290 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Mast cells proliferate in the peri-hippocampal space during early development and modulate local and peripheral immune cells
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    1. scibot 12 Dec 2024
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    sciencedirect.com/science/article/pii/S153458072400697X
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    Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia
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    1. scibot 10 Dec 2024
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    sciencedirect.com/science/article/pii/S2211124724014074
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    EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function
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    1. scibot 06 Dec 2024
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    sciencedirect.com/science/article/pii/S1535610824004410
  5. Nov 2024
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
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    1. scibot 08 Nov 2024
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      DOI: 10.1038/s44318-024-00238-7

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    pmc.ncbi.nlm.nih.gov/articles/PMC11535224/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ablation of PC1/3 in POMC-expressing Tissues but not in Immune Cells Induces Sepsis Hypersensitivity
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    1. scibot 07 Nov 2024
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      DOI: 10.1210/jendso/bvae171

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    pmc.ncbi.nlm.nih.gov/articles/PMC11492489/
  8. Oct 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Macrophage-mediated myelin recycling fuels brain cancer malignancy
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    1. scibot 02 Oct 2024
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      DOI: 10.1016/j.cell.2024.07.030

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    ncbi.nlm.nih.gov/pmc/articles/PMC11429458/
  10. Sep 2024
  11. www.sciencedirect.com www.sciencedirect.com
    Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S1931312824003202
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 25 Sep 2024
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      DOI: 10.7554/eLife.41627

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    ncbi.nlm.nih.gov/pmc/articles/PMC6435319/
  13. www.sciencedirect.com www.sciencedirect.com
    Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.stem.2018.08.016

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    sciencedirect.com/science/article/pii/S1934590918304016
  14. www.sciencedirect.com www.sciencedirect.com
    T-follicular regulatory cells expand to control germinal center plasma cell output but fail to curb autoreactivity
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    1. scibot 17 Sep 2024
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    sciencedirect.com/science/article/pii/S2589004224021126
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    SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation
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    1. scibot 10 Sep 2024
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    sciencedirect.com/science/article/pii/S1550413124003322
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    Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow
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    1. scibot 10 Sep 2024
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    sciencedirect.com/science/article/pii/S1535610824003076
  17. Aug 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Uncovering therapeutic targets for macrophage-mediated T cell suppression and PD-L1 therapy sensitization
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    1. scibot 27 Aug 2024
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    sciencedirect.com/science/article/pii/S2666379124004191
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    Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling
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    1. scibot 23 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124724010155
  20. www.sciencedirect.com www.sciencedirect.com
    Airway extracellular LTA4H concentrations are governed by release from liver hepatocytes and changes in lung vascular permeability
    1
    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S221112472400980X
  21. www.cell.com www.cell.com
    Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay
    1
    1. scibot 18 Aug 2024
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    cell.com/cell/abstract/S0092-8674(24)00774-8
  22. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A postnatal peak in microglial development in the mouse hippocampus is correlated with heightened sensitivity to seizure triggers
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    1. scibot 02 Aug 2024
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      DOI: 10.1002/brb3.403

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  23. Jul 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial perturbations in low-protein-diet-fed mice are associated with altered neutrophil development and effector functions
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    1. scibot 26 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114493

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    sciencedirect.com/science/article/pii/S2211124724008222
  25. www.sciencedirect.com www.sciencedirect.com
    Protocol to construct humanized mice with adult CD34+ hematopoietic stem and progenitor cells
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    1. scibot 20 Jul 2024
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      DOI: 10.1016/j.xpro.2024.103155

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    sciencedirect.com/science/article/pii/S2666166724003204
  26. www.sciencedirect.com www.sciencedirect.com
    Spatiotemporal single-cell analysis decodes cellular dynamics underlying different responses to immunotherapy in colorectal cancer
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    1. scibot 17 Jul 2024
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      DOI: 10.1016/j.ccell.2024.06.009

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    sciencedirect.com/science/article/pii/S1535610824002344
  27. Jun 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.immuni.2024.05.021

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    sciencedirect.com/science/article/pii/S1074761324002759
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    The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies
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    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.immuni.2024.05.017

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    sciencedirect.com/science/article/pii/S1074761324002711
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity
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    1. scibot 08 Jun 2024
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      DOI: 10.1158/2326-6066.CIR-23-1078

