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  1. Last 7 days
  2. www.nature.com www.nature.com
    Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
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  3. Dec 2024
  4. 52.53.155.43 52.53.155.43
    Article PDF-html.html
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      CellSignaling  Technology  (CST),  3936

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    Gibberellin and cytokinin signaling antagonistically control female-germline cell specification in Arabidopsis
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  6. Nov 2024
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    STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair
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    sciencedirect.com/science/article/pii/S0092867424012005
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    Regulatory mechanisms of strigolactone perception in rice
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    USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
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  10. Oct 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P16INK4A drives RB1 degradation by UTP14A-catalyzed K810 ubiquitination
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  12. Sep 2024
  13. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages
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    A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma
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    FYVE1/FREE1 is involved in glutamine-responsive TORC1 activation in plants
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  17. Aug 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis
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    MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating USP18/VDAC2 pathway
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    cell.com/iscience/abstract/S2589-0042(24)01708-5
  20. Jul 2024
  21. 52.53.155.43 52.53.155.43
    Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells
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      DOI: 10.1242/jcs.258391

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    Pro-survival signaling regulates lipophagy essential for multiple myeloma resistance to stress-induced death
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  23. Jun 2024
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    The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress
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  25. May 2024
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glial fibrillary acidic protein is pathologically modified in Alexander disease
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  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington’s disease
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    Mecp2 fine-tunes quiescence exit by targeting nuclear receptors
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      DOI: 10.7554/eLife.89912

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  29. www.biorxiv.org www.biorxiv.org
    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
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      3936; Cell Signaling Technology)

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    biorxiv.org/content/10.1101/2024.01.25.577280v1
  30. Apr 2024
  31. www.sciencedirect.com www.sciencedirect.com
    Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia
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    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
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  33. www.nature.com www.nature.com
    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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  34. Mar 2024
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    Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis
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    The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance
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  40. Feb 2024
  41. link.springer.com link.springer.com
    CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin
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    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
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  43. Jan 2024
  44. www.sciencedirect.com www.sciencedirect.com
    hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50
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    sciencedirect.com/science/article/pii/S1097276523009802
  45. Dec 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
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    ncbi.nlm.nih.gov/pmc/articles/PMC10804999/
  47. Nov 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Lidocaine induces apoptosis in head and neck squamous cell carcinoma through activation of bitter taste receptor T2R14
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    sciencedirect.com/science/article/pii/S2211124723014493
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    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    sciencedirect.com/science/article/pii/S2211124723013645
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mass isolation of staged Drosophila pupal intestines for analysis of protein ubiquitylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10682243/
  51. Oct 2023
  52. link.springer.com link.springer.com
    MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
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      DOI: 10.1186/s13041-023-01064-4

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    link.springer.com/article/10.1186/s13041-023-01064-4
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    Methotrexate-based PROTACs as DHFR-specific chemical probes
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      DOI: 10.1016/j.chembiol.2023.09.014

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    sciencedirect.com/science/article/pii/S2451945623003331
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    Hepatocytic lipocalin-2 controls HDL metabolism and atherosclerosis via Nedd4-1-SR-BI axis in mice
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    sciencedirect.com/science/article/pii/S153458072300494X
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    Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity
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    Chemoproteomic strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration
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  64. Jun 2023
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    A small-molecule inhibitor of Keap1–Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites
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  78. Nov 2022
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  80. Oct 2022
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  111. Oct 2021
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    Ca2+ sensor-mediated ROS scavenging suppresses rice immunity and is exploited by a fungal effector
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  115. Sep 2021
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    Long noncoding RNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5
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    SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape
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  118. Aug 2021
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    Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
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    The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis
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    The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules
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    Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing
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  136. Nov 2020
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    Unbiased Proteomic Screening Identifies a Novel Role for the E3 Ubiquitin Ligase Nedd4‐2 in Translational Suppression During ER Stress
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    Legionella Manipulates Non-canonical SNARE Pairing Using a Bacterial Deubiquitinase
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    Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis
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  147. Jan 2020
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    Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
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    Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells
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    A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling
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    C2‐lacking isoform of Nedd4‐2 regulates excitatory synaptic strength through GluA1 ubiquitination‐independent mechanisms
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    Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5
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    Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB
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    Processing of DNA Polymerase-Blocking Lesions during Genome Replication Is Spatially and Temporally Segregated from Replication Forks
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    Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan
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    Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State
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    Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions
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    Chloroplast Biogenesis Controlled by DELLA-TOC159 Interaction in Early Plant Development
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    BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation
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    Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
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  170. Nov 2017
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    Defining a Cancer Dependency Map
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    Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18
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    RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity
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