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STING engages PKR to drive lysosomal cell death in lung ischemia-reperfusion injury

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sciencedirect.com/science/article/pii/S1097276526006672
Jul 2026
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Enteropathogenic Escherichia coli-mediated fast and coordinated Ca²+ responses regulate NF-κB activation

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1. scibot 24 Jul 2026
  
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  DOI: 10.7554/eLife.108953
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13391085/
Jun 2026
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Lipid transfer protein ORP3 mediates lysosomal repair via LC3B and ubiquitin-TAK1-p38 signaling

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Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages

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Feb 2026
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Yinhuo Decoction attenuates depression-like behaviors and promotes M2 microglia polarization by regulating PI3K/Akt/NF-κB signaling pathway in a murine model of menopausal depression

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Triglycerides induce endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity

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Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death

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Nov 2025
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Potentiation of noncanonical NF-κB signaling and marginal zone B cell expansion by CARD11-mediated regulation of p100 processing

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Inhibition of Histone Deacetylases Induces Cancer Cell Apoptosis Through the PERK Pathway of ER Stress Response

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Sep 2025
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Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease

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Aug 2025
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1-s2.0-S2589004225015664-main-html.html

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pmc.ncbi.nlm.nih.gov/articles/PMC12396248/
Jul 2025
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Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors

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Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners

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1. scibot 22 Jul 2025
  
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MyoD is Essential in Rhabdomyosarcoma by Promoting Survival Through Differentiation and CYLD

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52.53.155.43/383127a3ba30f18153ba559aaeac9e14b54b55e6/1-s2.0-S2589004225014105-main-html.html
May 2025
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Inflammasome signaling in astrocytes modulates hippocampal plasticity

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sciencedirect.com/science/article/pii/S1074761325001700
Mar 2025
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The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis

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ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity

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Feb 2025
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Design, Synthesis, and Biological Evaluation of BODIPY-Caged Resiquimod as a Dual-Acting Phototherapeutic

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1. scibot 20 Feb 2025
  
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  DOI: 10.1021/acs.jmedchem.4c02606
  
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sciencedirect.com/org/science/article/pii/S1520480425002224
Aug 2024
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Inhibition of bromodomain and extra-terminal proteins targets constitutively active NFκB and STAT signaling in lymphoma and influences the expression of the antiapoptotic proteins BCL2A1 and c-MYC

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ncbi.nlm.nih.gov/pmc/articles/PMC11348570/
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Cordycepin exhibits both antiviral and anti-inflammatory effects against dengue virus infection

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Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence

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May 2024
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Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity

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The action mechanism by which C1q/tumor necrosis factor-related protein-6 alleviates cerebral ischemia/reperfusion injury in diabetic mice

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Apr 2024
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BPS Publications

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  DOI: 10.1111/bph.16374
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16374
Mar 2024
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Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis

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ncbi.nlm.nih.gov/pmc/articles/PMC10944492/
Feb 2024
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Mycobacterial Rv1804c binds to the PEST domain of IκBα and activates macrophage-mediated proinflammatory responses

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Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments

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52.53.155.43/678de3c1597500687437f22f538803a9927e4973/ducharme-et-al-2023-divergent-mechanisms-regulate-tlr4-expression-on-peripheral-blood-mononuclear-cells-following-html.html
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In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux

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Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation

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Jan 2024
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PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis

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Dec 2023
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SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells

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Nov 2023
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Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (−)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice

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Oct 2023
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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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Sep 2023
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Stimulated myotube contractions regulate membrane-bound and soluble TLR4 to prevent LPS-induced signaling and myotube atrophy in skeletal muscle cells

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52.53.155.43/ce44bd3bfe7a2a53a9ed1e34602a6657fb092ed7/ducharme-et-al-2023-stimulated-myotube-contractions-regulate-membrane-bound-and-soluble-tlr4-to-prevent-lps-induced-html.html
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Stimulated myotube contractions regulate membrane-bound and soluble TLR4 to prevent LPS-induced signaling and myotube atrophy in skeletal muscle cells

