunity

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1. scibot 25 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117587
  
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sciencedirect.com/science/article/pii/S2211124726006650
May 2026
www-cell-com.eproxy.lib.hku.hk www-cell-com.eproxy.lib.hku.hk

Whole-genome doubling drives immune evasion by silencing antigen presentation

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1. scibot 08 May 2026
  
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  DOI: 10.1016/j.ccell.2026.04.007
  
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www-cell-com.eproxy.lib.hku.hk/cancer-cell/fulltext/S1535-6108(26)00218-7
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mRNA lipid-nanoparticle-mediated mitochondrial apoptosis augments adoptive T cell immunotherapy

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1. scibot 06 May 2026
  
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  DOI: 10.1016/j.xcrm.2026.102706
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13130659/
Apr 2026
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Tumor-intrinsic FDFT1 determines coordinated macrophage anti-tumor immunity

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1. scibot 30 Apr 2026
  
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  DOI: 10.1016/j.devcel.2026.04.003
  
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sciencedirect.com/science/article/pii/S1534580726001504
Mar 2026
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Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102704
  
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sciencedirect.com/science/article/pii/S2666379126001217
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IL-4 treatment induces apoptosis of blood monocytes and proliferation of recruited injury-associated macrophages to resolve liver injury

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1. scibot 24 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117136
  
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sciencedirect.com/science/article/pii/S2211124726002147
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Ferritin aggregation cell engager for CAR T avidity engineering against refractory leukemias

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1. scibot 10 Mar 2026
  
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  DOI: 10.1016/j.cell.2026.02.005
  
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sciencedirect.com/science/article/pii/S0092867426001704
Feb 2026
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Fatty acid uptake mediated by FABP4 promotes the formation of CD8+T cell senescence through lipid peroxidation in the adipocyte-rich microenvironment of Ovarian Cancer

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1. scibot 19 Feb 2026
  
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  DOI: 10.1038/s41389-026-00600-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12905430/
Jan 2026
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MyD88 signaling in myeloid cells induces gastrointestinal tract injury and systemic inflammation after West Nile virus infection

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116852
  
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sciencedirect.com/science/article/pii/S2211124725016249
Dec 2025
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Metformin hijacks AMPK-ERK1/2 signaling to trigger a pathogenic “selection trap” and thymic atrophy

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1. scibot 25 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116762
  
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sciencedirect.com/science/article/pii/S2211124725015347
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An innovative engineered IL-10 monomer strengthens T cell-mediated anti-tumor responses through anti-PD-1 cis-delivery

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1. scibot 17 Dec 2025
  
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  DOI: 10.1016/j.xcrm.2025.102515
  
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sciencedirect.com:5037/science/article/pii/S2666379125005889
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Keratinocyte differentiation transcription factor ZNF750 coordinates the development of epidermal immunocytes

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1. scibot 11 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116648
  
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cell.com/cell-reports/fulltext/S2211-1247(25)01420-2
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BFAR promotes neutrophil infiltration and immunosuppressive reprogramming through the PRP19-YBX1 axis to induce immune evasion in gastric cancer

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1. scibot 06 Dec 2025
  
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  AB_312663
  
  DOI: 10.1158/2326-6066.CIR-24-1011
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12670071/
Oct 2025
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Cannabidivarin directly targets the immunosuppressive activity of regulatory myeloid cells in tumors

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1. scibot 28 Oct 2025
  
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  DOI: 10.1016/j.biopha.2025.118697
  
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sciencedirect.com/science/article/pii/S0753332225008911
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Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance

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1. scibot 25 Oct 2025
  
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  DOI: 10.1016/j.cell.2025.09.029
  
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sciencedirect.com/science/article/pii/S0092867425011298
Sep 2025
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Mitochondrial-activity-driven hematopoietic stem cell fate and lineage choice is first established in the aorta-gonad-mesonephros

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sciencedirect.com/science/article/pii/S2211124725010678
Aug 2025
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Bifidobacterium animalis suppresses non-small cell lung cancer progression and modulates tumor immunity through indole-3-acetic acid

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116132
  
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sciencedirect.com/science/article/pii/S2211124725009039
Jun 2025
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Immune imprinting blunts omicron pathogenicity fluctuations and highlights the essential role of cellular immunity in SARS-CoV-2 infection

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1. scibot 05 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115784
  
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sciencedirect.com/science/article/pii/S2211124725005558
May 2025
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Myeloid-lineage-specific membrane protein LRRC25 suppresses immunity in solid tumor and is a potential cancer immunotherapy checkpoint target

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115631
  
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sciencedirect.com/science/article/pii/S2211124725004024
Apr 2025
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Single-cell and spatial transcriptomics reveal the pathogenesis of chronic granulomatous disease in a natural model

