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Engineered receptor-biased IL-2–drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy

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  DOI: 10.1016/j.xcrm.2026.103127
  
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sciencedirect.com/science/article/pii/S2666379126005446
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Transcriptomic conservation defines autoimmune stem-like T cells and uncovers their dependence on Apex1

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  DOI: 10.1016/j.isci.2026.118067
  
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sciencedirect.com/science/article/pii/S2589004226034504
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A sex-specific platelet switch controls anti-tumor immunity in glioblastoma

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  DOI: 10.1016/j.ccell.2026.10.004
  
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sciencedirect.com/science/article/pii/S1535610826004708
Oct 2026
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Host metadherin coordinates hepatic lipid metabolism and CD8+ T cell immunity to promote tumor progression

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pmc.ncbi.nlm.nih.gov/articles/PMC13623212/
Sep 2026
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A pulmonary innate lymphoid cell-driven serotonergic neuroimmune axis orchestrates airway hyperreactivity and cough hypersensitivity

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1. scibot 09 Sep 2026
  
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  DOI: 10.1016/j.immuni.2026.08.004
  
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sciencedirect.com/science/article/pii/S1074761326003419
Aug 2026
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Host metadherin coordinates hepatic lipid metabolism and CD8+ T cell immunity to promote tumor progression

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pmc.ncbi.nlm.nih.gov/articles/PMC13623212/
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Lactobacillus salivarius potentiates gastrointestinal cancer immunotherapy through its metabolite chenodeoxycholic acid

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1. scibot 30 Aug 2026
  
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  DOI: 10.1016/j.xcrm.2026.103009
  
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sciencedirect.com/science/article/pii/S266637912600426X
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Targeting of tripartite neuron-cancer-immune cell crosstalk augments response to chemotherapy and immunotherapy

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  DOI: 10.1016/j.xcrm.2026.102994
  
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sciencedirect.com/science/article/pii/S2666379126004118
May 2026
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Fungal metabolite-based immunotherapy overcomes tumor-associated macrophage immunosuppression

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1. scibot 27 May 2026
  
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  DOI: 10.1016/j.xcrm.2026.102833
  
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sciencedirect.com/science/article/pii/S2666379126002508
Apr 2026
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Integrated analysis of stemness-associated immune modulatory circuits in squamous cell carcinomas

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1. scibot 10 Apr 2026
  
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  DOI: 10.64898/2026.04.02.716182
  
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biorxiv.org/content/10.64898/2026.04.02.716182v1
Mar 2026
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Collagen-bearing exosomes from breast cancer-associated fibroblasts promote T cell dysfunction

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1. scibot 26 Mar 2026
  
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  DOI: 10.1158/2767-9764.CRC-25-0259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13012019/
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TCR-NF-κB signaling activates the SENP1-NR4A1 axis to fine-tune effector activation of CD8+ T cells

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1. scibot 17 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117102
  
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sciencedirect.com/science/article/pii/S2211124726001804
Jan 2026
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IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma

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1. scibot 23 Jan 2026
  
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  DOI: 10.1016/j.ccell.2025.12.019
  
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IgG2c subclass dominance drives fatal lupus-like nephritis via FcγR and complement activation

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116775
  
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sciencedirect.com/science/article/pii/S2211124725015475
Dec 2025
54.241.53.176 54.241.53.176

1-s2.0-S2589004225026768-main-html.html

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1. scibot 23 Dec 2025
  
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54.241.53.176/ae86a4d7bd2bb12007a33d73a877aa48c665ccf6/1-s2.0-S2589004225026768-main-html.html
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Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche

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1. scibot 13 Dec 2025
  
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  DOI: 10.1016/j.ccell.2025.11.001
  
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sciencedirect.com:5037/science/article/pii/S1535610825004945
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BFAR promotes neutrophil infiltration and immunosuppressive reprogramming through the PRP19-YBX1 axis to induce immune evasion in gastric cancer

