127 Matching Annotations
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    Uncovering the individual immunotherapeutic roles of PTPN1 and PTPN2 in T cells during dual inhibition
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    sciencedirect.com/science/article/pii/S2589004225018711
  3. Oct 2025
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    Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis
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  5. Sep 2025
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    A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer
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  7. Aug 2025
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    The absence of IL17A favours cytotoxic cell function and improves antigen-specific immunotherapies in pancreatic adenocarcinoma
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    Stress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells
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  10. Jul 2025
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    Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors
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    The knockout of Moesin leads to excess microglia-mediated synaptic pruning and impairs social novelty in a mouse model
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    Activity-attenuated serum albumin-fused interleukin-33 suppresses experimental autoimmune encephalomyelitis
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  14. Jun 2025
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    Protocol to study in vivo organ-specific migration of apoptotic splenocytes in mice with tumor and immune checkpoint inhibitor-induced colitis
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    EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8+ T cell antitumor responses
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    RORγt is crucial for gut homeostasis by regulating the expression of HB-EGF rather than IL-22 in activated ILC3s
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    cell.com/cell-reports/abstract/S2211-1247(25)00564-9
  19. May 2025
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    Macrophages with different origins proliferate ex vivo and do not lose their core intrinsic features
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    Humanized mouse model reveals T cell ANXA2 as a potential therapeutic target in ischemic stroke
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  23. Apr 2025
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    METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation
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    PPARγ-dependent remodeling of translational machinery in adipose progenitors is impaired in obesity
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    Inhibition of EMT driver PTK6 enhances anti-tumor immune responses against triple-negative breast cancer
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    SOSTDC1 downregulation in CD4+ T cells confers protection against obesity-induced insulin resistance
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  29. Mar 2025
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    Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma
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  31. Feb 2025
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    Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity
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  34. Jan 2025
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    The intestinal fungus Aspergillus tubingensis promotes polycystic ovary syndrome through a secondary metabolite
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  37. Dec 2024
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    Single-Nucleus RNA Sequencing Reveals the Spatiotemporal Dynamics of Disease-Associated Microglia in Amyotrophic Lateral Sclerosis
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  39. Nov 2024
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    DHDH-mediated D-xylose metabolism induces immune evasion in triple-negative breast cancer
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  41. Oct 2024
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    Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy
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  43. Sep 2024
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    Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity
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    RNA-modifying enzyme Alkbh8 is involved in mouse embryonic development
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    Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow
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  47. Aug 2024
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    Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer
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    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
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    Machine learning predictions of T cell antigen specificity from intracellular calcium dynamics
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  51. Jul 2024
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    Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis
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    CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus
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  54. Jun 2024
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    Glycoengineering-based anti-PD-1-iRGD peptide conjugate boosts antitumor efficacy through T cell engagement
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  56. May 2024
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    Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite
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    Mast cells control lung type 2 inflammation via prostaglandin E2-driven soluble ST2
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    Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling
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  60. Apr 2024
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    Ultrasound-visible engineered bacteria for tumor chemo-immunotherapy
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    Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21
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    The crosstalk between intestinal microbiota and MDSCs fuels colitis associated cancer development
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    The ecotin-like peptidase inhibitor of Trypanosoma cruzi prevents TMPRSS2-PAR2-TLR4 crosstalk downmodulating infection and inflammation
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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
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    Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
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  67. Mar 2024
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    Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells
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    LC3-dependent extracellular vesicles (LDEVs) promote M-MDSC accumulation and immunosuppression in colorectal cancer.
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    Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity
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  72. Jan 2024
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    Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging
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    ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis
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  75. Dec 2023
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    Needle biopsy accelerates pro-metastatic changes and systemic dissemination in breast cancer: Implications for mortality by surgery delay
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    Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice
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  78. Nov 2023
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    Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses
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    Stress-induced β cell early senescence confers protection against type 1 diabetes
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    FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation
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    Lactobacillus acidophilus-derived indole lactic acid reverses colitis susceptibility in cesarean-born offspring via activation of AhR
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    CD4+LAG3+T cells are decreased in SSc-ILD and affects fibroblast mesenchymal transition by TGF-β3
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  84. Oct 2023
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    An early glycolysis burst in microglia regulates mitochondrial dysfunction in oligodendrocytes under neuroinflammation
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  86. Jul 2023
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    Development of a DNA aptamer targeting IDO1 with anti-tumor effects
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  88. Jun 2023
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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  90. May 2023
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    Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis
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    Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease
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    cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway
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    journals.aai.org/jimmunol/article/210/8/1098/263495/cGAS-Mediates-Inflammation-by-Polarizing
  94. Apr 2023
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    β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk and Tgfβ receptor signaling
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    INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
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  97. Mar 2023
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    A small-molecule inhibitor of Keap1–Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites
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  99. Feb 2023
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    Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis
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    Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer
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  102. Jan 2023
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    The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer
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    Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
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    A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9298960/
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    Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions
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    Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes
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    Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy
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  109. Nov 2022
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    Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis
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  111. Oct 2022
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    Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization
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    ncbi.nlm.nih.gov/pmc/articles/PMC9550614/
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    PD-1 expression on mouse intratumoral NK cells and its effects on NK cell phenotype
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    ncbi.nlm.nih.gov/pmc/articles/PMC9523278/
  114. Sep 2022
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    Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease
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    Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization
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  117. Aug 2022
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    The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
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    Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis
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