Hypothesis

185 Matching Annotations

Nov 2025
54.241.53.176 54.241.53.176

2025.11.16.688689v1.full-html.html

1
1. scibot 22 Nov 2025
  
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  AB_331743
  
  DOI: 10.1101/2025.11.16.688689
  
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54.241.53.176/ff0938d0c3d1496c2bb0e0f01693e3b2e489e60f/2025.11.16.688689v1.full-html.html
Oct 2025
www.sciencedirect.com www.sciencedirect.com

Targeted citrullination enables p53 binding to non-canonical sites

1
1. scibot 08 Oct 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.molcel.2025.09.004
  
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sciencedirect.com/science/article/pii/S1097276525007452
Sep 2025
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Nucleolar stress facilitates islet β cell senescence via hijacking the DNA damage response pathways

1
1. scibot 23 Sep 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.isci.2025.113508
  
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sciencedirect.com/science/article/pii/S2589004225017699
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Tumor suppressor protein p53 governs human trophoblast lineage development

1
1. scibot 19 Sep 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.celrep.2025.116310
  
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sciencedirect.com/science/article/pii/S2211124725010812
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p53-mediated regulation of epiblast cell numbers predicts reactivation during mouse embryonic diapause

1
1. scibot 19 Sep 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.celrep.2025.116298
  
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sciencedirect.com/science/article/pii/S2211124725010691
jbiomedsci.biomedcentral.com jbiomedsci.biomedcentral.com

PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region

1
1. scibot 16 Sep 2025
  
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  RRID:AB_331743
  
  DOI: 10.1186/s12929-025-01185-z
  
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jbiomedsci.biomedcentral.com/articles/10.1186/s12929-025-01185-z
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

1-s2.0-S2589004225015664-main-html.html

1
1. scibot 07 Aug 2025
  
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  AB_331743
  
  DOI: 10.1016/j.isci.2025.113305
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12396248/
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Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells

1
1. scibot 01 Aug 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.immuni.2025.07.008
  
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sciencedirect.com/science/article/pii/S1074761325003176
Jul 2025
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Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

1
1. scibot 25 Jul 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.ccell.2025.06.021
  
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sciencedirect.com/science/article/pii/S1535610825002715
www.cell.com www.cell.com

Divergent sex-specific effects on a ketogenic diet: Male, but not female, mice exhibit oxidative stress and cellular senescence

1
1. scibot 22 Jul 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.celrep.2025.116026
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00797-1
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Rebalancing of mitochondrial homeostasis through an NAD+-SIRT1 pathway preserves intestinal barrier function in severe malnutrition

1
1. scibot 16 Jul 2025
  
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  a
  
  DOI: 10.1016/j.ebiom.2023.104809
  
  Resource: (Cell Signaling Technology Cat# 2524, RRID:AB_331743)
  
  Curator: @areedewitt04
  
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sciencedirect.com/science/article/pii/S2352396423003754
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Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer

1
1. scibot 01 Jul 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.immuni.2025.06.005
  
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sciencedirect.com/science/article/pii/S1074761325002742
Jun 2025
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Microcurrent stimulation induces cell death in p53-mutant and 5-FU-resistant breast cancer

1
1. scibot 25 Jun 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.jbc.2025.110414
  
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sciencedirect.com/science/article/pii/S0021925825022641
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer

1
1. scibot 20 May 2025
  
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  RRID:AB_331743
  
  DOI: 10.1158/0008-5472.CAN-24-1940
  
  Resource: (Cell Signaling Technology Cat# 2524, RRID:AB_331743)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12046318/
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Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target

1
1. scibot 17 May 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.ccell.2025.04.014
  
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sciencedirect.com/science/article/pii/S1535610825001734
Mar 2025
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Vagal pathway activation links chronic stress to decline in intestinal stem cell function

1
1. scibot 24 Mar 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.stem.2025.02.016
  
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sciencedirect.com/science/article/pii/S1934590925000840
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death

2
1. scibot 06 Mar 2025
  
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  RRID:AB_331743
  
  DOI: 10.1111/bph.17464
  
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  Curator: @dhovakimyan1
  
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2. scibot 06 Mar 2025
  
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  RRID:AB_331743
  
  DOI: 10.1111/bph.17464
  
  Resource: (Cell Signaling Technology Cat# 2524, RRID:AB_331743)
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17464
www.sciencedirect.com www.sciencedirect.com

VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation

1
1. scibot 06 Mar 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.chembiol.2025.02.002
  
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sciencedirect.com/science/article/pii/S2451945625000340
52.53.155.43 52.53.155.43

1-s2.0-S2589004225003980-main-html.html

1
1. scibot 04 Mar 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.isci.2025.112138
  
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52.53.155.43/5cb7aee35160970f93d9910e96369ff58c9b35b0/1-s2.0-S2589004225003980-main-html.html
Feb 2025
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 28 Feb 2025
  
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  RRID:AB_331743
  
  DOI: 10.1158/0008-5472.can-24-1940
  
  Resource: (Cell Signaling Technology Cat# 2524, RRID:AB_331743)
  
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52.53.155.43/6f24610d8cabd5accb1107b92f842a9b344aae4e/PDF-html.html
www.sciencedirect.com www.sciencedirect.com

Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice

7
1. scibot 07 Feb 2025
  
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  RRID:AB_331743
  
  DOI: 10.1016/j.devcel.2024.12.021
  
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  Curator: @scibot
  
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2. scibot 06 Feb 2025
  
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  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
3. scibot 05 Feb 2025
  
