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    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
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  3. Apr 2024
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    Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α
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    sciencedirect.com/science/article/pii/S221112472400384X
  5. Mar 2024
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    Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina
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  7. Feb 2024
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    Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures
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    A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs
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  10. Dec 2023
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    De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function
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    sciencedirect.com/science/article/pii/S2211124723015309
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    Heterogeneity and transcriptional drivers of triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2211124723015760
  13. Oct 2023
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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  15. Aug 2023
  16. 52.53.155.43 52.53.155.43
    ccr-22-2976 (1)-html.html
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  17. Jul 2023
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    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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  19. Jun 2023
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    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
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    PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus
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  22. May 2023
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    Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin
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  24. Apr 2023
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    Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression
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    Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease
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    sciencedirect.com/science/article/abs/pii/S0092867423002751
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    INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
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  28. Mar 2023
  29. link.springer.com link.springer.com
    A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression
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  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neurovascular development in Pten and Tsc2 mouse mutants
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    ncbi.nlm.nih.gov/pmc/articles/PMC9953070/
  31. Feb 2023
  32. www.sciencedirect.com www.sciencedirect.com
    PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
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    sciencedirect.com/science/article/pii/S2589004223001475
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    A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs
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    biorxiv.org/content/10.1101/2023.01.24.525374v1
  34. Jan 2023
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct Cellular Origins and Differentiation Process Account for Distinct Oncogenic and Clinical Behaviors of Leiomyosarcomas
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      DOI: 10.3390/cancers15020534

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    ncbi.nlm.nih.gov/pmc/articles/PMC9856933/
  36. Nov 2022
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice
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    sciencedirect.com/science/article/pii/S2211124722013328
  40. Sep 2022
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    Ral GTPases are critical regulators of spinal cord myelination and homeostasis
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    sciencedirect.com/science/article/pii/S2211124722012542
  42. Jul 2022
  43. aacrjournals.org aacrjournals.org
    Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression
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    aacrjournals.org/cancerrescommun/article/2/7/679/707059/Bcl-xL-Inhibition-Radiosensitizes-PIK3CA-PTEN-Wild
  44. Jun 2022
  45. www.nature.com www.nature.com
    Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role
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      DOI: 10.1038/s41419-022-04988-2

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    nature.com/articles/s41419-022-04988-2
  46. May 2022
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    Stromal AR inhibits prostate tumor progression by restraining secretory luminal epithelial cells
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    sciencedirect.com/science/article/pii/S2211124722006210
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    Self-delivering RNAi compounds as therapeutic agents in the central nervous system to enhance axonal regeneration after injury
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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress
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      DOI: 10.7554/eLife.69255

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    ncbi.nlm.nih.gov/pmc/articles/PMC9064299/
  50. Apr 2022
  51. www.sciencedirect.com www.sciencedirect.com
    Single-cell proteomics defines the cellular heterogeneity of localized prostate cancer
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    sciencedirect.com/science/article/pii/S2666379122001215
  52. Mar 2022
  53. www.sciencedirect.com www.sciencedirect.com
    The mTOR chromatin-bound interactome in prostate cancer
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    sciencedirect.com/science/article/pii/S2211124722002753
  54. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    PTENα regulates endocytosis and modulates olfactory function
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      DOI: 10.1096/fj.201900588RR

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201900588RR
  55. Feb 2022
  56. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
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      DOI: 10.1016/j.stem.2022.01.001

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    sciencedirect.com/science/article/pii/S1934590922000017
  57. Sep 2021
  58. www.sciencedirect.com www.sciencedirect.com
    Dynamic interplay of two molecular switches enabled by the MEK1/2-ERK1/2 and IL-6-STAT3 signaling axes controls epithelial cell migration in response to growth factors
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    sciencedirect.com/science/article/pii/S0021925821009637
  59. Aug 2021
  60. www.sciencedirect.com www.sciencedirect.com
    Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors
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      DOI: 10.1016/j.devcel.2021.08.004

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    sciencedirect.com/science/article/pii/S1534580721006341
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    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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  62. www.fasebj.org www.fasebj.org
    PTENα regulates endocytosis and modulates olfactory function
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  63. Jun 2021
  64. www.sciencedirect.com www.sciencedirect.com
    Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver
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  66. www.sciencedirect.com www.sciencedirect.com
    Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling
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  67. May 2021
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    mTOR-driven neural circuit changes initiate an epileptogenic cascade
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    Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression
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    DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1
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  71. Apr 2021
  72. academic.oup.com academic.oup.com
    Ligand Binding Prolongs Androgen Receptor Protein Half-Life by Reducing its Degradation
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    In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions
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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis
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  75. Feb 2021
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    Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells
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  77. Dec 2020
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    miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling
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  79. Oct 2020
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
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  81. Sep 2020
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
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  83. www.sciencedirect.com www.sciencedirect.com
    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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  84. rupress.org rupress.org
    Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
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      PTEN

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  85. Jan 2020
  86. www.sciencedirect.com www.sciencedirect.com
    CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation
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  87. www.sciencedirect.com www.sciencedirect.com
    Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors?
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      DOI: 10.1016/j.expneurol.2019.113029

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    Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells
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      DOI: 10.1016/j.cmet.2019.05.016

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  89. www.sciencedirect.com www.sciencedirect.com
    Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing
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      DOI: 10.1016/j.celrep.2019.08.060

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    sciencedirect.com/science/article/pii/S2211124719311088
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    The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches
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      DOI: 10.1016/j.celrep.2019.10.039

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    sciencedirect.com/science/article/pii/S2211124719313531
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    Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis
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      RRID:AB_390810

      DOI: 10.1016/j.stem.2019.09.009

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    sciencedirect.com/science/article/pii/S1934590919304205
  92. www.sciencedirect.com www.sciencedirect.com
    PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1
    1
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      RRID:AB_390810

      DOI: 10.1016/j.molcel.2019.08.006

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    sciencedirect.com/science/article/pii/S1097276519306227
  93. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_390810

      DOI: 10.1016/j.cell.2019.03.005

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  94. www.jneurosci.org www.jneurosci.org
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      DOI: 10.1523/JNEUROSCI.0538-18.2018

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  95. www.sciencedirect.com www.sciencedirect.com
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  96. Nov 2018
  97. www.sciencedirect.com www.sciencedirect.com
    Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth
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  98. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas
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    The Polyploid State Plays a Tumor-Suppressive Role in the Liver
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    Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation
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    Neuronal PTEN deletion in adult cortical neurons triggers progressive growth of cell bodies, dendrites, and axons
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      AB_390810

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    Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation
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  103. Nov 2017
  104. www.sciencedirect.com www.sciencedirect.com
    Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function
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      9559

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  105. www.jneurosci.org www.jneurosci.org
    PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network
    1
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    PTEN deletion increases hippocampal granule cell excitability in male and female mice
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