93 Matching Annotations
  1. May 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A personalized therapeutic approach for liver cancers expressing the African-centric P47S variant of TP53
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    pmc.ncbi.nlm.nih.gov/articles/PMC13147292/
  3. Apr 2026
  4. www.sciencedirect.com www.sciencedirect.com
    Targeting RNase H2: A dual-mechanism strategy to elevate replication stress, DNA damage, and antitumor immunity in TNBC
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    sciencedirect.com/science/article/pii/S2666379126001679
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    mct-25-0268-html.html
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  6. Mar 2026
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    FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage Response
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    pmc.ncbi.nlm.nih.gov/articles/PMC13007557/
  8. Jan 2026
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    Targeting ZDHHC12-mediated PARP1 palmitoylation potentiates PARP inhibitor cytotoxicity
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    sciencedirect.com/science/article/pii/S2211124725016821
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    IGFBP3-SphK1/S1P Signaling Axis Drives Enzalutamide Resistance in Advanced Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12795166/
  11. Dec 2025
  12. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    A 20-amino-acid Cardiovirus protein exhibits cytokine-mimicry activity to regulate viral replication
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    sciencedirect.com:5037/science/article/pii/S2211124725015128
  13. Nov 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12530129/
  15. Sep 2025
  16. 52.53.155.43 52.53.155.43
    2025.09.04.674332v2.full-html.html
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    Disrupting the interaction between androgen receptor and its coregulator WDR77 delays the growth of treatment-resistant prostate cancer
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  18. Jul 2025
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    Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma
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    Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695179/
  21. Jun 2025
  22. www.sciencedirect.com www.sciencedirect.com
    Macrophages promote tumor growth by phagocytosis-mediated cytokine amplification in Drosophila
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    sciencedirect.com/science/article/pii/S0960982225006840
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    Targeted destruction of follicle stimulating hormone receptor-positive cancer cells in vitro and in vivo by a lytic peptide Phor21-FSHβ conjugate
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    link.springer.com/article/10.1186/s10020-025-01292-5
  25. May 2025
  26. www.cell.com www.cell.com
    1-s2.0-S258900422500848X-main-html.html
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  27. Apr 2025
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11992107/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a TNIK-CDK9 Axis as a Targetable Strategy for Platinum-Resistant Ovarian Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962390/
  30. Mar 2025
  31. journals.lww.com journals.lww.com
    Treadmill exercise in combination with acousto-optic and... : Neural Regeneration Research
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  32. Jan 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell analysis of neoplastic plasma cells identifies myeloma pathobiology mediators and potential targets
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  35. Dec 2024
  36. 52.53.155.43 52.53.155.43
    TRIM47 promotes head and neck squamous cell carcinoma malignant progression by degrading XAF1 through ubiquitination
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    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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    Circular RNAs trigger nonsense-mediated mRNA decay
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  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
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  40. Nov 2024
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    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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  42. Oct 2024
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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  44. Sep 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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  47. Jul 2024
  48. 52.53.155.43 52.53.155.43
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    Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies
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    A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
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  51. May 2024
  52. www.biorxiv.org www.biorxiv.org
    Activation of PKR by a short-hairpin RNA
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    biorxiv.org/content/10.1101/2024.05.08.592371v1
  53. Apr 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The role of RASA2 in predicting radioresistance in lung cancer through regulation of p53
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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993856/
  56. Mar 2024
  57. www.sciencedirect.com www.sciencedirect.com
    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10905675/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527992/
  60. Feb 2024
  61. 52.53.155.43 52.53.155.43
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGFBP3 Promotes Resistance to Olaparib via Modulating EGFR Signaling in Advanced Prostate Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10847745/
  63. Jan 2024
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10105475/
  65. www.sciencedirect.com www.sciencedirect.com
    Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer
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    sciencedirect.com/science/article/pii/S2666379123006171
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10762335/
  67. Dec 2023
  68. www.sciencedirect.com www.sciencedirect.com
    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
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  69. Sep 2023
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    Inhibition of the serine/threonine kinase BUB1 reverses taxane resistance in prostate cancer
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    sciencedirect.com/science/article/pii/S2589004223017583
  71. Aug 2023
  72. 52.53.155.43 52.53.155.43
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  73. aacrjournals.org aacrjournals.org
    Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
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    aacrjournals.org/mct/article/22/8/962/727921/Vincristine-Enhances-the-Efficacy-of-MEK
  74. Jun 2023
  75. aacrjournals.org aacrjournals.org
    Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer
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    aacrjournals.org/cancerres/article/83/5/735/716680/Enhanced-Glutaminolysis-Drives-Hypoxia-Induced
  76. Mar 2023
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC10035898/
  78. Sep 2022
  79. www.sciencedirect.com www.sciencedirect.com
    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
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    sciencedirect.com/science/article/pii/S2211124722011287
  80. Jul 2022
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    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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    sciencedirect.com/science/article/pii/S221112472200897X
  82. May 2022
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC9044500/
  84. Apr 2022
  85. aacrjournals.org aacrjournals.org
    DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models
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  86. Feb 2022
  87. www.sciencedirect.com www.sciencedirect.com
    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
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  88. Dec 2021
  89. mct.aacrjournals.org mct.aacrjournals.org
    Antibody-drug conjugate efficacy in neuroblastoma - role of payload, resistance mechanisms, target density, and antibody internalization
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  90. Oct 2021
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    Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival
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  92. Aug 2021
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    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  95. www.mdpi.com www.mdpi.com
    Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC
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    ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma
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  97. Jul 2021
  98. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Retinoic acid receptor‐related orphan receptor RORα regulates differentiation and survival of keratinocytes during hypoxia
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    A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope
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  100. Jun 2021
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    NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
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  102. Mar 2021
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    Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line
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  104. Oct 2020
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
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  106. Sep 2020
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    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
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    Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis
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  109. academic.oup.com academic.oup.com
    BIS-INDOLE DERIVED NUCLEAR RECEPTOR 4A1 (NR4A1, Nur77) LIGANDS AS INHIBITORS OF ENDOMETRIOSIS
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  110. mct.aacrjournals.org mct.aacrjournals.org
    Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
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    Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling
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  112. Aug 2020
  113. www.sciencedirect.com www.sciencedirect.com
    Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia
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  114. Jan 2020
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    Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity
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    YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
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    Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors
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    Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer
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  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
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  125. Apr 2019
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    An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors
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  127. Nov 2018
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    Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
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  129. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0576-6
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    Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
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  131. www.nature.com www.nature.com
    Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death
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    nature.com/articles/s41420-018-0044-7
  132. Nov 2017
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    Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma
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    RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
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  135. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
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    pmc.ncbi.nlm.nih.gov/articles/PMC5092050/