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Mar 2026
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Targeting the energy metabolism of melanoma cells: FX-11 acts as a mitochondrial uncoupler

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  DOI: 10.1016/j.ejphar.2026.178800
  
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Eukaryote initiation factor 6 modulates small-cell lung carcinoma plasticity via the integrin-FAK signaling axis

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  DOI: 10.1038/s41467-026-69899-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12946193/
Jan 2026
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Differential contribution of TFE3 isoforms to cell motility and invasion

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1. scibot 31 Jan 2026
  
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  DOI: 10.1038/s44319-025-00659-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12852735/
Dec 2025
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Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer

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1. scibot 23 Dec 2025
  
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  DOI: 10.1158/0008-5472.CAN-25-1507
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12717533/
Nov 2025
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1-s2.0-S258900422502259X-main-html.html

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  DOI: 10.1016/j.isci.2025.113998
  
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Oct 2025
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Ribosome dysregulation and intervention in age-related infertility

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  DOI: 10.1016/j.xcrm.2025.102424
  
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Arsenic regulates ALKBH1 abundance and substrate specificity to promote translation and tumorigenicity

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  DOI: 10.1016/j.celrep.2025.116311
  
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sciencedirect.com/science/article/pii/S2211124725010824
Sep 2025
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mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport

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  DOI: 10.1016/j.molcel.2025.08.021
  
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Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

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  DOI: 10.1158/1541-7786.MCR-24-1045
  
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aacrjournals.org/mcr/article/23/9/765/764255/Novel-Metastasis-Suppressor-PI3KC2-Is-Mediated-by
Jul 2025
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Transfer RNA acetylation regulates in vivo mammalian stress signaling

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PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

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1. scibot 17 Jul 2025
  
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  RRID:AB_330945
  
  DOI: 10.7554/eLife.103403
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12185105/
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PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability

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  DOI: 10.1158/0008-5472.CAN-24-2471
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735329/
Jun 2025
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PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

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1. scibot 25 Jun 2025
  
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  DOI: 10.7554/eLife.103403
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12185105/
May 2025
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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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  DOI: 10.1016/j.molcel.2025.05.003
  
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KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

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  DOI: 10.1016/j.celrep.2025.115444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12091147/
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Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis

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  DOI: 10.1016/j.devcel.2025.04.012
  
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sciencedirect.com/science/article/pii/S1534580725002503
Apr 2025
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Downregulation of PD-L1 expression by Wnt pathway inhibition to enhance PD-1 blockade efficacy in hepatocellular carcinoma

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1. scibot 11 Apr 2025
  
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  DOI: 10.1186/s13062-025-00645-8
  
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link.springer.com/article/10.1186/s13062-025-00645-8
Mar 2025
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The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

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1. scibot 24 Mar 2025
  
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  DOI: 10.1101/2025.03.18.644053
  
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  DOI: 10.1101/2025.03.18.644053
  
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biorxiv.org/content/10.1101/2025.03.18.644053v1
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Transfer RNA acetylation regulates in vivo mammalian stress signaling

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  DOI: 10.1126/sciadv.ads2923
  
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science.org/doi/10.1126/sciadv.ads2923
Feb 2025
52.53.155.43 52.53.155.43

PDF-html.html

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  DOI: 10.1101/2025.02.17.638725
  
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52.53.155.43/14aa111ce8a1e5484e892552f2e3d7e5be8c5aa9/PDF-html.html
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GDF-15 predicts epithelioid hemangioendothelioma aggressiveness and is down-regulated by sirolimus through ATF4/ATF5 suppression

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  DOI: 10.1158/1078-0432.CCR-23-3991
  
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aacrjournals.org/clincancerres/article/30/22/5122/749578/GDF-15-Predicts-Epithelioid-Hemangioendothelioma
Nov 2024
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β2-integrins control HIF1α activation in human neutrophils

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1. scibot 07 Nov 2024
  
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  DOI: 10.3389/fimmu.2024.1406967
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11513320/
Sep 2024
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A TBK1-independent primordial function of STING in lysosomal biogenesis

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  DOI: 10.1016/j.molcel.2024.08.026
  
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Jul 2024
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Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles

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  DOI: 10.14814/phy2.16145
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11245571/
Jun 2024
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Electron transport chain inhibition increases cellular dependence on purine transport and salvage

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  DOI: 10.1016/j.cmet.2024.05.014
  
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sciencedirect.com/science/article/pii/S1550413124001906
Dec 2023
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MORG1 limits mTORC1 signaling by inhibiting Rag GTPases

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  DOI: 10.1016/j.molcel.2023.11.023
  
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sciencedirect.com/science/article/pii/S1097276523009681
Nov 2023
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The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

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  DOI: 10.1016/j.cmet.2023.10.016
  
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sciencedirect.com/science/article/abs/pii/S1550413123003856
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Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism

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  DOI: 10.15252/embr.202357339
  
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embopress.org/doi/full/10.15252/embr.202357339
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CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions

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  DOI: 10.1016/j.celrep.2023.113306
  
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sciencedirect.com/science/article/pii/S2211124723013189
Oct 2023
www.embopress.org www.embopress.org

The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes

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  DOI: 10.15252/embr.202356815
  
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embopress.org/doi/10.15252/embr.202356815
Jul 2023
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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

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  DOI: 10.1016/j.celrep.2023.112868
  
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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

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  DOI: 10.1016/j.celrep.2023.112794
  
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Jun 2023
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Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model

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  DOI: 10.1016/j.xcrm.2023.101073
  
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sciencedirect.com/science/article/pii/S2666379123001921
May 2023
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Emx1-Cre-mediated inactivation of PDK1 prevents plaque deposition in an Alzheimer’s disease-like mouse model

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1. scibot 04 May 2023
  
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  DOI: 10.36922/an.v1i3.153
  
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52.53.155.43/438598aeab07baaec772d6c22da43b4baf80f7c8/202211301546121b45a6671-html.html
Apr 2023
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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions

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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix

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The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model

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Ring domains are essential for GATOR2-dependent mTORC1 activation

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Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation

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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function

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Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication

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Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation

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Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis

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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

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MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

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In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

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Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons

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Δ9‐Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo

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Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells

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Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

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UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

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β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy

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Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

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Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response

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Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

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Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

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Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster

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Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice

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Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice

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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

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Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

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Regulation of mTORC1 by lysosomal calcium and calmodulin

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Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model

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