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Multimodal targeting of metastatic renal cell carcinoma via CD70-directed allogeneic CAR-NKT cells

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1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102321
  
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sciencedirect.com/science/article/pii/S2666379125003945
Aug 2025
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Lymphoma accelerates T cell and tissue aging

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sciencedirect.com/science/article/pii/S1535610825003290
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Core fucosylation of IL-2RB is required for natural killer cell homeostasis

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  DOI: 10.1016/j.celrep.2025.116101
  
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cell.com/cell-reports/abstract/S2211-1247(25)00872-1
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2025.08.04.668473v1.full-html.html

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  DOI: 10.1101/2025.08.04.668473
  
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52.53.155.43/6bd96d0cd9216f8b3d407ab5399483a7f0f015ff/2025.08.04.668473v1.full-html.html
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Overcoming ovarian cancer resistance and evasion to CAR-T cell therapy by harnessing allogeneic CAR-NKT cells

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  DOI: 10.1016/j.medj.2025.100804
  
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Interleukin-4 induces CD11c+ microglia leading to amelioration of neuropathic pain in mice

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  DOI: 10.7554/eLife.105087
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12316456/
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Selective Alanine Transporter Utilization is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer

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1. scibot 05 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-25-0654
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12314749/
Jul 2025
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Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

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1. scibot 23 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.018
  
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Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

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  DOI: 10.1016/j.cell.2025.06.018
  
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cell.com/cell/fulltext/S0092-8674(25)00684-1
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Activated T Cells Break Tumor Immunosuppression by Macrophage Reeducation

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  DOI: 10.1158/2159-8290.CD-24-0415
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12223510/
Jun 2025
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iPSC-derived trimodal T cells engineered with CAR, TCR, and hnCD16 modalities can overcome antigen escape in heterogeneous tumors

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1. scibot 21 Jun 2025
  
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Bivalent chromatin instructs lineage specification during hematopoiesis

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  DOI: 10.1016/j.cell.2025.05.011
  
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Enhancing anti-tumor immunity of natural killer cells through targeting IL-15R signaling

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  DOI: 10.1016/j.ccell.2025.05.011
  
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An mRNA vaccine encoding the SARS-CoV-2 Omicron XBB.1.5 receptor-binding domain protects mice from the JN.1 variant

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.ebiom.2025.105794
  
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sciencedirect.com/science/article/pii/S2352396425002385
May 2025
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PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115735
  
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Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.cell.2025.04.032
  
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sciencedirect.com/science/article/pii/S0092867425005021
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MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors

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1. scibot 19 May 2025
  
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  DOI: 10.1084/jem.20240959
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11572484/
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Protocol for assessing mobilization of peritoneal B cells to the pre-metastatic omentum in an orthotopic mouse model of ovarian cancer

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1. scibot 19 May 2025
  
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  DOI: 10.1016/j.xpro.2025.103806
  
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1-s2.0-S2589004225009071-main-html.html

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112646
  
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Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.immuni.2025.03.019
  
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Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

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  DOI: 10.1016/j.ebiom.2025.105734
  
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Apr 2025
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Reprogramming liver metastasis-associated macrophages toward an anti-tumoral phenotype through enforced miR-342 expression

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B cell stimulation changes the structure and higher-order organization of the inactive X chromosome

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pmc.ncbi.nlm.nih.gov/articles/PMC11998099/
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Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis

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BPS Publications

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  DOI: 10.1111/bph.70025
  
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Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity

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sciencedirect.com/science/article/pii/S1074761325001232
Mar 2025
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Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors

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The local microenvironment suppresses the synergy between irradiation and anti-PD1 therapy in breast-to-brain metastasis

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  DOI: 10.1016/j.celrep.2025.115427
  
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cell.com/cell-reports/abstract/S2211-1247(25)00198-6
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Targeting mTOR in myeloid cells prevents infection-associated inflammation

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  DOI: 10.1016/j.isci.2025.112163
  
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Optimization of IgG1 immune complexes to stimulate cytokine production in innate cells

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  DOI: 10.1016/j.jim.2025.113851
  
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sciencedirect.com/science/article/pii/S0022175925000511
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A heart-brain-spleen axis controls cardiac remodeling to hypertensive stress

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Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells

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  DOI: 10.1016/j.immuni.2025.02.012
  
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Collaboration between interleukin-7 and -15 enables adaptation of tissue-resident and circulating memory CD8+ T cells to cytokine deficiency

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  DOI: 10.1016/j.immuni.2025.02.009
  
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Feb 2025
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CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct transcriptomic signatures associated with lupus

