79 Matching Annotations
  1. Jul 2024
  2. www.nature.com www.nature.com
    DNA ploidy and PTEN as biomarkers for predicting aggressive disease in prostate cancer patients under active surveillance
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    1. scibot 16 Jul 2024
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    nature.com/articles/s41416-024-02780-x
  3. www.sciencedirect.com www.sciencedirect.com
    Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer
    1
    1. scibot 12 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114487

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    sciencedirect.com/science/article/pii/S2211124724008167
  4. May 2024
  5. 52.53.155.43 52.53.155.43
    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
    2
    1. scibot 09 May 2024
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      DOI: 10.1016/j.celrep.2024.114173

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    2. scibot 03 May 2024
      RRID:AB_390810

      DOI: 10.1016/j.celrep.2024.114173

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    52.53.155.43/7165d3b920717872e9ecee45ef5f3cb3a7917c57/mmc6-html.html
  6. Apr 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
    1
    1. scibot 16 Apr 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11148513/
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α
    1
    1. scibot 09 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114056

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    ncbi.nlm.nih.gov/pmc/articles/PMC11112681/
  9. Mar 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina
    1
    1. scibot 29 Mar 2024
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      DOI: 10.1016/j.celrep.2024.114005

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    sciencedirect.com/science/article/pii/S2211124724003334
  11. Feb 2024
  12. www.sciencedirect.com www.sciencedirect.com
    Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures
    1
    1. scibot 21 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724001384
  13. link.springer.com link.springer.com
    A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs
    2
    1. scibot 01 Feb 2024
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      DOI: 10.1038/s41698-024-00500-5

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    2. scibot 01 Feb 2024
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      DOI: 10.1038/s41698-024-00500-5

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    link.springer.com/article/10.1038/s41698-024-00500-5
  14. Dec 2023
  15. www.sciencedirect.com www.sciencedirect.com
    De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function
    1
    1. scibot 21 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113518

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    sciencedirect.com/science/article/pii/S2211124723015309
  16. www.sciencedirect.com www.sciencedirect.com
    Heterogeneity and transcriptional drivers of triple-negative breast cancer
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113564

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    sciencedirect.com/science/article/pii/S2211124723015760
  17. Oct 2023
  18. www.sciencedirect.com www.sciencedirect.com
    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.ccell.2023.09.001

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    sciencedirect.com/science/article/pii/S1535610823003185
  19. Aug 2023
  20. 52.53.155.43 52.53.155.43
    ccr-22-2976 (1)-html.html
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    1. scibot 11 Aug 2023
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      DOI: 10.1158/1078-0432.ccr-22-2976

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    52.53.155.43/a9d00605441caddd3b84705fb749be834fef17fa/ccr-22-2976 (1)-html.html
  21. Jul 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
    1
    1. scibot 21 Jul 2023
      RRID:AB_390810

      DOI: 10.1016/j.celrep.2023.112794

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    sciencedirect.com/science/article/pii/S2211124723008057
  23. Jun 2023
  24. www.sciencedirect.com www.sciencedirect.com
    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
    1
    1. scibot 23 Jun 2023
      RRID:AB_390810

      DOI: 10.1016/j.ccell.2023.05.016

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    sciencedirect.com/science/article/pii/S1535610823001836
  25. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus
    1
    1. scibot 01 Jun 2023
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      DOI: 10.1111/jne.13187

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    onlinelibrary.wiley.com/doi/10.1111/jne.13187
  26. May 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin
    1
    1. scibot 11 May 2023
      RRID:AB_390810

      DOI: 10.1016/j.celrep.2023.112472

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    sciencedirect.com/science/article/pii/S2211124723004837
  28. Apr 2023
  29. www.sciencedirect.com www.sciencedirect.com
    Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression
    1
    1. scibot 21 Apr 2023
      RRID:AB_390810

      DOI: 10.1016/j.ccell.2023.03.021

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    sciencedirect.com/science/article/pii/S1535610823000946
  30. www.sciencedirect.com www.sciencedirect.com
    Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease
    1
    1. scibot 12 Apr 2023
      RRID:AB_390810

