461 Matching Annotations
  1. Last 7 days
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    ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
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      DOI: 10.7554/eLife.89261

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    ncbi.nlm.nih.gov/pmc/articles/PMC11006420/
  3. Apr 2024
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    A receptor required for chitin perception facilitates arbuscular mycorrhizal associations and distinguishes root symbiosis from immunity
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    sciencedirect.com/science/article/pii/S0960982224003129
  5. Mar 2024
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    RPGR is a guanine nucleotide exchange factor for the small GTPase RAB37 required for retinal function via autophagy regulation
    1
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    sciencedirect.com/science/article/pii/S2211124724003383
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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    The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5
    1
    1. scibot 09 Mar 2024
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      DOI: 10.1371/journal.pone.0298820

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    ncbi.nlm.nih.gov/pmc/articles/PMC10919853/
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    A Highlights from MBoC Selection: Preexisting tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia
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      DOI: 10.1091/mbc.E23-08-0337

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  10. Feb 2024
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    Bacterial host adaptation through sequence and structural variations of a single type III effector gene
    4
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    sciencedirect.com/science/article/pii/S2589004224004450
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    NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP
    1
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    sciencedirect.com/science/article/pii/S2211124724001888
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    53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication
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    1. scibot 22 Feb 2024
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      DOI: 10.1101/2023.09.27.559698

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    A metabolically controlled contact site between vacuoles and lipid droplets in yeast
    3
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    sciencedirect.com/science/article/pii/S1534580724000364
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    Search for Chromosomal Instability aiding Variants (CIVa) reveal naturally occurring kinetochore gene variants that perturb chromosome segregation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10867425/
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    LDO proteins and Vac8 form a vacuole-lipid droplet contact site to enable starvation-induced lipophagy in yeast
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      DOI: 10.1016/j.devcel.2024.01.014

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    sciencedirect.com/science/article/pii/S1534580724000340
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    A transcription factor complex in Dictyostelium enables adaptive changes in macropinocytosis during the growth-to-development transition
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    Mapping protein–RNA binding in plants with individual-nucleotide-resolution UV cross-linking and immunoprecipitation (plant iCLIP2)
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      DOI: 10.1038/s41596-023-00935-3

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    link.springer.com/article/10.1038/s41596-023-00935-3
  19. Jan 2024
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    BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution
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      DOI: 10.1016/j.molcel.2023.12.040

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    sciencedirect.com/science/article/pii/S1097276523010869
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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      DOI: 10.1016/j.molcel.2023.12.039

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  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Plant Toll/interleukin-1 receptor/resistance protein domains physically associate with enhanced disease susceptibility1 family proteins in immune signaling
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      DOI: 10.1016/j.isci.2024.108817

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    ncbi.nlm.nih.gov/pmc/articles/PMC10964261/
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    Dual phosphorylation of DGK5-mediated PA burst regulates ROS in plant immunity
    1
    1. scibot 20 Jan 2024
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      DOI: 10.1016/j.cell.2023.12.030

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    sciencedirect.com/science/article/pii/S0092867423014046
  24. Dec 2023
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    Pib2 is a cysteine sensor involved in TORC1 activation in Saccharomyces cerevisiae
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      DOI: 10.1016/j.celrep.2023.113599

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    sciencedirect.com/science/article/pii/S221112472301611X
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    Ratcheted transport and sequential assembly of the yeast telomerase RNP
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      DOI: 10.1016/j.celrep.2023.113565

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    Ferroptosis-protective membrane domains in quiescence
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    Synonymous codon usage regulates translation initiation
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  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
    1
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      DOI: 10.1016/j.molcel.2023.11.016

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  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Highlights from MBoC Selection: Membrane binding of endocytic myosin-1s is inhibited by a class of ankyrin repeat proteins
    1
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      DOI: 10.1091/mbc.E23-06-0233

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    Calmodulin regulates protease versus co-chaperone activity of a metacaspase
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      DOI: 10.1016/j.celrep.2023.113372

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    53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication
    1
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      DOI: 10.1016/j.celrep.2023.113412

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    IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis
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    sciencedirect.com/science/article/pii/S2211124723015206
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    Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines
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      DOI: 10.1158/0008-5472.CAN-22-2316

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    ncbi.nlm.nih.gov/pmc/articles/PMC10658995/
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    Reticulons bind sphingolipids to activate the endoplasmic reticulum cell cycle checkpoint, the ER surveillance pathway
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      DOI: 10.1016/j.celrep.2023.113403

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    sciencedirect.com/science/article/pii/S2211124723014158
  36. Nov 2023
  37. www.sciencedirect.com www.sciencedirect.com
    Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
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      DOI: 10.1016/j.cell.2023.09.025

