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  1. Last 7 days
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    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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      DOI: 10.1016/j.celrep.2024.115101

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    sciencedirect.com/science/article/pii/S2211124724014529
  3. Nov 2024
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    Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane
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    sciencedirect.com/science/article/pii/S0969212624004556
  5. Aug 2024
  6. www.embopress.org www.embopress.org
    EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
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      anti‐phospho‐AKT

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  7. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Untitled document
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    1. scibot 02 Aug 2024
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      DOI: 10.1002/jnr.23999

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    onlinelibrary.wiley.com/doi/10.1002/jnr.23999/full
  8. Jul 2024
  9. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway
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      DOI: 10.1111/acel.14258

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    Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways.
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  11. Jun 2024
  12. 52.53.155.43 52.53.155.43
    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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      DOI: 10.1101/2024.02.09.579580

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  13. May 2024
  14. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  15. 52.53.155.43 52.53.155.43
    2024.02.09.579580v1.full-html.html
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      DOI: 10.1038/nature05972

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  16. www.cell.com www.cell.com
    Discovery of SOCS7 as a versatile E3 ligase for protein-based degraders
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    cell.com/iscience/abstract/S2589-0042(24)01024-1
  17. 52.53.155.43 52.53.155.43
    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
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    1. scibot 09 May 2024
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  18. dx.doi.org dx.doi.org
    The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway
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    1. scibot 09 May 2024
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      DOI: 10.1210/endocr/bqae039

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  19. 52.53.155.43 52.53.155.43
    bqae039-html.html
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      DOI: 10.6084/m9.figshare.24398467.v2

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  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics
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      DOI: 10.7554/eLife.89100

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    ncbi.nlm.nih.gov/pmc/articles/PMC11060712/
  21. Apr 2024
  22. www.sciencedirect.com www.sciencedirect.com
    S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis
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      CST, #4058

      DOI: 10.1016/j.biopha.2024.116575

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    sciencedirect.com/science/article/pii/S0753332224004591
  23. Feb 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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      DOI: 10.1158/2767-9764.CRC-23-0321

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    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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  26. Nov 2023
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    Insulin receptor loss impairs mammary tumorigenesis in mice
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    sciencedirect.com/science/article/pii/S2211124723012639
  28. Sep 2023
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
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      DOI: 10.1158/2159-8290.CD-23-0475

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  30. Jul 2023
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro
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    ncbi.nlm.nih.gov/pmc/articles/PMC10368912/
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    Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes
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      DOI: 10.7717/peerj.15630

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    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
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  35. 52.53.155.43 52.53.155.43
    cd-23-0475-html.html
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  36. Jun 2023
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Age-Dependent Effects of Remote Preconditioning in Hypertensive Rat Hearts are Associated With Activation of RISK Signaling
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      DOI: 10.33549/physiolres.935019

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    ncbi.nlm.nih.gov/pmc/articles/PMC10292815/
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    Overcoming MET-mediated resistance in oncogene-driven NSCLC
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    sciencedirect.com/science/article/pii/S2589004223010830
  39. www.jneurosci.org www.jneurosci.org
    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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      DOI: 10.1523/JNEUROSCI.0146-23.2023

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    jneurosci.org/content/43/15/2631
  40. Apr 2023
  41. www.sciencedirect.com www.sciencedirect.com
    Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction
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    sciencedirect.com/science/article/pii/S2589004223005722
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphate Depletion in Insulin-Insensitive Skeletal Muscle Drives AMPD Activation and Sarcopenia in Chronic Kidney DIsease
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      DOI: 10.1016/j.isci.2023.106355

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    ncbi.nlm.nih.gov/pmc/articles/PMC10040733/
  43. Mar 2023
  44. www.sciencedirect.com www.sciencedirect.com
    SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression
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    sciencedirect.com/science/article/pii/S1550413123000827
  45. Dec 2022
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes
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      DOI: 10.3389/fcell.2022.1033501

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    ncbi.nlm.nih.gov/pmc/articles/PMC9716095/
  47. Nov 2022
  48. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.15971

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15971
  49. Sep 2022
  50. www.sciencedirect.com www.sciencedirect.com
    Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis
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    sciencedirect.com/science/article/pii/S1534580722005949
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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      DOI: 10.1158/2159-8290.CD-21-0551

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    ncbi.nlm.nih.gov/pmc/articles/PMC8904296/
  52. Aug 2022
  53. www.sciencedirect.com www.sciencedirect.com
    The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth
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    sciencedirect.com/science/article/pii/S2211124722010853
  54. Jul 2022
  55. www.sciencedirect.com www.sciencedirect.com
    FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
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    sciencedirect.com/science/article/pii/S1550413122002273
  56. Jun 2022
  57. link.springer.com link.springer.com
    The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin
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      DOI: 10.1186/s12964-022-00843-1

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    ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity
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  59. Apr 2022
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    The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression
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  61. Jan 2022
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    Nonphosphorylatable Src Ser75 Mutation Increases Ethanol Preference and Consumption in Mice
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  64. Dec 2021
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    Leptin coordinates efferent sympathetic outflow to the white adipose tissue through the midbrain centrally-projecting Edinger-Westphal nucleus in male rats
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  67. Nov 2021
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    p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts
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  69. Oct 2021
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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  71. Sep 2021
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    Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity
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  74. Aug 2021
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    Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis
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  76. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams
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    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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  80. Jul 2021
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    Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance
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    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
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      AB_331168u00a0

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    Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet–Induced Obesity
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      AB_329827

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    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
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  87. May 2021
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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  93. Apr 2021
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    Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice
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  95. Jan 2021
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  97. Nov 2020
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  99. Oct 2020
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    Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance
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  102. Sep 2020
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    Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway
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    Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation
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      anti-phospho-Akt (Ser473)

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    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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  108. Apr 2020
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    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
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  110. Jan 2020
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    A Targeted Protein Degradation Cell-Based Screening for Nanobodies Selective toward the Cellular RHOB GTP-Bound Conformation
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    Involvement of Akt-dependent CREB signaling pathway in hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced early growth response protein-1 (Egr-1) expression in vascular smooth muscle cells - Canadian Journal of Physiology and Pharmacology
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    Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation
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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  123. Nov 2018
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    Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen
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    Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase
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    In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver
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    Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets
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    Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)
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    Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy
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      Cell Signaling#4058

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  134. Nov 2017
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    Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling
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  136. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma
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    PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
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