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Cross-species graph-embedding unmasks the ageing microenvironment as a key determinant of pancreatic cancer malignant cell biology and therapy response

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1. scibot 25 Jun 2026
  
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  DOI: 10.64898/2026.02.02.703350
  
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biorxiv.org/content/10.64898/2026.02.02.703350v1
May 2026
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Activating an interleukin 4-FLT3-STAT6 axis in multipotent progenitors restores lymphopoiesis in inflammation and aging

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1. scibot 30 May 2026
  
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  DOI: 10.1016/j.immuni.2026.04.018
  
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sciencedirect.com/science/article/pii/S1074761326001809
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Maternal-fetal type I interferon signaling drives TREM2 dysregulation and synaptic dysfunction in neurodevelopmental disorders

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1. scibot 29 May 2026
  
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  DOI: 10.1016/j.neuron.2026.04.043
  
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sciencedirect.com/science/article/pii/S0896627326003387
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A longitudinal atlas of human psoriatic skin reveals the mechanisms of anti-IL-23 therapy in disrupting the type 17 inflammatory circuit

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1. scibot 29 May 2026
  
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  DOI: 10.1016/j.immuni.2026.05.002
  
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sciencedirect.com/science/article/pii/S1074761326002001
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Nesfatin-1 Ameliorates Acute Pancreatitis by Inhibiting the Pyroptosis of Acinar Cells and Inflammation Mediated by Macrophages and Neutrophils

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1. scibot 28 May 2026
  
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  DOI: 10.1096/fj.202504662RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202504662RR
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Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics

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1. scibot 14 May 2026
  
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  DOI: 10.1016/j.xcrm.2026.102800
  
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Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity

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1. scibot 09 May 2026
  
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  DOI: 10.1126/sciadv.aea6842
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13148304/
Apr 2026
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BPS Publications

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1. scibot 28 Apr 2026
  
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  DOI: 10.1111/bph.70455
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70455
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Macrophage-mediated refinement of the dural lymphatic regulates social behavior

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1. scibot 25 Apr 2026
  
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  DOI: 10.1016/j.neuron.2026.03.019
  
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sciencedirect.com/science/article/pii/S0896627326002102
Feb 2026
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1-s2.0-S2589004226004979-main-html.html

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1. scibot 26 Feb 2026
  
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54.241.53.176/3a5565e0c36e23bec6f2335c230912599926bc3d/1-s2.0-S2589004226004979-main-html.html
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Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia

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1. scibot 13 Feb 2026
  
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  DOI: 10.1016/j.ccell.2026.01.014
  
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sciencedirect.com/science/article/pii/S153561082600053X
Jan 2026
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Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections

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1. scibot 29 Jan 2026
  
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  DOI: 10.1016/j.chom.2026.01.002
  
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sciencedirect.com/science/article/pii/S1931312826000028
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Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.008
  
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sciencedirect.com/science/article/pii/S0092867425014217
Nov 2025
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StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models

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1. scibot 08 Nov 2025
  
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  DOI: 10.1016/j.cell.2025.10.007
  
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sciencedirect.com/science/article/pii/S0092867425011365
Oct 2025
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The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.immuni.2025.09.008
  
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sciencedirect.com/science/article/pii/S1074761325004194
Sep 2025
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IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation

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1. scibot 27 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116330
  
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sciencedirect.com/science/article/pii/S2211124725011015
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ZBP1 pathway promotes tumor immunogenicity in the combination of anti-HER2 therapy and epigenetic therapy

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1. scibot 17 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116314
  
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sciencedirect.com/science/article/pii/S221112472501085X
Aug 2025
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Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

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1. scibot 01 Aug 2025
  
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  RRID:AB_312798
  
  DOI: 10.1016/j.immuni.2025.07.007
  
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sciencedirect.com/science/article/pii/S1074761325003164
Jul 2025
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Activity-attenuated serum albumin-fused interleukin-33 suppresses experimental autoimmune encephalomyelitis

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102231
  
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sciencedirect.com/science/article/pii/S2666379125003040
Jun 2025
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Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis

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1. scibot 11 Jun 2025
  
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  AB_312798
  
  DOI: 10.1084/jem.20240109
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12139521/
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Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.immuni.2025.05.007
  
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sciencedirect.com/science/article/pii/S1074761325002286
May 2025
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IL-33/ST2 signaling in ILC2s drives exhaustion and myeloid skewing of HSCs in response to hematopoietic stress and aging

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112378
  
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Interferon-γ and IL-27 positively regulate type 1 regulatory T cell development during adaptive tolerance

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112308
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12018090/
Apr 2025
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Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis

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1. scibot 17 Apr 2025
  
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  DOI: 10.1016/j.xcrm.2025.102047
  
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Type I interferon signaling controls the early hematopoietic expansion in response to β-glucan

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  DOI: 10.1016/j.isci.2025.112347
  
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sciencedirect.com/science/article/pii/S258900422500608X
Feb 2025
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Pharmacological rescue of mutant p53 triggers spontaneous tumor regression via immune responses

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101976
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11970324/
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SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer

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1. scibot 11 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2330
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617379/
52.53.155.43 52.53.155.43

1-s2.0-S2589004225002354-main-html.html

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52.53.155.43/49ea408b68f233098d1bbcd6742291cc57e6f9e8/1-s2.0-S2589004225002354-main-html.html
Jan 2025
www.nature.com www.nature.com

Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis

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1. scibot 24 Jan 2025
  
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  DOI: 10.1038/s42255-024-01177-7
  
