150 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Maternal gut microbiota influence stem cell function in offspring
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    1. scibot 12 Dec 2024
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      DOI: 10.1016/j.stem.2024.10.003

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    sciencedirect.com/science/article/pii/S1934590924003655
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    Antibiotics/coccidiostat exposure induces gut-brain axis remodeling for Akt/mTOR activation and BDNF-mediated neuroprotection in APEC-infected turkeys
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    1. scibot 05 Dec 2024
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      DOI: 10.1016/j.psj.2024.104636

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    sciencedirect.com/science/article/pii/S0032579124012148
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    Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery
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    1. scibot 02 Dec 2024
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      DOI: 10.1016/j.stem.2024.10.015

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    sciencedirect.com/science/article/pii/S1934590924003771
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    Hypoxia-inducible factor 2α promotes pathogenic polarization of stem-like Th2 cells via modulation of phospholipid metabolism
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    1. scibot 02 Dec 2024
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      DOI: 10.1016/j.immuni.2024.11.001

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    2. scibot 02 Dec 2024
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      DOI: 10.1016/j.immuni.2024.11.001

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    sciencedirect.com/science/article/pii/S1074761324004965
  6. Nov 2024
  7. www.sciencedirect.com www.sciencedirect.com
    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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    1. scibot 14 Nov 2024
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      DOI: 10.1016/j.cub.2024.10.061

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    sciencedirect.com/science/article/pii/S096098222401457X
  8. Aug 2024
  9. link.springer.com link.springer.com
    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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    1. scibot 25 Aug 2024
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      DOI: 10.1007/s12035-024-04425-9

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    link.springer.com/article/10.1007/s12035-024-04425-9
  10. www.mdpi.com www.mdpi.com
    Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice
    1
    1. scibot 02 Aug 2024
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      DOI: 10.3390/cells10123314

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    mdpi.com/2073-4409/10/12/3314/htm
  11. Jul 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding sunitinib resistance in ccRCC: Metabolic-reprogramming-induced ABAT and GABAergic system shifts
    1
    1. scibot 19 Jul 2024
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      DOI: 10.1016/j.isci.2024.110415

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    ncbi.nlm.nih.gov/pmc/articles/PMC11295714/
  13. elifesciences.org elifesciences.org
    Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
    1
    1. scibot 04 Jul 2024
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      DOI: 10.7554/eLife.98649

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    elifesciences.org/articles/98649
  14. May 2024
  15. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
    1
    1. scibot 25 May 2024
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      DOI: 10.1113/JP285339

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP285339
  16. 52.53.155.43 52.53.155.43
    Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells
    2
    1. scibot 24 May 2024
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    2. scibot 24 May 2024
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    52.53.155.43/76598b44d554c4165a9f84a25bc34c671709ff41/lee-et-al-2024-everolimus-exerts-anticancer-effects-through-inhibiting-the-interaction-of-matrix-metalloproteinase-7-html.html
  17. Apr 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
    1
    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114149

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    sciencedirect.com/science/article/pii/S2211124724004777
  19. dx.doi.org dx.doi.org
    β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
    1
    1. scibot 10 Apr 2024
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      DOI: 10.1210/endocr/bqae044

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    dx.doi.org/10.1210/endocr/bqae044
  20. 52.53.155.43 52.53.155.43
    12958_2024_1204_MOESM1_ESM-html.html
    1
    1. scibot 05 Apr 2024
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      DOI: 10.1186/s12958-024-01204-y

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    52.53.155.43/d3bb518aa444c98d6cfb77a0666830bf57a4ed47/12958_2024_1204_MOESM1_ESM-html.html
  21. Mar 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway
    1
    1. scibot 09 Mar 2024
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      DOI: 10.1016/j.isci.2024.109249

