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Trappc4 is required for early mammalian development

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Aug 2026
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Astaxanthin Activates PI3K/AKT and AMPK Signaling to Alleviate Oxidative Stress and Improve Mouse Oocyte In Vitro Maturation

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Jul 2026
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Genome-wide CRISPR screen identifies AMBRA1 as a potential biomarker of response to platinum-based therapies in oral squamous cell carcinomas

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Histone H3.3 ensures cell proliferation and genomic stability during myeloid cell development

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Jun 2026
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ssrn-5400340-html.html

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Mutational signatures of environmental carcinogens in human tissue organoids revealed by duplex sequencing

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May 2026
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Phenylalanyl-tRNA synthetase FARS-1/FARSA balances longevity and immunity by downregulating endogenous mitochondrial double-stranded RNAs

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A personalized therapeutic approach for liver cancers expressing the African-centric P47S variant of TP53

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1. scibot 08 May 2026
  
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Mar 2026
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CREB2 Functions as a Central Mediator of Oxidative Neuronal Death Triggered by Microglial Glutamate Release Under Neuroinflammatory Conditions

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1. scibot 17 Mar 2026
  
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Feb 2026
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s10571-026-01695-w_reference-html.html

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Jan 2026
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Isoquercitrin induces melanogenesis in B16F10 melanoma cells and zebrafish via the p38 and PKA/CREB signaling pathways: an experimental study

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1. scibot 23 Jan 2026
  
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2026.01.07.697614v1.full-html.html

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54.241.53.176/87184a207210a45262d427988504be7f9d95d17e/2026.01.07.697614v1.full-html.html
Nov 2025
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Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope

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1. scibot 22 Nov 2025
  
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2025.11.06.687028v2.full-html.html

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CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability

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Jun 2025
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Microcurrent stimulation induces cell death in p53-mutant and 5-FU-resistant breast cancer

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1. scibot 25 Jun 2025
  
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Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss

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1. scibot 23 Jun 2025
  
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PDF-html.html

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DNA-PK Inhibition Shows Differential Radiosensitization in Orthotopic GBM PDX Models Based on DDR Pathway Deficits

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May 2025
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A lncRNA-mediated metabolic rewiring of cell senescence

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Trichosanthes kirilowii Maxim. and Bioactive Compound Cucurbitacin D Alleviate Cisplatin-Induced Peripheral Neuropathy In Vitro and In Vivo

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Nrf2- and p53-inducible REDD2/DDiT4L/Rtp801L confers pancreatic β-cell dysfunction, leading to glucose intolerance in high-fat diet-fed mice

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IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma

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Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target

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Mar 2025
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Dependence on Mdm2 for Mdm4 inhibition of p53 activity

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p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells

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  DOI: 10.1038/s41467-025-57229-3
  
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Feb 2025
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1-s2.0-S2589004225003785-main-html.html

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A non-catalytic function for Rad18 in sustaining glioblastoma proliferation

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52.53.155.43/bd241f9d9f184fcec259e1abcded858c2c8c9686/2024.09.05.611406.full-html.html
Jan 2025
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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint

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Dec 2024
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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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Microbiota-derived short-chain fatty acids determine stem cell characteristics of gastric chief cells

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Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

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  DOI: 10.1126/scisignal.adp1375
  
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Sep 2024
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Molecular basis of CX-5461-induced DNA damage response in primary vascular smooth muscle cells

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Aug 2024
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Redox heterogeneity in mouse embryonic stem cells individualizes cell fate decisions

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Loss of RBBP4 results in defective inner cell mass, severe apoptosis, hyperacetylated histones and preimplantation lethality in mice

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Endogenous p53 inhibitor TIRR dissociates systemic metabolic health from oncogenic activity

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Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC

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The ribotoxic stress response drives UV-mediated cell death

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Metabolic signature and response to glutamine deprivation are independent of p53 status in B cell malignancies

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Modulating PCGF4 stability is an efficient metastasis-regulatory strategy utilized by distinct subtypes of Cancer-Associated Fibroblasts in intrahepatic cholangiocarcinoma

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DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response

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A senescence restriction point acting on chromatin integrates oncogenic signals

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A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers

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Alternative polyadenylation determines the functional landscape of inverted Alu repeats

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FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination

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Breast Cancer Cells are Sensitized by Piperine to Radiotherapy through Estrogen Receptor-α mediated modulation of a Key NHEJ repair protein- DNA-PK

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Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

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Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response

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p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS

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A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer

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Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase

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Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia

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Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication

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Loss of epigenetic information as a cause of mammalian aging

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Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation

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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer

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Protein signaling in response to ex vivo dynamic contractions is independent of training status in rat skeletal muscle

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Dynamic stem cell selection safeguards the genomic integrity of the epidermis

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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

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Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells

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Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models

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Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction

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Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis

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A hydride transfer complex reprograms NAD metabolism and bypasses senescence

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Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations

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GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

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  AB_331464
  
  DOI: 10.1002/jcb.27885
  
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Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis

1
1. scibot 31 Jul 2021
  
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  rabbit anti‐phospho (Ser15) p53
  
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The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death

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  anti-phospho-p53
  
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An anterograde pathway for sensory axon degeneration gated by a cytoplasmic action of the transcriptional regulator P53

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p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)

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Systematic characterization of mutations altering protein degradation in human cancers

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Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness

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BPS Publications

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Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice

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A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability

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AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ

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A Broad Response to Intracellular Long-Chain Polyphosphate in Human Cells

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Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma

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Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response

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Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

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A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability

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53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

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Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation

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The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression

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Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

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Screening the expression of several miRNAs from TaqMan Low Density Array in traumatic brain injury: miR‐219a‐5p regulates neuronal apoptosis by modulating CCNA2 and CACUL1

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BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

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The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression

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Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

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Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy

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Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

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  Rabbit polyclonal anti-Phospho-p53 (Ser15)Cell SignalingCat# 9284
  
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DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis

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TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence

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