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1. scibot 26 Feb 2025
  
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  DOI: 10.3389/fimmu.2025.1441981
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11847871/
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Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2

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  DOI: 10.1016/j.cell.2025.01.025
  
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SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer

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  DOI: 10.1158/0008-5472.CAN-24-2330
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617379/
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Divergent sex-specific pannexin-1 mechanisms in microglia and T cells underlie neuropathic pain

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Recirculating regulatory T cells mediate thymic regeneration through amphiregulin following damage

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Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10

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Mast cells proliferate in the peri-hippocampal space during early development and modulate local and peripheral immune cells

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Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia

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EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function

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A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses

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Ablation of PC1/3 in POMC-expressing Tissues but not in Immune Cells Induces Sepsis Hypersensitivity

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Macrophage-mediated myelin recycling fuels brain cancer malignancy

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Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium

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Untitled document

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Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate

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T-follicular regulatory cells expand to control germinal center plasma cell output but fail to curb autoreactivity

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SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation

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Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow

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Uncovering therapeutic targets for macrophage-mediated T cell suppression and PD-L1 therapy sensitization

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Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling

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Airway extracellular LTA4H concentrations are governed by release from liver hepatocytes and changes in lung vascular permeability

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Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay

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A postnatal peak in microglial development in the mouse hippocampus is correlated with heightened sensitivity to seizure triggers

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Mitochondrial perturbations in low-protein-diet-fed mice are associated with altered neutrophil development and effector functions

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Protocol to construct humanized mice with adult CD34+ hematopoietic stem and progenitor cells

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Spatiotemporal single-cell analysis decodes cellular dynamics underlying different responses to immunotherapy in colorectal cancer

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Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity

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The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies

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The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity

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Protocol for in vitro co-culture assay for rapid expansion of human T cell acute lymphoblastic leukemia

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Silencing CD28 attenuated chest blast exposure-induced traumatic brain injury through the PI3K/AKT/NF-κB signaling pathway in male mice

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An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination

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SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer

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cir-23-1078-html.html

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SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production

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Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity

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Ependymal cells undergo astrocyte-like reactivity in response to neuroinflammation

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BPS Publications

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Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses

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4R-cembranoid suppresses glial cells inflammatory phenotypes and prevents hippocampal neuronal loss in LPS-treated mice

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  DOI: 10.1002/jnr.25336
  
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Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis

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TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation

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Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis

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Early-wave macrophages control late hematopoiesis

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CLEC-1 Restrains Acute Inflammatory Response and Recruitment of Neutrophils following Tissue Injury

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IKK2 controls the inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model

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P-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy

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Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response

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Engraftment of adult hematopoietic stem and progenitor cells in a novel model of humanized mice

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Altered DNA methylation underlies monocyte dysregulation and immune exhaustion memory in sepsis

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Engagement of CD99 activates distinct programs in Ewing sarcoma and macrophages

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Alleviation of monocyte exhaustion by BCG derivative mycolic acid

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Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolution

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Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms

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Evaluation of murine renal phagocyte-fungal interactions using intravital confocal microscopy and flow cytometry

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The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent

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Receptor activity-modifying proteins of adrenomedullin (RAMP2/3): Roles in the pathogenesis of ARDS.

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An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2

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In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target

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Trem2 deficiency attenuates microglial phagocytosis and autophagic-lysosomal activation in white matter hypoperfusion

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Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design

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Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration

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ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control

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Transcriptomics and translatomics identify a robust inflammatory gene signature in brain endothelial cells after ischemic stroke

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Tumoral P2Y2 receptor modulates tumor growth and host anti-tumor immune responses in a syngeneic murine model of oral cancer

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PIIS2589004223016036-html.html

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Genetically modified IL2 bone-marrow-derived myeloid cells reprogram the glioma immunosuppressive tumor microenvironment

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Jul 2023
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Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis

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Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression

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Jun 2023
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DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs

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Evaluating the function of murine quiescent hematopoietic stem cells following non-homologous end joining-based genome editing

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  DOI: 10.1016/j.xpro.2023.102347
  
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Intravenous heterologous prime-boost vaccination activates innate and adaptive immunity to promote tumor regression

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C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection

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Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy

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VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection

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Assessing the impact of an antigen-specific antibody response on atherosclerosis development in mice

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Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis

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Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment

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LMAN1 is a receptor for house dust mite allergens

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B cell receptor signaling in germinal centers prolongs survival and primes B cells for selection

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Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma

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The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse

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Colchicine exerts anti-atherosclerotic and ‑plaque-stabilizing effects targeting foam cell formation

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Endothelial and Leptin Receptor+ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow

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High-efficiency pharmacogenetic ablation of oligodendrocyte progenitor cells in the adult mouse CNS

