125 Matching Annotations
  1. Oct 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of SMN Impairs Osteoblast–Osteoclast Coupling via IGF1–Akt–OPG Axis in Spinal Muscular Atrophy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12516799/
  3. Sep 2025
  4. www.sciencedirect.com www.sciencedirect.com
    Development of a cyst-targeted therapy for polycystic kidney disease using an antagonistic dimeric IgA monoclonal antibody against cMET
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    sciencedirect.com/science/article/pii/S2666379125004082
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    ADSL deficiency is a secondary mitochondrial disease affecting organelle homeostasis and ERK2/AKT signaling in a linear genotype-phenotype relation
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    sciencedirect.com/science/article/pii/S2211124725010010
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    Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth
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    sciencedirect.com/science/article/pii/S0896627325005914
  7. Aug 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel roles for the GPI-anchor cleaving enzyme, GDE2, in hippocampal synaptic morphology and function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12320762/
  9. Jun 2025
  10. www.cell.com www.cell.com
    Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake
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    cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00236-8
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    Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer
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    sciencedirect.com/science/article/pii/S2211124725005637
  12. Feb 2025
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    Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk
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    sciencedirect.com/science/article/pii/S1550413124004935
  14. Jan 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
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    pmc.ncbi.nlm.nih.gov/articles/PMC11750134/
  16. Dec 2024
  17. www.pnas.org www.pnas.org
    Growth hormone receptor in VGLUT2 or Sim1 cells regulates glycemia and insulin sensitivity
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    pnas.org/doi/10.1073/pnas.2407225121
  18. bmcmedicine.biomedcentral.com bmcmedicine.biomedcentral.com
    Multiomics profiling of DNA methylation, microRNA, and mRNA in skeletal muscle from monozygotic twin pairs discordant for type 2 diabetes identifies dysregulated genes controlling metabolism
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    bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03789-y
  19. www.sciencedirect.com www.sciencedirect.com
    Hypoxia-inducible factor 2α promotes pathogenic polarization of stem-like Th2 cells via modulation of phospholipid metabolism
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    sciencedirect.com/science/article/pii/S1074761324004965
  20. Oct 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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    sciencedirect.com/science/article/pii/S2666379124004828
  22. Aug 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT
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    ncbi.nlm.nih.gov/pmc/articles/PMC11304919/
  24. Jul 2024
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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    ncbi.nlm.nih.gov/pmc/articles/PMC8328392/
  26. www.sciencedirect.com www.sciencedirect.com
    Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral sensitization
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    sciencedirect.com/science/article/pii/S2666379124003276
  27. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astrocytes facilitate gabazine-evoked electrophysiological hyperactivity and distinct biochemical responses in mature neuronal cultures
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16182
  28. Apr 2024
  29. pathsocjournals.onlinelibrary.wiley.com pathsocjournals.onlinelibrary.wiley.com
    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
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    pathsocjournals.onlinelibrary.wiley.com/doi/full/10.1002/path.6282
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  31. Feb 2024
  32. onlinelibrary.wiley.com onlinelibrary.wiley.com
    l-Methionine potentiates anticancer activity of Sorafenib by epigenetically altering DUSP3/ERK pathway in hepatocellular carcinoma
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    onlinelibrary.wiley.com/doi/10.1002/jbt.23663
  33. Dec 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
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    ncbi.nlm.nih.gov/pmc/articles/PMC10691799/
  35. Nov 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
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    sciencedirect.com/science/article/pii/S2666379123004846
  37. www.sciencedirect.com www.sciencedirect.com
    Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
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    sciencedirect.com/science/article/pii/S2211124723014018
  38. Oct 2023
  39. www.sciencedirect.com www.sciencedirect.com
    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    sciencedirect.com/science/article/pii/S1535610823003185
  40. Aug 2023
  41. www.science.org www.science.org
    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
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    science.org/doi/10.1126/scisignal.ade6737
  42. www.sciencedirect.com www.sciencedirect.com
    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
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    sciencedirect.com/science/article/pii/S2589004223015547
  43. Jul 2023
  44. www.sciencedirect.com www.sciencedirect.com
    GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism
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    sciencedirect.com/science/article/abs/pii/S1550413123002267
  45. May 2023
  46. www.nature.com www.nature.com
    Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
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    nature.com/articles/s41467-022-31905-0
  47. aacrjournals.org aacrjournals.org
    Transcriptional repression by FoxM1 suppresses tumor differentiation and promotes metastasis of breast cancer
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    aacrjournals.org/cancerres/article/82/13/2458/705024/Transcriptional-Repression-by-FoxM1-Suppresses
  48. Apr 2023
  49. www.sciencedirect.com www.sciencedirect.com
    AKT activity orchestrates marginal zone B cell development in mice and humans
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    sciencedirect.com/science/article/pii/S2211124723003893
  50. iubmb.onlinelibrary.wiley.com iubmb.onlinelibrary.wiley.com
    Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel
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    iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.2722
  51. www.sciencedirect.com www.sciencedirect.com
    FGF21/FGFR1-β-KL cascade in cardiomyocytes modulates angiogenesis and inflammation under metabolic stress
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    sciencedirect.com/science/article/pii/S240584402302159X
  52. Mar 2023
  53. www.sciencedirect.com www.sciencedirect.com
    SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression
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    sciencedirect.com/science/article/pii/S1550413123000827
  54. Feb 2023
  55. www.sciencedirect.com www.sciencedirect.com
    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
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    sciencedirect.com/science/article/pii/S1535610823000077
  56. Dec 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
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    sciencedirect.com/science/article/pii/S1550413122005034
  58. Nov 2022
  59. academic.oup.com academic.oup.com
    Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells
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    academic.oup.com/endo/article-abstract/163/12/bqac170/6763139
  60. Sep 2022
  61. www.mdpi.com www.mdpi.com
    Stimulation of Akt Phosphorylation and Glucose Transport by Metalloporphyrins with Peroxynitrite Decomposition Catalytic Activity