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    sciencedirect.com/science/article/pii/S0092867423010796
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    Cytochrome c regulates hyphal morphogenesis by interfering with cAMP-PKA signaling in Candida albicans
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    sciencedirect.com/science/article/pii/S2211124723014857
  39. onlinelibrary.wiley.com onlinelibrary.wiley.com
    OGT-1 regulates synaptic assembly through the insulin signaling pathway
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      DOI: 10.1002/jcb.30497

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    onlinelibrary.wiley.com/doi/10.1002/jcb.30497
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    Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless
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    sciencedirect.com/science/article/pii/S1097276523008638
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma
    1
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      DOI: 10.7554/eLife.85654

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    ncbi.nlm.nih.gov/pmc/articles/PMC10629828/
  42. Oct 2023
  43. www.science.org www.science.org
    Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase
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      DOI: 10.1126/scisignal.add3269

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    science.org/doi/10.1126/scisignal.add3269
  44. www.biorxiv.org www.biorxiv.org
    Molecular model of a bacterial flagellar motor in situ reveals a “parts-list” of protein adaptations to increase torque
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      DOI: 10.1101/2023.09.08.556779

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  45. www.tandfonline.com www.tandfonline.com
    Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders
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  46. Sep 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Global analysis of aging-related protein structural changes uncovers enzyme-polymerization-based control of longevity
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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A dual‐function SNF2 protein drives chromatid resolution and nascent transcripts removal in mitosis
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      DOI: 10.15252/embr.202256463

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    Mechanism and evolutionary origins of alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10
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    Regulation of Rim4 distribution, function, and stability during meiosis by PKA, Cdc14, and 14-3-3 proteins
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    Autophagy-mediated surveillance of Rim4-mRNA interaction safeguards programmed meiotic translation
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    Anillin forms linear structures and facilitates furrow ingression after septin and formin depletion
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    Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion
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  54. Aug 2023
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    PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development
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    GSK3 and lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration
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    Divergence of cytokinesis and dimorphism control by myosin II regulatory light chain in fission yeasts
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    Fast drosophila enterocyte regrowth after infection involves a reverse metabolic flux driven by an amino acid transporter
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission
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  61. Jul 2023
  62. www.sciencedirect.com www.sciencedirect.com
    Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation
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    PGAM5 is an MFN2 phosphatase that plays an essential role in the regulation of mitochondrial dynamics
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    Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein
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  65. 52.53.155.43 52.53.155.43
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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  66. dx.doi.org dx.doi.org
    A dual, catalytic role for the fission yeast Ccr4-Not complex in gene silencing and heterochromatin spreading
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      DOI: 10.1093/genetics/iyad108

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  67. 52.53.155.43 52.53.155.43
    Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial organization
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  68. Jun 2023
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activating FcγR function depends on endosomal-signaling platforms
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    Protein kinase ATR inhibits E3 ubiquitin ligase CRL4PRL1 to stabilize ribonucleotide reductase in response to replication stress
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    Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control
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    Long noncoding RNA ARTA controls ABA response through MYB7 nuclear trafficking in Arabidopsis
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    The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins
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  74. May 2023
  75. www.embopress.org www.embopress.org
    Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions
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      DOI: 10.15252/msb.202211164

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    HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
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  77. www.biorxiv.org www.biorxiv.org
    Membrane binding of endocytic myosin-1s is inhibited by a class of ankyrin repeat proteins
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  78. Apr 2023
  79. www.sciencedirect.com www.sciencedirect.com
    Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates
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    A dual, catalytic role for the fission yeast Ccr4-Not complex in gene silencing and heterochromatin spreading
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein
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  82. Mar 2023
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes
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  84. rupress.org rupress.org
    Yeast Svf1 binds ceramides and contributes to sphingolipid metabolism at the ER cis-Golgi interface
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2
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      DOI: 10.7554/eLife.84492

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    S-acylation stabilizes ligand-induced receptor kinase complex formation during plant pattern-triggered immune signaling
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  87. elifesciences.org elifesciences.org
    Myosin II regulatory light chain phosphorylation and formin availability modulate cytokinesis upon changes in carbohydrate metabolism
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    Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs
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    Evolutionarily conserved midbody remodeling precedes ring canal formation during gametogenesis
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome
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      DOI: 10.1038/s41467-023-36818-0

