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Intracellular cyclization-coupled peptide library screening yields potent transcription factor antagonists

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1. scibot 05 Mar 2026
  
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  DOI: 10.1016/j.chembiol.2026.02.002
  
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sciencedirect.com/science/article/pii/S2451945626000346
Feb 2026
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BPS Publications

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1. scibot 26 Feb 2026
  
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  DOI: 10.1111/bph.70364
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70364
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MEDAG functions as an A-kinase-anchoring protein in adipocytes

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.02.001
  
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sciencedirect.com/science/article/pii/S1097276526000961
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GPR3 is an immediate-early gene-like GPCR regulating CREB-dependent neuronal differentiation

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.isci.2026.114944
  
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sciencedirect.com/science/article/pii/S2589004226003196
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Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia

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1. scibot 13 Feb 2026
  
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  DOI: 10.1016/j.ccell.2026.01.014
  
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sciencedirect.com/science/article/pii/S153561082600053X
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Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment

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1. scibot 06 Feb 2026
  
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  DOI: 10.1016/j.cell.2026.01.001
  
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sciencedirect.com/science/article/pii/S0092867426000486
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Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppressing GSDME-dependent pyroptosis

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1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.cmet.2025.12.017
  
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A neuron subtype-specific role of MEK-ERK signaling in axon survival via transcriptional regulation of Nmnat2

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1. scibot 03 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116931
  
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sciencedirect.com/science/article/pii/S2211124726000094
Jan 2026
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Genome-wide CRISPR screening reveals a PKA-driven resistance mechanism to metformin for oral cancer prevention that can be exploited by combination with NSAIDs

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1. scibot 28 Jan 2026
  
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  DOI: 10.1158/1940-6207.CAPR-25-0264
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12826122/
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Regulation of stress tolerance by CREB1 sustains multiple myeloma cell survival

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1. scibot 22 Jan 2026
  
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  DOI: 10.1038/s41419-025-08246-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12811356/
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Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndrome

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116857
  
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sciencedirect.com/science/article/pii/S2211124725016298
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Afatinib exerts an inhibitory effect on T cell-mediated cytotoxicity

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1. scibot 16 Jan 2026
  
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  DOI: 10.1007/s00262-025-04279-7
  
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link.springer.com/article/10.1007/s00262-025-04279-7
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Sinapic acid balances the excitatory and inhibitory neurotransmitter systems to mitigate post-traumatic stress disorder-like behaviors

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1. scibot 13 Jan 2026
  
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  DOI: 10.1016/j.lfs.2026.124201
  
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sciencedirect.com/science/article/pii/S0024320526000093
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Endometrial stromal cell-derived TMAO sustains decidualization to prevent recurrent spontaneous abortion

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.cmet.2025.11.014
  
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sciencedirect.com/science/article/pii/S1550413125005285
Nov 2025
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1-s2.0-S2589004225024678-main-html.html

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.isci.2025.114206
  
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54.241.53.176/2cfc5b8ad2f9272e3f881028ee22a4318423a04e/1-s2.0-S2589004225024678-main-html.html
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The effects of doxorubicin on blood-brain barrier integrity in hCMEC/D3

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.neuro.2025.103355
  
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sciencedirect.com/science/article/pii/S0161813X25001615
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Deficiency of HMGN2 enhances antibacterial activity of macrophages by promoting H3 histone modification-mediated CD14/iNOS expression

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1. scibot 15 Nov 2025
  
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  DOI: 10.3389/fimmu.2025.1621440
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12611830/
Oct 2025
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TREK-1 Channel Blockade Mediates the Antidepressant-like Effects of Hydroxynorketamine

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1. scibot 29 Oct 2025
  
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  DOI: 10.1016/j.neuropharm.2025.110751
  
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sciencedirect.com/science/article/pii/S0028390825004599
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A non-canonical immunometabolic function of BRD3 during sepsis

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1. scibot 22 Oct 2025
  
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  DOI: 10.1016/j.devcel.2025.09.016
  
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sciencedirect.com/science/article/pii/S153458072500601X
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Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses

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1. scibot 01 Oct 2025
  
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  DOI: 10.1016/j.ccell.2025.09.003
  
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sciencedirect.com/science/article/pii/S1535610825003952
Sep 2025
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Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling

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1. scibot 27 Sep 2025
  
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  DOI: 10.1126/sciadv.adq7665
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12459396/
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Spirodelae Herba ethanol extract attenuates neurotoxicity in hippocampal cells and improves scopolamine-induced cognitive impairment in mice

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1. scibot 20 Sep 2025
  
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  DOI: 10.3389/fphar.2025.1638068
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12422933/
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Sympathetic Neurons Promote Small Cell Lung Cancer Through the Beta-2 Adrenergic Receptor

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1. scibot 07 Sep 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0718
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11875942/
Aug 2025
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BPS Publications

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1. scibot 21 Aug 2025
  
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  DOI: 10.1111/bph.70158
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70158
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Inhaling Eugenol Inhibits NAFLD by Activating the Hepatic Ectopic Olfactory Receptor Olfr544 and Modulating the Gut Microbiota

