112 Matching Annotations
  1. May 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging
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    1. scibot 08 May 2024
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      DOI: 10.1016/j.isci.2024.109708

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    ncbi.nlm.nih.gov/pmc/articles/PMC11066433/
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    Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size
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    1. scibot 02 May 2024
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      DOI: 10.1016/j.neuron.2024.04.006

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    sciencedirect.com/science/article/pii/S0896627324002447
  4. Apr 2024
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    Genetic interactions reveal distinct biological and therapeutic implications in breast cancer
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    1. scibot 09 Apr 2024
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    sciencedirect.com/science/article/pii/S1535610824000916
  6. Mar 2024
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    Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway
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    1. scibot 27 Mar 2024
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    sciencedirect.com/science/article/pii/S1534580724001424
  8. Feb 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
    1
    1. scibot 16 Feb 2024
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      DOI: 10.1158/1535-7163.MCT-22-0627

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    ncbi.nlm.nih.gov/pmc/articles/PMC10866396/
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    p53 promotes antiviral innate immunity by driving hexosamine metabolism
    1
    1. scibot 07 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113724

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    sciencedirect.com/science/article/pii/S2211124724000524
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    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
    1
    1. scibot 06 Feb 2024
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      DOI: 10.1016/j.molcel.2024.01.008

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    sciencedirect.com/science/article/pii/S1097276524000091
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
    1
    1. scibot 01 Feb 2024
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      DOI: 10.1038/s41698-024-00496-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  13. Jan 2024
  14. www.sciencedirect.com www.sciencedirect.com
    Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging
    1
    1. scibot 23 Jan 2024
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      DOI: 10.1016/j.immuni.2024.01.001

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    sciencedirect.com/science/article/pii/S1074761324000268
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
    1
    1. scibot 10 Jan 2024
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      DOI: 10.1158/1078-0432.CCR-23-0964

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    ncbi.nlm.nih.gov/pmc/articles/PMC10767302/
  16. Dec 2023
  17. www.sciencedirect.com www.sciencedirect.com
    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
    1
    1. scibot 29 Dec 2023
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      DOI: 10.1016/j.isci.2023.108659

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    sciencedirect.com/science/article/pii/S2589004223027360
  18. Sep 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis
    1
    1. scibot 30 Sep 2023
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      DOI: 10.7554/eLife.84710

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    ncbi.nlm.nih.gov/pmc/articles/PMC10519710/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress
    1
    1. scibot 07 Sep 2023
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      DOI: 10.1016/j.isci.2023.107505

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    ncbi.nlm.nih.gov/pmc/articles/PMC10470315/
  21. Jul 2023
  22. www.sciencedirect.com www.sciencedirect.com
    A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112833

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    sciencedirect.com/science/article/pii/S2211124723008446
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    Modeling epigenetic lesions that cause gliomas
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.cell.2023.06.022

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    sciencedirect.com/science/article/abs/pii/S0092867423007298
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    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
    1
    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112794

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    sciencedirect.com/science/article/pii/S2211124723008057
  25. Jun 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response
    1
    1. scibot 27 Jun 2023
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      DOI: 10.1016/j.isci.2023.107090

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    sciencedirect.com/science/article/pii/S2589004223011677
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
    1
    1. scibot 24 Jun 2023
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      DOI: 10.1016/j.isci.2023.107028

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    ncbi.nlm.nih.gov/pmc/articles/PMC10285549/
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    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
    1
    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.ccell.2023.05.016

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    sciencedirect.com/science/article/pii/S1535610823001836
  29. May 2023
  30. www.sciencedirect.com www.sciencedirect.com
    p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
    1
    1. scibot 13 May 2023
      RRID:AB_331743

      DOI: 10.1016/j.celrep.2023.112479

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    sciencedirect.com/science/article/pii/S2211124723004904
  31. Apr 2023
  32. www.sciencedirect.com www.sciencedirect.com
    Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells
    1
    1. scibot 21 Apr 2023
      RRID_331743

      DOI: 10.1016/j.devcel.2023.03.021

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    sciencedirect.com/science/article/pii/S153458072300148X
  33. www.sciencedirect.com www.sciencedirect.com
    Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response
    1
    1. scibot 20 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112400

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    sciencedirect.com/science/article/pii/S2211124723004114
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    Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development
    1
    1. scibot 13 Apr 2023
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      DOI: 10.1016/j.devcel.2023.03.016

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    sciencedirect.com/science/article/pii/S1534580723001326
  35. Feb 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase
    1
    1. scibot 17 Feb 2023
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      DOI: 10.1016/j.isci.2023.106107

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    sciencedirect.com/science/article/pii/S2589004223001840
  37. www.sciencedirect.com www.sciencedirect.com
    Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia
    1
    1. scibot 03 Feb 2023
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      DOI: 10.1016/j.stem.2023.01.006