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1. scibot 06 Dec 2025
  
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  DOI: 10.1158/2326-6066.CIR-24-1011
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12670071/
Oct 2025
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In situ extended immune activation instantly after tumor resection by oncolytic virus controls postoperative tumor recurrence

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.xcrm.2025.102399
  
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sciencedirect.com/science/article/pii/S2666379125004720
Aug 2025
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TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity

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1. scibot 19 Aug 2025
  
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  DOI: 10.1186/s13046-025-03513-5
  
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jeccr.biomedcentral.com/articles/10.1186/s13046-025-03513-5
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DNASE1L3-expressing dendritic cells promote CD8+ T cell function and anti-PD-(L)1 therapy efficacy by degrading neutrophil extracellular traps

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.014
  
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cell.com/cancer-cell/abstract/S1535-6108(25)00320-4
Jun 2025
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MET pathway inhibition increases chemo-immunotherapy efficacy in small cell lung cancer

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  DOI: 10.1016/j.xcrm.2025.102194
  
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sciencedirect.com/science/article/pii/S2666379125002678
May 2025
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Overcoming NK-mediated rejection by anti-3rd-party central memory veto CD8 T cells through downregulation of DNAM-1 on alloreactive NK cells

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115674
  
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sciencedirect.com/science/article/pii/S2211124725004450
Apr 2025
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KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115595
  
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sciencedirect.com/science/article/pii/S2211124725003663
52.53.155.43 52.53.155.43

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1. scibot 13 Apr 2025
  
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  DOI: 10.1101/2025.04.04.647324
  
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52.53.155.43/4c68cb20c96f9831d654e32b29866141bc56f76e/PDF-html.html
Mar 2025
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Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis

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1. scibot 04 Mar 2025
  
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Feb 2025
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NFAT single-deficient murine T cells reduce the risk of aGvHD while controlling cytomegalovirus infection

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1. scibot 13 Feb 2025
  
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  DOI: 10.1016/j.isci.2025.111937
  
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Jan 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225000641-main-html.html

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52.53.155.43/bb0038ac4731f895cea6a9b8553ebcc516f55d21/1-s2.0-S2589004225000641-main-html.html
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Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infection

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.chom.2024.12.017
  
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sciencedirect.com/science/article/pii/S1931312824004840
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High-resolution mapping of cell cycle dynamics during steady-state T cell development and regeneration in vivo

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  DOI: 10.1016/j.celrep.2024.115132
  
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Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance

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  DOI: 10.1016/j.celrep.2024.115125
  
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sciencedirect.com/science/article/pii/S2211124724014761
Dec 2024
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Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells

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1. scibot 20 Dec 2024
  
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  DOI: 10.1126/scisignal.adi8753
  
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science.org/doi/10.1126/scisignal.adi8753
Aug 2024
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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.cmet.2017.10.006
  
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sciencedirect.com/science/article/pii/S1550413117306186
Jul 2024
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Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor

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1. scibot 30 Jul 2024
  
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  DOI: 10.1016/j.chom.2024.06.010
  
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cell.com/cell-host-microbe/abstract/S1931-3128(24)00228-2
May 2024
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Intestinal CXCR6+ ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression

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1. scibot 30 May 2024
  
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  DOI: 10.1016/j.immuni.2024.05.004
  
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sciencedirect.com/science/article/pii/S1074761324002553
Apr 2024
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CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.immuni.2024.04.003
  
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sciencedirect.com/science/article/pii/S1074761324002085
Jan 2024
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Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells

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1. scibot 19 Jan 2024
  
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  DOI: 10.1016/j.xcrm.2023.101377
  
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The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer

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Unedited allogeneic iNKT cells show extended persistence in MHC-mismatched canine recipients

1
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High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma

1
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High-resolution mapping of cell-cycle dynamics during steady-state T-cell development and regeneration in vivo

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Low dietary fiber intake impairs small intestinal Th17 and intraepithelial T cell development over generations

