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NicheSphere reveals an Spp1-centered multicellular niche in myeloproliferative neoplasm-associated fibrosis

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Protocol for establishing a murine Toscana virus infection model and downstream cellular analysis of skin tissue and cells

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sciencedirect.com/science/article/pii/S2666166726005381
Oct 2026
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ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia

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Chemotherapy enhances cancer vaccine efficacy and expands stem-like TCF1+CD8+ T cells

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An extramedullary bone model of metastatic dormancy reveals an increased rate of metastatic reactivation upon distant insults

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Sep 2026
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Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity

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1. scibot 24 Sep 2026
  
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IL-1α Expands SLC2A1highSPP1highIFNlow Myeloid Cells to Drive Immune Escape and Malignant Transformation of Pre-cancers

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1. scibot 09 Sep 2026
  
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Dendritic cell centric nanoengineering couples antigen acquisition and STING activation for cancer immunotherapy

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Aug 2026
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Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune-stromal interactions as a therapeutic target

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1. scibot 28 Aug 2026
  
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Single-allele chromatin tracing reveals cytokine-dependent super-enhancer repositioning in CD4+ T cells

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Distinct myeloid precursors and their interaction with mesenchymal cells orchestrate the spreading of psoriatic disease from the skin to the joints

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1. scibot 20 Aug 2026
  
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  DOI: 10.1101/2025.08.14.665302
  
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Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human

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  DOI: 10.1016/j.cell.2026.07.043
  
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Biophysical reprogramming of immunosuppressive neutrophils by cold atmospheric plasma reinvigorates antitumor immunity

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1. scibot 13 Aug 2026
  
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  DOI: 10.1126/sciadv.aee2483
  
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Biophysical reprogramming of immunosuppressive neutrophils by cold atmospheric plasma reinvigorates antitumor immunity

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1. scibot 08 Aug 2026
  
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  DOI: 10.1126/sciadv.aee2483
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13440387/
Jul 2026
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LRMDA promotes intestinal mucosal barrier integrity and limits colitis and colon cancer

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  DOI: 10.1016/j.isci.2026.116785
  
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Kir2.1 channels drive macrophage migration through enhancing store-operated Ca2+ entry. | American Journal of Physiology-Cell Physiology | American Physiological Society

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1. scibot 09 Jul 2026
  
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  DOI: 10.1152/ajpcell.00901.2024
  
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54.241.53.176/19ea8b6c5092e8eef27b40f25ccba69fca644b16/suzuki-et-al-2025-kir2-1-channels-drive-macrophage-migration-through-enhancing-store-operated-ca2-entry-html.html
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Protocol for inducing deep vein thrombosis in C57BL/6J mice using the inferior vena cava stenosis model

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Targeting cholesterol esterification sensitizes liver cancer to CD8+ T cell attack by impairing metabolic and redox resilience

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1. scibot 07 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.002
  
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Jun 2026
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Chronic stress unleashes an intratumor phage-fibroblast-B cell circuit to promote tumor growth

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Genetic ablation of Sfxn5 induces mitochondrial dysfunction and precipitates lethal metabolic crisis in mice

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The MLLT3 YEATS domain binds histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking transcription and RNA signaling to regulate hematopoiesis

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May 2026
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Dexamethasone ameliorates dermatologic adverse effects of PEGylated liposomal doxorubicin

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Fungal metabolite-based immunotherapy overcomes tumor-associated macrophage immunosuppression

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CCL1-AMFR facilitates glioblastoma progression by modulating the crosstalk between glioma cells and tumor-associated macrophages

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Apr 2026
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MMRN1-EGFR drives sialylglycan-Siglec immune evasion in AML leukemia stem cells

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B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism

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Ets1-dependent Mek-Erk signaling drives adipose tissue macrophage anti-inflammatory polarization to ameliorates insulin resistance

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  DOI: 10.1016/j.celrep.2026.117244
  
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Mar 2026
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A hierarchical Rorc(γt) cis-regulatory cascade orchestrates differentiation of RORγt⁺ innate immune cells

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Kindlin-2-mediated hematopoiesis remodeling regulates triple-negative breast cancer immune evasion

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  DOI: 10.1158/1541-7786.MCR-24-0698
  