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    sciencedirect.com/science/article/pii/S1934590923000061
  38. Jan 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Loss of epigenetic information as a cause of mammalian aging
    1
    1. scibot 19 Jan 2023
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      DOI: 10.1016/j.cell.2022.12.027

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    sciencedirect.com/science/article/pii/S0092867422015707
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Downregulation of UBE4B promotes CNS axon regrowth and functional recovery after stroke
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    1. scibot 18 Jan 2023
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      DOI: 10.1016/j.isci.2022.105885

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    ncbi.nlm.nih.gov/pmc/articles/PMC9840934/
  41. 52.53.155.43 52.53.155.43
    SSRN-id4254233-html.html
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    1. scibot 14 Jan 2023
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      DOI: 10.2139/ssrn.4254233

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    52.53.155.43/188141f4acbfd62dc4b76a20cf1f2f08129d78fe/SSRN-id4254233-html.html
  42. Dec 2022
  43. aacrjournals.org aacrjournals.org
    Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis and promotes breast cancer
    1
    1. scibot 03 Dec 2022
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      DOI: 10.1158/2159-8290.CD-21-0865

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    aacrjournals.org/cancerdiscovery/article/12/12/2930/711188/Loss-of-Epigenetic-Regulation-Disrupts-Lineage
  44. Nov 2022
  45. www.sciencedirect.com www.sciencedirect.com
    Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway
    1
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      DOI: 10.1016/j.celrep.2022.111571

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    sciencedirect.com/science/article/pii/S2211124722014322
  46. Oct 2022
  47. www.sciencedirect.com www.sciencedirect.com
    Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival
    1
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      DOI: 10.1016/j.celrep.2022.111435

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    sciencedirect.com/science/article/pii/S2211124722012761
  48. academic.oup.com academic.oup.com
    Aspirin mediates its antitumoral effect through inhibiting PTTG1 in pituitary adenoma
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      DOI: 10.1210/clinem/dgac496

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac496/6691809
  49. May 2022
  50. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    A human breast atlas integrating single-cell proteomics and transcriptomics
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      DOI: 10.1016/j.devcel.2022.05.003

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    pubmed.ncbi.nlm.nih.gov/35617956/
  51. www.sciencedirect.com www.sciencedirect.com
    The Mettl3 epitranscriptomic writer amplifies p53 stress responses
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      DOI: 10.1016/j.molcel.2022.04.010

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    sciencedirect.com/science/article/pii/S1097276522003215
  52. Apr 2022
  53. academic.oup.com academic.oup.com
    Inflammasome activation and pyroptosis via a lipid-regulated SIRT1-p53-ASC axis in macrophages from male mice and humans
    1
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      DOI: 10.1210/endocr/bqac014

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    academic.oup.com/endo/article/163/4/bqac014/6523230
  54. Mar 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Caveolin-1 Peptide Regulates p53-microRNA-34a Feedback in Fibrotic Lung Fibroblasts
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      DOI: 10.1016/j.isci.2022.104022

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    sciencedirect.com/science/article/pii/S2589004222002929
  56. elifesciences.org elifesciences.org
    Pathway-specific effects of ADSL deficiency on neurodevelopment
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    1. scibot 04 Mar 2022
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      DOI: 10.7554/eLife.70518

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    elifesciences.org/articles/70518
  57. Jan 2022
  58. www.sciencedirect.com www.sciencedirect.com
    Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1
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    1. scibot 12 Jan 2022
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      DOI: 10.1016/j.celrep.2021.110211

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    sciencedirect.com/science/article/pii/S2211124721017150
  59. Dec 2021
  60. www.sciencedirect.com www.sciencedirect.com
    NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis
    1
    1. scibot 08 Dec 2021
      RRID:AB_33174

      DOI: 10.1016/j.cmet.2021.11.011

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      Curator comments: p53 (1C12) Mouse mAb antibody Cell Signaling Technology Cat# 2524

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    sciencedirect.com/science/article/pii/S1550413121005398
  61. Nov 2021
  62. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53
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    A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability
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    ATR expands embryonic stem cell fate potential in response to replication stress
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  117. www.mdpi.com www.mdpi.com
    Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability
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  118. Aug 2020
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    Endonuclease VIII-like 1 deficiency impairs survival of newly generated hippocampal neurons and memory performance in young-adult male mice
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  120. Jan 2020
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    PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
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    UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma
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    Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer
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    Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells
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    A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis
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  126. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Screening the expression of several miRNAs from TaqMan Low Density Array in traumatic brain injury: miR‐219a‐5p regulates neuronal apoptosis by modulating CCNA2 and CACUL1
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    Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy
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  128. mcr.aacrjournals.org mcr.aacrjournals.org
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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  133. Nov 2018
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    The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression
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    Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM
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    The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells
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  138. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas
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    A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity
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    Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53
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    Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis
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    Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy
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    Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice
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    Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice
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    Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas
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  146. Nov 2017
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    TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence
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    Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2
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    p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo
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