94 Matching Annotations
  1. Jul 2024
  2. www.biorxiv.org www.biorxiv.org
    Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor
    1
    1. scibot 04 Jul 2024
      RRID:AB_331692

      DOI: 10.1101/2024.06.11.598518

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    biorxiv.org/content/10.1101/2024.06.11.598518v2
  3. Jun 2024
  4. www.sciencedirect.com www.sciencedirect.com
    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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    1. scibot 21 Jun 2024
      RRID:AB_331692

      DOI: 10.1016/j.cmet.2024.05.015

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    sciencedirect.com/science/article/pii/S1550413124001918
  5. Oct 2023
  6. www.sciencedirect.com www.sciencedirect.com
    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
    1
    1. scibot 28 Oct 2023
      RRID:AB_331692

      DOI: 10.1016/j.molcel.2021.03.009

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    sciencedirect.com/science/article/pii/S1097276521001775
  7. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
    1
    1. scibot 20 Oct 2023
      RRID:AB_331692

      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
  8. Sep 2023
  9. www.sciencedirect.com www.sciencedirect.com
    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
    1
    1. scibot 29 Sep 2023
      RRID:AB_331692

      DOI: 10.1016/j.tjnut.2023.02.037

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    sciencedirect.com/science/article/pii/S0022316623352799
  10. Aug 2023
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection
    1
    1. scibot 31 Aug 2023
      RRID:AB_331692

      DOI: 10.1016/j.isci.2023.107552

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    ncbi.nlm.nih.gov/pmc/articles/PMC10460994/
  12. Jul 2023
  13. www.sciencedirect.com www.sciencedirect.com
    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
    1
    1. scibot 11 Jul 2023
      RRID:AB_331692

      DOI: 10.1016/j.isci.2023.107131

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    sciencedirect.com/science/article/pii/S2589004223012087
  14. Jun 2023
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice
    1
    1. scibot 03 Jun 2023
      RRID:AB_331692

      DOI: 10.4103/1673-5374.367928

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    ncbi.nlm.nih.gov/pmc/articles/PMC10233788/
  16. May 2023
  17. www.embopress.org www.embopress.org
    A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy
    1
    1. scibot 25 May 2023
      RRID:AB_331692

      DOI: 10.15252/emmm.202216951

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    embopress.org/doi/full/10.15252/emmm.202216951
  18. Apr 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
    1
    1. scibot 27 Apr 2023
      RRID:AB_331692

      DOI: 10.1016/j.neuron.2023.04.006

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    sciencedirect.com/science/article/pii/S0896627323002684
  20. Dec 2022
  21. www.sciencedirect.com www.sciencedirect.com
    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
    1
    1. scibot 24 Dec 2022
      RRID:AB_331692

      DOI: 10.1016/j.celrep.2022.111837

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    sciencedirect.com/science/article/pii/S2211124722017296
  22. www.sciencedirect.com www.sciencedirect.com
    Ring domains are essential for GATOR2-dependent mTORC1 activation
    1
    1. scibot 18 Dec 2022
      RRID:AB_331692

      DOI: 10.1016/j.molcel.2022.11.021

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    sciencedirect.com/science/article/pii/S1097276522011340
  23. link.springer.com link.springer.com
    Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells
    1
    1. scibot 02 Dec 2022
      RRID:AB_331692

      DOI: 10.1186/s40360-022-00633-y

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    link.springer.com/article/10.1186/s40360-022-00633-y
  24. Nov 2022
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice
    1
    1. scibot 19 Nov 2022
      RRID:AB_331692

      DOI: 10.1158/2767-9764.crc-22-0256

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    ncbi.nlm.nih.gov/pmc/articles/PMC9648418/
  26. Oct 2022
  27. www.sciencedirect.com www.sciencedirect.com
    An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs
    1
    1. scibot 13 Oct 2022
      AB_331692

      DOI: 10.1016/j.celrep.2022.111467

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    sciencedirect.com/science/article/pii/S2211124722013171
  28. Aug 2022
  29. www.sciencedirect.com www.sciencedirect.com
    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
    1
    1. scibot 23 Aug 2022
      RRID:AB_331692