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  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
4. scibot 04 Feb 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
5. scibot 03 Feb 2025
  
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  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
6. scibot 02 Feb 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
7. scibot 01 Feb 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
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sciencedirect.com/science/article/pii/S1534580724007603
Jan 2025
www.sciencedirect.com www.sciencedirect.com

Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice

25
1. scibot 31 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
2. scibot 30 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
3. scibot 29 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
4. scibot 28 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
5. scibot 27 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
6. scibot 26 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
7. scibot 25 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
8. scibot 24 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
9. scibot 23 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
10. scibot 22 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
11. scibot 21 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
12. scibot 20 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
13. scibot 19 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
14. scibot 18 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
15. scibot 17 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
16. scibot 16 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
17. scibot 15 Jan 2025
  
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  RRID:AB_331743
  
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  RRID:AB_331743
18. scibot 14 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
19. scibot 13 Jan 2025
  
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  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
20. scibot 12 Jan 2025
  
  in Public
  
  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
21. scibot 11 Jan 2025
  
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  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
22. scibot 10 Jan 2025
  
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  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
23. scibot 09 Jan 2025
  
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  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
24. scibot 08 Jan 2025
  
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  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_331743
25. scibot 07 Jan 2025
  
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  RRID:AB_331743
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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Missense Mutant p53 Transactivates Wnt/β-Catenin Signaling in Neighboring p53-Destabilized Cells through the COX-2/PGE2 Pathway

2
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Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control

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Gut microbiota protect against colorectal tumorigenesis through lncRNA Snhg9

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The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis

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Mapping functional elements of the DNA damage response through base editor screens

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Greater TIMP‐1 protein levels and neointimal formation represent sex‐dependent cellular events limiting aortic vessel expansion in female rats

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ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss

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Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation

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On the role of p53 in the cellular response to aneuploidy

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RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4

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Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy

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Autophagy regulates age-related delayed jawbone regeneration and decreased osteoblast osteogenesis by degrading FABP3

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Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance

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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

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Renal inflammation combined with renal function reserve reduction accelerate kidney aging via pentose phosphate pathway

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Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC

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Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice

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Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia

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2024.02.25.581951v1.full-html.html

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Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging

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Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size

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Genetic interactions reveal distinct biological and therapeutic implications in breast cancer

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Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway

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Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression

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p53 promotes antiviral innate immunity by driving hexosamine metabolism

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Alternative polyadenylation determines the functional landscape of inverted Alu repeats

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Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer

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Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging

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FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner

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Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

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Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis

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C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress

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A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression

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Modeling epigenetic lesions that cause gliomas

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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

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Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response

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Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss

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Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

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p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS

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Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells

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Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response

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Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development

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Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase

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Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia

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Loss of epigenetic information as a cause of mammalian aging

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Downregulation of UBE4B promotes CNS axon regrowth and functional recovery after stroke

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SSRN-id4254233-html.html

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Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis and promotes breast cancer

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Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway

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Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival

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Aspirin mediates its antitumoral effect through inhibiting PTTG1 in pituitary adenoma

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A human breast atlas integrating single-cell proteomics and transcriptomics

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The Mettl3 epitranscriptomic writer amplifies p53 stress responses

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Inflammasome activation and pyroptosis via a lipid-regulated SIRT1-p53-ASC axis in macrophages from male mice and humans

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Caveolin-1 Peptide Regulates p53-microRNA-34a Feedback in Fibrotic Lung Fibroblasts

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Pathway-specific effects of ADSL deficiency on neurodevelopment

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Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1

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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

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BPS Publications

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Short-chain fatty acids activate acetyltransferase p300

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Interleukin 6 reduces vascular smooth muscle cell apoptosis via Prep1 and is associated with aging

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Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development

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Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy

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Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system

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GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

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Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells

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The Cancer SENESCopedia: A delineation of cancer cell senescence

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Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low‐dose cisplatin exposure

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The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

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p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino

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Involvement of plasminogen activator inhibitor-1 and its related molecules in atrial fibrosis in patients with atrial fibrillation

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Bacterial genotoxins induce T cell senescence

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Endogenous p53 expression in human and mouse is not regulated by its 3′UTR

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Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

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An anterograde pathway for sensory axon degeneration gated by a cytoplasmic action of the transcriptional regulator P53

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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

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p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)

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MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer

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On the role of p53 in the cellular response to aneuploidy

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Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence

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Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity

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Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants

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A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability

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Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor

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An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming

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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

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G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program

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A Broad Response to Intracellular Long-Chain Polyphosphate in Human Cells

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E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration

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iTAG-RNA Isolates Cell-Specific Transcriptional Responses to Environmental Stimuli and Identifies an RNA-Based Endocrine Axis

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FBXW7 Confers Radiation Survival by Targeting p53 for Degradation

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PRMT1-p53 Pathway Controls Epicardial EMT and Invasion

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Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

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Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis

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A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53

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A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability

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ATR expands embryonic stem cell fate potential in response to replication stress

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Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability

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Endonuclease VIII-like 1 deficiency impairs survival of newly generated hippocampal neurons and memory performance in young-adult male mice

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PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism

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UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

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Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

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Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells

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A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis

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Screening the expression of several miRNAs from TaqMan Low Density Array in traumatic brain injury: miR‐219a‐5p regulates neuronal apoptosis by modulating CCNA2 and CACUL1

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Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy

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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

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The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression

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Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM

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The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells

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Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas

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A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity

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Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53

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Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy

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Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

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Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice

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Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

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TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence

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Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

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p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo

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