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    ncbi.nlm.nih.gov/pmc/articles/PMC10915561/
  23. Feb 2024
  24. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    1. scibot 27 Feb 2024
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      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  25. Jan 2024
  26. www.sciencedirect.com www.sciencedirect.com
    Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation
    1
    1. scibot 25 Jan 2024
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    sciencedirect.com/science/article/pii/S1097276524000030
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
    1
    1. scibot 20 Jan 2024
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      DOI: 10.1016/j.isci.2023.108733

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    ncbi.nlm.nih.gov/pmc/articles/PMC10792243/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P. mirabilis-derived pore-forming haemolysin, HpmA drives intestinal alpha-synuclein aggregation in a mouse model of neurodegeneration
    1
    1. scibot 18 Jan 2024
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      DOI: 10.1016/j.ebiom.2023.104887

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    ncbi.nlm.nih.gov/pmc/articles/PMC10709029/
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    Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
    1
    1. scibot 12 Jan 2024
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      DOI: 10.1016/j.ccell.2023.12.019

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    sciencedirect.com/science/article/pii/S1535610823004476
  30. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
    1. scibot 10 Jan 2024
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      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice
    1
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      DOI: 10.1152/ajpregu.00274.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC9799154/
  32. Dec 2023
  33. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    sciencedirect.com/science/article/pii/S1097276523009681
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    PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
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      DOI: 10.1016/j.nbd.2023.106370

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    sciencedirect.com/science/article/pii/S0969996123003868
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Amniotic MSC affect CD8 naive polarization toward SLEC/MPEC subsets by down-modulating IL-12Rβ1 and IL-2Rα signaling pathways
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    1. scibot 14 Dec 2023
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      DOI: 10.1016/j.isci.2023.108483

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    ncbi.nlm.nih.gov/pmc/articles/PMC10709131/
  36. www.sciencedirect.com www.sciencedirect.com
    Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy
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    1. scibot 07 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113529

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    sciencedirect.com/science/article/pii/S2211124723015413
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions
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      DOI: 10.1016/j.isci.2023.108446

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    ncbi.nlm.nih.gov/pmc/articles/PMC10687339/
  38. Nov 2023
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
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      DOI: 10.1172/jci.insight.170065

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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  40. Oct 2023
  41. www.sciencedirect.com www.sciencedirect.com
    Temporal dynamics of BDNF signaling recruitment in the rat prefrontal cortex and hippocampus following a single infusion of a translational dose of ketamine
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      DOI: 10.1016/j.neuropharm.2023.109767

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    sciencedirect.com/science/article/pii/S002839082300357X
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
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      DOI: 10.1186/s12967-023-04542-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC10577912/
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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      DOI: 10.1016/j.celrep.2023.113202

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    sciencedirect.com/science/article/pii/S2211124723012147
  44. Sep 2023
  45. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury
    1
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      DOI: 10.1113/EP091284

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    physoc.onlinelibrary.wiley.com/doi/10.1113/EP091284
  46. dx.doi.org dx.doi.org
    Insulin Signaling Is Preserved in Skeletal Muscle During Early Diabetic Ketoacidosis
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      DOI: 10.1210/clinem/dgad464

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  47. Aug 2023
  48. 52.53.155.43 52.53.155.43
    PIIS2589004223017029-html.html
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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting
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      DOI: 10.1016/j.cmet.2023.07.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC10432853/
  50. Jul 2023
  51. www.sciencedirect.com www.sciencedirect.com
    Recency memory is altered in cocaine-withdrawn adolescent rats: Implication of cortical mTOR signaling
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      DOI: 10.1016/j.pnpbp.2023.110822

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    sciencedirect.com/science/article/pii/S0278584623001082
  52. Jun 2023
  53. www.nature.com www.nature.com
    Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells
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      DOI: 10.1038/s41417-023-00637-8

