121 Matching Annotations
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    Pro-survival signaling regulates lipophagy essential for multiple myeloma resistance to stress-induced death
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  3. Jun 2024
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    The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress
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  5. May 2024
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    Glial fibrillary acidic protein is pathologically modified in Alexander disease
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  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC11100560/
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    Mecp2 fine-tunes quiescence exit by targeting nuclear receptors
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    ncbi.nlm.nih.gov/pmc/articles/PMC11095939/
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    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
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    biorxiv.org/content/10.1101/2024.01.25.577280v1
  10. Apr 2024
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    Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia
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    sciencedirect.com/science/article/pii/S2666379124001903
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    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
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    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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  14. Mar 2024
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    Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis
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    The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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    sciencedirect.com/science/article/pii/S1097276524001722
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance
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    sciencedirect.com/science/article/pii/S2211124724002365
  20. Feb 2024
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    CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin
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    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
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  23. Jan 2024
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    hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50
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  25. Dec 2023
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    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
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  27. Nov 2023
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    Lidocaine induces apoptosis in head and neck squamous cell carcinoma through activation of bitter taste receptor T2R14
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    sciencedirect.com/science/article/pii/S2211124723014493
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    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    Mass isolation of staged Drosophila pupal intestines for analysis of protein ubiquitylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10682243/
  31. Oct 2023
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    MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
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    Methotrexate-based PROTACs as DHFR-specific chemical probes
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    Hepatocytic lipocalin-2 controls HDL metabolism and atherosclerosis via Nedd4-1-SR-BI axis in mice
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    sciencedirect.com/science/article/pii/S153458072300494X
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    Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity
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    AMER1 deficiency promotes the distant metastasis of colorectal cancer by inhibiting SLC7A11- and FTL-mediated ferroptosis
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    cell.com/cell-reports/abstract/S2211-1247(23)01121-X
  37. Sep 2023
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    Chemoproteomic strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration
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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10492219/
  40. Aug 2023
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    E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response
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  42. Jul 2023
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    The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy
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  44. Jun 2023
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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    LEAFY homeostasis is regulated via ubiquitin-dependent degradation and sequestration in cytoplasmic condensates
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    sciencedirect.com/science/article/pii/S2589004223009574
  47. May 2023
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    Pancreatic ductal adenocarcinoma ubiquitination profiling reveals specific prognostic and theranostic markers
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  49. Apr 2023
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    Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD
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    sciencedirect.com/science/article/pii/S2211124723003303
  51. Mar 2023
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    The RNA binding protein RALY suppresses p53 activity and promotes lung tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124723002991
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    A small-molecule inhibitor of Keap1–Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites
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    sciencedirect.com/science/article/pii/S2352396423000452
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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    sciencedirect.com/science/article/pii/S2211124723001997
  55. Jan 2023
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    Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma
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    Global cancer statistics, 2012
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  58. Nov 2022
  59. www.sciencedirect.com www.sciencedirect.com
    Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation
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  60. Oct 2022
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chemical screen uncovers novel structural classes of inhibitors of the papain-like protease of coronaviruses
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      DOI: 10.1016/j.isci.2022.105254

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    OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis
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    The protease DDI2 regulates NRF1 activation in response to cadmium toxicity
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    SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis
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    Sox9 mediates Autophagy-dependent vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis
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  66. Sep 2022
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    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
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    GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A
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  69. Jul 2022
  70. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
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    Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death
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    sciencedirect.com/science/article/pii/S258900422200904X
  73. Jun 2022
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    Prkn knockout mice show autistic-like behaviors and aberrant synapse formation
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    Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway.
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    Effects of Alexander disease–associated mutations on the assembly and organization of GFAP intermediate filaments
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  77. May 2022
  78. www.sciencedirect.com www.sciencedirect.com
    Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes
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    sciencedirect.com/science/article/pii/S2211124722006337
  79. Apr 2022
  80. www.sciencedirect.com www.sciencedirect.com
    Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB
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    CCT2 is an aggrephagy receptor for clearance of solid protein aggregates
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  83. Mar 2022
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization
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    ncbi.nlm.nih.gov/pmc/articles/PMC8923662/
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    Delicate regulation of IL-1β-mediated inflammation by cyclophilin A
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    sciencedirect.com/science/article/pii/S2211124722002492
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    Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments
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    Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass
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    sciencedirect.com/science/article/pii/S1097276522001393
  88. Feb 2022
  89. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency
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    ncbi.nlm.nih.gov/pmc/articles/PMC8786646/
  91. Oct 2021
  92. www.sciencedirect.com www.sciencedirect.com
    RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage
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    sciencedirect.com/science/article/pii/S2211124721013218
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    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
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    Ca2+ sensor-mediated ROS scavenging suppresses rice immunity and is exploited by a fungal effector
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    sciencedirect.com/science/article/pii/S0092867421010564
  95. Sep 2021
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    Long noncoding RNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5
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    SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape
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  98. Aug 2021
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    Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
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    Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins
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  101. Jul 2021
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    The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis
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  103. Jun 2021
  104. www.cell.com www.cell.com
    Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity
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    cell.com/molecular-cell/fulltext/S1097-2765(21)00451-2
  105. May 2021
  106. www.sciencedirect.com www.sciencedirect.com
    The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules
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    Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting
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    Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function
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  109. Apr 2021
  110. www.sciencedirect.com www.sciencedirect.com
    Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing
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    Unbiased Proteomic Screening Identifies a Novel Role for the E3 Ubiquitin Ligase Nedd4‐2 in Translational Suppression During ER Stress
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  119. Sep 2020
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    Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis
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    Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
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    Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells
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    A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling
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    Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila
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    Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB
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    CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation
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    Processing of DNA Polymerase-Blocking Lesions during Genome Replication Is Spatially and Temporally Segregated from Replication Forks
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    Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan
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    Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions
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    BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation
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    Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
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    Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18
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