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    mdpi.com/2073-4344/12/8/849
  62. www.nature.com www.nature.com
    Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
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    nature.com/articles/s42003-022-03942-4
  63. Aug 2022
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PH domain-mediated autoinhibition and oncogenic activation of Akt
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    ncbi.nlm.nih.gov/pmc/articles/PMC9417420/
  65. www.sciencedirect.com www.sciencedirect.com
    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
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    sciencedirect.com/science/article/pii/S2667237522001485
  66. Jun 2022
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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    ncbi.nlm.nih.gov/pmc/articles/PMC9218363/
  68. May 2022
  69. www.sciencedirect.com www.sciencedirect.com
    Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
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    sciencedirect.com/science/article/pii/S2211124722005630
  70. Mar 2022
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8714968/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARM1 Suppresses Axon Branching Through Attenuation of Axonal Cytoskeletal Dynamics
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    ncbi.nlm.nih.gov/pmc/articles/PMC8899016/
  73. www.sciencedirect.com www.sciencedirect.com
    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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    sciencedirect.com/science/article/pii/S2211124722001735
  74. Feb 2022
  75. www.sciencedirect.com www.sciencedirect.com
    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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    sciencedirect.com/science/article/pii/S221112472200033X
  76. Jan 2022
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4
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    ncbi.nlm.nih.gov/pmc/articles/PMC8762293/
  78. Dec 2021
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC8605346/
  80. Nov 2021
  81. academic.oup.com academic.oup.com
    Nobiletin-induced partial abrogation of deleterious effects of AKT inhibition on preimplantation bovine embryo development in vitro
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    academic.oup.com/biolreprod/advance-article/doi/10.1093/biolre/ioab184/6382539
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states
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    ncbi.nlm.nih.gov/pmc/articles/PMC8555985/
  83. Oct 2021
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons
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    ncbi.nlm.nih.gov/pmc/articles/PMC8497901/
  85. Aug 2021
  86. www.nature.com www.nature.com
    Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen
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    nature.com/articles/s41467-021-24968-y
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
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    ncbi.nlm.nih.gov/pmc/articles/PMC8313754/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP3 Turnover and Insulin Signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC6591132/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5589416/
  90. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S2211124719303973
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
  92. Jul 2021
  93. jcs.biologists.org jcs.biologists.org
    The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3
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    jcs.biologists.org/content/132/20/jcs233221
  94. academic.oup.com academic.oup.com
    Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance
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    academic.oup.com/endo/article/160/5/1179/5434897
  95. www.sciencedirect.com www.sciencedirect.com
    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
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    sciencedirect.com/science/article/pii/S0092867418313060
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase
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    ncbi.nlm.nih.gov/pmc/articles/PMC6030672/
  97. www.sciencedirect.com www.sciencedirect.com
    Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
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    sciencedirect.com/science/article/pii/S1074761319300950
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6289175/
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AhR ligand aminoflavone suppresses α6‐integrin–Src–Akt signaling to attenuate tamoxifen resistance in breast cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC6202151/
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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    ncbi.nlm.nih.gov/pmc/articles/PMC8328392/
  102. Jun 2021
  103. www.sciencedirect.com www.sciencedirect.com
    D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling
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    sciencedirect.com/science/article/pii/S235239642100205X
  104. May 2021
  105. cancerres.aacrjournals.org cancerres.aacrjournals.org
    Integrated Screens Identify CDK1 as a Therapeutic Target in Advanced Gastrointestinal Stromal Tumors
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    cancerres.aacrjournals.org/content/81/9/2481
  106. www.sciencedirect.com www.sciencedirect.com
    Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes
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    sciencedirect.com/science/article/pii/S193459092030268X
  107. Apr 2021
  108. www.sciencedirect.com www.sciencedirect.com
    Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S1550413120305519
  109. Feb 2021
  110. www.cell.com www.cell.com
    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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    cell.com/developmental-cell/abstract/S1534-5807(20)30420-2
  111. www.sciencedirect.com www.sciencedirect.com
    ARHGEF3 regulates skeletal muscle regeneration and strength through autophagy
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    sciencedirect.com/science/article/pii/S2211124721000449
  112. Jan 2021
  113. www.sciencedirect.com www.sciencedirect.com
    ARHGEF3 Regulates Skeletal Muscle Regeneration and Strength through Autophagy
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    sciencedirect.com/science/article/pii/S2211124720315837
  114. link.springer.com link.springer.com
    Microglia induce neurogenic protein expression in primary cortical cells by stimulating PI3K/AKT intracellular signaling in vitro
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    link.springer.com/article/10.1007/s11033-020-06092-0
  115. elifesciences.org elifesciences.org
    Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division
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    elifesciences.org/articles/63835
  116. Dec 2020
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2
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    ncbi.nlm.nih.gov/pmc/articles/PMC7674017/
  118. Oct 2020
  119. www.cell.com www.cell.com
    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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    cell.com/developmental-cell/abstract/S1534-5807(20)30420-2
  120. Sep 2020
  121. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas
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    pubmed.ncbi.nlm.nih.gov/32997991/
  122. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring
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    pubmed.ncbi.nlm.nih.gov/32539156/
  123. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Δ9‐Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo
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    onlinelibrary.wiley.com/doi/10.1002/glia.23911
  124. www.nature.com www.nature.com
    Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy
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    nature.com/articles/s41419-020-2615-9
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    Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras
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    Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion
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