112 Matching Annotations
  1. Oct 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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    1. scibot 02 Oct 2024
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      DOI: 10.1016/j.xcrm.2024.101752

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    sciencedirect.com/science/article/pii/S2666379124004828
  3. Aug 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT
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    1. scibot 21 Aug 2024
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      DOI: 10.1186/s40170-024-00352-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC11304919/
  5. Jul 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
    1
    1. scibot 24 Jul 2024
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      DOI: 10.1016/j.celrep.2021.109363

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    ncbi.nlm.nih.gov/pmc/articles/PMC8328392/
  7. www.sciencedirect.com www.sciencedirect.com
    Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral sensitization
    1
    1. scibot 23 Jul 2024
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    sciencedirect.com/science/article/pii/S2666379124003276
  8. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astrocytes facilitate gabazine-evoked electrophysiological hyperactivity and distinct biochemical responses in mature neuronal cultures
    1
    1. scibot 18 Jul 2024
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      DOI: 10.1111/jnc.16182

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16182
  9. Apr 2024
  10. pathsocjournals.onlinelibrary.wiley.com pathsocjournals.onlinelibrary.wiley.com
    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
    1
    1. scibot 18 Apr 2024
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      DOI: 10.1002/path.6282

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    pathsocjournals.onlinelibrary.wiley.com/doi/full/10.1002/path.6282
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
    1
    1. scibot 10 Apr 2024
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      DOI: 10.1038/s41598-024-58716-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  12. Feb 2024
  13. onlinelibrary.wiley.com onlinelibrary.wiley.com
    l-Methionine potentiates anticancer activity of Sorafenib by epigenetically altering DUSP3/ERK pathway in hepatocellular carcinoma
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1002/jbt.23663

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    onlinelibrary.wiley.com/doi/10.1002/jbt.23663
  14. Dec 2023
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
    1
    1. scibot 06 Dec 2023
      RRID:AB_329828

      DOI: 10.7554/eLife.80944

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    ncbi.nlm.nih.gov/pmc/articles/PMC10691799/
  16. Nov 2023
  17. www.sciencedirect.com www.sciencedirect.com
    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
    1
    1. scibot 22 Nov 2023
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      DOI: 10.1016/j.xcrm.2023.101290

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    sciencedirect.com/science/article/pii/S2666379123004846
  18. www.sciencedirect.com www.sciencedirect.com
    Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
    1
    1. scibot 10 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113389

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    sciencedirect.com/science/article/pii/S2211124723014018
  19. Oct 2023
  20. www.sciencedirect.com www.sciencedirect.com
    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.ccell.2023.09.001

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    sciencedirect.com/science/article/pii/S1535610823003185
  21. Aug 2023
  22. www.science.org www.science.org
    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
    1
    1. scibot 29 Aug 2023
      RRID:AB_329828

      DOI: 10.1126/scisignal.ade6737

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    science.org/doi/10.1126/scisignal.ade6737
  23. www.sciencedirect.com www.sciencedirect.com
    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
    1
    1. scibot 05 Aug 2023
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      DOI: 10.1016/j.isci.2023.107477

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    sciencedirect.com/science/article/pii/S2589004223015547
  24. Jul 2023
  25. www.sciencedirect.com www.sciencedirect.com
    GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism
    1
    1. scibot 21 Jul 2023
      RRID:AB_329828

      DOI: 10.1016/j.cmet.2023.06.016

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    sciencedirect.com/science/article/abs/pii/S1550413123002267
  26. May 2023
  27. www.nature.com www.nature.com
    Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
    1
    1. scibot 05 May 2023
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      DOI: 10.1038/s41467-022-31905-0

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    nature.com/articles/s41467-022-31905-0
  28. aacrjournals.org aacrjournals.org
    Transcriptional repression by FoxM1 suppresses tumor differentiation and promotes metastasis of breast cancer
    1
    1. scibot 05 May 2023
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      DOI: 10.1158/0008-5472.CAN-22-0410

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    aacrjournals.org/cancerres/article/82/13/2458/705024/Transcriptional-Repression-by-FoxM1-Suppresses
  29. Apr 2023
  30. www.sciencedirect.com www.sciencedirect.com
    AKT activity orchestrates marginal zone B cell development in mice and humans
    1
    1. scibot 15 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112378

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    sciencedirect.com/science/article/pii/S2211124723003893
  31. iubmb.onlinelibrary.wiley.com iubmb.onlinelibrary.wiley.com
    Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel
    1
    1. scibot 08 Apr 2023
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      DOI: 10.1002/iub.2722

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    iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.2722
  32. www.sciencedirect.com www.sciencedirect.com
    FGF21/FGFR1-β-KL cascade in cardiomyocytes modulates angiogenesis and inflammation under metabolic stress
    1
    1. scibot 06 Apr 2023
      RRID:AB_329828

      DOI: 10.1016/j.heliyon.2023.e14952

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    sciencedirect.com/science/article/pii/S240584402302159X
  33. Mar 2023
  34. www.sciencedirect.com www.sciencedirect.com
    SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression
    2
    1. scibot 28 Mar 2023
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      DOI: 10.1016/j.cmet.2023.03.004

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      DOI: 10.1016/j.cmet.2023.03.004

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    sciencedirect.com/science/article/pii/S1550413123000827
  35. Feb 2023
  36. www.sciencedirect.com www.sciencedirect.com
    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
    2
    1. scibot 16 Feb 2023
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      DOI: 10.1016/j.ccell.2023.01.007