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    nature.com/articles/s41417-023-00637-8
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    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex
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  60. Apr 2023
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    Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel
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    Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity
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    Translational patterns of ionotropic glutamate and GABA receptors during brain development and behavioral stimuli revealed by polysome profiling
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    Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
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    Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer
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  73. Dec 2022
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  76. Nov 2022
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  78. Oct 2022
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    Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation
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    Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome
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    Gold(III)-P-chirogenic complex induce mitochondrial dysfunction in triple-negative breast cancer
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  90. Mar 2022
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    Undercarboxylated Osteocalcin Improves Insulin-Stimulated Glucose Uptake in Muscles of Corticosterone-Treated Mice
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    Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases
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  95. Feb 2022
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  98. Jan 2022
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    Approaches and Protocols to Analyze Autophagy and Its Role in Death of Apoptosis-Resistant Senescent Tumor Cells
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  101. Dec 2021
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    The combination of dapagliflozin and statins ameliorates renal injury through attenuating the activation of inflammasome-mediated autophagy in insulin-resistant rats
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    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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    GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway
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  105. Nov 2021
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
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    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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  108. Oct 2021
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    Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth
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    sciencedirect.com/science/article/pii/S1074761318302425
  161. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
    1
    1. scibot 04 Sep 2020
      mTOR

      DOI: 10.15252/embr.201949898

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    embopress.org/doi/abs/10.15252/embr.201949898
  162. onlinelibrary.wiley.com onlinelibrary.wiley.com
    IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway
    1
    1. scibot 03 Sep 2020
      RRID: AB_330 978

      DOI: 10.1002/advs.202001502

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  163. www.sciencedirect.com www.sciencedirect.com
    Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice
    1
    1. scibot 03 Sep 2020
      RRID:AB_330978

      DOI: 10.1016/j.celrep.2020.107835

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    sciencedirect.com/science/article/pii/S2211124720308160
  164. www.sciencedirect.com www.sciencedirect.com
    Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis
    1
    1. scibot 03 Sep 2020
      RRID:AB_330978

      DOI: 10.1016/j.phrs.2020.104751

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    sciencedirect.com/science/article/pii/S1043661820303479
  165. Jan 2020
  166. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Rapamycin blocks the neuroprotective effects of sex steroids in the adult birdsong system
    1
    1. scibot 13 Jan 2020
      RRID:AB_330978

      DOI: 10.1002/dneu.22719

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    onlinelibrary.wiley.com/doi/full/10.1002/dneu.22719
  167. www.sciencedirect.com www.sciencedirect.com
    Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
    1
    1. scibot 13 Jan 2020
      RRID:AB_330978

      DOI: 10.1016/j.molcel.2019.07.023

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    sciencedirect.com/science/article/pii/S1097276519305532
  168. www.sciencedirect.com www.sciencedirect.com
    A Simple DMSO-Based Method for Cryopreservation of Primary Hippocampal and Cortical Neurons
    1
    1. scibot 13 Jan 2020
      AB_330978

      DOI: 10.1016/j.jneumeth.2019.108578

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    sciencedirect.com/science/article/pii/S0165027019304352
  169. www.sciencedirect.com www.sciencedirect.com
    Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells
    1
    1. scibot 13 Jan 2020
      AB_330978

      DOI: 10.1016/j.celrep.2019.05.020

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    sciencedirect.com/science/article/pii/S221112471930631X
  170. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 13 Jan 2020
      AB_330978

      DOI: 10.1111/bph.14706

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    bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14706
  171. www.sciencedirect.com www.sciencedirect.com
    Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages
    1
    1. scibot 13 Jan 2020
      RRID:AB_330978

      DOI: 10.1016/j.celrep.2019.05.093

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    sciencedirect.com/science/article/pii/S2211124719307326
  172. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway
    1
    1. scibot 13 Jan 2020
      RRID:AB_330978

      DOI: 10.1002/jcb.29123

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    onlinelibrary.wiley.com/doi/full/10.1002/jcb.29123
  173. www.sciencedirect.com www.sciencedirect.com
    IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties
    1
    1. scibot 13 Jan 2020
      RRID:AB_330978

