52 Matching Annotations
  1. Jun 2026
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    Distinct ERK and PI3K dependencies mediate a heterogeneous response to RAS(ON) inhibition in KRAS-mutant colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124726006376
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    PI3Kα inhibitor and degrader inavolisib can co-opt FGFR2 to enhance responses in patients with PIK3CA-mutated solid tumors and in preclinical models
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    aacrjournals.org/clincancerres/article/32/1/56/771272/PI3K-Inhibitor-and-Degrader-Inavolisib-Can-Co-opt
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    PCBP1 orchestrates amino acid metabolism burst during the naïve-to-primed pluripotency transition
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    sciencedirect.com/science/article/pii/S221367112600161X
  5. May 2026
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    An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies of peritoneal carcinomatosis
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    sciencedirect.com/science/article/pii/S1534580726001619
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    The REDD1–NF-κB–miRNAs–eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension
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    nature.com/articles/s41467-026-70601-1
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    Mechanism by which a linoleic acid metabolite suppresses cancer cell growth by inhibiting mTOR
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    sciencedirect.com/science/article/pii/S2451945626001376
  9. Jan 2026
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    Discovery, delineation, and therapeutic targeting of a hyper-translation pathway driving cytokine release syndrome
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    sciencedirect.com/science/article/pii/S2666379125006044
  11. Dec 2025
  12. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Mitochondrial VHL rewires cell metabolism in hypoxia
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    sciencedirect.com:5037/science/article/pii/S1550413125005273
  13. Nov 2025
  14. 54.241.53.176 54.241.53.176
    kato-et-al-2025-effects-of-repetition-duration-on-skeletal-muscle-hypertrophy-in-a-rat-model-of-resistance-exercise-html.html
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  15. Jul 2025
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    Lactoferrin attenuates renal fibrosis and uremic sarcopenia in a mouse model of adenine-induced chronic kidney disease
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    sciencedirect.com/science/article/pii/S0955286325002025
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    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    science.org/doi/10.1126/sciadv.ads2923
  18. Jun 2025
  19. 52.53.155.43 52.53.155.43
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    Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling
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  21. Mar 2025
  22. www.science.org www.science.org
    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    science.org/doi/10.1126/sciadv.ads2923
  23. link.springer.com link.springer.com
    A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer
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    link.springer.com/article/10.1038/s41698-025-00838-4
  24. Feb 2025
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  26. Dec 2024
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    The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity
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    sciencedirect.com/science/article/pii/S2211124724013846
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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  29. Apr 2024
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    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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  31. Sep 2023
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    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
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    sciencedirect.com/science/article/pii/S0022316623352799
  33. Jul 2023
  34. dx.doi.org dx.doi.org
    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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    dx.doi.org/10.1158/1535-7163.MCT-22-0224
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  36. Apr 2023
  37. www.sciencedirect.com www.sciencedirect.com
    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
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    sciencedirect.com/science/article/pii/S0896627323002684
  38. Oct 2022
  39. www.sciencedirect.com www.sciencedirect.com
    Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
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    sciencedirect.com/science/article/pii/S2451945622003609
  40. Jul 2022
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    Context-dependent regulation of ferroptosis sensitivity
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    sciencedirect.com/science/article/pii/S2451945622002367
  42. May 2022
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    sciencedirect.com/science/article/pii/S1534580722002866
  44. Apr 2022
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased Expression of Syncytin-1 in Skeletal Muscle of Humans With Increased Body Mass Index
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    ncbi.nlm.nih.gov/pmc/articles/PMC9013906/
  46. Feb 2022
  47. www.sciencedirect.com www.sciencedirect.com
    An AMPKα2-specific phospho-switch controls lysosomal targeting for activation
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    sciencedirect.com/science/article/pii/S2211124722000869
  48. Dec 2021
  49. journals.physiology.org journals.physiology.org
    Anemic Hypoxemia Reduces Myoblast Proliferation and Muscle Growth in Late Gestation Fetal Sheep
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    journals.physiology.org/doi/abs/10.1152/ajpregu.00342.2020
  50. Nov 2021
  51. 52.53.155.43 52.53.155.43
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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genomic alterations in PIK3CA-mutated breast cancer result in mTORC1 activation and limit the sensitivity to PI3Kα inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC8137641/
  54. link.springer.com link.springer.com
    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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    link.springer.com/article/10.1007/s00213-021-06015-2
  55. Oct 2021
  56. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adults
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP281907
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    Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability
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    sciencedirect.com/science/article/pii/S1534580721007310
  58. Sep 2021
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
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    ncbi.nlm.nih.gov/pmc/articles/PMC8439657/
  60. Feb 2021
  61. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15351
  62. www.cell.com www.cell.com
    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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    cell.com/molecular-cell/fulltext/S1097-2765(20)30836-4
  63. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP278933
  64. Nov 2020
  65. www.sciencedirect.com www.sciencedirect.com
    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S2666379120301737
  66. Oct 2020
  67. www.sciencedirect.com www.sciencedirect.com
    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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    sciencedirect.com/science/article/pii/S2211124720312195
  68. Sep 2020
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    mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression
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    sciencedirect.com/science/article/pii/S2211124720308925
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    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14979
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    Kinetic Heterogeneity of Cancer Cell Fractional Killing
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    sciencedirect.com/science/article/pii/S2211124720308263
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    Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade
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    sciencedirect.com/science/article/pii/S2211124720307336
  73. Jan 2020
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    A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease
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    sciencedirect.com/science/article/pii/S1550413119303080
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    Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
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    sciencedirect.com/science/article/pii/S1934590918306039
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  78. Nov 2018
  79. www.jneurosci.org www.jneurosci.org
    Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase–mTORC1 Translational Pathway
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    m6A Facilitates eIF4F-Independent mRNA Translation
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    Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice
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    academic.oup.com/endo/article/159/1/519/4562294