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  1. Last 7 days
  2. www.cell.com www.cell.com
    Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma
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    cell.com/cell-metabolism/fulltext/S1550-4131(25)00021-X
  3. www.sciencedirect.com www.sciencedirect.com
    The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma
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  4. Feb 2025
  5. 52.53.155.43 52.53.155.43
    PDF-html.html
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  6. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cannabinoid Receptor Type 2 Agonist, GW405833, Reduced the Impacts of MDA-MB-231 Breast Cancer Cells on Bone Cells
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  7. dx.doi.org dx.doi.org
    Progesterone Receptor Signaling Promotes Cancer Associated Fibroblast Mediated Tumorigenicity in ER+ Breast Cancer
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    KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC
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  9. aacrjournals.org aacrjournals.org
    C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia
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    aacrjournals.org/cancerdiscovery/article/13/7/1720/727640/C-EBP-Confers-Dependence-to-Fatty-Acid-Anabolic
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    ASCL1 restrains ERK1/2 to promote survival of a subset of neuroendocrine lung cancers
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    aacrjournals.org/mct/article/23/12/1789/750248/ASCL1-Restrains-ERK1-2-to-Promote-Survival-of-a
  11. 52.53.155.43 52.53.155.43
    pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A
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  12. 52.53.155.43 52.53.155.43
    ouellette-et-al-2025-altered-sphingolipid-profile-in-response-to-skeletal-muscle-injury-in-a-mouse-model-of-type-1-html.html
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  13. journals.physiology.org journals.physiology.org
    Altered Sphingolipid Profile in Response to Skeletal Muscle Injury in a Mouse Model of Type 1 Diabetes Mellitus.
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  14. 52.53.155.43 52.53.155.43
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    Taste receptor type 1 member 3 in osteoclasts regulates osteoclastogenesis via detection of glucose
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    Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk
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  17. 52.53.155.43 52.53.155.43
    Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis
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  18. Jan 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of Oxytocin (OT)-elicited reductions of body weight gain and adiposity in male diet-induced obese rats
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  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fgfr3 enhancer deletion markedly improves all skeletal features in a mouse model of achondroplasia
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    Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring
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    ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells
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  23. 52.53.155.43 52.53.155.43
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    Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation
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  25. Dec 2024
  26. aacrjournals.org aacrjournals.org
    Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma
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  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activation of Bradykinin B2 Receptors in Astrocytes Stimulates the Release of Leukemia Inhibitory Factor for Autocrine and Paracrine Signaling
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  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic and transcriptomic landscape of human gastrointestinal stromal tumors
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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A corticostriatal deficit promotes temporal distortion of automatic action in ageing
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  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development
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  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell analysis reveals host S phase drives large T antigen expression during BK polyomavirus infection
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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    Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity
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    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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    sciencedirect.com/science/article/pii/S235239642400495X
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    Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
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    sciencedirect.com/science/article/pii/S1931312824004384
  38. Nov 2024
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior
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    pmc.ncbi.nlm.nih.gov/articles/PMC11573748/
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    In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy
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    sciencedirect.com/science/article/pii/S1535610824003970
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
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      DOI: 10.1158/0008-5472.CAN-23-3574

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    pmc.ncbi.nlm.nih.gov/articles/PMC11532783/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
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      DOI: 10.3389/fimmu.2024.1470620

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    pmc.ncbi.nlm.nih.gov/articles/PMC11487346/
  43. Oct 2024
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Photobiomodulation regulates astrocyte activity and ameliorates scopolamine-induced cognitive behavioral decline
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      DOI: 10.3389/fncel.2024.1448005

