111 Matching Annotations
  1. Last 7 days
  2. www.science.org www.science.org
    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
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    1. scibot 18 Jul 2024
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    science.org/doi/10.1126/science.adk0850
  3. www.science.org www.science.org
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    1. scibot 18 Jul 2024
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    science.org/doi/10.1126/science.adk0775
  4. Jul 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic expression of RAS Degrader RRSP in Pancreatic Cancer via Nanocarrier-mediated mRNA delivery
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    1. scibot 03 Jul 2024
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      DOI: 10.1101/2024.06.11.598439

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    ncbi.nlm.nih.gov/pmc/articles/PMC11212117/
  6. May 2024
  7. aacrjournals.org aacrjournals.org
    Discovery of a novel potent EGFR inhibitor against EGFR activating mutations and on-target resistance in NSCLC
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    1. scibot 23 May 2024
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      DOI: 10.1158/1078-0432.CCR-23-2951

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    aacrjournals.org/clincancerres/article/30/8/1582/742134/Discovery-of-a-Novel-Potent-EGFR-Inhibitor-Against
  8. Apr 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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    1. scibot 20 Apr 2024
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    sciencedirect.com/science/article/pii/S1534580724002004
  10. Mar 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation
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    1. scibot 22 Mar 2024
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      DOI: 10.7554/eLife.92873

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    ncbi.nlm.nih.gov/pmc/articles/PMC10948148/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
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    1. scibot 09 Mar 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10916047/
  13. Feb 2024
  14. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    1. scibot 27 Feb 2024
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
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    The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish
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    1. scibot 02 Feb 2024
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    sciencedirect.com/science/article/pii/S0896627324000011
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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    1. scibot 01 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  17. Jan 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies
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    1. scibot 18 Jan 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10788224/
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
    1
    1. scibot 18 Jan 2024
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  20. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
    1. scibot 10 Jan 2024
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  21. Dec 2023
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    Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes
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    1. scibot 22 Dec 2023
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    sciencedirect.com/science/article/pii/S2211124723016157
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    Wildtype C-Raf gene dosage and dimerization drive prostate cancer metastasis
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    sciencedirect.com/science/article/pii/S2589004223025579
  24. Oct 2023
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    Brain Registration and Evaluation for Zebrafish (BREEZE)-mapping: A pipeline for whole-brain structural and activity analyses
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    sciencedirect.com/science/article/pii/S2666166723006147
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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    sciencedirect.com/science/article/pii/S221112472301210X
  27. Jul 2023
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
    1
    1. scibot 29 Jul 2023
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      DOI: 10.1016/j.isci.2023.107283

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    ncbi.nlm.nih.gov/pmc/articles/PMC10372839/
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    Calnexin controls TrkB cell surface transport and ER-phagy in mouse cerebral cortex development
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    sciencedirect.com/science/article/abs/pii/S1534580723003349
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    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
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    1. scibot 21 Jul 2023
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    sciencedirect.com/science/article/abs/pii/S2405471223001588
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
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      DOI: 10.1158/0008-5472.CAN-21-4309

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    ncbi.nlm.nih.gov/pmc/articles/PMC9938728/
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    Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin
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    1. scibot 06 Jul 2023
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    sciencedirect.com/science/article/pii/S1074761323002637
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    Oncogenic K-Ras suppresses global miRNA function
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    sciencedirect.com/science/article/pii/S109727652300429X
  34. Jun 2023
  35. www.science.org www.science.org
    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    science.org/doi/10.1126/sciadv.ade1155
  36. May 2023
  37. www.sciencedirect.com www.sciencedirect.com
    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    1. scibot 31 May 2023
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    sciencedirect.com/science/article/pii/S2211124723005818
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    Multimodal characterization of murine gastruloid development
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      DOI: 10.1016/j.stem.2023.04.018

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    sciencedirect.com/science/article/pii/S1934590923001704
  39. Apr 2023
  40. www.sciencedirect.com www.sciencedirect.com
    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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    sciencedirect.com/science/article/pii/S2211124723004473
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    ncbi.nlm.nih.gov/pmc/articles/PMC10115456/
  42. Mar 2023
  43. www.sciencedirect.com www.sciencedirect.com
    High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways
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    sciencedirect.com/science/article/pii/S2211124723002541
  44. onlinelibrary.wiley.com onlinelibrary.wiley.com
    COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by upregulating Krox20
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15764
  45. Feb 2023
  46. www.sciencedirect.com www.sciencedirect.com
    Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release
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    sciencedirect.com/science/article/pii/S2212877823000261
  47. Dec 2022
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    AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer
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    link.springer.com/article/10.1007/s00018-022-04638-y
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    The calcium-sensing receptor (CaSR) regulates zebrafish sensorimotor decision making via a genetically defined cluster of hindbrain neurons
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    sciencedirect.com/science/article/pii/S2211124722016783
  50. Oct 2022
  51. www.sciencedirect.com www.sciencedirect.com
    Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts
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    sciencedirect.com/science/article/pii/S1534580722007195
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    Using pERK immunostaining to quantify neuronal activity induced by stress in zebrafish larvae
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    sciencedirect.com/science/article/pii/S2666166722006116
  53. Aug 2022
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioral and cellular dopamine D1 and D3 receptor-mediated synergy: Implications for L-DOPA-induced dyskinesia
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      DOI: 10.1016/j.neuropharm.2018.06.024

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    ncbi.nlm.nih.gov/pmc/articles/PMC9380415/
  55. Jun 2022
  56. 52.53.155.43 52.53.155.43
    Control of coronary vascular resistance by eicosanoids via a novel GPCR
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      DOI: 10.1152/ajpcell.00454.2021

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    52.53.155.43/0732bd1f17e397dfb1827c6408f13737d86b3d38/ajpcell.00454.2021-html.html
  57. journals.physiology.org journals.physiology.org
    Control of coronary vascular resistance by eicosanoids via a novel GPCR
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    journals.physiology.org/doi/10.1152/ajpcell.00454.2021
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    Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice
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  59. May 2022
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    Proteolytic pan-RAS cleavage leads to tumor regression in patient-derived pancreatic cancer xenografts
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    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs
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  64. Mar 2022
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    Transcriptomic and Physiological Analysis of Endocrine Disrupting Chemicals Impacts on 3D Zebrafish Liver Cell Culture System
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  71. Dec 2021
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  75. Oct 2021
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    Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas
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  77. Sep 2021
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  79. Aug 2021
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    Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling
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    Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion
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  87. Jul 2021
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    Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations
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  92. Jun 2021
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    Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch
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  97. May 2021
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    Chronic restraint stress promotes the mobilization and recruitment of myeloid-derived suppressor cells through β-adrenergic-activated CXCL5-CXCR2-Erk signaling cascades
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  102. Apr 2021
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    Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways
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    Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
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  106. Feb 2021
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    Hypothalamic Dopamine Neurons Control Sensorimotor Behavior by Modulating Brainstem Premotor Nuclei in Zebrafish
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    Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells
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    Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers
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  110. Dec 2020
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  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  113. Oct 2020
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  115. Sep 2020
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    Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
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    Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes
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  119. elifesciences.org elifesciences.org
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    Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer
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  124. Jan 2020
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    Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions
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  134. Nov 2018
  135. watermark.silverchair.com watermark.silverchair.com
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    Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation
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    A Hierarchical, Data-Driven Approach to Modeling Single-Cell Populations Predicts Latent Causes of Cell-To-Cell Variability
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    Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
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  144. Nov 2017
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    Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes
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