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Apr 2025
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CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers

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  DOI: 10.1016/j.chembiol.2025.03.006
  
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Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors

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pmc.ncbi.nlm.nih.gov/articles/PMC11967718/
Mar 2025
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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

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sciencedirect.com/science/article/pii/S1535610825000583
Feb 2025
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PDF-html.html

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52.53.155.43/14aa111ce8a1e5484e892552f2e3d7e5be8c5aa9/PDF-html.html
Nov 2024
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p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb

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pmc.ncbi.nlm.nih.gov/articles/PMC11574164/
Jul 2024
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A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

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ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
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The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway

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1. scibot 23 Jul 2024
  
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  DOI: 10.1111/acel.14258
  
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onlinelibrary.wiley.com/doi/10.1111/acel.14258
May 2024
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Molecular subtypes of neuroendocrine carcinomas: A cross-tissue classification framework based on five transcriptional regulators

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sciencedirect.com/science/article/pii/S1535610824001636
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Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma

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ncbi.nlm.nih.gov/pmc/articles/PMC11060649/
Mar 2024
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CDK-independent role of D-type cyclins in regulating DNA mismatch repair

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sciencedirect.com/science/article/pii/S1097276524001291
Aug 2023
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Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells

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1. scibot 01 Aug 2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10380721/
Apr 2023
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Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance

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  DOI: 10.1016/j.celrep.2023.112314
  
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sciencedirect.com/science/article/pii/S221112472300325X
Oct 2022
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Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors

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sciencedirect.com/science/article/pii/S2666634022004032
Mar 2022
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CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities

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sciencedirect.com/science/article/pii/S2211124722001759
Nov 2021
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Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, Rb and E2F.

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sciencedirect.com/science/article/pii/S0021925821011716
Aug 2021
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Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation

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sciencedirect.com/science/article/pii/S2211124721009992
Jul 2021
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Untitled document

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  DOI: 10.1016/j.ccell.2018.08.015
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6179967/
Jun 2021
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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

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1. scibot 30 Jun 2021
  
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  DOI: 10.1016/j.celrep.2021.109291
  
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sciencedirect.com/science/article/pii/S2211124721006628
Apr 2021
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An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

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sciencedirect.com/science/article/pii/S0092867420313878
Mar 2021
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An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

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sciencedirect.com/science/article/pii/S1535610820306097
Oct 2020
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A Marine Alkaloid, Ascomylactam A, Suppresses Lung Tumorigenesis via Inducing Cell Cycle G1/S Arrest through ROS/Akt/Rb Pathway

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pubmed.ncbi.nlm.nih.gov/32992455/
Sep 2020
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Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

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CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma

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Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation

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sciencedirect.com/science/article/pii/S2211124720311402
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The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

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cell.com/cancer-cell/fulltext/S1535-6108(18)30375-1
Jan 2020
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MicroRNA-1-Mediated Inhibition of Cardiac Fibroblast Proliferation Through Targeting Cyclin D2 and CDK6

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ncbi.nlm.nih.gov/pmc/articles/PMC6533459/
Nov 2018
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Untitled document

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ncbi.nlm.nih.govhttp://europepmc.org/articles/PMC6179967/
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Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints

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Untitled document

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β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

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An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential

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Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps

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sciencedirect.com/science/article/pii/S1534580717308262