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    A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer
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    Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma
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  4. Mar 2025
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    The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma
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  6. Feb 2025
  7. 52.53.155.43 52.53.155.43
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    Cannabinoid Receptor Type 2 Agonist, GW405833, Reduced the Impacts of MDA-MB-231 Breast Cancer Cells on Bone Cells
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    Progesterone Receptor Signaling Promotes Cancer Associated Fibroblast Mediated Tumorigenicity in ER+ Breast Cancer
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    KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC
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    C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia
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    ASCL1 restrains ERK1/2 to promote survival of a subset of neuroendocrine lung cancers
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    pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A
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  15. journals.physiology.org journals.physiology.org
    Altered Sphingolipid Profile in Response to Skeletal Muscle Injury in a Mouse Model of Type 1 Diabetes Mellitus.
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    Taste receptor type 1 member 3 in osteoclasts regulates osteoclastogenesis via detection of glucose
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    Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk
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    Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis
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  20. Jan 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of Oxytocin (OT)-elicited reductions of body weight gain and adiposity in male diet-induced obese rats
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    Fgfr3 enhancer deletion markedly improves all skeletal features in a mouse model of achondroplasia
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    Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring
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    ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells
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    Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation
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  27. Dec 2024
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    Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma
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    Activation of Bradykinin B2 Receptors in Astrocytes Stimulates the Release of Leukemia Inhibitory Factor for Autocrine and Paracrine Signaling
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    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    Genomic and transcriptomic landscape of human gastrointestinal stromal tumors
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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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    A corticostriatal deficit promotes temporal distortion of automatic action in ageing
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    An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development
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    Single-cell analysis reveals host S phase drives large T antigen expression during BK polyomavirus infection
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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    Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity
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    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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    Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
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  40. Nov 2024
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior
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    In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy
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  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
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      DOI: 10.1158/0008-5472.CAN-23-3574

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  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
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      DOI: 10.3389/fimmu.2024.1470620

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  45. Oct 2024
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Photobiomodulation regulates astrocyte activity and ameliorates scopolamine-induced cognitive behavioral decline
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    Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
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  48. aacrjournals.org aacrjournals.org
    RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
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    Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases
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    Frontiers | Gestodene, a novel positive allosteric modulator of PAR1, enhances PAR1-mediated human platelet aggregation
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    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
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    Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer
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    Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell
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    Functional Regeneration of the Sensory Root via Axonal Invasion
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    Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer
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    The Orphan G Protein‐coupled Receptor 75 Signaling is Activated by the Chemokine CCL5
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    Exposure to far‐infrared ray attenuates methamphetamine‐induced impairment in recognition memory through inhibition of protein kinase C δ in male mice: Comparison with the antipsychotic clozapine
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    Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma
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    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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    Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance
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    Reiterated Male-to-Female Violence Disrupts Hippocampal Estrogen Receptor β Expression, Prompting Anxiety-Like Behavior
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    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
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    Ubiquitination and degradation of plant helper NLR by the Ralstonia solanacearum effector RipV2 overcome tomato bacterial wilt resistance
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    Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome
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    Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy
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    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    Purinergic receptor P2Y6 contributes to 1‐methyl‐4‐phenylpyridinium‐induced oxidative stress and cell death in neuronal SH‐SY5Y cells
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    A Comprehensive Protocol for Efficient Differentiation of Human NPCs into Electrically Competent Neurons
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    Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
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    A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation
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    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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    Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice
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    Direct GPCR-EGFR interaction enables synergistic membrane-to-nucleus information transfer
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    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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    Evaluation of the role of AXL in fusion-positive pediatric rhabdomyosarcoma identifies the small-molecule inhibitor bemcentinib (BGB324) as potent chemosensitizer
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    Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanoma
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    Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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    Spatial transcriptomics suggests that alterations occur in the preneoplastic breast microenvironment of BRCA1/2 mutation carriers
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    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
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  130. onlinelibrary.wiley.com onlinelibrary.wiley.com
    l-Methionine potentiates anticancer activity of Sorafenib by epigenetically altering DUSP3/ERK pathway in hepatocellular carcinoma
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    Axon-derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities
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    Pim kinase inhibitors increase gilteritinib cytotoxicity in FLT3-ITD acute myeloid leukemia through GSK-3β activation and c-Myc and Mcl-1 proteasomal degradation
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    Membrane-associated NRPM proteins are novel suppressors of stomatal production in Arabidopsis
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    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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    DGK5β-derived phosphatidic acid regulates ROS production in plant immunity by stabilizing NADPH oxidase
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    CHTOP Alleviates Cerebral Ischemia/Reperfusion-Induced Injury by Regulating RNA Alternative Splicing
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    MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet
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    A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling
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    The Na/K-ATPase α1/Src Signaling Axis Regulates Mitochondrial Metabolic Function and Redox Signaling in Human iPSC-Derived Cardiomyocytes
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    MAPK-ERK-CREB signaling pathway upregulates Nav1.6 in oxaliplatin-induced neuropathic pain in the rat
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    Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis
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  172. www.sciencedirect.com www.sciencedirect.com
    Screening in serum-derived medium reveals differential response to compounds targeting metabolism
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    RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    Tumoral P2Y2 receptor modulates tumor growth and host anti-tumor immune responses in a syngeneic murine model of oral cancer
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    Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes
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  182. Jul 2023
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    Banana MKK1 modulates fruit ripening via the MKK1-MPK6-3/11-4-bZIP21 module
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    T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity
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    Sphingosine 1-phosphate elicits a ROS-mediated proinflammatory response in human endometrial stromal cells via ERK5 activation
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  192. Jun 2023
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    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    Age-Dependent Effects of Remote Preconditioning in Hypertensive Rat Hearts are Associated With Activation of RISK Signaling
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    Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
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    Spatial single-cell sequencing of meiosis I arrested oocytes indicates acquisition of maternal transcripts from the soma
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