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    ncbi.nlm.nih.gov/pmc/articles/PMC11148535/
  31. www.sciencedirect.com www.sciencedirect.com
    Protocol for in vitro co-culture assay for rapid expansion of human T cell acute lymphoblastic leukemia
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    1. scibot 07 Jun 2024
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      DOI: 10.1016/j.xpro.2024.103103

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    sciencedirect.com/science/article/pii/S2666166724002685
  32. www.sciencedirect.com www.sciencedirect.com
    Silencing CD28 attenuated chest blast exposure-induced traumatic brain injury through the PI3K/AKT/NF-κB signaling pathway in male mice
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      DOI: 10.1016/j.brainresbull.2024.110987

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    sciencedirect.com/science/article/pii/S0361923024001205
  33. May 2024
  34. www.sciencedirect.com www.sciencedirect.com
    An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination
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    1. scibot 31 May 2024
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    sciencedirect.com/science/article/pii/S1074761324002589
  35. www.biorxiv.org www.biorxiv.org
    SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer
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    1. scibot 23 May 2024
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      DOI: 10.1101/2024.04.28.591518

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    biorxiv.org/content/10.1101/2024.04.28.591518v1
  36. 52.53.155.43 52.53.155.43
    cir-23-1078-html.html
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    1. scibot 23 May 2024
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      DOI: 10.1158/2326-6066.cir-23-1078

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    52.53.155.43/ee0bd7762d373e957152429ed1d9032329c895e5/cir-23-1078-html.html
  37. www.sciencedirect.com www.sciencedirect.com
    SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production
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    sciencedirect.com/science/article/pii/S1934590924001760
  38. www.sciencedirect.com www.sciencedirect.com
    Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity
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    1. scibot 10 May 2024
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      DOI: 10.1016/j.xcrm.2024.101560

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    sciencedirect.com/science/article/pii/S2666379124002520
  39. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Ependymal cells undergo astrocyte-like reactivity in response to neuroinflammation
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      DOI: 10.1111/jnc.16120

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16120
  40. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.16356

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16356
  41. Apr 2024
  42. www.sciencedirect.com www.sciencedirect.com
    Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses
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    sciencedirect.com/science/article/pii/S1074761324001432
  43. onlinelibrary.wiley.com onlinelibrary.wiley.com
    4R-cembranoid suppresses glial cells inflammatory phenotypes and prevents hippocampal neuronal loss in LPS-treated mice
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      DOI: 10.1002/jnr.25336

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    onlinelibrary.wiley.com/doi/10.1002/jnr.25336
  44. aacrjournals.org aacrjournals.org
    Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis
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      DOI: 10.1158/0008-5472.CAN-23-1542

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    aacrjournals.org/cancerres/article/84/4/527/734130/Mesothelin-Secretion-by-Pancreatic-Cancer-Cells-Co
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation
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      DOI: 10.1084/jem.20231236

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    ncbi.nlm.nih.gov/pmc/articles/PMC11010340/
  46. elifesciences.org elifesciences.org
    Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis
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      DOI: 10.7554/eLife.87674

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    elifesciences.org/articles/87674
  47. www.sciencedirect.com www.sciencedirect.com
    Early-wave macrophages control late hematopoiesis
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      DOI: 10.1016/j.devcel.2024.03.013

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    sciencedirect.com/science/article/pii/S1534580724001825
  48. Mar 2024
  49. dx.doi.org dx.doi.org
    CLEC-1 Restrains Acute Inflammatory Response and Recruitment of Neutrophils following Tissue Injury
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      DOI: 10.4049/jimmunol.2300479

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    dx.doi.org/10.4049/jimmunol.2300479
  50. www.nature.com www.nature.com
    IKK2 controls the inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model
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      DOI: 10.1038/s41467-024-45870-3

