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    Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
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    Phosphorylation of Plectin by Akt3 Promotes Triple-Negative Breast Cancer Cell Invasive Migration
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  4. Sep 2025
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    Spirodelae Herba ethanol extract attenuates neurotoxicity in hippocampal cells and improves scopolamine-induced cognitive impairment in mice
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  7. Jul 2025
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    Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis
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  9. Jun 2025
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    EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer
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  11. Apr 2025
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    Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression
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  13. Mar 2025
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    PAI-1-driven SFRP2high cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy
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    Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes
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  16. Jan 2025
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    CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
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  18. Nov 2024
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    Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981
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  20. Oct 2024
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    Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice
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    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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  23. Sep 2024
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    “β-Hydroxybutyrate Recapitulates the Beneficial Effects of Ketogenic Metabolic Therapy in Polycystic Kidney Disease”
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  25. Aug 2024
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    EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
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    Linking Hypothermia and Altered Metabolism with TrkB Activation
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  28. Jul 2024
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    Non-canonical NF-κB signaling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologies
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  30. Jun 2024
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    Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation
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  32. May 2024
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    Phenotype-specific melanoma uptake of fatty acid from human adipocytes activates AXL and CAV1-dependent β-catenin nuclear accumulation
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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    The relevance between abnormally elevated serum ceramide and cognitive impairment in Alzheimer’s disease model mice and its mechanism
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  39. Jan 2024
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  43. Jul 2023
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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  45. Jun 2023
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    Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition
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    Increased fibrosis in white adipose tissue of male and female bGH transgenic mice appears independent of TGF-β action
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  48. May 2023
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    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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    PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity
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    Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
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  52. Apr 2023
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    Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort
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  54. Mar 2023
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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  56. Feb 2023
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    CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2
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  58. Jan 2023
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    Hippocampal dentate gyri proteomics reveals Wnt signaling involvement in the behavioral impairment in the THRSP-overexpressing ADHD mouse model
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    SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2
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  61. Dec 2022
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    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
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  63. Nov 2022
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  65. Oct 2022
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    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
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  67. Sep 2022
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    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
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  69. Aug 2022
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    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
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  71. Jul 2022
  72. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Altered amyloid precursor protein, tau-regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1-month following repetitive mild traumatic brain injury
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  73. Jun 2022
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    Influence of maternal exercise on glucose and lipid metabolism in offspring stem cells: ENHANCED by Mom
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  75. May 2022
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    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
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  77. Feb 2022
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    A mouse model of inherited choline kinase β-deficiency presents with specific cardiac abnormalities and a predisposition to arrhythmia
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  79. Oct 2021
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    RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage
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  81. Sep 2021
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  83. Aug 2021
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    Leukemia associated RUNX1T1 gene reduced proliferation and invasiveness of glioblastoma cells
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  88. Jul 2021
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    KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis
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  94. May 2021
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    PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex
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    A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade
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    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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  98. Mar 2021
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  100. Feb 2021
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    Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring
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    MicroRNA‐34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle
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    onlinelibrary.wiley.com/doi/10.1002/jcb.29312
  103. Jan 2021
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  105. Dec 2020
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    The cGMP system in normal and degenerating mouse neuroretina: New proteins with cGMP interaction potential identified by a proteomics approach
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    Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement
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  108. Sep 2020
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    Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice
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    β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy
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    IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway
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  112. Jan 2020
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    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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    SFRPs Are Biphasic Modulators of Wnt-Signaling-Elicited Cancer Stem Cell Properties beyond Extracellular Control
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    Role of hepatic glucocorticoid receptor in metabolism in models of 5αR1 Deficiency in Male Mice
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    Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons
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  118. Nov 2018
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    Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β
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    FGF23 Regulates Wnt/β-Catenin Signaling-Mediated Osteoarthritis in Mice Overexpressing High-Molecular-Weight FGF2
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    Pathology of nNOS expressing GABAergic neurons in mouse model of Alzheimer’s disease
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    Lithium Inhibits GSK3β and Augments GluN2A Receptor Expression in the Prefrontal Cortex
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    ncbi.nlm.nih.gov/pmc/articles/PMC5799274/
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    Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy
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  124. Nov 2017
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    Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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  127. www.nature.com www.nature.com
    ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury
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    nature.com/articles/s41598-017-11654-7
  128. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Brief isoflurane anesthesia regulates striatal AKT‐GSK3β signaling and ameliorates motor deficits in a rat model of early‐stage Parkinson′s disease
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14066/full
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    TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway
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    jneurosci.org/content/37/7/1772
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    sciencedirect.com/science/article/pii/S2405471216304082