      DOI: 10.1016/j.cell.2023.03.014

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    sciencedirect.com/science/article/abs/pii/S0092867423002751
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
    1
    1. scibot 09 Apr 2023
      RRID:AB_390810

      DOI: 10.1016/j.isci.2023.106375

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    ncbi.nlm.nih.gov/pmc/articles/PMC10074152/
  32. Mar 2023
  33. link.springer.com link.springer.com
    A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression
    2
    1. scibot 31 Mar 2023
      AB_823618

      DOI: 10.1007/s43032-023-01190-3

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      AB_823618

      DOI: 10.1007/s43032-023-01190-3

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    link.springer.com/article/10.1007/s43032-023-01190-3
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neurovascular development in Pten and Tsc2 mouse mutants
    2
    1. scibot 02 Mar 2023
      RRID: AB_390810

      DOI: 10.1523/ENEURO.0340-22.2023

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      DOI: 10.1523/ENEURO.0340-22.2023

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    ncbi.nlm.nih.gov/pmc/articles/PMC9953070/
  35. Feb 2023
  36. www.sciencedirect.com www.sciencedirect.com
    PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
    1
    1. scibot 17 Feb 2023
      RRID:AB_390810

      DOI: 10.1016/j.isci.2023.106070

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    sciencedirect.com/science/article/pii/S2589004223001475
  37. www.biorxiv.org www.biorxiv.org
    A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs
    1
    1. scibot 07 Feb 2023
      RRID:AB_390810

      DOI: 10.1101/2023.01.24.525374

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    biorxiv.org/content/10.1101/2023.01.24.525374v1
  38. Jan 2023
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct Cellular Origins and Differentiation Process Account for Distinct Oncogenic and Clinical Behaviors of Leiomyosarcomas
    1
    1. scibot 25 Jan 2023
      RRID:AB_390810

      DOI: 10.3390/cancers15020534

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    ncbi.nlm.nih.gov/pmc/articles/PMC9856933/
  40. Nov 2022
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression
    1
    1. scibot 19 Nov 2022
      RRID:AB_390810

      DOI: 10.1158/2767-9764.crc-22-0024

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    ncbi.nlm.nih.gov/pmc/articles/PMC9648413/
  42. www.sciencedirect.com www.sciencedirect.com
    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
    1
    1. scibot 10 Nov 2022
      RRID:AB_390810

      DOI: 10.1016/j.isci.2022.105184

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    sciencedirect.com/science/article/pii/S2589004222014560
  43. www.sciencedirect.com www.sciencedirect.com
    Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice
    1
    1. scibot 05 Nov 2022
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      DOI: 10.1016/j.celrep.2022.111482

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    sciencedirect.com/science/article/pii/S2211124722013328
  44. Sep 2022
  45. www.sciencedirect.com www.sciencedirect.com
    Ral GTPases are critical regulators of spinal cord myelination and homeostasis
    1
    1. scibot 29 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111413

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    sciencedirect.com/science/article/pii/S2211124722012542
  46. Jul 2022
  47. aacrjournals.org aacrjournals.org
    Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression
    1
    1. scibot 29 Jul 2022
      RRID:AB_390810

      DOI: 10.1158/2767-9764.CRC-22-0024

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    aacrjournals.org/cancerrescommun/article/2/7/679/707059/Bcl-xL-Inhibition-Radiosensitizes-PIK3CA-PTEN-Wild
  48. Jun 2022
  49. www.nature.com www.nature.com
    Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role
    1
    1. scibot 07 Jun 2022
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      DOI: 10.1038/s41419-022-04988-2

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    nature.com/articles/s41419-022-04988-2
  50. May 2022
  51. www.sciencedirect.com www.sciencedirect.com
    Stromal AR inhibits prostate tumor progression by restraining secretory luminal epithelial cells
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    1. scibot 26 May 2022
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      DOI: 10.1016/j.celrep.2022.110848

