89 Matching Annotations
  1. Jan 2026
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    Targeting ZDHHC12-mediated PARP1 palmitoylation potentiates PARP inhibitor cytotoxicity
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    sciencedirect.com/science/article/pii/S2211124725016821
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    IGFBP3-SphK1/S1P Signaling Axis Drives Enzalutamide Resistance in Advanced Prostate Cancer
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  4. Dec 2025
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    A 20-amino-acid Cardiovirus protein exhibits cytokine-mimicry activity to regulate viral replication
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  6. Nov 2025
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    PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer
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  8. Sep 2025
  9. 52.53.155.43 52.53.155.43
    2025.09.04.674332v2.full-html.html
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    Disrupting the interaction between androgen receptor and its coregulator WDR77 delays the growth of treatment-resistant prostate cancer
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  11. Jul 2025
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    Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma
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    Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695179/
  14. Jun 2025
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    Macrophages promote tumor growth by phagocytosis-mediated cytokine amplification in Drosophila
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    Targeted destruction of follicle stimulating hormone receptor-positive cancer cells in vitro and in vivo by a lytic peptide Phor21-FSHβ conjugate
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  18. May 2025
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  20. Apr 2025
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    Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer
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  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a TNIK-CDK9 Axis as a Targetable Strategy for Platinum-Resistant Ovarian Cancer
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  23. Mar 2025
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    Treadmill exercise in combination with acousto-optic and... : Neural Regeneration Research
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  25. Jan 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell analysis of neoplastic plasma cells identifies myeloma pathobiology mediators and potential targets
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  28. Dec 2024
  29. 52.53.155.43 52.53.155.43
    TRIM47 promotes head and neck squamous cell carcinoma malignant progression by degrading XAF1 through ubiquitination
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    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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    Circular RNAs trigger nonsense-mediated mRNA decay
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    The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
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  33. Nov 2024
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    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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  35. Oct 2024
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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  37. Sep 2024
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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  40. Jul 2024
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    Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies
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    A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
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  44. May 2024
  45. www.biorxiv.org www.biorxiv.org
    Activation of PKR by a short-hairpin RNA
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  46. Apr 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The role of RASA2 in predicting radioresistance in lung cancer through regulation of p53
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    Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
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  49. Mar 2024
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    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
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    INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors
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    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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  53. Feb 2024
  54. 52.53.155.43 52.53.155.43
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    IGFBP3 Promotes Resistance to Olaparib via Modulating EGFR Signaling in Advanced Prostate Cancer
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  56. Jan 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
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    Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10762335/
  60. Dec 2023
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    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
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  62. Sep 2023
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    Inhibition of the serine/threonine kinase BUB1 reverses taxane resistance in prostate cancer
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  64. Aug 2023
  65. 52.53.155.43 52.53.155.43
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  66. aacrjournals.org aacrjournals.org
    Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
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  67. Jun 2023
  68. aacrjournals.org aacrjournals.org
    Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer
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  69. Mar 2023
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo
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  71. Sep 2022
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    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
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  73. Jul 2022
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    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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  75. May 2022
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair
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  77. Apr 2022
  78. aacrjournals.org aacrjournals.org
    DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models
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  79. Feb 2022
  80. www.sciencedirect.com www.sciencedirect.com
    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
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  81. Dec 2021
  82. mct.aacrjournals.org mct.aacrjournals.org
    Antibody-drug conjugate efficacy in neuroblastoma - role of payload, resistance mechanisms, target density, and antibody internalization
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  83. Oct 2021
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    Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival
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  85. Aug 2021
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    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
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    Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC
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    ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma
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  90. Jul 2021
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    Retinoic acid receptor‐related orphan receptor RORα regulates differentiation and survival of keratinocytes during hypoxia
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    A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope
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  93. Jun 2021
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    NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
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  95. Mar 2021
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    Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line
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  97. Oct 2020
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    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
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  99. Sep 2020
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    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
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    Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis
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  102. academic.oup.com academic.oup.com
    BIS-INDOLE DERIVED NUCLEAR RECEPTOR 4A1 (NR4A1, Nur77) LIGANDS AS INHIBITORS OF ENDOMETRIOSIS
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  103. mct.aacrjournals.org mct.aacrjournals.org
    Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
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    Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling
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  105. Aug 2020
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    Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia
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  107. Jan 2020
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    Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity
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    YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
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    Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors
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    Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer
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    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
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  118. Apr 2019
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    An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors
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  120. Nov 2018
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    Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
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    VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
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    Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
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    Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death
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    nature.com/articles/s41420-018-0044-7
  125. Nov 2017
  126. www.sciencedirect.com www.sciencedirect.com
    Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma
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    sciencedirect.com/science/article/pii/S153561081730346X
  127. www.sciencedirect.com www.sciencedirect.com
    RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
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    sciencedirect.com/science/article/pii/S1535610817301575
  128. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
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    pmc.ncbi.nlm.nih.gov/articles/PMC5092050/