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115612
  
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sciencedirect.com/science/article/pii/S2211124725003833
Jan 2025
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Postprandial parasympathetic signals promote lung type 2 immunity

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.neuron.2024.12.020
  
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sciencedirect.com/science/article/pii/S089662732400919X
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Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance

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1. scibot 03 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115125
  
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sciencedirect.com/science/article/pii/S2211124724014761
Dec 2024
www.nature.com www.nature.com

Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner

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1. scibot 06 Dec 2024
  
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  DOI: 10.1038/s41522-024-00625-2
  
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nature.com/articles/s41522-024-00625-2
Nov 2024
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Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response

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  DOI: 10.1016/j.medj.2024.10.007
  
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sciencedirect.com/science/article/pii/S2666634024004057
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TUMOR-INFILTRATING NOCICEPTOR NEURONS PROMOTE IMMUNOSUPPRESSION

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1. scibot 18 Sep 2024
  
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  DOI: 10.1101/2024.08.23.609450
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11382997/
Aug 2024
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Engineered probiotic ameliorates ulcerative colitis by restoring gut microbiota and redox homeostasis

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1. scibot 28 Aug 2024
  
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  DOI: 10.1016/j.chom.2024.07.028
  
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sciencedirect.com/science/article/pii/S1931312824002877
Jul 2024
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Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner

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1. scibot 25 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114542
  
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  DOI: 10.1016/j.celrep.2024.114542
  
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sciencedirect.com/science/article/pii/S2211124724008714
Jun 2024
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Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss

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1. scibot 05 Jun 2024
  
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  DOI: 10.1016/j.cell.2024.05.003
  
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  RRID:AB_312663 DOI:10.1016/j.cell.2024.05.003
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sciencedirect.com/science/article/pii/S0092867424004926
May 2024
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Development of a PAK4-targeting PROTAC for renal carcinoma therapy: concurrent inhibition of cancer cell proliferation and enhancement of immune cell response

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1. scibot 30 May 2024
  
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  DOI: 10.1016/j.ebiom.2024.105162
  
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sciencedirect.com/science/article/pii/S235239642400197X
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The Gut Microbiome Controls Liver Tumors via the Vagus Nerve

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1. scibot 09 May 2024
  
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  DOI: 10.1101/2024.01.23.576951
  
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Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration

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Differentiation route determines the functional outputs of adult megakaryopoiesis

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An axon-T cell feedback loop enhances inflammation and axon degeneration

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Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution

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Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms

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FGFR3 alterations in bladder cancer stimulate serine synthesis to induce immune-inert macrophages that suppress T-cell recruitment and activation

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A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis

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can-23-1065-html.html

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Stress regulates Alzheimer’s disease progression via selective enrichment of CD8+ T cells

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Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity

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Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy

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METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy

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Systematic dissection of coordinated stromal remodeling identifies Sox10+ glial cells as a therapeutic target in myelofibrosis

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A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation

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Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis

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Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation

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An immune cell lipid atlas reveals the basis of susceptibility to ferroptosis

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Mar 2023
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Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis

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A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma

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An axon – T cell feedback loop enhances inflammation and axon degeneration

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Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

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T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

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Microbiota-dependent and -independent postnatal development of salivary immunity

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RAGE deficiency ameliorates autoimmune hepatitis involving inhibition of IL-6 production via suppressing protein Arid5a in mice

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Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease

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ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes

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Bone marrow hematopoiesis drives multiple sclerosis progression

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Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis

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Virulence factors perforate the pathogen-containing vacuole to signal efferocytosis

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Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging

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Untitled document

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A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia

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Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth

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Maturation of the neonatal oral mucosa involves unique epithelium-microbiota interactions

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Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

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sciencedirect.com:5037/science/article/pii/S1550413121001091
Mar 2021
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IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models

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1. scibot 02 Mar 2021
  
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  DOI: 10.3389/fimmu.2020.614667
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7897681/
Feb 2021
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DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity

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1. scibot 28 Feb 2021
  
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  DOI: 10.1016/j.ccell.2020.11.006
  
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Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy

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1. scibot 24 Feb 2021
  
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  DOI: 10.1016/j.celrep.2021.108751
  
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sciencedirect.com/science/article/pii/S2211124721000644
Sep 2020
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Marginal Zone Formation Requires ACKR3 Expression on B Cells

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1. scibot 23 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107951
  
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Visualization of T Cell Migration in the Spleen Reveals a Network of Perivascular Pathways that Guide Entry into T Zones

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1. scibot 17 Sep 2020
  
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  DOI: 10.1016/j.immuni.2020.03.010
  
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Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

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1. scibot 15 Sep 2020
  
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  DOI: 10.1016/j.cell.2020.02.050
  
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Jan 2020
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S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer’s Patches

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.10.091
  
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sciencedirect.com/science/article/pii/S2211124719314135
Nov 2018
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Untitled document

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SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

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