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    sciencedirect.com/science/article/pii/S2211124722006210
  52. www.sciencedirect.com www.sciencedirect.com
    Self-delivering RNAi compounds as therapeutic agents in the central nervous system to enhance axonal regeneration after injury
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    1. scibot 20 May 2022
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      DOI: 10.1016/j.isci.2022.104379

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    sciencedirect.com/science/article/pii/S2589004222006502
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress
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    1. scibot 11 May 2022
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      DOI: 10.7554/eLife.69255

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    ncbi.nlm.nih.gov/pmc/articles/PMC9064299/
  54. Apr 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Single-cell proteomics defines the cellular heterogeneity of localized prostate cancer
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    1. scibot 21 Apr 2022
      RRID:AB_390810

      DOI: 10.1016/j.xcrm.2022.100604

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    sciencedirect.com/science/article/pii/S2666379122001215
  56. Mar 2022
  57. www.sciencedirect.com www.sciencedirect.com
    The mTOR chromatin-bound interactome in prostate cancer
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    1. scibot 23 Mar 2022
      RRID:AB_390810

      DOI: 10.1016/j.celrep.2022.110534

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    sciencedirect.com/science/article/pii/S2211124722002753
  58. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    PTENα regulates endocytosis and modulates olfactory function
    1
    1. scibot 19 Mar 2022
      RRID:AB_390810

      DOI: 10.1096/fj.201900588RR

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201900588RR
  59. Feb 2022
  60. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
    1
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      DOI: 10.1016/j.stem.2022.01.001

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    sciencedirect.com/science/article/pii/S1934590922000017
  61. Sep 2021
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    Dynamic interplay of two molecular switches enabled by the MEK1/2-ERK1/2 and IL-6-STAT3 signaling axes controls epithelial cell migration in response to growth factors
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      9559

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  63. Aug 2021
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    Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors
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    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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  66. www.fasebj.org www.fasebj.org
    PTENα regulates endocytosis and modulates olfactory function
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  67. Jun 2021
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    Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver
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    Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling
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  71. May 2021
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    mTOR-driven neural circuit changes initiate an epileptogenic cascade
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    Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression
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    DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1
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  75. Apr 2021
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    Ligand Binding Prolongs Androgen Receptor Protein Half-Life by Reducing its Degradation
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    In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis
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  79. Feb 2021
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    Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells
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  81. Dec 2020
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    miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling
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  83. Oct 2020
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
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  85. Sep 2020
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
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  87. www.sciencedirect.com www.sciencedirect.com
    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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  88. rupress.org rupress.org
    Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
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      PTEN

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  89. Jan 2020
  90. www.sciencedirect.com www.sciencedirect.com
    CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation
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  91. www.sciencedirect.com www.sciencedirect.com
    Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors?
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      DOI: 10.1016/j.expneurol.2019.113029

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  92. www.cell.com www.cell.com
    Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells
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      DOI: 10.1016/j.cmet.2019.05.016

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    cell.com/cell-metabolism/fulltext/S1550-4131(19)30256-6
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    Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing
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      DOI: 10.1016/j.celrep.2019.08.060

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    The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches
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    Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis
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      RRID:AB_390810

      DOI: 10.1016/j.stem.2019.09.009

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    PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1
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      RRID:AB_390810

      DOI: 10.1016/j.molcel.2019.08.006

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  98. www.jneurosci.org www.jneurosci.org
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  100. Nov 2018
  101. www.sciencedirect.com www.sciencedirect.com
    Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth
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  102. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas
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    The Polyploid State Plays a Tumor-Suppressive Role in the Liver
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    Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation
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    Neuronal PTEN deletion in adult cortical neurons triggers progressive growth of cell bodies, dendrites, and axons
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    Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation
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  107. Nov 2017
  108. www.sciencedirect.com www.sciencedirect.com
    Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function
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      9559

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  109. www.jneurosci.org www.jneurosci.org
    PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network
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    PTEN deletion increases hippocampal granule cell excitability in male and female mice
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