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Spatiotemporal profiling reveals distinct dynamics and checkpoint regulations of CAR-T and CAR-NKT cells against solid tumors

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  DOI: 10.1038/s41392-026-02602-x
  
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Retinoid-X-Receptor as a Mediator of Poststroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Hematogenous Macrophages

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  DOI: 10.1523/JNEUROSCI.0248-25.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12424960/
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A tumor-resident bacterium promotes cervical cancer progression through lysoPC-mediated c-Jun/c-Fos activation

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Feb 2026
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CLIM-TIME identifies metastatic microenvironment modulators for T cell therapy response

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1. scibot 12 Feb 2026
  
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  DOI: 10.1016/j.cell.2025.12.042
  
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Strain- and species-specific immune responses to human adipose stem cell-derived extracellular vesicles: A comparative pharmacological evaluation in mice and human PBMCs

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1. scibot 03 Feb 2026
  
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sciencedirect.com/science/article/pii/S0939641126000299
Jan 2026
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IL-17A is increased in diabetic wounds and impairs keratinocyte function via histone demethylase JMJD3

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1. scibot 28 Jan 2026
  
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  DOI: 10.1038/s41467-025-67456-3
  
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Myeloid CD209 impairs T-cell activation by inducing ICAM-2–ERM–dependent cortical stiffening

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1-s2.0-S2589004226000933-main-html.html

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Depletion of myeloid cells in AG129 mice reduces the infection-mediated oxidative stress and restrains dengue virus-induced thymic atrophy

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Second-order regulation: IFN-γ suppresses IL-17A-mediated neutrophilic inflammation

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ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia

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Gut microbiota promotes immune tolerance at the maternal-fetal interface

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Nuclear exosome targeting complex safeguards hematopoietic stem cell self-renewal and genomic integrity through resolving R loops

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Olaparib and radiotherapy induce type I interferon and CD8+ T cell-dependent sensitization to immunotherapy in pancreatic cancer

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Cryptococcus exploits delayed microglial activation, and microglial osteopontin/Spp1 impairs peripheral host control

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MHC-II-restricted neoantigen vaccine reverses immune microenvironment and overcomes resistance to immune-checkpoint inhibitors in cold tumors

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jaeckstein-et-al-2025-purinergic-adipocyte-macrophage-crosstalk-promotes-degeneration-of-thermogenic-brown-adipose-html.html

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Sand fly saliva reprograms skin fibroblasts to enhance arbovirus infection

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An atlas of ferroptosis-induced secretomes

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RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition

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In situ extended immune activation instantly after tumor resection by oncolytic virus controls postoperative tumor recurrence

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Spliceosome inhibition induces Z-RNA and ZBP1-driven cell death in small cell lung cancer

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Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas

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GATA2 decommissioning of enhancers: A mechanism to constrain inflammatory signaling

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RSK1 reprograms the ubiquitin pathway to promote immune suppression

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Mitochondrial-activity-driven hematopoietic stem cell fate and lineage choice is first established in the aorta-gonad-mesonephros

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Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity

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Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity

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A vascular-associated fibroblastic cell controls pancreatic islet immunity

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Targeting fibroblast TNF receptor 1 attenuates type 17 skin inflammation

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CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases

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Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma

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TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC

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Impact of CD11c+ cells in conducting airway lumen on Aspergillus fumigatus conidia deposition in neutropenic mice

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Table 1 Resource table.

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Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells

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Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity

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Ocular immune privilege in action: The living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cells

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Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells

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B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8+ T cell function

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Intestinal-region-specific functions of AHR in intrinsic enteric neurons during infections

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Remote limb ischemic conditioning alleviates steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk

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Innate immune training of osteoclastogenesis promotes inflammatory bone loss in mice

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Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution

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Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10

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Dynamic tracking of native precursors in adult mice

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Meningeal neutrophil immune signaling influences behavioral adaptation following threat

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CCL28 modulates neutrophil responses during infection with mucosal pathogens

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A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8+ T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis

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Alarmin-loaded extracellular lipid droplets induce airway neutrophil infiltration during type 2 inflammation

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Protocol for monitoring phagocytosis of cancer cells by TAM-like macrophages using imaging cytometry

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A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation

