48 Matching Annotations
  1. Aug 2026
  2. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Magnesium Attenuates Renal Senescence and Fibrosis With Reduced <fc>DNA</fc> Damage Response and <fc>H</fc>3<fc>K</fc>4me3 Enrichment at the <fi>p16<sup>INK4a</sup></fi> Promoter
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202504665RR
  3. May 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CDK6/4 inactivates BAP1 deubiquitinase destabilizing VHL to promote metastatic colonization in liver
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    pmc.ncbi.nlm.nih.gov/articles/PMC13202817/
  5. Apr 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004226009855-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC13138062/
  7. Feb 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aberrant CDK4/6-driven cell-cycle reentry drives neuronal loss and defines a therapeutic target in C9orf72 ALS/FTD
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    pmc.ncbi.nlm.nih.gov/articles/PMC12856326/
  9. Jan 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A low-level Cdkn1c/p57kip2 expression in spinal progenitors drives the transition from proliferative to neurogenic modes of division
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    pmc.ncbi.nlm.nih.gov/articles/PMC12852696/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting the LHX1-LDB1 Complex Restores STING-dependent Senescence Surveillance and Inhibits Head and Neck Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12836506/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
  13. www.nature.com www.nature.com
    CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction
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    nature.com/articles/s41467-025-67865-4
  14. Oct 2025
  15. www.biorxiv.org www.biorxiv.org
    CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma
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    biorxiv.org/content/10.1101/2025.10.14.681840v1
  16. Jul 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    18F-FLT PET, a Noninvasive Pharmacodynamic Biomarker of Tumor Cell Proliferation, Detected Differential Response to Various Cyclin-Dependent Kinase (CDK) Inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214877/
  18. May 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CDK4 loss-of-function mutations cause microcephaly and short stature
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617628/
  20. Mar 2025
  21. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/b715c1a68ef0cb7b0448e003b2c7b73d6290765e/PDF-html.html
  22. www.sciencedirect.com www.sciencedirect.com
    CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety
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    sciencedirect.com/science/article/pii/S1535610825000583
  23. Feb 2025
  24. 52.53.155.43 52.53.155.43
    Uneven mitochondrial segregation during embryonic neurogenesis
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    52.53.155.43/69b7405c3f385ca181d40351a59e3a3273af371c/2024.11.08.622699.full-html.html
  25. Dec 2024
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC11609823/
  27. Nov 2024
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11532780/
  29. Sep 2024
  30. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas
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    pubmed.ncbi.nlm.nih.gov/32142668/
  31. Jul 2024
  32. www.sciencedirect.com www.sciencedirect.com
    Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton
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    sciencedirect.com/science/article/pii/S2211124724008398
  33. May 2024
  34. www.sciencedirect.com www.sciencedirect.com
    Molecular subtypes of neuroendocrine carcinomas: A cross-tissue classification framework based on five transcriptional regulators
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    sciencedirect.com/science/article/pii/S1535610824001636
  35. Mar 2024
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527992/
  37. Nov 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication
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    sciencedirect.com/science/article/pii/S1097276521001714
  39. Sep 2023
  40. www.sciencedirect.com www.sciencedirect.com
    Palbociclib releases the latent differentiation capacity of neuroblastoma cells
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    sciencedirect.com/science/article/pii/S1534580723004434
  41. Aug 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
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    ncbi.nlm.nih.gov/pmc/articles/PMC10441460/
  43. 52.53.155.43 52.53.155.43
    mct-23-0025 (1)-html.html
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    52.53.155.43/1629e82c15a2ef751662f24158b1c1b52e5a2112/mct-23-0025 (1)-html.html
  44. Jul 2023
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9812929/
  46. Jun 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response
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    sciencedirect.com/science/article/pii/S2589004223011677
  48. Aug 2022
  49. www.sciencedirect.com www.sciencedirect.com
    The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells
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    sciencedirect.com/science/article/pii/S2211124722009834
  50. Mar 2022
  51. www.nature.com www.nature.com
    Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma
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    nature.com/articles/s41467-022-28515-1
  52. www.sciencedirect.com www.sciencedirect.com
    Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis
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    sciencedirect.com/science/article/pii/S2211124722001711
  53. Oct 2021
  54. www.sciencedirect.com www.sciencedirect.com
    Quantitative differences between cyclin-dependent kinases underlie the unique functions of CDK1 in human cells
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    sciencedirect.com/science/article/pii/S2211124721012687
  55. Aug 2021
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6350781/
  57. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S2211124718317352
  58. Jul 2021
  59. www.sciencedirect.com www.sciencedirect.com
    Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
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    sciencedirect.com/science/article/pii/S0092867418312637
  60. May 2021
  61. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer
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    sciencedirect.com/science/article/pii/S1097276520302690
  62. Apr 2021
  63. www.sciencedirect.com www.sciencedirect.com
    Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication
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    sciencedirect.com/science/article/pii/S1097276521001714
  64. Jan 2021
  65. www.sciencedirect.com www.sciencedirect.com
    A FOXO-dependent replication checkpoint restricts proliferation of damaged cells
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    sciencedirect.com/science/article/pii/S2211124720316648
  66. Oct 2020
  67. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    A Marine Alkaloid, Ascomylactam A, Suppresses Lung Tumorigenesis via Inducing Cell Cycle G1/S Arrest through ROS/Akt/Rb Pathway
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    pubmed.ncbi.nlm.nih.gov/32992455/
  68. Sep 2020
  69. www.sciencedirect.com www.sciencedirect.com
    CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma
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    sciencedirect.com/science/article/pii/S1535610820300465
  70. www.sciencedirect.com www.sciencedirect.com
    A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex
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    sciencedirect.com/science/article/pii/S1097276519309529
  71. Jan 2020
  72. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1550413118306910
  73. www.sciencedirect.com www.sciencedirect.com
    MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance
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    sciencedirect.com/science/article/pii/S2211124719301937
  74. Nov 2018
  75. www.sciencedirect.com www.sciencedirect.com
    Patient-Derived Xenografts for Prognostication and Personalized Treatment for Head and Neck Squamous Cell Carcinoma
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    sciencedirect.com/science/article/pii/S2211124718315675
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints
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    ncbi.nlm.nih.gov/pmc/articles/PMC3635462/
  77. www.sciencedirect.com www.sciencedirect.com
    β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4
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    sciencedirect.com/science/article/pii/S1097276518306051
  78. www.sciencedirect.com www.sciencedirect.com
    Systematic Functional Annotation of Somatic Mutations in Cancer
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    sciencedirect.com/science/article/pii/S1535610818300217
  79. Nov 2017
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
  81. www.sciencedirect.com www.sciencedirect.com
    Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug
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    sciencedirect.com/science/article/pii/S2405471217303319
  82. www.sciencedirect.com www.sciencedirect.com
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    sciencedirect.com/science/article/pii/S2405471216304082