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      DOI: 10.1016/j.ccell.2023.01.007

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    sciencedirect.com/science/article/pii/S1535610823000077
  37. Dec 2022
  38. www.sciencedirect.com www.sciencedirect.com
    Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
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    1. scibot 17 Dec 2022
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      DOI: 10.1016/j.cmet.2022.11.012

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    sciencedirect.com/science/article/pii/S1550413122005034
  39. Nov 2022
  40. academic.oup.com academic.oup.com
    Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells
    1
    1. scibot 03 Nov 2022
      RRID:AB_329828

      DOI: 10.1210/endocr/bqac170

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    academic.oup.com/endo/article-abstract/163/12/bqac170/6763139
  41. Sep 2022
  42. www.mdpi.com www.mdpi.com
    Stimulation of Akt Phosphorylation and Glucose Transport by Metalloporphyrins with Peroxynitrite Decomposition Catalytic Activity
    1
    1. scibot 16 Sep 2022
      RRID:AB_329828

      DOI: 10.3390/catal12080849

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    mdpi.com/2073-4344/12/8/849
  43. www.nature.com www.nature.com
    Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
    1
    1. scibot 15 Sep 2022
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      DOI: 10.1038/s42003-022-03942-4

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    nature.com/articles/s42003-022-03942-4
  44. Aug 2022
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PH domain-mediated autoinhibition and oncogenic activation of Akt
    1
    1. scibot 31 Aug 2022
      RRID:AB_329828

      DOI: 10.7554/eLife.80148

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    ncbi.nlm.nih.gov/pmc/articles/PMC9417420/
  46. www.sciencedirect.com www.sciencedirect.com
    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
    1
    1. scibot 23 Aug 2022
      RRID:AB_329828

      DOI: 10.1016/j.crmeth.2022.100271

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    sciencedirect.com/science/article/pii/S2667237522001485
  47. Jun 2022
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
    1
    1. scibot 25 Jun 2022
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      DOI: 10.1016/j.isci.2022.104518

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    ncbi.nlm.nih.gov/pmc/articles/PMC9218363/
  49. May 2022
  50. www.sciencedirect.com www.sciencedirect.com
    Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
    1
    1. scibot 11 May 2022
      RRID:AB_329828

      DOI: 10.1016/j.celrep.2022.110796

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    sciencedirect.com/science/article/pii/S2211124722005630
  51. Mar 2022
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
    1
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      DOI: 10.1152/ajpendo.00236.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8714968/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARM1 Suppresses Axon Branching Through Attenuation of Axonal Cytoskeletal Dynamics
    1
    1. scibot 09 Mar 2022
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      DOI: 10.3389/fnmol.2022.726962

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    ncbi.nlm.nih.gov/pmc/articles/PMC8899016/
  54. www.sciencedirect.com www.sciencedirect.com
    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
    1
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      RRID: 329828

      DOI: 10.1016/j.celrep.2022.110446

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    sciencedirect.com/science/article/pii/S2211124722001735
  55. Feb 2022
  56. www.sciencedirect.com www.sciencedirect.com
    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
    2
    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110322

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      DOI: 10.1016/j.celrep.2022.110322

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    sciencedirect.com/science/article/pii/S221112472200033X
  57. Jan 2022
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4
    1
    1. scibot 20 Jan 2022
      RRID:AB_329828

      DOI: 10.3389/fendo.2021.750261

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    ncbi.nlm.nih.gov/pmc/articles/PMC8762293/
  59. Dec 2021
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
    1
    1. scibot 01 Dec 2021
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      DOI: 10.1016/j.isci.2021.103382

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    ncbi.nlm.nih.gov/pmc/articles/PMC8605346/
  61. Nov 2021
  62. academic.oup.com academic.oup.com
    Nobiletin-induced partial abrogation of deleterious effects of AKT inhibition on preimplantation bovine embryo development in vitro
    1
    1. scibot 18 Nov 2021
      RRID:AB_329828

      DOI: 10.1093/biolre/ioab184

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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  64. Oct 2021
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    Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons
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  66. Aug 2021
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3
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    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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    Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling
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    Myc‐dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor‐2
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    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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    Hepatic gluconeogenic response to single and long-term SGLT2 inhibition in lean/obese male hepatic G6pc-reporter mice
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    Protein kinase B mediates insulin‐like growth factor 1‐induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells
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    Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance
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    Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity
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    The Orphan G Protein‐coupled Receptor 75 Signaling is Activated by the Chemokine CCL5
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    Tyrosine kinase receptor c‐ros‐oncogene 1 inhibition alleviates aberrant bone formation of TWIST‐1 haploinsufficient calvarial cells from Saethre–Chotzen syndrome patients
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    Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity
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    Combined Hyperglycemia- and Hyperinsulinemia-Induced Insulin Resistance in Adipocytes Is Associated With Dual Signaling Defects Mediated by PKC-ζ
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    Calreticulin Is Involved in Invasion of Human Extravillous Trophoblasts Through Functional Regulation of Integrin β1
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  142. Nov 2017
  143. elifesciences.org elifesciences.org
    Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
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    Brief isoflurane anesthesia regulates striatal AKT‐GSK3β signaling and ameliorates motor deficits in a rat model of early‐stage Parkinson′s disease
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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