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    nature.com/articles/s41467-024-45870-3
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    P-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy
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    Engraftment of adult hematopoietic stem and progenitor cells in a novel model of humanized mice
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    Altered DNA methylation underlies monocyte dysregulation and immune exhaustion memory in sepsis
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    Engagement of CD99 activates distinct programs in Ewing sarcoma and macrophages
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    Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms
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    Evaluation of murine renal phagocyte-fungal interactions using intravital confocal microscopy and flow cytometry
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    The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent
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    Receptor activity-modifying proteins of adrenomedullin (RAMP2/3): Roles in the pathogenesis of ARDS.
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    An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2
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    In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
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  68. Oct 2023
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    Trem2 deficiency attenuates microglial phagocytosis and autophagic-lysosomal activation in white matter hypoperfusion
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  71. Sep 2023
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    Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration
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    ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control
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    Transcriptomics and translatomics identify a robust inflammatory gene signature in brain endothelial cells after ischemic stroke
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    Genetically modified IL2 bone-marrow-derived myeloid cells reprogram the glioma immunosuppressive tumor microenvironment
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    Evaluating the function of murine quiescent hematopoietic stem cells following non-homologous end joining-based genome editing
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    Intravenous heterologous prime-boost vaccination activates innate and adaptive immunity to promote tumor regression
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    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
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    LMAN1 is a receptor for house dust mite allergens
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    B cell receptor signaling in germinal centers prolongs survival and primes B cells for selection
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    Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma
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    The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse
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    Colchicine exerts anti-atherosclerotic and ‑plaque-stabilizing effects targeting foam cell formation
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    Endothelial and Leptin Receptor+ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow
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    High-efficiency pharmacogenetic ablation of oligodendrocyte progenitor cells in the adult mouse CNS
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  102. Feb 2023
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer
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    Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease
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    Whole-mount immunofluorescence imaging and isolation of mesothelium-bound immune cell aggregates during mouse peritoneal inflammation
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    Plasmodium infection disrupts the T follicular helper cell response to heterologous immunization
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  107. Jan 2023
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    Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2
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    Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia
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    In vitro clonal multilineage differentiation of distinct murine hematopoietic progenitor populations
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    Specialized functions and sexual dimorphism explain the functional diversity of the myeloid populations during glioma progression
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    Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer
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    CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy
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  116. Dec 2022
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    Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis
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    Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development
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    A culture platform to study quiescent hematopoietic stem cells following genome editing
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  120. Nov 2022
  121. www.cell.com www.cell.com
    Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop
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    Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry
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    The quality of energy- and macronutrient-balanced diets regulates host susceptibility to influenza in mice
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    Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity
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    Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection
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    The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages
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  127. Oct 2022
  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Systemic vaccination induces CD8+ T cells and remodels the tumor microenvironment
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T cell kinetics reveal expansion of distinct lung T cell subsets in acute versus in resolved influenza virus infection
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    MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses
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  132. Sep 2022
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    Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice
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    Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter
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    Protocol to isolate and enrich mouse splenic naive CD4+ T cells for in vitro CD4+CD8αα+ cell induction
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    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
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    Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation
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  138. Aug 2022
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    DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential
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    Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation
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    Off-The-Shelf Third-Party HSC-Engineered iNKT Cells for Ameliorating GvHD While Preserving GvL Effect in the Treatment of Blood Cancers
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    Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy
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    Spinal Cord Injury Impairs Lung Immunity in Mice
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  144. Jul 2022
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  146. Jun 2022
  147. 52.53.155.43 52.53.155.43
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A diminished immune response underlies age-related SARS-CoV-2 pathologies
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    Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation
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    The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer
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    A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts
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    Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling
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    MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
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    The TLR4–TRIF–type 1 IFN–IFN-γ pathway is crucial for gastric MALT lymphoma formation after Helicobacter suis infection
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    AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy
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    An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
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    An intranasal vaccine durably protects against SARS-CoV-2 variants in mice
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    Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING
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    COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge
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    Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1
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    Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
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    Megakaryocyte production is sustained by direct differentiation from erythromyeloid progenitors in the yolk sac until midgestation
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    Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function
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    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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    Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development
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    Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue
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    Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
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    Modulation of neuropathology and cognitive deficits by lipopolysaccharide preconditioning in a mouse pilocarpine model of status epilepticus
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    A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization
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    High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity
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    Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche That Maintains and Replenishes Splenic Red Pulp Macrophages
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    Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis
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    m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development
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    Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population
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    Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy
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    Effects of Chlorpyrifos on Serine Hydrolase Activities, Lipid Mediators, and Immune Responses in Lungs of Neonatal and Adult Mice
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  227. Apr 2021
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    Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells
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    Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis
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    Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors
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    Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells
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    TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate
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    Emergence of a High-Plasticity Cell State during Lung Cancer Evolution
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    PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression
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    Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality
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    Ontogenic shifts in cellular fate are linked to proteotype changes in lineage-biased hematopoietic progenitor cells
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    Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen
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    Quick and easy purification of murine untouched naive B cells or germinal center B cells by MACS
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