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Diet-induced diabetes driven by proinsulin misfolding reversed by β-cell rest

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  DOI: 10.1016/j.molmet.2026.102461
  
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sciencedirect.com/science/article/pii/S2212877826001456
Aug 2026
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A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer

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sciencedirect.com/science/article/pii/S1535610826003120
Apr 2026
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A stress-induced PI3P complex controls autophagy in erythroid precursors

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  DOI: 10.1016/j.isci.2026.115182
  
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Systematic profiling of cytosolic membraneless organelles reveals enrichment of oncogenic mRNA upon oxidative stress

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  DOI: 10.1016/j.celrep.2026.117203
  
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sciencedirect.com/science/article/pii/S2211124726002810
Mar 2026
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Gcn2 deficiency triggers anemia and hypoxic intolerance in zebrafish

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sciencedirect.com/science/article/pii/S2211124726002706
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RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response

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  DOI: 10.1016/j.molcel.2026.02.024
  
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sciencedirect.com/science/article/pii/S1097276526001383
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Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer

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Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

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  DOI: 10.1016/j.cell.2026.01.028
  
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sciencedirect.com/science/article/pii/S0092867426001157
Feb 2026
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The Role of STING-Mediated Activation of the Integrated Stress Response in Inflammation-Induced Depletion of Ovarian Reserve

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1. scibot 27 Feb 2026
  
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  DOI: 10.1096/fj.202502370RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202502370RR
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Heritable ER stress impairs mitochondrial metabolism and maintenance of hematopoietic stem cells after low-dose irradiation

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  DOI: 10.1016/j.isci.2026.114738
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12886522/
Jan 2026
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Limiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis

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1. scibot 23 Jan 2026
  
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  DOI: 10.1172/JCI187341
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12807472/
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Endometrial stromal cell-derived TMAO sustains decidualization to prevent recurrent spontaneous abortion

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  DOI: 10.1016/j.cmet.2025.11.014
  
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sciencedirect.com/science/article/pii/S1550413125005285
Nov 2025
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A retrograde, non-canonical integrated stress response cascade maintains synaptic strength under amino acid deprivation

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1. scibot 13 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116522
  
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sciencedirect.com/science/article/pii/S2211124725012938
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Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation

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  DOI: 10.1016/j.cmet.2025.10.003
  
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sciencedirect.com/science/article/pii/S1550413125004371
Sep 2025
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ER stress tolerance is regulated by copper-dependent PERK kinase activity

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1. scibot 27 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116318
  
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sciencedirect.com/science/article/pii/S2211124725010897
Jul 2025
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Ceftriaxone ameliorates tau phosphorylation and mislocalization in APP/PS1 AD mice by inhibiting endoplasmic reticulum stress

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.neuropharm.2025.110600
  
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sciencedirect.com/science/article/pii/S0028390825003089
Mar 2025
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Outer radial glia promotes white matter regeneration after neonatal brain injury

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  DOI: 10.1016/j.xcrm.2025.101986
  
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cell.com/cell-reports-medicine/abstract/S2666-3791(25)00059-X
Dec 2024
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DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.114984
  
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sciencedirect.com/science/article/pii/S2211124724013354
Sep 2024
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Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation

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1. scibot 27 Sep 2024
  
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Neuronal and glial cell alterations involved in the retinal degeneration of the familial dysautonomia optic neuropathy

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  DOI: 10.1002/glia.24612
  
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onlinelibrary.wiley.com/doi/10.1002/glia.24612
Apr 2024
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miR-217 regulates normal and tumor cell fate following induction of Endoplasmic Reticulum Stress

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  DOI: 10.1158/1541-7786.MCR-23-0676
  
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aacrjournals.org/mcr/article/22/4/360/741846/miR-217-Regulates-Normal-and-Tumor-Cell-Fate
Mar 2024
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Collective cell migration relies on PPP1R15-mediated regulation of the endoplasmic reticulum stress response

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sciencedirect.com/science/article/pii/S0960982224001568
Nov 2023
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RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks