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KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer

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Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease

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Whole-mount immunofluorescence imaging and isolation of mesothelium-bound immune cell aggregates during mouse peritoneal inflammation

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Plasmodium infection disrupts the T follicular helper cell response to heterologous immunization

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Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2

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Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia

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Lymphatic vessels in bone support regeneration after injury

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BPS Publications

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In vitro clonal multilineage differentiation of distinct murine hematopoietic progenitor populations

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Specialized functions and sexual dimorphism explain the functional diversity of the myeloid populations during glioma progression

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Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer

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CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy

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Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis

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Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development

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A culture platform to study quiescent hematopoietic stem cells following genome editing

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Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

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Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry

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The quality of energy- and macronutrient-balanced diets regulates host susceptibility to influenza in mice

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Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity

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Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

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The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages

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Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens

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Systemic vaccination induces CD8+ T cells and remodels the tumor microenvironment

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T cell kinetics reveal expansion of distinct lung T cell subsets in acute versus in resolved influenza virus infection

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MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses

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Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice

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Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter

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Protocol to isolate and enrich mouse splenic naive CD4+ T cells for in vitro CD4+CD8αα+ cell induction

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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

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Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation

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DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential

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Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation

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Off-The-Shelf Third-Party HSC-Engineered iNKT Cells for Ameliorating GvHD While Preserving GvL Effect in the Treatment of Blood Cancers

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Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy

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Spinal Cord Injury Impairs Lung Immunity in Mice

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Jul 2022
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cir-22-0088-html.html

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Jun 2022
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cd-21-0680-html.html

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A diminished immune response underlies age-related SARS-CoV-2 pathologies

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Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation

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The SETDB1–TRIM28 complex suppresses antitumor immunity

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Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis

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Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells

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Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction

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PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents

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Characterization of adipose depot-specific stromal cell populations by single-cell mass cytometry

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Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses

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Macrophage network dynamics depend on haptokinesis for optimal local surveillance

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Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes

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The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

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A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts

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Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36

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Macrophages are metabolically heterogeneous within the tumor microenvironment

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The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition

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Epithelial colonization by gut dendritic cells promotes their functional diversification

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A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae

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Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability

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Nov 2021
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Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling

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Toward comprehensive imaging of oncolytic viroimmunotherapy

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Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy

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  DOI: 10.1016/j.xcrm.2021.100449
  
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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

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1. scibot 12 Nov 2021
  
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  DOI: 10.1016/j.immuni.2021.10.011
  
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Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection

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1. scibot 10 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.109961
  
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Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics

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1. scibot 09 Nov 2021
  
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  DOI: 10.1016/j.isci.2021.103339
  
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RSV infection-elicited high MMP-12–producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration

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1. scibot 28 Oct 2021
  
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  DOI: 10.1016/j.isci.2021.103201
  
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Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

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1. scibot 19 Oct 2021
  
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  DOI: 10.1016/j.ccell.2021.09.005
  
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The TLR4–TRIF–type 1 IFN–IFN-γ pathway is crucial for gastric MALT lymphoma formation after Helicobacter suis infection

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  DOI: 10.1016/j.isci.2021.103064
  
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PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis

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  DOI: 10.1016/j.molcel.2021.08.039
  
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Methods for Studying Mouse and Human Invariant Natural Killer T Cells

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1. scibot 21 Sep 2021
  
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  DOI: 10.1007/978-1-0716-1775-5_4
  
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CD38 Deficiency Ameliorates Chronic Graft-Versus-Host Disease Murine Lupus via a B-Cell-Dependent Mechanism

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  DOI: 10.3389/fimmu.2021.713697
  
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Aug 2021
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Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy

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1. scibot 25 Aug 2021
  
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  DOI: 10.1016/j.celrep.2021.109578
  
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Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation

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  DOI: 10.1016/j.isci.2021.102871
  
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ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

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1. scibot 15 Aug 2021
  
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  DOI: 10.1016/j.celrep.2021.109500
  
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Expansion of CD10neg neutrophils and CD14+HLA-DRneg/low monocytes driving proinflammatory responses in patients with acute myocardial infarction

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1. scibot 15 Aug 2021
  
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  DOI: 10.7554/eLife.66808
  
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Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-β-Smads signaling and myofibroblast differentiation

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1. scibot 14 Aug 2021
  
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  DOI: 10.1210/endocr/bqab090
  
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Untitled document

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  DOI: 10.1016/j.cell.2018.10.014
  
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High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice

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1. scibot 08 Aug 2021
  
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  DOI: 10.1016/j.immuni.2018.09.009
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6269138/

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