54 Matching Annotations
  1. Jul 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20–Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12260510/
  3. Jun 2025
  4. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202503322
  5. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/3e81ed4154fee0b68ed39cd7c108fb3e26bd25fc/PDF-html.html
  6. May 2025
  7. www.sciencedirect.com www.sciencedirect.com
    Genetic biomarker study of sunvozertinib for clinical prognosis and prediction in NSCLC with EGFR exon 20 insertion mutation
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    sciencedirect.com/science/article/pii/S2666379125001946
  8. Mar 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromosomal Instability Is Associated with cGAS–STING Activation in EGFR-TKI Refractory Non-Small-Cell Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11941500/
  10. Jan 2025
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    Neoadjuvant immunotherapy with or without chemotherapy in locally advanced oral squamous cell carcinoma: Randomized, two-arm, phase 2 trial
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    sciencedirect.com/science/article/pii/S2666379125000035
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    The potential of lazertinib and amivantamab combination therapy as a treatment strategy for uncommon EGFR-mutated NSCLC
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    sciencedirect.com/science/article/pii/S2666379125000023
  13. Sep 2024
  14. www.sciencedirect.com www.sciencedirect.com
    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
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    sciencedirect.com/science/article/pii/S2666379124004245
  15. Jul 2024
  16. www.mdpi.com www.mdpi.com
    Impact of Interleukin-6 Activation and Arthritis on Epidermal Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the Spinal Cord
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    mdpi.com/1422-0067/25/13/7168
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11225835/
  18. Jun 2024
  19. www.cell.com www.cell.com
    Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies
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    cell.com/iscience/abstract/S2589-0042(24)01293-8
  20. May 2024
  21. aacrjournals.org aacrjournals.org
    Discovery of a novel potent EGFR inhibitor against EGFR activating mutations and on-target resistance in NSCLC
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    aacrjournals.org/clincancerres/article/30/8/1582/742134/Discovery-of-a-Novel-Potent-EGFR-Inhibitor-Against
  22. Apr 2024
  23. www.sciencedirect.com www.sciencedirect.com
    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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    sciencedirect.com/science/article/pii/S2211124724004479
  24. Mar 2024
  25. www.sciencedirect.com www.sciencedirect.com
    Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124724002407
  26. Feb 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGFBP3 Promotes Resistance to Olaparib via Modulating EGFR Signaling in Advanced Prostate Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10847745/
  29. Jan 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10762335/
  31. Aug 2023
  32. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
  33. Jun 2023
  34. aacrjournals.org aacrjournals.org
    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
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    aacrjournals.org/cancerres/article/83/9/1490/726058/RBM10-Loss-Promotes-EGFR-Driven-Lung-Cancer-and
  35. Apr 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
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    sciencedirect.com/science/article/pii/S2211124723003352
  37. Mar 2023
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9444924/
  39. Feb 2023
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9528501/
  41. Jan 2023
  42. aacrjournals.org aacrjournals.org
    Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non–Small Cell Lung Cancer Cells
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    aacrjournals.org/mcr/article/20/12/1785/710999/Loss-of-VOPP1-Contributes-to-BET-Inhibitor
  43. link.springer.com link.springer.com
    Cyclooxygenase-2 activates EGFR–ERK1/2 pathway via PGE2-mediated ADAM-17 signaling in testosterone-induced benign prostatic hyperplasia
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    link.springer.com/article/10.1007/s10787-022-01123-7
  44. Nov 2022
  45. www.sciencedirect.com www.sciencedirect.com
    Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling
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    sciencedirect.com/science/article/pii/S1534580722007638
  46. Sep 2022
  47. www.sciencedirect.com www.sciencedirect.com
    GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer
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    sciencedirect.com/science/article/pii/S221112472201172X
  48. Dec 2021
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo efficacy of tesevatinib in patient-derived xenograft glioblastoma models may be limited by tissue binding and compensatory signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC8172524/
  50. Nov 2021
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AXL cooperates with EGFR to mediate neutrophil elastase-induced migration of prostate cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8567381/
  52. Sep 2021
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Establishment and genetic characterization of cell lines derived from proliferating nasal polyps and sinonasal inverted papillomas
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    ncbi.nlm.nih.gov/pmc/articles/PMC8384845/
  54. Aug 2021
  55. www.sciencedirect.com www.sciencedirect.com
    Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments
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    sciencedirect.com/science/article/pii/S2666379121002275
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers
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    ncbi.nlm.nih.gov/pmc/articles/PMC5429090/
  57. academic.oup.com academic.oup.com
    Untitled document
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    academic.oup.com/jes/article/1/2/127/2930778
  58. www.sciencedirect.com www.sciencedirect.com
    Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma
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    sciencedirect.com/science/article/pii/S2211124718316942
  59. Jul 2021
  60. www.sciencedirect.com www.sciencedirect.com
    Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma
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    sciencedirect.com/science/article/pii/S2211124718316942
  61. Jun 2021
  62. www.sciencedirect.com www.sciencedirect.com
    Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function
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    sciencedirect.com/science/article/pii/S0960982221006801
  63. www.sciencedirect.com www.sciencedirect.com
    Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
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    sciencedirect.com/science/article/pii/S1535610821002683
  64. May 2021
  65. www.sciencedirect.com www.sciencedirect.com
    PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR
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    sciencedirect.com/science/article/pii/S221112472100526X
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC8118655/
  67. Apr 2021
  68. www.sciencedirect.com www.sciencedirect.com
    Cell Lineage-Based Stratification for Glioblastoma
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    sciencedirect.com/science/article/pii/S153561082030307X
  69. www.sciencedirect.com www.sciencedirect.com
    Capturing human trophoblast development with naive pluripotent stem cells in vitro
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    sciencedirect.com/science/article/pii/S1934590921001193
  70. Sep 2020
  71. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    HSP90 Inhibitor, 17-DMAG, Alone and in Combination with Lapatinib Attenuates Acquired Lapatinib-Resistance in ER-positive, HER2-Overexpressing Breast Cancer Cell Line
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    pubmed.ncbi.nlm.nih.gov/32942617/
  72. mcr.aacrjournals.org mcr.aacrjournals.org
    Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
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    mcr.aacrjournals.org/content/18/8/1142
  73. Jan 2020
  74. www.sciencedirect.com www.sciencedirect.com
    Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors
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    sciencedirect.com/science/article/pii/S2211124719307922
  75. Nov 2018
  76. www.sciencedirect.com www.sciencedirect.com
    Mechanism of Allosteric Coupling into and through the Plasma Membrane by EGFR
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    sciencedirect.com/science/article/pii/S2451945618301193
  77. www.sciencedirect.com www.sciencedirect.com
    EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation
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    sciencedirect.com/science/article/pii/S1097276518302211
  78. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Epiregulin (EREG) is upregulated through an IL‐1β autocrine loop in Caco‐2 epithelial cells with reduced CFTR function
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    onlinelibrary.wiley.com/doi/10.1002/jcb.26483/full
  79. Nov 2017
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
  81. www.sciencedirect.com www.sciencedirect.com
    EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR
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    sciencedirect.com/science/article/pii/S0092867416314593
  82. academic.oup.com academic.oup.com
    EGFR Induces E2F1-Mediated Corticotroph Tumorigenesis
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    academic.oup.com/jes/article/1/2/127/2930778/EGFR-Induces-E2F1-Mediated-Corticotroph
  83. www.sciencedirect.com www.sciencedirect.com
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    sciencedirect.com/science/article/pii/S2405471216304082