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Differential Ire1 determines loser cell fate in tumor-suppressive cell competition

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Oct 2023
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Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice

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  DOI: 10.1016/j.isci.2023.108082
  
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cell.com/iscience/abstract/S2589-0042(23)02159-4
May 2023
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FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis

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  DOI: 10.1101/2023.05.20.541585
  
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biorxiv.org/content/10.1101/2023.05.20.541585v1
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Piezo1 suppression reduces demyelination after... : Neural Regeneration Research

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  DOI: 10.4103/1673-5374.361531
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10154511/
Apr 2023
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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression

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sciencedirect.com/science/article/pii/S1535610823000946
Mar 2023
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Safety and efficacy of intraventricular immunovirotherapy with oncolytic HSV-1 for CNS cancers

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  DOI: 10.1158/1078-0432.CCR-22-1382
  
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aacrjournals.org/clincancerres/article/28/24/5419/711437/Safety-and-Efficacy-of-Intraventricular
Jan 2023
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Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging

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sciencedirect.com/science/article/pii/S2211124723000530
Dec 2022
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ccr-22-1382-html.html

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  DOI: 10.1158/1078-0432.CCR-22-1382
  
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52.53.155.43/6d2b403121fa025e13c6da7e664df49c19b35c74/ccr-22-1382-html.html
Nov 2022
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V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

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  DOI: 10.1083/jcb.202205045
  
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rupress.org/jcb/article/222/1/e202205045/213623/V-ATPase-TORC1-mediated-ATFS-1-translation-directs
Sep 2022
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Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction

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1. scibot 09 Sep 2022
  
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  DOI: 10.3389/fragi.2022.975129
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9450999/
May 2022
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Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2α via the Hsp70-Bag3 module

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1. scibot 10 May 2022
  
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  DOI: 10.1016/j.isci.2022.104282
  
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sciencedirect.com/science/article/pii/S2589004222005521
Mar 2022
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Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication

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  DOI: 10.1016/j.molcel.2022.02.031
  
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PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen

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The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

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Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection

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Clusterin is involved in mediating the metabolic function of adipose SIRT1

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Cytosolic adaptation to mitochondria-induced proteostatic stress causes progressive muscle wasting

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mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion

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Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy

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Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis

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Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

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Untitled document

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Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence

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Pumilio2 and Staufen2 selectively balance the synaptic proteome

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OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21

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Selective Translation of Cell Fate Regulators Mediates Tolerance to Broad Oncogenic Stress

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A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

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Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism

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Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine revealed activation of the eIF2α/ATF4 integrated stress response in two in vitro placental models

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ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila

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Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP

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ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase

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Evolutionarily Conserved Regulation of Sleep by the Protein Translational Regulator PERK

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Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy

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The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4

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Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

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NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase

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BPS Publications

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Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration

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Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

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Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

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Tracing MYC Expression for Small Molecule Discovery

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The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis

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Endoplasmic reticulum stress contributes to the loss of newborn hippocampal neurons after traumatic brain injury

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Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

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Nov 2017
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The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation

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  RRID:AB_390740
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1097276517305798
academic.oup.com academic.oup.com

Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis

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1. scibot 08 Nov 2017
  
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  AB_390740
  
  Curator: @bandrow
  
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  (Cell Signaling Technology Cat# 3597, RRID:AB_390740)
  
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academic.oup.com/endo/article/158/6/1659/3058741/Guanabenz-Sensitizes-Pancreatic-Cells-to-Lipotoxic
elifesciences.org elifesciences.org

The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration

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1. scibot 08 Nov 2017
  
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  AB_390740
  
  Curator: @kaitlinsung
  
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  (Cell Signaling Technology Cat# 3597, RRID:AB_390740)
  
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elifesciences.org/content/6/e22871
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Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes

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1. scibot 08 Nov 2017
  
  in Public
  
  3597
  
  Curator: @gabimpine
  
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  (Cell Signaling Technology Cat# 3597, RRID:AB_390740)
  
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sciencedirect.com/science/article/pii/S1550413117301705

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