151 Matching Annotations
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    Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation
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    sciencedirect.com/science/article/pii/S2211124726001245
  3. Mar 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Opposing lineage specifiers induce a protumor hybrid identity state in lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12404196/
  5. Feb 2026
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    SHP2 regulates VEGFR2 Y1175/ PLCγ signaling to impair tumor endothelial barrier stability
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    Hypoxia restores the acidosis-induced inhibition of cancer cell dissemination
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  8. Jan 2026
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    Dynamic control of Raf–ERK signaling modulates neuronal activity across biological scales
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  11. Dec 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer
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  13. Nov 2025
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    Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer
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  15. Oct 2025
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    Tuning insulin receptor signaling using de novo-designed agonists
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    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    science.org/doi/10.1126/scisignal.adu7145
  18. Sep 2025
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    BRAFV600E-Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor Signaling
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    Cooperativity between Ras pathway mutations in colonic tumorigenesis
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  21. Aug 2025
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    Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer
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    KRAS-driven pancreatic ductal adenocarcinoma cell lines harbour putative cancer stem cells
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  24. Jul 2025
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    Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse.
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    SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma
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  27. Jun 2025
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    Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake
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  29. May 2025
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    Surrogate GPR139 Agonists Reverse Short‐Term Startle Habituation Impairment in Larval Zebrafish
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    The biased OTR ligands -atosiban and carbetocin- differentially inhibit early or late formalin-induced nociception in rats
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    Independent and synergistic roles of MEK-ERK1/2 and PKC pathways in regulating functional changes in vascular tissue following flow cessation
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  34. Mar 2025
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    Large-scale control over collective cell migration using light-activated epidermal growth factor receptors
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  36. Jan 2025
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells
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    Orthogonal RNA replication enables directed evolution and Darwinian adaptation in mammalian cells
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    Ketamine and Major Ketamine Metabolites Function as Allosteric Modulators of Opioid Receptors
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  40. Dec 2024
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    Single-Cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations
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  42. Nov 2024
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    Single-Cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations
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  44. Oct 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
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    Suppression of Extracellular Vesicle VEGF-C–mediated Lymphangiogenesis and Pancreatic Cancer Early Dissemination By a Selective HDAC1/2 Inhibitor
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    RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
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  48. Sep 2024
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  50. Aug 2024
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    Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection
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    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
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    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
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    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    Exploring visceral and subcutaneous adipose tissue secretomes in human obesity: implications for metabolic disease
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  57. Jul 2024
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    Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice
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    Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance
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    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
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    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    Therapeutic expression of RAS Degrader RRSP in Pancreatic Cancer via Nanocarrier-mediated mRNA delivery
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    ncbi.nlm.nih.gov/pmc/articles/PMC11212117/
  63. May 2024
  64. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Discovery of a novel potent EGFR inhibitor against EGFR activating mutations and on-target resistance in NSCLC
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  65. Apr 2024
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    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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  67. Mar 2024
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    Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation
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    Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
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  70. Feb 2024
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish
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    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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  74. Jan 2024
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    In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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  78. Dec 2023
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    Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes
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    Wildtype C-Raf gene dosage and dimerization drive prostate cancer metastasis
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  81. Oct 2023
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    Brain Registration and Evaluation for Zebrafish (BREEZE)-mapping: A pipeline for whole-brain structural and activity analyses
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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  84. Jul 2023
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    A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
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    Calnexin controls TrkB cell surface transport and ER-phagy in mouse cerebral cortex development
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    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
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    Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
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    Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin
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    Oncogenic K-Ras suppresses global miRNA function
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  91. Jun 2023
  92. www.science.org www.science.org
    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    science.org/doi/10.1126/sciadv.ade1155
  93. May 2023
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    Multimodal characterization of murine gastruloid development
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  96. Apr 2023
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    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    ncbi.nlm.nih.gov/pmc/articles/PMC10115456/
  99. Mar 2023
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    High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways
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    COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by upregulating Krox20
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  102. Feb 2023
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    Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release
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  104. Dec 2022
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    AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer
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    The calcium-sensing receptor (CaSR) regulates zebrafish sensorimotor decision making via a genetically defined cluster of hindbrain neurons
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  107. Oct 2022
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    Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts
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    Using pERK immunostaining to quantify neuronal activity induced by stress in zebrafish larvae
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  110. Aug 2022
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioral and cellular dopamine D1 and D3 receptor-mediated synergy: Implications for L-DOPA-induced dyskinesia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9380415/
  112. Jun 2022
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    Control of coronary vascular resistance by eicosanoids via a novel GPCR
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    Control of coronary vascular resistance by eicosanoids via a novel GPCR
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    journals.physiology.org/doi/10.1152/ajpcell.00454.2021
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    Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice
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  116. May 2022
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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    sciencedirect.com/science/article/pii/S1097276522004348
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    Proteolytic pan-RAS cleavage leads to tumor regression in patient-derived pancreatic cancer xenografts
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    aacrjournals.org/mct/article/21/5/810/694769/Proteolytic-pan-RAS-Cleavage-Leads-to-Tumor
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    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs
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    elifesciences.org/articles/76495
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    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
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