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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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  3. Dec 2024
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    TTF2 promotes replisome eviction from stalled forks in mitosis
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  5. Nov 2024
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    Human monocyte-derived macrophages shift subcellular metalloprotease activity depending on their activation state
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    STK19 positions TFIIH for cell-free transcription-coupled DNA repair
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    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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    Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms
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  10. Sep 2024
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    Untitled document
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  12. Aug 2024
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    Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
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    Intergenerational Epigenetic Inheritance Mediated by MYS-2/MOF in the Pathogenesis of Alzheimer’s Disease
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  15. Jul 2024
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    Identification of the main barriers to Ku accumulation in chromatin
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    PARP1-driven repair of topoisomerase IIIα DNA-protein crosslinks by FEN1
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    Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila
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    Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer
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  20. Jun 2024
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    The TERT Promoter is Polycomb-Repressed in Neuroblastoma Cells with Long Telomeres
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    CRISPR activation screens identify the SWI/SNF ATPases as suppressors of ferroptosis
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    Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice
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  24. May 2024
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    Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62
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    SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells
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    Deregulation of multiple mechanisms shapes the onset of LAMA2-congenital muscular dystrophy
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  28. Apr 2024
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    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
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    QDPR deficiency drives immune suppression in pancreatic cancer
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    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
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    BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing
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  33. Mar 2024
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    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
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    The zinc-finger protein Z4 cooperates with condensin II to regulate somatic chromosome pairing and 3D chromatin organization
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    Eukaryotic release factor 1 from Euplotes promotes frameshifting at premature stop codons in human cells
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  37. Feb 2024
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    FOXA1 forms biomolecular condensates that unpack condensed chromatin to function as a pioneer factor
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    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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  40. Jan 2024
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    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres
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    Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade
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    aacrjournals.org/cancerdiscovery/article/13/12/2566/731588/Formate-Supplementation-Enhances-Antitumor-CD8-T
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    Repression of latent NF-κB enhancers by PDX1 regulates β cell functional heterogeneity
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  45. Dec 2023
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    Subcytoplasmic location of translation controls protein output
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    An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling
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    cd-22-1301-html.html
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  49. Oct 2023
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    Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer
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    PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly
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    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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  56. Aug 2023
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    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    Targeted deprivation of methionine with engineered Salmonella leads to oncolysis and suppression of metastasis in broad types of animal tumor models
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    Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling
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  76. Mar 2023
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    Targeting Mutant Dicer Tumorigenesis in Pleuropulmonary Blastoma via Inhibition of RNA Polymerase I
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    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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    Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
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    PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression
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    Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival
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    A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability
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    Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis
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    Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9
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