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nature.com/articles/s42255-024-01177-7
Nov 2024
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IL-21/IL-21R signaling renders acute myeloid leukemia stem cells more susceptible to cytarabine treatment and CAR T cell therapy

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.xcrm.2024.101826
  
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Sep 2024
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Neoself-antigens are the primary target for autoreactive T cells in human lupus

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  DOI: 10.1016/j.cell.2024.08.025
  
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sciencedirect.com/science/article/pii/S0092867424009139
Jul 2024
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Lack of canonical thyroid hormone receptor α signaling changes regulatory T cell phenotype in female mice

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  DOI: 10.1016/j.isci.2024.110547
  
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52.53.155.43/ec8bf473a95e0f0a14821b5e61884b766010f004/1-s2.0-S2589004224017723-main-html.html
May 2024
www.biorxiv.org www.biorxiv.org

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer

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1. scibot 23 May 2024
  
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  DOI: 10.1101/2024.04.28.591518
  
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biorxiv.org/content/10.1101/2024.04.28.591518v1
Mar 2024
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Protocol to examine immune subpopulations in murine conjunctiva and lacrimal gland using flow cytometry

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1. scibot 05 Mar 2024
  
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  DOI: 10.1016/j.xpro.2024.102921
  
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  DOI: 10.1016/j.xpro.2024.102921
  
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  RRID:AB_312798
  
  DOI: 10.1016/j.xpro.2024.102921
  
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sciencedirect.com/science/article/pii/S2666166724000868
Feb 2024
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Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans

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1. scibot 08 Feb 2024
  
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A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection

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EGFR-activated myofibroblasts promote metastasis of pancreatic cancer

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Needle biopsy accelerates pro-metastatic changes and systemic dissemination in breast cancer: Implications for mortality by surgery delay

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FGFR3 alterations in bladder cancer stimulate serine synthesis to induce immune-inert macrophages that suppress T-cell recruitment and activation

1
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2
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Microbial-dependent recruitment of immature myeloid cells promotes intestinal regeneration.

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CD4+ T cell-derived IL21 regulates stem cell fate in acute myeloid leukemia by activation of p38-MAPK signaling

1
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SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification

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Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity

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Depletion of conventional type-1 dendritic cells in established tumors suppresses immunotherapy efficacy

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can-22-1046-html.html

1
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Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury

1
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Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization

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Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1

1
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Translocator Protein Ligand Etifoxine Attenuates MPTP-Induced Neurotoxicity

1
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Mycobacterium tuberculosis impedes CD40-dependent notch signaling to restrict Th17 polarization during infection

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Immune translational control by CPEB4 regulates intestinal inflammation resolution and colorectal cancer development

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Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells

1
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ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

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Virulence factors perforate the pathogen-containing vacuole to signal efferocytosis

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Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction

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The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo

1
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IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation

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A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells

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Modulating tumor infiltrating myeloid cells to enhance bispecific antibody-driven T cell infiltration and anti-tumor response

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Untitled document

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Loss of Zbtb32 in NOD mice does not significantly alter T cell responses.

1
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Untitled document

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Untitled document

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Loss of Zbtb32 in NOD mice does not significantly alter T cell responses.

3
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Dissecting FcγR Regulation through a Multivalent Binding Model

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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

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May 2021
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Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge

1
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Apr 2021
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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

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  RRID:AB_312798
  
  DOI: 10.1016/j.cell.2020.11.009
  
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Induction of interferon signaling and allograft inflammatory factor 1 in macrophages in a mouse model of breast cancer metastases

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  RRID:AB_312798
  
  DOI: 10.12688/wellcomeopenres.16569.1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8008350/
Mar 2021
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Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

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  DOI: 10.7554/eLife.63838
  
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Feb 2021
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A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages

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  DOI: 10.1016/j.immuni.2020.11.007
  
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Sep 2020
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DAGL-Beta Functions as a PUFA-Specific Triacylglycerol Lipase in Macrophages

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1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.chembiol.2020.01.005
  
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Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration

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  DOI: 10.1016/j.celrep.2020.107796
  
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Protocol for Efficient CRISPR/Cas9/AAV-Mediated Homologous Recombination in Mouse Hematopoietic Stem and Progenitor Cells

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1. scibot 14 Sep 2020
  
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  DOI: 10.1016/j.xpro.2020.100028
  
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Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System

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  anti-CD11b (M1/70)
  
  DOI: 10.1016/j.celrep.2020.02.109
  
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Jan 2020
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Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units

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  DOI: 10.1016/j.celrep.2019.10.003
  
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Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

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  DOI: 10.1016/j.celrep.2019.08.036
  
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Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression

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  DOI: 10.1016/j.celrep.2019.10.016
  
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Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells

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  DOI: 10.1016/j.celrep.2019.08.065
  
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Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

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1. scibot 13 Jan 2020
  
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  RRID:AB_312798
  
  DOI: 10.1016/j.stem.2019.07.001
  
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Untitled document

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  DOI: 10.1016/j.celrep.2018.12.030
  
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Untitled document

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1. scibot 12 Jan 2020
  
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  RRID:AB_312798
  
  DOI: 10.1016/j.immuni.2018.11.013
  
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sciencedirect.com/science/article/pii/S1074761318304953
Nov 2018
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Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution

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1. scibot 05 Nov 2018
  
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Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing

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sciencedirect.com/science/article/pii/S2405471218301960
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Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1550413118303127
Nov 2017
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Dietary Manganese Promotes Staphylococcal Infection of the Heart

1
1. scibot 08 Nov 2017
  
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Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain

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1. scibot 08 Nov 2017
  
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Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C− Cells

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sciencedirect.com/science/article/pii/S1074761317301838

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