      DOI: 10.1016/j.cmet.2019.01.006

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    sciencedirect.com/science/article/pii/S1550413119300063
  174. onlinelibrary.wiley.com onlinelibrary.wiley.com
    MicroRNA501‐5p induces p53 proteasome degradation through the activation of the mTOR/MDM2 pathway in ADPKD cells
    1
    1. scibot 13 Jan 2020
      RRID:AB_330978

      DOI: 10.1002/jcp.26473

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    onlinelibrary.wiley.com/doi/full/10.1002/jcp.26473
  175. academic.oup.com academic.oup.com
    Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice
    1
    1. scibot 13 Jan 2020
      RRID:AB_330978

      DOI: 10.1210/en.2018-00989

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    academic.oup.com/endo/article/160/4/716/5307699
  176. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_330978

      DOI: 10.1016/j.molcel.2018.12.001

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    sciencedirect.com/science/article/pii/S1097276518310311
  177. www.sciencedirect.com www.sciencedirect.com
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    1. scibot 13 Jan 2020
      RRID:AB_330978

      DOI: 10.1016/j.chembiol.2019.03.012

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    sciencedirect.com/science/article/pii/S2451945619301084
  178. www.sciencedirect.com www.sciencedirect.com
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    1. scibot 12 Jan 2020
      RRID:AB_330978

      DOI: 10.1016/j.immuni.2019.01.021

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    sciencedirect.com/science/article/pii/S1074761319300445
  179. Nov 2018
  180. www.sciencedirect.com www.sciencedirect.com
    Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
    1
    1. scibot 05 Nov 2018
      RRID:AB_330978

      Curator: @evieth

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    sciencedirect.com/science/article/pii/S155041311830514X
  181. www.sciencedirect.com www.sciencedirect.com
    Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin
    1
    1. scibot 05 Nov 2018
      RRID:AB_330978

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    sciencedirect.com/science/article/pii/S1550413118304479
  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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      RRID:AB_330978

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    ncbi.nlm.nih.gov/pmc/articles/PMC6063731/
  183. www.sciencedirect.com www.sciencedirect.com
    Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
    1
    1. scibot 05 Nov 2018
      RRID:AB_330978

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    sciencedirect.com/science/article/pii/S1097276517307049
  184. www.jneurosci.org www.jneurosci.org
    Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase–mTORC1 Translational Pathway
    1
    1. scibot 05 Nov 2018
      330978

      Curator: @bandrow

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    jneurosci.org/content/38/11/2780
  185. europepmc.org europepmc.org
    Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1.
    1
    1. scibot 05 Nov 2018
      RRID:AB_330978

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    europepmc.org/articles/PMC5652135/
  186. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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      RRID:AB_330978

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    sciencedirect.com/science/article/pii/S2352396417303705
  187. Nov 2017
  188. www.sciencedirect.com www.sciencedirect.com
    Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
    1
    1. scibot 08 Nov 2017
      2972

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S0092867416315318
  189. www.sciencedirect.com www.sciencedirect.com
    Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
    1
    1. scibot 08 Nov 2017
      RRID:AB_330978

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S2451945617302830
  190. www.sciencedirect.com www.sciencedirect.com
    A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
    1
    1. scibot 08 Nov 2017
      RRID:AB_330978

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1550413117304904
  191. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pimozide reduces toxic forms of tau in TauC3 mice via AMPK‐mediated autophagy
    1
    1. scibot 08 Nov 2017
      AB_330978

      Curator: @chewbeccax

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14109/full
  192. www.sciencedirect.com www.sciencedirect.com
    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
    1
    1. scibot 08 Nov 2017
      AB_330978

      Curator: @chewbeccax

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  193. academic.oup.com academic.oup.com
    Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS
    1
    1. scibot 08 Nov 2017
      AB 330978 

      Curator: @chewbeccax

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    academic.oup.com/endo/article/157/12/4641/2758409/Developmental-Programming-Insulin-Sensitizer