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111 Matching Annotations

Oct 2025
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Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors

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  DOI: 10.1016/j.chembiol.2025.09.003
  
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sciencedirect.com/science/article/pii/S2451945625002685
Sep 2025
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Trefoil factor 2 interacts with A4GNT to regulate inflammation to protect against pneumonia during influenza virus infection

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  DOI: 10.1016/j.isci.2025.113370
  
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sciencedirect.com/science/article/pii/S2589004225016311
Jul 2025
52.53.155.43 52.53.155.43

NE-activated β2-AR/β-arrestin 2/Src pathway mediates duodenal hyperpermeability induced by water-immersion restraint stress

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1. scibot 31 Jul 2025
  
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  DOI: 10.1152/ajpcell.00412.2022
  
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  AB_331697
  
  DOI: 10.1152/ajpcell.00412.2022
  
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52.53.155.43/aa11c879e9e1e4947e7d807b75499a792887d07f/yan-et-al-2023-ne-activated-2-ar--arrestin-2-src-pathway-mediates-duodenal-hyperpermeability-induced-by-water-html.html
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TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC

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  DOI: 10.1016/j.celrep.2025.115972
  
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cell.com/cell-reports/abstract/S2211-1247(25)00743-0
Apr 2025
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Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition

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  DOI: 10.1016/j.cels.2025.101239
  
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sciencedirect.com/science/article/pii/S2405471225000729
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Coordination of Focal Adhesion Nanoarchitecture and Dynamics in Mechanosensing for Cardiomyoblast Differentiation

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  DOI: 10.1021/acsami.4c15459
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11758775/
Dec 2024
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Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer

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  DOI: 10.1038/s44321-024-00161-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11628624/
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Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.11.005
  
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sciencedirect.com/science/article/pii/S107476132400520X
Sep 2024
onlinelibrary.wiley.com onlinelibrary.wiley.com

Function of a complex of p-Y42 RhoA GTPase and pyruvate kinase M2 in EGF signaling pathway in glioma cells

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1. scibot 27 Sep 2024
  
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  DOI: 10.1111/jnc.16210
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16210
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Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity

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1. scibot 25 Sep 2024
  
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sciencedirect.com/science/article/pii/S2211124724011136
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Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer

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  DOI: 10.1038/s41467-024-51831-7
  
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nature.com/articles/s41467-024-51831-7
Aug 2024
www.cell.com www.cell.com

Calcineurin is an adaptor required for assembly of the TCR signaling complex

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1. scibot 18 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114568
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00897-0
www.biorxiv.org www.biorxiv.org

Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy

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1. scibot 18 Aug 2024
  
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  DOI: 10.1101/2024.07.31.605623
  
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biorxiv.org/content/10.1101/2024.07.31.605623v1
Jul 2024
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Paradoxical activation of c-Src as a drug-resistant mechanism

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1. scibot 10 Jul 2024
  
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  RRID:AB_331697
  
  DOI: 10.1016/j.celrep.2021.108876
  
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2. scibot 10 Jul 2024
  
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  RRID:AB_331697
  
  DOI: 10.1016/j.celrep.2021.108876
  
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sciencedirect.com/science/article/pii/S221112472100190X
Jun 2024
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p38 MAPK activation and STIM1-Orai3 association mediate TRPC6 externalization

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1. scibot 07 Jun 2024
  
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  DOI: 10.1152/ajpcell.00425.2022
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10228675/
Mar 2024
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Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions

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1. scibot 13 Mar 2024
  
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  DOI: 10.1016/j.immuni.2024.02.014
  
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  DOI: 10.1016/j.immuni.2024.02.014
  
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sciencedirect.com/science/article/pii/S1074761324000906
Feb 2024
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Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats

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1. scibot 16 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108926
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10864204/
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Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas

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1. scibot 06 Feb 2024
  
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  DOI: 10.1158/2159-8290.CD-22-1401
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10524254/
Dec 2023
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Protocol to characterize extracellular c-Src tyrosine kinase function through substrate interaction and phosphorylation

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1. scibot 10 Dec 2023
  
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  DOI: 10.1016/j.xpro.2023.102755
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10701435/
Nov 2023
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Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation

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  DOI: 10.1016/j.celrep.2023.113361
  
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sciencedirect.com/science/article/pii/S2211124723013736
Aug 2023
52.53.155.43 52.53.155.43

Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function

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1. scibot 17 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112947
  
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  DOI: 10.1016/j.celrep.2023.112947
  
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52.53.155.43/1ebffb0e500c938d4759cf06bd212c5ef05c3aed/PIIS2211124723009580-html.html
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase

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1. scibot 25 Jul 2023
  
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  DOI: 10.7554/eLife.82428
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10361714/
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A back-door insight into the modulation of Src kinase activity by the polyamine spermidine

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1. scibot 12 Jul 2023
  
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  DOI: 10.7554/eLife.85872
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10328509/
May 2023
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PhosY-secretome profiling combined with kinase-substrate interaction screening defines active c-Src-driven extracellular signaling

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1. scibot 27 May 2023
  
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  DOI: 10.1016/j.celrep.2023.112539
  
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sciencedirect.com/science/article/pii/S2211124723005508
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Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment

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1. scibot 13 May 2023
  
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  DOI: 10.1016/j.cmet.2023.04.017
  
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sciencedirect.com/science/article/pii/S1550413123001717
Mar 2023
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Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis

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  DOI: 10.1016/j.celrep.2023.112164
  