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QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations

1
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Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation

1
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A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity

1
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Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment

1
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A hypometabolic defense strategy against malaria

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Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes

1
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The altering cellular components and function in tumor microenvironment during remissive and relapsed stages of anti-CD19 CAR T-cell treated lymphoma mice

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Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake

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Across-cancer immune responses induced by nanovaccines or microvaccines to prevent different cancers and cancer metastasis

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The ketone body β-hydroxybutyrate mitigates ILC2-driven airway inflammation by regulating mast cell function

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Quantitative Increase in T Regulatory Cells Enhances Bone Remodeling in Osteogenesis Imperfecta

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Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis

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Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function

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  DOI: 10.1158/0008-5472.CAN-21-3155
  
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Apr 2022
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TNFɑ Antagonist in Combination with PD-1 Blocker to Prevent or Retard Malignant Transformation of B[a]P-induced Chronic Lung Inflammation

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Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer

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AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells

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Cold exposure protects from neuroinflammation through immunologic reprogramming

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Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis

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Untitled document

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Untitled document

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Untitled document

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Untitled document

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Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection

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Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity

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Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

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CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance

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Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation

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NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

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Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity

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Self-renewal of double-negative 3 early thymocytes enables thymus autonomy but compromises the β-selection checkpoint

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sciencedirect.com/science/article/pii/S2211124721002813
Feb 2021
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Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction

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1. scibot 25 Feb 2021
  
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  RRID:AB_312707
  
  DOI: 10.1016/j.immuni.2017.11.003
  
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cell.com/immunity/abstract/S1074-7613(17)30480-6
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Dynamic adoption of anergy by antigen-exhausted CD4+ T cells

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1. scibot 10 Feb 2021
  
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  RRID:AB_312707
  
  DOI: 10.1016/j.celrep.2021.108748
  
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cell.com/cell-reports/fulltext/S2211-1247(21)00061-9
Sep 2020
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Cell Competition, the Kinetics of Thymopoiesis, and Thymus Cellularity Are Regulated by Double-Negative 2 to 3 Early Thymocytes

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1. scibot 26 Sep 2020
  
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  RRID:AB_312707
  
  DOI: 10.1016/j.celrep.2020.107910
  
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sciencedirect.com/science/article/pii/S2211124720308913
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Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth

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1. scibot 23 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107628
  
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sciencedirect.com/science/article/pii/S2211124720305817
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Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

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1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.stem.2019.12.006
  
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sciencedirect.com/science/article/pii/S1934590919305247
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Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts

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1. scibot 14 Sep 2020
  
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  DOI: 10.1016/j.cell.2020.07.019
  
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sciencedirect.com/science/article/pii/S0092867420308849
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Distinct Waves from the Hemogenic Endothelium Give Rise to Layered Lymphoid Tissue Inducer Cell Ontogeny

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1. scibot 14 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108004
  
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sciencedirect.com/science/article/pii/S221112472030989X
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Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

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1. scibot 09 Sep 2020
  
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  DOI: 10.7554/eLife.58463
  
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elifesciences.org/articles/58463
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Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles

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1. scibot 03 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107756
  
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sciencedirect.com/science/article/pii/S2211124720307361
Jan 2020
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cmet.2019.01.019
  
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sciencedirect.com/science/article/pii/S1550413119300191
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Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.chom.2019.03.003
  
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sciencedirect.com/science/article/pii/S1931312819301155
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_312707
  
  DOI: 10.1016/j.molcel.2019.02.013
  
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sciencedirect.com/science/article/pii/S1097276519301030
Nov 2018
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CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1934590918300171
onlinelibrary.wiley.com onlinelibrary.wiley.com

Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis

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1. scibot 05 Nov 2018
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14294/full
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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1550413117306186
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Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction

1
1. scibot 05 Nov 2018
  
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  RRID:AB_312707
  
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sciencedirect.com/science/article/pii/S1074761317304806

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