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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase
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  92. Feb 2023
  93. www.sciencedirect.com www.sciencedirect.com
    Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subtype-Specific Roles of Ellipsoid Body Ring Neurons in Sleep Regulation in Drosophila
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  95. www.nature.com www.nature.com
    The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
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  96. www.sciencedirect.com www.sciencedirect.com
    RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1
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  97. Jan 2023
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    Drosophila transition fibers are essential for IFT-dependent ciliary elongation but not basal body docking and ciliary budding
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    Gene-by-gene screen of the unknown proteins encoded on Plasmodium falciparum chromosome 3
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rho-Kinase/ROCK Phosphorylates PSD-93 Downstream of NMDARs to Orchestrate Synaptic Plasticity
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    Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates
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    CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart
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  104. Dec 2022
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice
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  106. Nov 2022
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    Loss of MTCH-1 suppresses age-related proteostasis collapse through the inhibition of programmed cell death factors
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    Autophagy promotes cell survival by maintaining NAD levels
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    Divergent neurocircuitry dissociates two components of the stress response: glucose mobilization and anxiety-like behavior
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  110. www.cell.com www.cell.com
    Loss of heat shock factor initiates intracellular lipid surveillance by actin destabilization
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  111. Oct 2022
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Maternal Wnt11b regulates cortical rotation during Xenopus axis formation: analysis of maternal-effect wnt11b mutants
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  113. www.sciencedirect.com www.sciencedirect.com
    Nuclear mRNA metabolism drives selective basket assembly on a subset of nuclear pore complexes in budding yeast
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    Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites
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  115. Sep 2022
  116. www.sciencedirect.com www.sciencedirect.com
    ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains
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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling
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    SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA
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    The predatory soil bacterium Myxococcus xanthus combines a Tad- and an atypical type 3-like protein secretion system to kill bacterial cells
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    Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior
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  121. Aug 2022
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    Structural basis for activation of Arf1 at the Golgi complex
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    A VQ-motif-containing protein fine-tunes rice immunity and growth by a hierarchical regulatory mechanism
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  124. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Constitutive expression of JASMONATE RESISTANT 1 induces molecular changes that prime the plants to better withstand drought
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    Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation
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    Conversion of anterograde into retrograde trains is an intrinsic property of intraflagellar transport
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  127. Jul 2022
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    Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis
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    Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cells
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    Mitotic checkpoint gene expression is tuned by codon usage bias
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    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
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    Dynamin is primed at endocytic sites for ultrafast endocytosis
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    EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks
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  134. Jun 2022
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    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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    The type V myosin-containing complex HUM is a RAB11 effector powering movement of secretory vesicles
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  137. May 2022
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    Rho–Rho-Kinase Regulates Ras-ERK Signaling Through SynGAP1 for Dendritic Spine Morphology
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      DOI: 10.1007/s11064-022-03623-y

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  139. elifesciences.org elifesciences.org
    MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior
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  140. Apr 2022
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    Septin filament compaction into rings requires the anillin Mid2 and contractile ring constriction
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    Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition or apoptosis
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    CCT2 is an aggrephagy receptor for clearance of solid protein aggregates
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  144. Mar 2022
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    K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
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    Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
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    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
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    Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase
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    A trio of ubiquitin ligases sequentially drives ubiquitylation and autophagic degradation of dysfunctional yeast proteasomes
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    Semaphorin3A/PlexinA3 association with the Scribble scaffold for cGMP increase is required for apical dendrite development
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    Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass
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    Identification of 14-3-3 proteins, Polo kinase, and RNA-binding protein Pes4 as key regulators of meiotic commitment in budding yeast
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    Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis
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  155. Feb 2022
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    Sesquiterpene Lactones Potentiate Olaparib-Induced DNA Damage in p53 Wildtype Cancer Cells
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    Arabidopsis pavement cell shape formation involves spatially confined ROPGAP regulators
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  158. Jan 2022
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    Global RNA interactome of Salmonella discovers a 5′ UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity
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    HsfA7 coordinates the transition from mild to strong heat stress response by controlling the activity of the master regulator HsfA1a in tomato
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    Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells
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    Identification and functional characterization of transcriptional activators in human cells
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  163. Dec 2021
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    Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway
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    A novel CARM1-HuR axis involved in muscle differentiation and plasticity misregulated in spinal muscular atrophy
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    Microvilli-derived extracellular vesicles carry Hedgehog morphogenic signals for Drosophila wing imaginal disc development
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    TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules
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  168. Nov 2021
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    The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair
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    ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress
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    cAMP controls a trafficking mechanism that maintains the neuron specificity and subcellular placement of electrical synapses
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  172. Oct 2021
  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification and characterization of CYPs induced in the Drosophila antenna by exposure to a plant odorant
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      DOI: 10.1038/s41598-021-99910-9

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    Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
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    Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas
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    Protein Kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons
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    RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis
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  178. Sep 2021
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    Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity
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    Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins
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    Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress
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    Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1
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    Not4 and Not5 modulate translation elongation by Rps7A ubiquitination, Rli1 moonlighting, and condensates that exclude eIF5A
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  184. Aug 2021
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    Reprogrammed lipid metabolism protects inner nuclear membrane against unsaturated fat
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    Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells
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    Separase cleaves the kinetochore protein Meikin at the meiosis I/II transition
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    A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity
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    A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity
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    Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor
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    Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization
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