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Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis

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1. scibot 20 Aug 2026
  
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  DOI: 10.1038/s41418-026-01846-y
  
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nature.com/articles/s41418-026-01846-y
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Intratumoral Bacillus cereus orchestrates stem-like lymphoid niches to potentiate immunotherapy response in hepatocellular carcinoma

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  DOI: 10.1016/j.ccell.2026.07.016
  
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sciencedirect.com/science/article/pii/S1535610826003545
Jul 2026
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Myeloid MMP14 couples extracellular proteolysis to inflammatory and metabolic remodeling during obesity

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1. scibot 11 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117681
  
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sciencedirect.com/science/article/pii/S221112472600759X
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Neoantigens and shared MICB α3 antigen dual-targeted vaccine generates potent antitumor immunity

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  DOI: 10.1038/s44321-026-00424-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13269783/
Apr 2026
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MMRN1-EGFR drives sialylglycan-Siglec immune evasion in AML leukemia stem cells

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sciencedirect.com/science/article/pii/S1934590926001220
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Activation of T cell-intrinsic p53 by acetylation elicits antitumor immunity to boost cancer immunotherapy

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  DOI: 10.1158/2159-8290.CD-25-0649
  
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aacrjournals.org/cancerdiscovery/article/16/1/155/771238/Activation-of-T-Cell-Intrinsic-p53-by-Acetylation
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Tumor cell-derived microparticles induced by methotrexate reprogram neutrophil antitumor response via lysosomal ROS mediated degranulation

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1. scibot 23 Apr 2026
  
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  DOI: 10.1158/1541-7786.MCR-25-0615
  
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aacrjournals.org/mcr/article/24/4/293/775480/Tumor-Cell-Derived-Microparticles-Induced-by
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Pan-cancer macrophage atlas uncovers that MHC-IIhigh TAMs induce Treg activation through physical interactions

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sciencedirect.com/science/article/pii/S2211124726003086
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BPS Publications

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  DOI: 10.1111/bph.70423
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70423
Mar 2026
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Synthetic M13 phage engagers expand CAR-T cell antigen recognition to overcome tumor heterogeneity

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  DOI: 10.1016/j.tibtech.2026.02.008
  
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sciencedirect.com/science/article/pii/S0167779926000478
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IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members

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  DOI: 10.1016/j.celrep.2026.117054
  
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sciencedirect.com/science/article/pii/S2211124726001324
Feb 2026
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Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer

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1. scibot 19 Feb 2026
  
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  DOI: 10.1016/j.xcrm.2026.102621
  
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sciencedirect.com/science/article/pii/S2666379126000388
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Divergent tumor immunity determined by bacteria-cancer cell engagement

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1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.cell.2025.12.044
  
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sciencedirect.com/science/article/pii/S009286742501493X
Jan 2026
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Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin

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  DOI: 10.1016/j.cell.2025.12.043
  
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cell.com/cell/fulltext/S0092-8674(25)01492-8
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Engineered probiotics recruit CAR macrophages and establish immune memory to eradicate heterogeneous glioblastoma in mice

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1. scibot 29 Jan 2026
  
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  DOI: 10.1016/j.chom.2025.12.014
  
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sciencedirect.com/science/article/pii/S1931312825005335
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METTL3/CD98-mediated glutamate efflux in CAFs drives CD8+ T cell exhaustion and impedes neoadjuvant immunochemotherapy

1
1. scibot 29 Jan 2026
  
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  DOI: 10.1016/j.celrep.2026.116933
  
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Loss of EHMT2 enhances NK cell-driven anti-tumor immunity through TGF-β1 suppression

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1. scibot 22 Jan 2026
  
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  DOI: 10.1038/s44321-025-00357-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12808752/
Dec 2025
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Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti–PD-1 Immunotherapy

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1. scibot 03 Dec 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-3095
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12666320/
Nov 2025
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Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.devcel.2025.10.017
  
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sciencedirect.com:5037/science/article/pii/S1534580725006914
Oct 2025
54.241.53.176 54.241.53.176

2025.10.24.684274v1.full-html.html

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  DOI: 10.1101/2025.10.24.684274
  
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54.241.53.176/560b23241d86210770f41b5bc2071167c8b2fca6/2025.10.24.684274v1.full-html.html
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Development of retinoid nuclear receptor pathway antagonists through targeting aldehyde dehydrogenase 1A3

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  DOI: 10.1016/j.isci.2025.113675
  
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sciencedirect.com/science/article/pii/S2589004225019364
Sep 2025
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Adoptive macrophages suppress glioblastoma growth by reversing immunosuppressive microenvironment through programmed phenotype repolarization

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  DOI: 10.1016/j.celrep.2025.116350
  
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Comparison of immunogenicity and protection efficacy of self-amplifying and circular mRNA vaccines against SARS-CoV-2

