93 Matching Annotations
  1. Last 7 days
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    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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    sciencedirect.com/science/article/pii/S2211124724014529
  3. Dec 2024
  4. 52.53.155.43 52.53.155.43
    can-24-0456-html.html
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  5. Nov 2024
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    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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    sciencedirect.com/science/article/pii/S096098222401457X
  7. Aug 2024
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    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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    E2F1-associated purine synthesis pathway is a major component of the MET-DNA damage response network
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    1. scibot 01 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11288008/
  10. Jul 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    1. scibot 16 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
  12. May 2024
  13. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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    1. scibot 25 May 2024
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP285339
  14. Feb 2024
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    1. scibot 11 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
  16. Jan 2024
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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    1. scibot 06 Jan 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
  18. Dec 2023
  19. www.sciencedirect.com www.sciencedirect.com
    D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder
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    1. scibot 16 Dec 2023
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    sciencedirect.com/science/article/pii/S1534580723006159
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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    1. scibot 02 Dec 2023
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    sciencedirect.com/science/article/pii/S0092867423010814
  21. Nov 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
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    1. scibot 29 Nov 2023
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    sciencedirect.com/science/article/pii/S2589004223023556
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    1. scibot 03 Nov 2023
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    sciencedirect.com/science/article/pii/S1097276521001775
  24. Oct 2023
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development
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    1. scibot 14 Oct 2023
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      DOI: 10.1523/ENEURO.0159-23.2023

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    ncbi.nlm.nih.gov/pmc/articles/PMC10566546/
  26. Aug 2023
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    VEGF signaling governs the initiation of biliary-mediated liver regeneration through the PI3K-mTORC1 axis
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    sciencedirect.com/science/article/pii/S2211124723010392
  28. Jul 2023
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    Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
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    sciencedirect.com/science/article/pii/S2211124723008124
  30. dx.doi.org dx.doi.org
    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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      DOI: 10.1158/1535-7163.MCT-22-0224

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    IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression
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  32. 52.53.155.43 52.53.155.43
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  33. Jun 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months
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    sciencedirect.com/science/article/pii/S096999612300205X
  35. May 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Restoring the youthful state of striatal plasticity in aged mice re-enables cognitive control of action
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    sciencedirect.com/science/article/pii/S0960982223004682
  37. Apr 2023
  38. www.sciencedirect.com www.sciencedirect.com
    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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    sciencedirect.com/science/article/pii/S2589004223006557
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    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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    sciencedirect.com/science/article/pii/S2666379123001179
  40. Feb 2023
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    TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
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    sciencedirect.com/science/article/pii/S2211124723001407
  42. Jan 2023
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
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      DOI: 10.1523/JNEUROSCI.0010-22.2022

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    pmc.ncbi.nlm.nih.gov/articles/PMC9888514/
  44. Nov 2022
  45. elifesciences.org elifesciences.org
    Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity
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    1. scibot 10 Nov 2022
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      DOI: 10.7554/eLife.82810

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    elifesciences.org/articles/82810
  46. Oct 2022
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9579025/
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    An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs
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    sciencedirect.com/science/article/pii/S2211124722013171
  49. Sep 2022
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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      DOI: 10.1158/2159-8290.CD-21-0551

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    ncbi.nlm.nih.gov/pmc/articles/PMC8904296/
  51. Aug 2022
  52. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids
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    sciencedirect.com/science/article/pii/S2211124722010154
  53. Jul 2022
  54. www.sciencedirect.com www.sciencedirect.com
    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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    sciencedirect.com/science/article/pii/S1097276522005445
  55. Jun 2022
  56. 52.53.155.43 52.53.155.43
    Single unit analysis and wide-field imaging reveal alterations in excitatory and inhibitory neurons in glioma
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      DOI: 10.1093/brain/awac168

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  57. May 2022
  58. www.sciencedirect.com www.sciencedirect.com
    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    sciencedirect.com/science/article/pii/S2211124722005952
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    PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease
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      DOI: 10.1016/j.cell.2022.04.020

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    sciencedirect.com/science/article/pii/S0092867422004676
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling
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      DOI: 10.1158/1541-7786.MCR-20-0753

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    ncbi.nlm.nih.gov/pmc/articles/PMC8568653/
  61. Apr 2022
  62. academic.oup.com academic.oup.com
    Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
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      DOI: 10.1210/endocr/bqac035

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    academic.oup.com/endo/article/163/5/bqac035/6550639
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    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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      DOI: 10.7554/eLife.76963

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    ncbi.nlm.nih.gov/pmc/articles/PMC9007586/
  64. Mar 2022
  65. www.sciencedirect.com www.sciencedirect.com
    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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    sciencedirect.com/science/article/pii/S2211124722002583
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    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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  67. Feb 2022
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  70. Nov 2021
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    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
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  75. Oct 2021
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  79. Sep 2021
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    Single dose of amphetamine induces delayed subregional attenuation of cholinergic interneuron activity in the striatum
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  82. Aug 2021
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    Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
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    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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  88. Jul 2021
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    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
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  91. Jun 2021
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    Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
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  93. May 2021
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    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
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    Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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  99. Apr 2021
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    Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis
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    Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas
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  106. Jan 2021
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  108. Oct 2020
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    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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  110. Sep 2020
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    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers
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    Metabolic Control over mTOR-Dependent Diapause-like State
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    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
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    Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module
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    mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis
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    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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  118. rupress.org rupress.org
    Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of MatriptaseThe double face of Matriptase
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  120. www.sciencedirect.com www.sciencedirect.com
    Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression
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    A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation
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  122. Jan 2020
  123. www.sciencedirect.com www.sciencedirect.com
    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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    Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension
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    Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
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    Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan
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  127. www.sciencedirect.com www.sciencedirect.com
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  128. Nov 2018
  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    m6A Facilitates eIF4F-Independent mRNA Translation
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    mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
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  132. Nov 2017
  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression
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