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102 Matching Annotations

Jul 2025
www.science.org www.science.org

Transfer RNA acetylation regulates in vivo mammalian stress signaling

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1. scibot 25 Jul 2025
  
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  DOI: 10.1126/sciadv.ads2923
  
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science.org/doi/10.1126/sciadv.ads2923
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability

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1. scibot 16 Jul 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2471
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735329/
Jun 2025
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Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102133
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12147910/
May 2025
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KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

1
1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12091147/
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Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor

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1. scibot 19 May 2025
  
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  DOI: 10.1016/j.xcrm.2025.102133
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12147910/
Mar 2025
www.science.org www.science.org

Transfer RNA acetylation regulates in vivo mammalian stress signaling

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1. scibot 21 Mar 2025
  
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  DOI: 10.1126/sciadv.ads2923
  
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science.org/doi/10.1126/sciadv.ads2923
Feb 2025
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RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis

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1. scibot 27 Feb 2025
  
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  DOI: 10.1038/s44318-024-00353-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11832924/
Dec 2024
www.cell.com www.cell.com

TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression

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1. scibot 29 Dec 2024
  
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  DOI: 10.1016/j.devcel.2024.12.005
  
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cell.com/developmental-cell/fulltext/S1534-5807(24)00727-5
Jul 2024
www.biorxiv.org www.biorxiv.org

Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor

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1. scibot 04 Jul 2024
  
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  DOI: 10.1101/2024.06.11.598518
  
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biorxiv.org/content/10.1101/2024.06.11.598518v2
Jun 2024
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PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.cmet.2024.05.015
  
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sciencedirect.com/science/article/pii/S1550413124001918
Oct 2023
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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

1
1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.molcel.2021.03.009
  
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sciencedirect.com/science/article/pii/S1097276521001775
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The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes

1
1. scibot 20 Oct 2023
  
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  DOI: 10.15252/embr.202356815
  
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embopress.org/doi/10.15252/embr.202356815
Sep 2023
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Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults

1
1. scibot 29 Sep 2023
  
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  DOI: 10.1016/j.tjnut.2023.02.037
  
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sciencedirect.com/science/article/pii/S0022316623352799
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection

1
1. scibot 31 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107552
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10460994/
Jul 2023
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Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects

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1. scibot 11 Jul 2023
  
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  DOI: 10.1016/j.isci.2023.107131
  
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sciencedirect.com/science/article/pii/S2589004223012087
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice

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1. scibot 03 Jun 2023
  
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  DOI: 10.4103/1673-5374.367928
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10233788/
May 2023
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A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy

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1. scibot 25 May 2023
  
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  DOI: 10.15252/emmm.202216951
  
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embopress.org/doi/full/10.15252/emmm.202216951
Apr 2023
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Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

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1. scibot 27 Apr 2023
  
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  DOI: 10.1016/j.neuron.2023.04.006
  
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sciencedirect.com/science/article/pii/S0896627323002684
Dec 2022
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The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model

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1. scibot 24 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111837
  
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sciencedirect.com/science/article/pii/S2211124722017296
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Ring domains are essential for GATOR2-dependent mTORC1 activation

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1. scibot 18 Dec 2022
  
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  DOI: 10.1016/j.molcel.2022.11.021
  
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sciencedirect.com/science/article/pii/S1097276522011340
link.springer.com link.springer.com

Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells

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1. scibot 02 Dec 2022
  
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  DOI: 10.1186/s40360-022-00633-y
  
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link.springer.com/article/10.1186/s40360-022-00633-y
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice

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1. scibot 19 Nov 2022
  
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  DOI: 10.1158/2767-9764.crc-22-0256
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9648418/
Oct 2022
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An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs

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1. scibot 13 Oct 2022
  
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  AB_331692
  
  DOI: 10.1016/j.celrep.2022.111467
  
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sciencedirect.com/science/article/pii/S2211124722013171
Aug 2022
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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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1. scibot 23 Aug 2022
  
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  DOI: 10.1016/j.crmeth.2022.100271
  
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sciencedirect.com/science/article/pii/S2667237522001485
Jul 2022
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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

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1. scibot 02 Jul 2022
  
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  DOI: 10.1016/j.molcel.2022.06.008
  
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sciencedirect.com/science/article/pii/S1097276522005445
Jun 2022
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BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors

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1. scibot 29 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.111019
  
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sciencedirect.com/science/article/pii/S2211124722008087
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Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine

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1. scibot 03 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.110884
  
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sciencedirect.com/science/article/pii/S2211124722006593
May 2022
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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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1. scibot 19 May 2022
  
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  DOI: 10.1016/j.devcel.2022.04.018
  
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sciencedirect.com/science/article/pii/S1534580722002866
Apr 2022
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Increased Expression of Syncytin-1 in Skeletal Muscle of Humans With Increased Body Mass Index

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1. scibot 22 Apr 2022
  
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  DOI: 10.3389/fphys.2022.858341
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9013906/
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A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration

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1. scibot 08 Apr 2022
  
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  DOI: 10.1016/j.stem.2022.03.009
  
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sciencedirect.com/science/article/pii/S1934590922001072
Mar 2022
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Neurons undergo pathogenic metabolic reprogramming in models of familial ALS

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1. scibot 24 Mar 2022
  
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  DOI: 10.1016/j.molmet.2022.101468
  
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sciencedirect.com/science/article/pii/S2212877822000370
Feb 2022
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Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation

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  DOI: 10.1016/j.celrep.2022.110407
  
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sciencedirect.com/science/article/pii/S2211124722001310
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An AMPKα2-specific phospho-switch controls lysosomal targeting for activation

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1. scibot 16 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110365
  
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sciencedirect.com/science/article/pii/S2211124722000869
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E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

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1. scibot 04 Feb 2022
  
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  DOI: 10.1016/j.molcel.2022.01.002
  
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sciencedirect.com/science/article/pii/S1097276522000028
Dec 2021
journals.physiology.org journals.physiology.org

Anemic Hypoxemia Reduces Myoblast Proliferation and Muscle Growth in Late Gestation Fetal Sheep

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1. scibot 08 Dec 2021
  
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  DOI: 10.1152/ajpregu.00342.2020
  
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journals.physiology.org/doi/abs/10.1152/ajpregu.00342.2020
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Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation

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1. scibot 01 Dec 2021
  
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japplphysiol.00295.2021-html.html

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ajpregu.00342.2020-html.html

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Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex

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Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity

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Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

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Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adults

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Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice

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Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia

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Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway

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Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism

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Regulation of human mTOR complexes by DEPTOR

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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

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Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns

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Untitled document

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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Intrinsically Disordered Protein TEX264 Mediates ER-phagy

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  Rabbit polyclonal anti-PARP
  
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

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Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity

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mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis

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Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity

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β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells

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cell.com/current-biology/abstract/S0960-9822(21)00146-9
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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

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In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

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cell.com/molecular-cell/fulltext/S1097-2765(20)30827-3
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Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity

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Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer

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Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons

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Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

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β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy

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  DOI: 10.1096/fj.201902305R
  
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Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation

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mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis

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Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain

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Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells

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Environmental arginine controls multinuclear giant cell metabolism and formation

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Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade

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Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

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Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

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α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development

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An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

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A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

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Lysosome Positioning Influences mTORC2 and AKT Signaling

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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

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Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

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Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

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Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

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SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation

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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase–mTORC1 Translational Pathway

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m6A Facilitates eIF4F-Independent mRNA Translation

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Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations

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Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice

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mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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