108 Matching Annotations
  1. Last 7 days
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    TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12669767/
  3. Nov 2025
  4. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004225024654-main-html.html
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    kato-et-al-2025-effects-of-repetition-duration-on-skeletal-muscle-hypertrophy-in-a-rat-model-of-resistance-exercise-html.html
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  6. Oct 2025
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    HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis
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    sciencedirect.com/science/article/pii/S2211124725011532
  8. Sep 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Efficacy of ATR Kinase Inhibitor Elimusertib Monotherapy or Combination in Tumors with DNA Damage Response Pathway and Other Genomic Alterations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12402799/
  10. Aug 2025
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    HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma
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    5-HT6 Receptor Inverse Agonists Modulate Diabetic Neuropathic Pain in Female Rats: Evidence for 5-HT6 Receptor Constitutive Activity
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    onlinelibrary.wiley.com/doi/10.1111/jnc.70179
  13. Jul 2025
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    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs
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  16. Jun 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA-driven refractory vascular malformations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12162881/
  18. May 2025
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    De novo serine biosynthesis is protective in mitochondrial disease
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  20. Mar 2025
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    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    science.org/doi/10.1126/sciadv.ads2923
  22. Feb 2025
  23. 52.53.155.43 52.53.155.43
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    Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA-Driven refractory vascular malformations
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    biorxiv.org/lookup/doi/10.1101/2024.10.16.618777
  25. Jan 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Steroid hormone receptors, exome sequencing and treatment responsiveness of breast cancer patient-derived xenografts originated in a South American country
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  27. Dec 2024
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    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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  30. Nov 2024
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    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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  32. Aug 2024
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    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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    E2F1-associated purine synthesis pathway is a major component of the MET-DNA damage response network
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  35. Jul 2024
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    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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  37. May 2024
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    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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  39. Feb 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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  41. Jan 2024
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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  43. Dec 2023
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    D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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  46. Nov 2023
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    Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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  49. Oct 2023
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    Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development
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  51. Aug 2023
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    VEGF signaling governs the initiation of biliary-mediated liver regeneration through the PI3K-mTORC1 axis
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  53. Jul 2023
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    Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
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    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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    dx.doi.org/10.1158/1535-7163.MCT-22-0224
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    IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression
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  58. Jun 2023
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    Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months
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  60. May 2023
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    Restoring the youthful state of striatal plasticity in aged mice re-enables cognitive control of action
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  62. Apr 2023
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    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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  65. Feb 2023
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    TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
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  67. Jan 2023
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
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  69. Nov 2022
  70. elifesciences.org elifesciences.org
    Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity
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    elifesciences.org/articles/82810
  71. Oct 2022
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
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    An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs
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  74. Sep 2022
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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  76. Aug 2022
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    Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids
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  78. Jul 2022
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    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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  80. Jun 2022
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    Single unit analysis and wide-field imaging reveal alterations in excitatory and inhibitory neurons in glioma
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  82. May 2022
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    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease
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    Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC8568653/
  86. Apr 2022
  87. academic.oup.com academic.oup.com
    Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
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    academic.oup.com/endo/article/163/5/bqac035/6550639
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    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9007586/
  89. Mar 2022
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    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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  92. Feb 2022
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    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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    embopress.org/doi/abs/10.15252/embj.2021108119
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  95. Nov 2021
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
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    ncbi.nlm.nih.gov/pmc/articles/PMC8598234/
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    mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion
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    SLC1A5 provides glutamine and asparagine necessary for bone development in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC8553342/
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    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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    link.springer.com/article/10.1007/s00213-021-06015-2
  100. Oct 2021
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    Tyrosine Phosphorylation of DEPTOR Functions as a Molecular Switch to Activate mTOR Signaling
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    Functional heterogeneity of POMC neurons relies on mTORC1 signaling
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    Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability
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  104. Sep 2021
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single dose of amphetamine induces delayed subregional attenuation of cholinergic interneuron activity in the striatum
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    ncbi.nlm.nih.gov/pmc/articles/PMC8454923/
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    Oncogene-dependent sloppiness in mRNA translation
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  107. Aug 2021
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apocynin prevents cigarette smoking‐induced loss of skeletal muscle mass and function in mice by preserving proteostatic signalling
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    ncbi.nlm.nih.gov/pmc/articles/PMC8362135/
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    Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
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    sciencedirect.com/science/article/pii/S0092867418313230
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    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14311
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    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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  113. Jul 2021
  114. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14874
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  116. Jun 2021
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    Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
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  118. May 2021
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    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
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    Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
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    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
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  124. Apr 2021
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    Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis
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    Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer
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    SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis
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    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
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