      DOI: 10.1016/j.crmeth.2022.100271

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    sciencedirect.com/science/article/pii/S2667237522001485
  30. Jul 2022
  31. www.sciencedirect.com www.sciencedirect.com
    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
    1
    1. scibot 02 Jul 2022
      RRID:AB_331692

      DOI: 10.1016/j.molcel.2022.06.008

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    sciencedirect.com/science/article/pii/S1097276522005445
  32. Jun 2022
  33. www.sciencedirect.com www.sciencedirect.com
    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
    1
    1. scibot 29 Jun 2022
      RRID:AB_331692

      DOI: 10.1016/j.celrep.2022.111019

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    sciencedirect.com/science/article/pii/S2211124722008087
  34. www.sciencedirect.com www.sciencedirect.com
    Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine
    1
    1. scibot 03 Jun 2022
      RRID:AB_331692

      DOI: 10.1016/j.celrep.2022.110884

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    sciencedirect.com/science/article/pii/S2211124722006593
  35. May 2022
  36. www.sciencedirect.com www.sciencedirect.com
    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
    1
    1. scibot 19 May 2022
      RRID:AB_331692

      DOI: 10.1016/j.devcel.2022.04.018

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    sciencedirect.com/science/article/pii/S1534580722002866
  37. Apr 2022
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased Expression of Syncytin-1 in Skeletal Muscle of Humans With Increased Body Mass Index
    1
    1. scibot 22 Apr 2022
      RRID:AB_331692

      DOI: 10.3389/fphys.2022.858341

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    ncbi.nlm.nih.gov/pmc/articles/PMC9013906/
  39. www.sciencedirect.com www.sciencedirect.com
    A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration
    1
    1. scibot 08 Apr 2022
      RRID:AB_331692

      DOI: 10.1016/j.stem.2022.03.009

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    sciencedirect.com/science/article/pii/S1934590922001072
  40. Mar 2022
  41. www.sciencedirect.com www.sciencedirect.com
    Neurons undergo pathogenic metabolic reprogramming in models of familial ALS
    1
    1. scibot 24 Mar 2022
      RRID:AB_331692

      DOI: 10.1016/j.molmet.2022.101468

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    sciencedirect.com/science/article/pii/S2212877822000370
  42. Feb 2022
  43. www.sciencedirect.com www.sciencedirect.com
    Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation
    1
    1. scibot 23 Feb 2022
      RRID:AB_331692

      DOI: 10.1016/j.celrep.2022.110407

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    sciencedirect.com/science/article/pii/S2211124722001310
  44. www.sciencedirect.com www.sciencedirect.com
    An AMPKα2-specific phospho-switch controls lysosomal targeting for activation
    1
    1. scibot 16 Feb 2022
      RRID:AB_331692

      DOI: 10.1016/j.celrep.2022.110365

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    sciencedirect.com/science/article/pii/S2211124722000869
  45. www.sciencedirect.com www.sciencedirect.com
    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
    1
    1. scibot 04 Feb 2022
      RRID:AB_331692

      DOI: 10.1016/j.molcel.2022.01.002

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    sciencedirect.com/science/article/pii/S1097276522000028
  46. Dec 2021
  47. journals.physiology.org journals.physiology.org
    Anemic Hypoxemia Reduces Myoblast Proliferation and Muscle Growth in Late Gestation Fetal Sheep
    1
    1. scibot 08 Dec 2021
      RRID:AB_331692

      DOI: 10.1152/ajpregu.00342.2020

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    journals.physiology.org/doi/abs/10.1152/ajpregu.00342.2020
  48. www.sciencedirect.com www.sciencedirect.com
    Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation
    1
    1. scibot 01 Dec 2021
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      DOI: 10.1016/j.devcel.2021.11.009

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    sciencedirect.com/science/article/pii/S1534580721008947
  49. Nov 2021
  50. 52.53.155.43 52.53.155.43
    japplphysiol.00295.2021-html.html
    1
    1. scibot 24 Nov 2021
      RRID:AB_331692