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1. scibot 21 Aug 2025
  
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  RRID:AB_331
  
  DOI: 10.1002/advs.202510321
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510321
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Preadipocyte-induced upregulation of IGFBP5 enhances ovarian cancer tumorigenesis via CREB signaling

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1. scibot 11 Aug 2025
  
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  DOI: 10.1016/j.isci.2025.113034
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12304763/
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Dissection of surface area-dependent lipolysis at a single organelle level

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116100
  
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sciencedirect.com/science/article/pii/S221112472500871X
Jul 2025
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PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

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1. scibot 30 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116071
  
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sciencedirect.com/science/article/pii/S2211124725008423
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Preadipocyte-induced upregulation of IGFBP5 enhances ovarian cancer tumorigenesis via CREB signaling

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1. scibot 22 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113034
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12304763/
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Neuronal PAC1 deletion impairs structural plasticity

1
1. scibot 08 Jul 2025
  
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  AB_3492056
  
  DOI: 10.1016/j.lfs.2025.123843
  
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sciencedirect.com/science/article/pii/S0024320525004783
Apr 2025
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PDF-html.html

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1. scibot 24 Apr 2025
  
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  DOI: 10.5281/zenodo.15149909
  
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52.53.155.43/b645d57731bbad4da56bb2d7f98fed3df22d621f/PDF-html.html
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Donepezil Improves PSD95 Expression, Mitigates Neuroinflammation via PI3K/Akt/NF-κB and Mitochondrial Dysfunction in a Rodent Model of Subarachnoid Haemorrhage

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1. scibot 17 Apr 2025
  
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  DOI: 10.1111/jnc.70063
  
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  RRID:AB_331277 DOI:10.1111/jnc.70063
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onlinelibrary.wiley.com/doi/10.1111/jnc.70063
Jan 2025
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Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115155
  
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sciencedirect.com/science/article/pii/S2211124724015067
Dec 2024
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BPS Publications

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1. scibot 12 Dec 2024
  
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  RRID:AB_331277
  
  DOI: 10.1111/bph.17403
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17403
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Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay

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1. scibot 12 Dec 2024
  
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  RRID:AB_331277
  
  DOI: 10.1016/j.celrep.2024.115075
  
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sciencedirect.com/science/article/pii/S2211124724014268
Nov 2024
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Overactive PKA signaling underlies the hyperalgesia in an ADHD mouse model

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1. scibot 10 Nov 2024
  
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Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation

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Chronic Lithium Treatment Alters NMDA and AMPA Receptor Synaptic Availability and Dendritic Spine Organization in the Rat Hippocampus

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Garcinia cambogia attenuates adipogenesis by affecting CEBPB and SQSTM1/p62-mediated selective autophagic degradation of KLF3 through RPS6KA1 and STAT3 suppression

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Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma

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IGF2BP2-Shox2 axis regulates hippocampal-neuronal senescence to alleviate microgravity-induced recognition disturbance

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NRAS mutant dictates AHCYL1-governed ER calcium homeostasis for melanoma tumor growth

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Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity

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TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice

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Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis

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Sorl1 knockout inhibits expression of brain-derived neurotrophic factor: involvement in the development of late-onset Alzheimer's disease

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Suppressive action of nesfatin-1 and nesfatin-1-like peptide on cortisol synthesis in human adrenal cortex cells

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Stromal-derived MAOB promotes prostate cancer growth and progression

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Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling

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Blocking AMPKαS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity

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Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice

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CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling

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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

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Metabolic regulation of CTCF expression and chromatin association dictates starvation response in mice and flies

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Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration

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Mettl3-m6A-Creb1 forms an intrinsic regulatory axis in maintaining iNKT cell pool and functional differentiation

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Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis

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The activation of GIP/GIPR axis via Sonic hedgehog signaling promotes the bridging of gapped nerves in sciatic nerve injury

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LAPTM4B-YAP loop feedback amplification enhances the stemness of hepatocellular carcinoma

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Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor

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Optogenetic Activation of UCP1-Dependent Thermogenesis in Brown Adipocytes

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Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting

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Aspirin suppresses hepatic glucagon signaling through decreasing production of thromboxane A2

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BPS Publications

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Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease

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Neuroprotective and Anti-Neuroinflammatory Properties of Vignae Radiatae Semen in Neuronal HT22 and Microglial BV2 Cell Lines

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EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer

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Proteomic-Based Approach Reveals the Involvement of Apolipoprotein A-I in Related Phenotypes of Autism Spectrum Disorder in the BTBR Mouse Model

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The κ-opioid receptor-induced autophagy is implicated in stress-driven synaptic alterations

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Chronic Trazodone and Citalopram Treatments Increase Trophic Factor and Circadian Rhythm Gene Expression in Rat Brain Regions Relevant for Antidepressant Efficacy

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Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes

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Poly-L-ornithine blocks the inhibitory effects of... : Neural Regeneration Research

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Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia

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BPS Publications

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Melatonin Inhibits NF-κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification