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Smyd3-mediated immuno-modulation in HPV-negative head and neck squamous cell carcinoma mouse models

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Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection

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Released bacterial ATP shapes local and systemic inflammation during abdominal sepsis

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Obesity intensifies sex-specific interferon signaling to selectively worsen central nervous system autoimmunity in females

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Human liver sinusoidal endothelial cells support the development of functional human pluripotent stem cell-derived Kupffer cells

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Stromal cell and B cell dialogue potentiates IL-33-enriched lymphoid niches to support eosinophil recruitment and function during type 2 immunity

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Baf155 controls hematopoietic differentiation and regeneration through chromatin priming

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Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner

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Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity

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Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening

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Engineering an energy-dissipating hybrid tissue in vivo for obesity treatment

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Extracellular vesicles from alveolar macrophages harboring phagocytosed methicillin-resistant Staphylococcus aureus induce necroptosis

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Reactive oxygen species regulation by NCF1 governs ferroptosis susceptibility of Kupffer cells to MASH

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Glycoengineering-based anti-PD-1-iRGD peptide conjugate boosts antitumor efficacy through T cell engagement

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Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss

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Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

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Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG

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An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination

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SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis

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CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8+ T cells in diabetic autoimmunity

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Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis

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Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program

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A dopamine D1-like receptor-specific agonist improves the survival of septic mice

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Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer

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Nanodrug-bacteria conjugates-mediated oncogenic collagen depletion enhances immune checkpoint blockade therapy against pancreatic cancer

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Type-I-interferon-responsive microglia shape cortical development and behavior

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Differentiation route determines the functional outputs of adult megakaryopoiesis

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Inflammatory dendritic cells restrain CD11b+CD4+ CTLs via CD200R in human NSCLC

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Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury

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Maresin 1 repletion improves muscle regeneration after volumetric muscle loss

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Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolution

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Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells

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Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution

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Apoptosis recognition receptors regulate skin tissue repair in mice

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Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms

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Identification of ZIP8-induced ferroptosis as a major type of cell death in monocytes under sepsis conditions

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Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance

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Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals

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Protocol for the isolation of mouse muscle stem cells using fluorescence-activated cell sorting

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Retinoid X receptor gamma dictates the activation threshold of group 2 innate lymphoid cells and limits type 2 inflammation in the small intestine

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In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities

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A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8+ T cells

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Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing

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Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury

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Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas

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Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin

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ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression

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MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis

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Characterizing microglial senescence: Tau as a key player

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Systematic dissection of coordinated stromal remodeling identifies Sox10+ glial cells as a therapeutic target in myelofibrosis

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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity

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Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation

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Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma

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Temporal dynamics of TNF-mediated changes in hematopoietic stem cell function and recovery

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Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance

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A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages

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bcd-22-0082-html.html

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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment

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Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease

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cd-22-0561-html.html

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Isolation of mouse mammary carcinoma-derived macrophages and cancer cells for co-culture assays

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TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

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Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output

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Cbl-b Restrains Priming of Pathogenic Th17 Cells via the Inhibition of IL-6 Production by Macrophages

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Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells

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Nanocarriers based on bacterial membrane materials for cancer vaccine delivery

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PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny

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B cell-mediated regulatory mechanisms control tumor-promoting intestinal inflammation

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A TLR4-independent critical role for CD14 in intracellular LPS sensing

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Nasally-delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron

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Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution

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Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia

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Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses

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SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization

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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

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Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis

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Distinct hepatic immunological patterns are associated with the progression or inhibition of hepatocellular carcinoma

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Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity

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An oncogenic enhancer encodes selective selenium dependency in AML

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Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses

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Arthritis flares mediated by tissue-resident memory T cells in the joint

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BPS Publications

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Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges

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Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

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Activating a collaborative innate-adaptive immune response to control metastasis

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Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

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Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance

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Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity

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Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging

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Untitled document

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Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection

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Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury

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Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation

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An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

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Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia

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A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis

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A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression

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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

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Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity

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Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML

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Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth

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Effects of Chlorpyrifos on Serine Hydrolase Activities, Lipid Mediators, and Immune Responses in Lungs of Neonatal and Adult Mice

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Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

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Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

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Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense

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The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells

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Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

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Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration

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Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy

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