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  DOI: 10.1152/ajpcell.00007.2023
  
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journals.physiology.org/doi/10.1152/ajpcell.00007.2023
Jun 2023
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Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in severe patients with COVID-19

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NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

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May 2023
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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

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Apr 2023
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PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1

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Jan 2023
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SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD

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Dec 2022
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GABA regulates IL-1β production in macrophages

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Nov 2022
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The epigenetic state of IL-4-polarized macrophages enables inflammatory cistromic expansion and extended synergistic response to TLR ligands

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Sep 2022
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Na/K-ATPase Suppresses LPS-Induced Pro-Inflammatory Signaling Through Lyn

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Aug 2022
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The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

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Jun 2022
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Undercarboxylated, but not Carboxylated, Osteocalcin suppresses TNF-α induced inflammatory signaling pathway in Myoblast

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Apr 2022
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The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade

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Oct 2021
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Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

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Insulin increases adipose adiponectin in pregnancy by inhibiting ubiquitination and degradation: Impact of obesity

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  DOI: 10.1210/clinem/dgab680
  
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academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab680/6370132
Sep 2021
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Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

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Jul 2021
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Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death

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1. scibot 31 Jul 2021
  
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  Rabbit polyclonal anti-IκBα
  
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Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-κB signaling pathways

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  IκBα
  
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Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity

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MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages

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Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells

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A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade

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Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

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CDKN2A Deletion in Melanoma Excludes T Cell Infiltration by Repressing Chemokine Expression in a Cell Cycle-Dependent Manner

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Oct 2020
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Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos

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Sep 2020
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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

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mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression

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Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

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Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway

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The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis

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Passenger Mutations Confound Phenotypes of SARM1-Deficient Mice

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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

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BPS Publications

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  DOI: 10.1111/bph.15182
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15182
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DPP-4 inhibition with anagliptin reduces lipotoxicity-induced insulin resistance and steatohepatitis in male mice

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  DOI: 10.1210/endocr/bqaa139
  
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academic.oup.com/endo/article/161/10/bqaa139/5892311
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Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways

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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

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1. scibot 04 Sep 2020
  
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  RRID:AB_331623
  
  DOI: 10.1016/j.cell.2020.05.053
  
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sciencedirect.com/science/article/pii/S0092867420306863
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The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

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1. scibot 13 Jan 2020
  
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  RRID:AB_331623
  
  DOI: 10.1016/j.cell.2019.05.035
  
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Expression of the double‐stranded RNA‐dependent kinase PKR influences osteosarcoma attachment independent growth, migration, and invasion

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1. scibot 13 Jan 2020
  
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  RRID:AB_331623
  
  DOI: 10.1002/jcp.29024
  
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onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29024
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Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

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1. scibot 13 Jan 2020
  
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  RRID:AB_331623
  
  DOI: 10.1016/j.ccell.2019.08.005
  
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sciencedirect.com/science/article/pii/S1535610819303733
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_331623
  
  DOI: 10.1016/j.celrep.2019.02.024
  
  Resource: (Cell Signaling Technology Cat# 9242, RRID:AB_331623)
  
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sciencedirect.com/science/article/pii/S2211124719301949
Nov 2018
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SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer

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1. scibot 05 Nov 2018
  
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  RRID:AB_331623
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S107476131830387X
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Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling

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1. scibot 05 Nov 2018
  
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  RRID:AB_331623
  
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sciencedirect.com/science/article/pii/S1097276518300455
Nov 2017
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Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis

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1. scibot 08 Nov 2017
  
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  AB_331623
  
  Curator: @chewbeccax
  
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  (Cell Signaling Technology Cat# 9242, RRID:AB_331623)
  
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The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior

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1. scibot 08 Nov 2017
  
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  AB_331623
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S2352396417301585

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