      DOI: 10.1152/japplphysiol.00295.2021

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    52.53.155.43/85154116abc6e4afa906554661d7a2cf52c5921d/japplphysiol.00295.2021-html.html
  51. 52.53.155.43 52.53.155.43
    ajpregu.00342.2020-html.html
    1
    1. scibot 24 Nov 2021
      RRID:AB_331692

      DOI: 10.1152/ajpregu.00342.2020

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    52.53.155.43/929b6923868831e320580be57c2774b268327ec6/ajpregu.00342.2020-html.html
  52. link.springer.com link.springer.com
    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
    1
    1. scibot 02 Nov 2021
      AB_331692

      DOI: 10.1007/s00213-021-06015-2

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    link.springer.com/article/10.1007/s00213-021-06015-2
  53. Oct 2021
  54. www.sciencedirect.com www.sciencedirect.com
    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    1. scibot 29 Oct 2021
      RRID:AB_331692

      DOI: 10.1016/j.isci.2021.103177

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    sciencedirect.com/science/article/pii/S2589004221011457
  55. www.sciencedirect.com www.sciencedirect.com
    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
    1
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      DOI: 10.1016/j.celrep.2021.109870

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    sciencedirect.com/science/article/pii/S2211124721013371
  56. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adults
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    1. scibot 20 Oct 2021
      RRID:AB_331692

      DOI: 10.1113/JP281907

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP281907
  57. www.sciencedirect.com www.sciencedirect.com
    Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice
    1
    1. scibot 13 Oct 2021
      RRID:AB_331692

      DOI: 10.1016/j.celrep.2021.109831

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    sciencedirect.com/science/article/pii/S221112472101295X
  58. Sep 2021
  59. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia
    1
    1. scibot 25 Sep 2021
      AB_331692

      DOI: 10.14814/phy2.15033

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    physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15033
  60. www.pnas.org www.pnas.org
    Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway
    1
    1. scibot 24 Sep 2021
      9452S

      DOI: 10.1073/pnas.2104577118

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    pnas.org/content/118/37/e2104577118
  61. www.sciencedirect.com www.sciencedirect.com
    Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism
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    1. scibot 22 Sep 2021
      RRID:AB_331692

      DOI: 10.1016/j.celrep.2021.109742

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    sciencedirect.com/science/article/pii/S2211124721011955
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of human mTOR complexes by DEPTOR
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    1. scibot 18 Sep 2021
      RRID:AB_331692

      DOI: 10.7554/eLife.70871

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    ncbi.nlm.nih.gov/pmc/articles/PMC8439649/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
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  64. www.sciencedirect.com www.sciencedirect.com
    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
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  65. Aug 2021
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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  69. Jul 2021
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    Intrinsically Disordered Protein TEX264 Mediates ER-phagy
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      Rabbit polyclonal anti-PARP

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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
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  75. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity
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    mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
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  77. May 2021
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    Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity
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  79. Apr 2021
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    β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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  82. Mar 2021
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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  84. Feb 2021
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    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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  86. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
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  87. Nov 2020
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    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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      RRID:AB_331692

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  89. Sep 2020
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons
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      RRID:AB_331692

      DOI: 10.1523/JNEUROSCI.0642-19.2019

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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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      RRID:AB_331692

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    β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy
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      RRID:AB_331692

      DOI: 10.1096/fj.201902305R

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    Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation
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      RRID:AB_331692

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    sciencedirect.com/science/article/pii/S2211124719317309
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    mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis
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      RRID:AB_331692

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  95. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
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      RRID:AB_331692

      DOI: 10.1111/jnc.14979

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    Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells
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      AB_331692

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    Environmental arginine controls multinuclear giant cell metabolism and formation
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      4EBP1

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    Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade
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      RRID:AB_331692

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  99. Jan 2020
  100. www.sciencedirect.com www.sciencedirect.com
    Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension
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    eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
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    Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
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    α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development
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    An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis
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    A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease
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    Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer
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    Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
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    Lysosome Positioning Influences mTORC2 and AKT Signaling
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    Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
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    Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan
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      DOI: 10.1016/j.cub.2019.01.029

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    Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models
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