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  DOI: 10.1016/j.isci.2025.113498
  
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RSK1 reprograms the ubiquitin pathway to promote immune suppression

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  DOI: 10.1016/j.celrep.2025.116323
  
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sciencedirect.com/science/article/pii/S2211124725010940
Aug 2025
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Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene

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  DOI: 10.1016/j.xgen.2025.100978
  
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sciencedirect.com/science/article/pii/S2666979X25002344
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Caveolin-1/PPARα axis suppresses T follicular helper cell response in primary Sjögren disease

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  DOI: 10.1016/j.celrep.2025.116156
  
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52.53.155.43 52.53.155.43

1-s2.0-S2589004225010338-main-html.html

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52.53.155.43/8b0897d2d35a8ab9ab351db77e0eeb32b8358112/1-s2.0-S2589004225010338-main-html.html
Jul 2025
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CINTER-seq: Chemical profiling reveals interaction-dependent cell landscapes and gene signatures in vivo

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  DOI: 10.1016/j.immuni.2025.06.011
  
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sciencedirect.com/science/article/pii/S1074761325002808
Mar 2025
www.cell.com www.cell.com

Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity

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  DOI: 10.1016/j.xcrm.2025.102035
  
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cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00108-9
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The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation

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  DOI: 10.1016/j.immuni.2025.02.011
  
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sciencedirect.com/science/article/pii/S1074761325000780
Jan 2025
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Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infection

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  DOI: 10.1016/j.chom.2024.12.017
  
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Targeting the mevalonate pathway potentiates NUAK1 inhibition-induced immunogenic cell death and antitumor immunity

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  DOI: 10.1016/j.xcrm.2024.101913
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866496/
Dec 2024
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Neoadjuvant chemotherapy by liposomal doxorubicin boosts immune protection of tumor membrane antigens-based nanovaccine

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  DOI: 10.1016/j.xcrm.2024.101877
  
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sciencedirect.com/science/article/pii/S2666379124006487
Nov 2024
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Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy

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  DOI: 10.1016/j.xcrm.2024.101751
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11513825/
Sep 2024
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Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.ccell.2024.08.018
  
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sciencedirect.com/science/article/pii/S1535610824003179
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

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1. scibot 22 Aug 2024
  
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  DOI: 10.7554/eLife.93273
  
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Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity

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Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening

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A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

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Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity

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Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21

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Adipose stem cells control obesity-induced T cell infiltration into adipose tissue

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Feb 2024
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T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections

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Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche

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Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor

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Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells

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Ascomylactam C Induces an Immunogenic Cell Death Signature via Mitochondria-Associated ER Stress in Lung Cancer and Melanoma

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Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses

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Endogenous CCL21-Ser deficiency reduces B16–F10 melanoma growth by enhanced antitumor immunity

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SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification

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CCL21-Ser expression in melanoma cells recruits CCR7+ naïve T cells to tumor tissues and promotes tumor growth

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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection

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ERK Inhibition Promotes Engraftment of Allografts by Reprogramming T-Cell Metabolism

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Mar 2023
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Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis

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Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions

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Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation

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Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages

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Immunostaining of tumor-infiltrating immune-cell-related markers and cytokines in the tumor fractional radiation model of host PD-L1-deficient mice

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MYC-mediated silencing of miR-181a-5p promotes pathogenic Th17 responses by modulating AKT3-FOXO3 signaling

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Phospholipid metabolites of the gut microbiota promote hypoxia-induced intestinal injury via CD1d-dependent γδ T cells

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Jul 2022
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Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING mediated T cell activation

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Poroptosis: a form of cell death depending on plasma membrane nanopores formation

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May 2022
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Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases

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Nov 2021
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Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice

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6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

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Aug 2021
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ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis

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Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging

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Untitled document

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Untitled document

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Untitled document

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An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis

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A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus

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Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells

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Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

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UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability

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Self-renewal of double-negative 3 early thymocytes enables thymus autonomy but compromises the β-selection checkpoint

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Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function

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Dynamic adoption of anergy by antigen-exhausted CD4+ T cells

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Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation

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Cell Competition, the Kinetics of Thymopoiesis, and Thymus Cellularity Are Regulated by Double-Negative 2 to 3 Early Thymocytes

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Multi-lineage Lung Regeneration by Stem Cell Transplantation across Major Genetic Barriers

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Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function

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C9orf72 in myeloid cells suppresses STING-induced inflammation

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Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation

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Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

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TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases

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IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection

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ebiomedicine.com/article/S2352-3964(17)30347-X/abstract
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Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells

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Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection.

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Nov 2017
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Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate

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Follicular Helper T Cells are Essential for the Elimination of Plasmodium Infection - ScienceDirect

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IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

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