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sciencedirect.com/science/article/pii/S2211124723001754
Feb 2023
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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment

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  DOI: 10.1016/j.ccell.2023.01.003
  
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sciencedirect.com/science/article/pii/S153561082300003X
Dec 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

α5 integrin regulates hepatic tight junctions through SRC-TET1-mediated DNA hydroxymethylation

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1. scibot 02 Dec 2022
  
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  DOI: 10.1016/j.isci.2022.105611
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9709229/
Nov 2022
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Reelin regulates the migration of late-born hippocampal CA1 neurons via cofilin phosphorylation

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1. scibot 24 Nov 2022
  
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  DOI: 10.1016/j.mcn.2022.103794
  
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sciencedirect.com/science/article/pii/S1044743122001002
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RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation

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1. scibot 10 Nov 2022
  
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  DOI: 10.1016/j.isci.2022.105184
  
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sciencedirect.com/science/article/pii/S2589004222014560
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Niraparib-induced STAT3 inhibition increases its antitumor effects

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1. scibot 04 Nov 2022
  
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  DOI: 10.3389/fonc.2022.966492
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9618811/
Oct 2022
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Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

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1. scibot 07 Oct 2022
  
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  DOI: 10.1016/j.isci.2022.105171
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9530850/
Sep 2022
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Targeting of c-MET and AXL by cabozantinib is a potential therapeutic strategy for patients with head and neck cell carcinoma

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1. scibot 21 Sep 2022
  
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  DOI: 10.1016/j.xcrm.2022.100659
  
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Identification of Src as a Therapeutic Target in Oesophageal Adenocarcinoma through Functional Genomic and High-Throughput Drug Screening Approaches

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β-Glucocerebrosidase Deficiency Activates an Aberrant Lysosome-Plasma Membrane Axis Responsible for the Onset of Neurodegeneration

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Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude

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Translational Strategies for Repotrectinib in Neuroblastoma

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HO-1 Upregulation by Kaempferol via ROS-Dependent Nrf2-ARE Cascade Attenuates Lipopolysaccharide-Mediated Intercellular Cell Adhesion Molecule-1 Expression in Human Pulmonary Alveolar Epithelial Cells

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Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells

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Canonical Wnt Signaling Induces Focal Adhesion and Integrin Beta-1 Endocytosis

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The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice

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Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells

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Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus

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Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis

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GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis

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EGFR transactivates RON to drive oncogenic crosstalk

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In vivo efficacy of tesevatinib in patient-derived xenograft glioblastoma models may be limited by tissue binding and compensatory signaling

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Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling

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Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

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TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment

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Dissecting VEGF-induced acute versus chronic vascular hyperpermeability: Essential roles of dimethylarginine dimethylaminohydrolase-1

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A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

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Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity

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Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity

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Senescent immune cells release grancalcin to promote skeletal aging

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Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC

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Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs

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Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation

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VEGF counteracts amyloid-β-induced synaptic dysfunction

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Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation

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Parallel Chemoselective Profiling for Mapping Protein Structure

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NOX1/NADPH oxidase promotes synaptic facilitation induced by repeated D2 receptor stimulation; involvement in behavioral repetition

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Paradoxical activation of c-Src as a drug-resistant mechanism

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The tumor suppressor LATS2 reduces v‐Src‐induced membrane blebs in a kinase activity‐independent manner

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  rabbit polyclonal anti‐phospho‐Src
  
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Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists

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Gangliosides in the differentiation process of primary neurons: the specific role of GM1-oligosaccharide

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L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness

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Leptin controls glutamatergic synaptogenesis and NMDA-receptor trafficking via Fyn kinase regulation of NR2B

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Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

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Staphylococcus aureus Panton‐Valentine Leukocidin triggers an alternative NETosis process targeting mitochondria

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GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth

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Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex

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Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration

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SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst

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Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

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Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr307 on PP2Ac

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Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway

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c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly

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mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease

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Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

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HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry

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Loss of tau and Fyn reduces compensatory effects of MAP2 for tau and reveals a Fyn‐independent effect of tau on calcium

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Astrocyte truncated tropomyosin receptor kinase B mediates brain‐derived neurotrophic factor anti‐apoptotic effect leading to neuroprotection

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Haem oxygenase‐1 up‐regulation by rosiglitazone via ROS‐dependent Nrf2‐antioxidant response elements axis or PPARγ attenuates LPS‐mediated lung inflammation

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Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice

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Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss

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Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

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The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response

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Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth

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Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions

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YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

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Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)

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Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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1. scibot 08 Nov 2017
  
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  RRID:AB_331697
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
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A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45

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1. scibot 08 Nov 2017
  
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  AB_331697
  
  Curator: @chewbeccax
  
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  (Cell Signaling Technology Cat# 2101, RRID:AB_331697)
  
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sciencedirect.com/science/article/pii/S1097276517304586
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_331697
  
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  (Cell Signaling Technology Cat# 2101, RRID:AB_331697)
  
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sciencedirect.com/science/article/pii/S2405471216304082
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks

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1. scibot 08 Nov 2017
  
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  AB_331697
  
  Curator: @kaitlinsung
  
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  (Cell Signaling Technology Cat# 2101, RRID:AB_331697)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5376188/
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The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

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1. scibot 08 Nov 2017
  
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  2101
  
  Curator: @bandrow
  
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  (Cell Signaling Technology Cat# 2101, RRID:AB_331697)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC4931344/

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