118 Matching Annotations
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    Engineered receptor-biased IL-2–drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy
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  3. Oct 2026
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    A common germline 3′ UTR variant controls DDIT4 translation efficiency and stress responses in cancer cells
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    Nutrient deprivation enhances the cytotoxic effects of a sulfonamide-chalcone hybrid in PC-3 prostate cancer cells
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    Transcriptome-wide splicing analysis reveals HuR-regulated post-transcriptional programs in osteocytes
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  9. Jun 2026
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    Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies
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    eIF4G2-Dependent Translation Restrains Pancreatic Cancer Progression
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    PCBP1 orchestrates amino acid metabolism burst during the naïve-to-primed pluripotency transition
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  13. May 2026
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    The REDD1–NF-κB–miRNAs–eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension
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    Graded activation of the CLEAR network through mTORC1 suppression on cargo-harboring lysosomes
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  17. Mar 2026
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    Valine availability controls oncogenic cell-cycle progression through translation of D-type cyclins
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    Mitochondrial VHL rewires cell metabolism in hypoxia
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    Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
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  24. Nov 2025
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    Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
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  28. Jul 2025
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    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability
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  31. Jun 2025
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    Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
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  33. May 2025
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    KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation
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  36. Mar 2025
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    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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  38. Feb 2025
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    RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis
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  40. Dec 2024
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    TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression
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  42. Jul 2024
  43. www.biorxiv.org www.biorxiv.org
    Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor
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    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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  46. Oct 2023
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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  49. Sep 2023
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    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
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  51. Aug 2023
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    A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection
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  53. Jul 2023
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    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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  55. Jun 2023
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    Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice
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  57. May 2023
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  59. Apr 2023
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    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
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  61. Dec 2022
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    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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    Ring domains are essential for GATOR2-dependent mTORC1 activation
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    Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells
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  65. Nov 2022
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    A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice
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  67. Oct 2022
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    An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs
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  69. Aug 2022
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    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
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  71. Jul 2022
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    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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  73. Jun 2022
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    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
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    Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine
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  76. May 2022
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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  78. Apr 2022
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    Increased Expression of Syncytin-1 in Skeletal Muscle of Humans With Increased Body Mass Index
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    A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration
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  81. Mar 2022
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    Neurons undergo pathogenic metabolic reprogramming in models of familial ALS
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  83. Feb 2022
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    Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation
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    An AMPKα2-specific phospho-switch controls lysosomal targeting for activation
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  87. Dec 2021
  88. journals.physiology.org journals.physiology.org
    Anemic Hypoxemia Reduces Myoblast Proliferation and Muscle Growth in Late Gestation Fetal Sheep
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  90. Nov 2021
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    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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  94. Oct 2021
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    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice
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  99. Sep 2021
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    Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia
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    Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway
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    Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism
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    Regulation of human mTOR complexes by DEPTOR
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    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
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  106. Aug 2021
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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  110. Jul 2021
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    Intrinsically Disordered Protein TEX264 Mediates ER-phagy
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
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    Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14306
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    mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
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  118. May 2021
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    Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity
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  120. Apr 2021
  121. www.cell.com www.cell.com
    β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells
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    cell.com/current-biology/abstract/S0960-9822(21)00146-9
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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  123. Mar 2021
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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  125. Feb 2021
  126. www.cell.com www.cell.com
    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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    cell.com/molecular-cell/fulltext/S1097-2765(20)30827-3
  127. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP278933
  128. Nov 2020
  129. www.sciencedirect.com www.sciencedirect.com
    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S2666379120301737
  130. Sep 2020
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