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    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
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    Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect
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    Context-dependent roles for ubiquitous mitochondrial creatine kinase CKMT1 in breast cancer progression
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    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
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    The regulation of enteric neuron connectivity by Semaphorin 5A is affected by the autism-associated S956G missense mutation
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    Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1
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    Zona Glomerulosa–Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice
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    Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
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    Extracellular signal‐regulated kinase regulates microglial immune responses in Alzheimer’s disease
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    Systematic Omics Analysis Identifies CCR6 as a Therapeutic Target to Overcome Cancer Resistance to EGFR Inhibitors
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  13. Mar 2024
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    Extracellular signal‐regulated kinases 2 (Erk2) and Erk5 in the central nervous system differentially contribute to central sensitization in male mice
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    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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    IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF
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    Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation
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    First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
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    Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway
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    Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT
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    Substrate-bound and soluble domains of tenascin-C regulate differentiation, proliferation and migration of neural stem and progenitor cells
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    PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay
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    The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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    Spatial transcriptomics suggests that alterations occur in the preneoplastic breast microenvironment of BRCA1/2 mutation carriers
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    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
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    l-Methionine potentiates anticancer activity of Sorafenib by epigenetically altering DUSP3/ERK pathway in hepatocellular carcinoma
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    Axon-derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities
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    Pim kinase inhibitors increase gilteritinib cytotoxicity in FLT3-ITD acute myeloid leukemia through GSK-3β activation and c-Myc and Mcl-1 proteasomal degradation
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    mTOR regulates mineralocorticoid receptor transcriptional activity by ULK1- dependent and independent mechanisms
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    Membrane-associated NRPM proteins are novel suppressors of stomatal production in Arabidopsis
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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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    DGK5β-derived phosphatidic acid regulates ROS production in plant immunity by stabilizing NADPH oxidase
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    Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M
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  38. Jan 2024
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    Dual phosphorylation of DGK5-mediated PA burst regulates ROS in plant immunity
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    MIF modulates p38/ERK phosphorylation via MKP-1 induction in sarcoidosis
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    Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk
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    CHTOP Alleviates Cerebral Ischemia/Reperfusion-Induced Injury by Regulating RNA Alternative Splicing
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  44. Dec 2023
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    MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet
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    A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling
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    Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk
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    B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling
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    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
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    The Na/K-ATPase α1/Src Signaling Axis Regulates Mitochondrial Metabolic Function and Redox Signaling in Human iPSC-Derived Cardiomyocytes
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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    Reticulons bind sphingolipids to activate the endoplasmic reticulum cell cycle checkpoint, the ER surveillance pathway
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  54. Nov 2023
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    Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
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    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
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    GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function
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  60. www.nature.com www.nature.com
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    ASCL1-ERK1/2 Axis: ASCL1 restrains ERK1/2 via the dual specificity phosphatase DUSP6 to promote survival of a subset of neuroendocrine lung cancers
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    TAK1 is an essential kinase for STING trafficking
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    MAPK-ERK-CREB signaling pathway upregulates Nav1.6 in oxaliplatin-induced neuropathic pain in the rat
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    Screening in serum-derived medium reveals differential response to compounds targeting metabolism
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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  80. Jul 2023
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    Banana MKK1 modulates fruit ripening via the MKK1-MPK6-3/11-4-bZIP21 module
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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    T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity
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    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System
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  169. europepmc.org europepmc.org
    Antibody Registry: ten years of registering antibodies
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    Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma
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    STAT3 is activated by CTGF-mediated tumor-stroma cross talk to promote HCC progression.
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    DHODH inhibition impedes glioma stem cell proliferation, induces DNA damage, and prolongs survival in orthotopic glioblastoma xenografts
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    Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis
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    Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling
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    Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep
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  177. Oct 2022
  178. www.sciencedirect.com www.sciencedirect.com
    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
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    Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein
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    COMPREHENSIVE DRUG RESPONSE PROFILING AND PAN-OMIC ANALYSIS IDENTIFIED THERAPEUTIC CANDIDATES AND PROGNOSTIC BIOMARKERS FOR ASIAN CHOLANGIOCARCINOMA
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    PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
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    D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
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    Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas
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    Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy
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  185. Sep 2022
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    GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP
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    Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor
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    Behaviorally penetrant, anomalous dopamine efflux exposes sex and circuit dependent regulation of dopamine transporters
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    Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
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    Multi-omics profiling shows BAP1 loss is associated with upregulated cell adhesion molecules in uveal melanoma
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    Na/K-ATPase Suppresses LPS-Induced Pro-Inflammatory Signaling Through Lyn
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    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
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    Anti-inflammatory effects of neutral lipids, glycolipids, phospholipids from Halocynthia aurantium tunic by suppressing the activation of NF-κB and MAPKs in LPS-stimulated RAW264.7 macrophages
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    Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses
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    S-nitrosylation is required for β2AR desensitization and experimental asthma
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    Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ1-42 Mice via α7nAChR-Dependent BDNF Upregulation
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    Mislocalization of protein kinase A drives pathology in Cushing’s syndrome
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  202. Jun 2022
  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat
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    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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