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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
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    RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
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    Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases
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    Frontiers | Gestodene, a novel positive allosteric modulator of PAR1, enhances PAR1-mediated human platelet aggregation
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    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
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    Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer
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    Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell
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    Functional Regeneration of the Sensory Root via Axonal Invasion
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    Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer
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    The Orphan G Protein‐coupled Receptor 75 Signaling is Activated by the Chemokine CCL5
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    Exposure to far‐infrared ray attenuates methamphetamine‐induced impairment in recognition memory through inhibition of protein kinase C δ in male mice: Comparison with the antipsychotic clozapine
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    Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma
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    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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    Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance
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    Reiterated Male-to-Female Violence Disrupts Hippocampal Estrogen Receptor β Expression, Prompting Anxiety-Like Behavior
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    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
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    Ubiquitination and degradation of plant helper NLR by the Ralstonia solanacearum effector RipV2 overcome tomato bacterial wilt resistance
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    Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome
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    Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy
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    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    Regulation of synaptic MAPK/ERK phosphorylation in the rat striatum and medial prefrontal cortex by dopamine and muscarinic acetylcholine receptors
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  77. Jul 2024
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    A Comprehensive Protocol for Efficient Differentiation of Human NPCs into Electrically Competent Neurons
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    Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
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    A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation
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    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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    Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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  87. Jun 2024
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    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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    Evaluation of the role of AXL in fusion-positive pediatric rhabdomyosarcoma identifies the small-molecule inhibitor bemcentinib (BGB324) as potent chemosensitizer
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    Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanoma
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    The regulation of enteric neuron connectivity by Semaphorin 5A is affected by the autism-associated S956G missense mutation
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    Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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    Spatial transcriptomics suggests that alterations occur in the preneoplastic breast microenvironment of BRCA1/2 mutation carriers
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  127. 52.53.155.43 52.53.155.43
    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
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  128. onlinelibrary.wiley.com onlinelibrary.wiley.com
    l-Methionine potentiates anticancer activity of Sorafenib by epigenetically altering DUSP3/ERK pathway in hepatocellular carcinoma
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    Axon-derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pim kinase inhibitors increase gilteritinib cytotoxicity in FLT3-ITD acute myeloid leukemia through GSK-3β activation and c-Myc and Mcl-1 proteasomal degradation
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    mTOR regulates mineralocorticoid receptor transcriptional activity by ULK1- dependent and independent mechanisms
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    Membrane-associated NRPM proteins are novel suppressors of stomatal production in Arabidopsis
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    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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    DGK5β-derived phosphatidic acid regulates ROS production in plant immunity by stabilizing NADPH oxidase
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    Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
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  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M
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    Dual phosphorylation of DGK5-mediated PA burst regulates ROS in plant immunity
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    MIF modulates p38/ERK phosphorylation via MKP-1 induction in sarcoidosis
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHTOP Alleviates Cerebral Ischemia/Reperfusion-Induced Injury by Regulating RNA Alternative Splicing
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  144. Dec 2023
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    MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet
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    A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling
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    The Na/K-ATPase α1/Src Signaling Axis Regulates Mitochondrial Metabolic Function and Redox Signaling in Human iPSC-Derived Cardiomyocytes
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    Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
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    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice
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    MAPK-ERK-CREB signaling pathway upregulates Nav1.6 in oxaliplatin-induced neuropathic pain in the rat
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    Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis
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  170. www.sciencedirect.com www.sciencedirect.com
    Screening in serum-derived medium reveals differential response to compounds targeting metabolism
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    An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development
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    RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
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    Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    Tumoral P2Y2 receptor modulates tumor growth and host anti-tumor immune responses in a syngeneic murine model of oral cancer
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    Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes
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  180. Jul 2023
  181. www.sciencedirect.com www.sciencedirect.com
    Banana MKK1 modulates fruit ripening via the MKK1-MPK6-3/11-4-bZIP21 module
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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    T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity
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    Sphingosine 1-phosphate elicits a ROS-mediated proinflammatory response in human endometrial stromal cells via ERK5 activation
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  190. Jun 2023
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    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
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    Spatial single-cell sequencing of meiosis I arrested oocytes indicates acquisition of maternal transcripts from the soma
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    Sphingosine 1-phosphate activates S1PR3 to induce a pro-inflammatory phenotype in human myometrial cells
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