230 Matching Annotations
  1. Aug 2025
  2. www.sciencedirect.com www.sciencedirect.com
    ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis
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    sciencedirect.com/science/article/pii/S1534580725004733
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Plasma hepcidin level is elevated by water immersion‐induced central fatigue via hepatic inflammatory response in male and female rats
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    pmc.ncbi.nlm.nih.gov/articles/PMC12320131/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuronal Reg3β/macrophage TNF-α–mediated positive feedback signaling contributes to pain chronicity in a rat model of CRPS-I
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    pmc.ncbi.nlm.nih.gov/articles/PMC12315989/
  5. www.science.org www.science.org
    Neuronal Reg3β/macrophage TNF-α–mediated positive feedback signaling contributes to pain chronicity in a rat model of CRPS-I
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    science.org/doi/10.1126/sciadv.adu4270
  6. Jul 2025
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MSN/STAT3 drives cancer stemness and chemoresistance via IL-6/LPAR1 ligand receptor complex in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12281688/
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    Cancer-associated fibroblast-derived fibulin-5 promotes radioresistance in non-small-cell lung cancer
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    sciencedirect.com/science/article/pii/S2211124725007892
  9. 52.53.155.43 52.53.155.43
    Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state
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    52.53.155.43/1c70dafeeeda06325918fe95f6455c023d1ce5ae/March-2025-Carla-Kim-li-et-al-2025-organoid-modeling-reveals-the-tumorigenic-potential-of-the-alveolar-progenitor-cell-state-html.html
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    Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer
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    sciencedirect.com/science/article/pii/S2666379125002848
  11. Jun 2025
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    Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy
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    sciencedirect.com/science/article/pii/S1074761325002274
  13. May 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming
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    pmc.ncbi.nlm.nih.gov/articles/PMC12118437/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GuBenPeiYuan Formula Inhibits Lung Cancer Metastasis by Suppressing Myeloid-Derived Suppressor Cells and Related Immune Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12035261/
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    Development of SOCS1 mimetics as novel approach to harmonize inflammation, oxidative stress, and fibrogenesis in metabolic dysfunction-associated steatotic liver disease
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    sciencedirect.com/science/article/pii/S2213231725001831
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    Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer
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    sciencedirect.com/science/article/pii/S2211124725004474
  18. Apr 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory gene expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12014907/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11960706/
  21. Mar 2025
  22. 52.53.155.43 52.53.155.43
    Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state
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    52.53.155.43/1c70dafeeeda06325918fe95f6455c023d1ce5ae/March-2025-Carla-Kim-li-et-al-2025-organoid-modeling-reveals-the-tumorigenic-potential-of-the-alveolar-progenitor-cell-state-html.html
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    The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis
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    sciencedirect.com/science/article/pii/S2211124725001743
  24. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225004043-main-html.html
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    ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity
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    sciencedirect.com/science/article/pii/S2211124725001688
  26. Feb 2025
  27. aacrjournals.org aacrjournals.org
    MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming
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    aacrjournals.org/cancerimmunolres/article/12/9/1268/747083/MerTK-Induces-Dysfunctional-Dendritic-Cells-by
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    Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease
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    sciencedirect.com/science/article/pii/S1550413125000075
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    Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling
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    sciencedirect.com/science/article/pii/S221112472500052X
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617379/
  31. Jan 2025
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquired resistance to PD-L1 inhibition enhances a type I IFN-regulated secretory program in tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11772817/
  33. www.sciencedirect.com www.sciencedirect.com
    Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing
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    sciencedirect.com/science/article/pii/S0896627324009115
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    IL-21 shapes the B cell response in a context-dependent manner
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    sciencedirect.com/science/article/pii/S2211124724015419
  35. Dec 2024
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    YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
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    sciencedirect.com/science/article/pii/S0092867424013242
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC11617384/
  38. Nov 2024
  39. www.sciencedirect.com www.sciencedirect.com
    Integrated multiomic analysis identifies TRIP13 as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis
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    sciencedirect.com/science/article/pii/S0925443924005660
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    Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy
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    sciencedirect.com/science/article/pii/S1535610824003969
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    β2-integrins control HIF1α activation in human neutrophils
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    pmc.ncbi.nlm.nih.gov/articles/PMC11513320/
  42. Oct 2024
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
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    ncbi.nlm.nih.gov/pmc/articles/PMC11426993/
  44. Sep 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11401886/
  46. www.nature.com www.nature.com
    Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
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    nature.com/articles/s41467-024-51831-7
  47. www.sciencedirect.com www.sciencedirect.com
    H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
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    sciencedirect.com/science/article/pii/S2211124724010374
  48. Aug 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of bromodomain and extra-terminal proteins targets constitutively active NFκB and STAT signaling in lymphoma and influences the expression of the antiapoptotic proteins BCL2A1 and c-MYC
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    ncbi.nlm.nih.gov/pmc/articles/PMC11348570/
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    LIFR regulates cholesterol-driven bidirectional hepatocyte–neutrophil cross-talk to promote liver regeneration
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    nature.com/articles/s42255-024-01110-y
  51. Jul 2024
  52. www.sciencedirect.com www.sciencedirect.com
    Protocol for constructing tumor-targeting ANM-PROTACs for degradation of transcription factors
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    sciencedirect.com/science/article/pii/S266616672400385X
  53. www.sciencedirect.com www.sciencedirect.com
    Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner
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    sciencedirect.com/science/article/pii/S2211124724008714
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    Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity
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    sciencedirect.com/science/article/pii/S1074761324002796
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Influenza A virus infection activates STAT3 to enhance SREBP2 expression, cholesterol biosynthesis, and virus replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC11301072/
  56. 52.53.155.43 52.53.155.43
    cir-23-0666-html.html
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Combination of ß-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC11207547/
  58. Jun 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
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    ncbi.nlm.nih.gov/pmc/articles/PMC11166698/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAT3 drives the expression of ACSL4 in acute kidney injury
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    ncbi.nlm.nih.gov/pmc/articles/PMC11126884/
  61. May 2024
  62. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial RelA empowers mtDNA G-quadruplex formation for hypoxia adaptation in cancer cells
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    sciencedirect.com/science/article/pii/S2451945624001818
  63. www.biorxiv.org www.biorxiv.org
    SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer
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    biorxiv.org/content/10.1101/2024.04.28.591518v1
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11094425/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
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    The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias
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    sciencedirect.com/science/article/pii/S2666379124002519
  67. 52.53.155.43 52.53.155.43
    Phenotype-specific melanoma uptake of fatty acid from human adipocytes activates AXL and CAV1-dependent β-catenin nuclear accumulation
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    52.53.155.43/5631ba0ece03be5b6bc39fba9c8a58e52d07c519/2024.01.21.576568v1.full-html.html
  68. Apr 2024
  69. www.sciencedirect.com www.sciencedirect.com
    Repurposing AS1411 for constructing ANM-PROTACs
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    sciencedirect.com/science/article/pii/S2451945624001272
  70. www.sciencedirect.com www.sciencedirect.com
    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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    sciencedirect.com/science/article/pii/S2666379124001666
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983107/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout
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    ncbi.nlm.nih.gov/pmc/articles/PMC10973142/
  73. Mar 2024
  74. www.sciencedirect.com www.sciencedirect.com
    Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion
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    sciencedirect.com/science/article/pii/S2211124724003309
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    Mecp2 knock-out astrocytes affect synaptogenesis by Interleukin 6 dependent mechanisms
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    sciencedirect.com/science/article/pii/S2589004224005170
  76. www.sciencedirect.com www.sciencedirect.com
    Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice
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    sciencedirect.com/science/article/pii/S2211124724002031
  77. www.sciencedirect.com www.sciencedirect.com
    Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon
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    sciencedirect.com/science/article/pii/S1534580724000765
  78. Feb 2024
  79. www.sciencedirect.com www.sciencedirect.com
    The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes
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    sciencedirect.com/science/article/pii/S2211124724001414
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  81. www.biorxiv.org www.biorxiv.org
    A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory target gene expression
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    biorxiv.org/content/10.1101/2024.02.14.580367v1
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gut-Brain Axis Interplay via STAT3 pathway: Implications of Helicobacter pylori derived secretome on inflammation and Alzheimer's disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10854367/
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    Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124724000998
  84. www.sciencedirect.com www.sciencedirect.com
    Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs
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    sciencedirect.com/science/article/pii/S2211124724000792
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831336/
  86. Jan 2024
  87. dx.doi.org dx.doi.org
    Crosstalk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells
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    dx.doi.org/10.1158/0008-5472.CAN-22-3965
  88. www.sciencedirect.com www.sciencedirect.com
    Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling
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    sciencedirect.com/science/article/pii/S2211124724000160
  89. www.sciencedirect.com www.sciencedirect.com
    Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
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    sciencedirect.com/science/article/pii/S2666379123006031
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10788290/
  91. www.science.org www.science.org
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    science.org/doi/10.1126/sciadv.ade1282
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    Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells
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    sciencedirect.com/science/article/pii/S2211124723016248
  93. Dec 2023
  94. www.sciencedirect.com www.sciencedirect.com
    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S1074761323004831
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    PIM kinases regulate early human Th17 cell differentiation
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    sciencedirect.com/science/article/pii/S221112472301481X
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines
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    ncbi.nlm.nih.gov/pmc/articles/PMC10658995/
  97. Nov 2023
  98. www.sciencedirect.com www.sciencedirect.com
    A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression
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    sciencedirect.com/science/article/pii/S1534580723005518
  99. 52.53.155.43 52.53.155.43
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    Exosomes derived from platelet-rich plasma promote diabetic wound healing via the JAK2/STAT3 pathway
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    sciencedirect.com/science/article/pii/S2589004223023131
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10617673/
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    Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer
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  103. Oct 2023
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10605716/
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    Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma
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    sciencedirect.com/science/article/pii/S2666379123004159
  106. www.sciencedirect.com www.sciencedirect.com
    Targeting VCP potentiates immune checkpoint therapy for colorectal cancer
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  218. Apr 2021
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  221. Feb 2021
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  225. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells
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  230. Jan 2021
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  233. Dec 2020
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    CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci
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  237. Sep 2020
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