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The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin

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Requirement of hippocampal DG nNOS-CAPON dissociation for the anxiolytic and antidepressant effects of fluoxetine

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Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway

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Aquaporin 4 deficiency eliminates the beneficial effects of voluntary exercise in a mouse model of Alzheimer's disease

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Histone Acetylation Defects in Brain Precursor Cells: A Potential Pathogenic Mechanism Causing Proliferation and Differentiation Dysfunctions in Mitochondrial Aspartate-Glutamate Carrier Isoform 1 Deficiency

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Opioid receptor signaling suppresses leukemia through both catalytic and non-catalytic functions of TET2

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TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver

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Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

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Cadherin-12 Regulates Neurite Outgrowth Through the PKA/Rac1/Cdc42 Pathway in Cortical Neurons

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TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states

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Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity

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The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy

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Connected neurons in multiple neocortical areas, comprising parallel circuits, encode essential information for visual shape learning

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A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength

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11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice

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Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway

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Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation

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Developmental Exposure to Psychostimulant Primes Activity‐dependent Gene Induction in Frontal Cortex

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The mechanosensitive Piezo1 channel is required for bone formation

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Sprouty1 regulates neuritogenesis and survival of cortical neurons

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Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway

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ZL006 promotes migration and differentiation of transplanted neural stem cells in male rats after stroke

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11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice

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Nucleobindin-derived Nesfatin-1 and nesfatin-1-like peptide stimulate pro-opiomelanocortin synthesis in murine AtT-20 corticotrophs through the cAMP/PKA/CREB signaling pathway

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Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD

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A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression

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Cleaved PINK1 induces neuronal plasticity through PKA-mediated BDNF functional regulation

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Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model

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Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation

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A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

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Activation and expression of endogenous CREB‐regulated transcription coactivators (CRTC) 1, 2 and 3 in the rat adrenal gland

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The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity

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Ins1-Cre and Ins1-Cre ER gene replacement alleles are susceptible to silencing by DNA hypermethylation

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BPS Publications

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Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells

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Methamphetamine Activates Trace Amine Associated Receptor 1 to Regulate Astrocyte Excitatory Amino Acid Transporter-2 via Differential CREB Phosphorylation During HIV-Associated Neurocognitive Disorders

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Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma

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Nesfatin-1 and nesfatin-1-like peptide suppress growth hormone synthesis via the AC/PKA/CREB pathway in mammalian somatotrophs

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Zonisamide Ameliorates Cognitive Impairment by Inhibiting ER Stress in a Mouse Model of Type 2 Diabetes Mellitus

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The role of nucleus accumbens CREB attenuation in rescuing low voluntary running behavior in female rats

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Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium

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Melatonin alters neuronal architecture and increases cysteine‐rich protein 1 signaling in the male mouse hippocampus

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Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages

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Nicotine-induced upregulation of miR-132-5p enhances cell survival in PC12 cells by targeting the anti-apoptotic protein Bcl-2

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Nicotine-induced upregulation of miR-132-5p enhances cell survival in PC12 cells by targeting the anti-apoptotic protein Bcl-2

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Nicotine-induced upregulation of miR-132-5p enhances cell survival in PC12 cells by targeting the anti-apoptotic protein Bcl-2

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Nicotine-induced upregulation of miR-132-5p enhances cell survival in PC12 cells by targeting the anti-apoptotic protein Bcl-2

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Transcriptional regulation of ZNF638 in thermogenic cells by the cAMP response element binding protein CREB in male mice

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Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors

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Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine‐deficient mice

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Localization of area prostriata and its connections with primary visual cortex in rodent

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Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

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G protein‐coupled estrogen receptor (GPER) stimulation ameliorates iron‐ and ovariectomy‐induced memory impairments through the cAMP/PKA/CREB signaling pathway

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Sustained GRK2-dependent CREB activation is essential for α2-adrenergic receptor-induced PC12 neuronal differentiation

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Hepatic gluconeogenic response to single and long-term SGLT2 inhibition in lean/obese male hepatic G6pc-reporter mice

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In Vivo Imaging of the Coupling between Neuronal and CREB Activity in the Mouse Brain

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The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4

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Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum

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Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity

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Maternal separation stress reduced prenatal-ethanol-induced increase in exploratory behaviour and extracellular signal-regulated kinase activity

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Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes

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GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses

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Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues

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β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

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cGMP/PKG-I Pathway–Mediated GLUT1/4 Regulation by NO in Female Rat Granulosa Cells

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Vitamin C modulates glutamate transport and NMDA receptor function in the retina

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NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis

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Liver NF-κB-Inducing Kinase Promotes Liver Steatosis and Glucose Counterregulation in Male Mice With Obesity

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Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease

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STIM‐1 and ORAI‐1 channel mediate angiotensin‐II‐induced expression of Egr‐1 in vascular smooth muscle cells

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Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes

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Soluble cpg15 from Astrocytes Ameliorates Neurite Outgrowth Recovery of Hippocampal Neurons after Mouse Cerebral Ischemia

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