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Dual roles of AXIN1 as a β-catenin p-S60-dependent cytokinesis machinery and an ESCRT component

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1. scibot 17 Oct 2026
  
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  DOI: 10.1016/j.isci.2026.117923
  
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sciencedirect.com/science/article/pii/S2589004226033067
Aug 2026
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MICAL2 as a key effector of β-catenin signaling driving melanoma progression and therapeutic resistance

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  DOI: 10.1038/s41418-026-01811-9
  
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  DOI: 10.1038/s41418-026-01811-9
  
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Jun 2026
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STRAP promotes hepatocellular carcinoma progression through activation of an STRAP/Wnt-β-catenin/STRAP positive feedback loop

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1. scibot 17 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.116377
  
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sciencedirect.com/science/article/pii/S2589004226017529
May 2026
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Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation

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  DOI: 10.1016/j.devcel.2026.04.012
  
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Apr 2026
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The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo

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1. scibot 25 Apr 2026
  
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  DOI: 10.7554/eLife.97717
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13095210/
Mar 2026
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MYCT1–IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion

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  DOI: 10.1084/jem.20251497
  
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Molecular insights into early malignant transition of hepatocellular carcinoma

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.ccell.2026.03.005
  
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sciencedirect.com/science/article/pii/S1535610826001571
Dec 2025
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The role of aging on endothelial cell–cell junctions and pulmonary microvascular permeability in male mice

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1. scibot 23 Dec 2025
  
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  DOI: 10.14814/phy2.70686
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12717451/
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Hepatic adaptation to chronic metabolic stress primes tumorigenesis

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.cell.2025.11.031
  
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Nov 2025
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Off-pore nucleoporin sPOM121 transcriptionally propels β-Catenin driven tumor progression and immune escape in prostate cancer

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1. scibot 24 Nov 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12580793/
Oct 2025
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STT3A is essential for Wnt signaling and represents a target for cancers driven by RNF43 deficiency

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1. scibot 23 Oct 2025
  
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  DOI: 10.1016/j.chembiol.2025.10.001
  
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Sep 2025
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The desmosome-intermediate filament system facilitates mechanotransduction at adherens junctions for epithelial homeostasis

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.cub.2024.07.074
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11387132/
Aug 2025
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Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin–Independent Targets by Proteomics

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1. scibot 29 Aug 2025
  
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  DOI: 10.1158/1541-7786.MCR-18-1154
  
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1-s2.0-S2589004225015962-main-html.html

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1. scibot 12 Aug 2025
  
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52.53.155.43/1929f01baa91ec4dd41d4abcfe59a4f9a16b0a93/1-s2.0-S2589004225015962-main-html.html
Jul 2025
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TNF-α induces VE-cadherin-dependent gap/JAIL cycling through an intermediate state essential for neutrophil transmigration

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1. scibot 30 Jul 2025
  
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  DOI: 10.1101/2025.07.20.665739
  
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52.53.155.43/438f2dbe5734822a66a808feb7b930f03eaf1a36/2025.07.20.665739v1.full-html.html
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Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis

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1. scibot 08 Jul 2025
  
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  DOI: 10.1038/s42003-025-08440-x
  
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nature.com/articles/s42003-025-08440-x
May 2025
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Harmonizing TUNEL with multiplexed iterative immunofluorescence enriches spatial contextualization of cell death

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.crmeth.2025.101047
  
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sciencedirect.com/science/article/pii/S2667237525000839
Apr 2025
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Downregulation of PD-L1 expression by Wnt pathway inhibition to enhance PD-1 blockade efficacy in hepatocellular carcinoma

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1. scibot 11 Apr 2025
  
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  DOI: 10.1186/s13062-025-00645-8
  
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link.springer.com/article/10.1186/s13062-025-00645-8
Feb 2025
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TGF-β signaling controls neural crest developmental plasticity via SMAD2/3

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  DOI: 10.1016/j.devcel.2025.01.018
  
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Lactate controls cancer stemness and plasticity through epigenetic regulation

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  DOI: 10.1016/j.cmet.2025.01.002
  
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cell.com/cell-metabolism/fulltext/S1550-4131(25)00002-6
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Novel Pannexin 1 isoform is increased in cancer

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  DOI: 10.1101/2024.09.09.612143
  
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52.53.155.43/248e2b0e257da849dadde63c071f77bcede2b26b/2024.09.09.612143v3.full-html.html
Nov 2024
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Arp2/3 complex activity enables nuclear YAP for naïve pluripotency of human embryonic stem cells

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1. scibot 07 Nov 2024
  
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  DOI: 10.7554/eLife.89725
  
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elifesciences.org/articles/89725
Sep 2024
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Cyclophilin D, regulator of the mitochondrial permeability transition, impacts bone development and fracture repair

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.bone.2024.117258
  
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Aug 2024
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Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition

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1. scibot 27 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114654
  
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sciencedirect.com/science/article/pii/S2211124724010052
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Ventricular-subventricular zone stem cell niche adaptations in a mouse model of post-infectious hydrocephalus

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1. scibot 22 Aug 2024
  
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  DOI: 10.3389/fnins.2024.1429829
  
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Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

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  DOI: 10.7554/eLife.17047
  
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Jul 2024
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Regulation of the DLC3 tumor suppressor by a novel phosphoswitch

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  DOI: 10.1016/j.isci.2024.110203
  
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cell.com/iscience/abstract/S2589-0042(24)01428-7
Jun 2024
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PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

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  DOI: 10.1016/j.cmet.2024.05.015
  
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Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation

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  DOI: 10.1016/j.isci.2024.110199
  
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May 2024
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Cell competition drives bronchiolization and pulmonary fibrosis

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  DOI: 10.21203/rs.3.rs-4177351/v1
  
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SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells

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1. scibot 04 May 2024
  
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  DOI: 10.1101/2024.01.21.576539
  
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52.53.155.43/696f49a3546de66e1af8cab87bfc89cda4bd0257/2024.01.21.576539v1.full-html.html
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Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling

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1. scibot 04 May 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-2268
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11063763/
Mar 2024
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RhoA downregulation in the murine intestinal epithelium results in chronic Wnt activation and increased tumorigenesis

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1. scibot 27 Mar 2024
  
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  DOI: 10.1016/j.isci.2024.109400
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10959657/
Jan 2024
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An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate

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1. scibot 18 Jan 2024
  
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  DOI: 10.1126/sciadv.adg4055
  
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science.org/doi/10.1126/sciadv.adg4055
Dec 2023
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Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth

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1. scibot 20 Dec 2023
  
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  DOI: 10.1016/j.chembiol.2023.11.006
  
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Targeted perturbation of signaling-driven condensates

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An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion

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An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate

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ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation

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A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma

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Efficient and scalable generation of primordial germ cells in 2D culture using basement membrane extract overlay

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Modeling human ectopic pregnancies with trophoblast and vascular organoids

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Multimodal characterization of murine gastruloid development

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Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development

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A micropattern-based assay to study contact inhibition of locomotion and entosis of adherent human and canine cells in vitro

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Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma

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Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma

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CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2

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Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver

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Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis

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Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin

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Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/β-Catenin Signaling

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Wnt antagonism without TGFβ induces rapid MSC chondrogenesis via increasing AJ interactions and restricting lineage commitment

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Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development

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mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity

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Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfments

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Wnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions

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Vitamin D receptor activation is a feasible therapeutic target to impair adrenocortical tumorigenesis

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SOX transcription factors direct TCF-independent WNT/β-catenin responsive transcription to govern cell fate in human pluripotent stem cells

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Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth

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An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling

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5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis

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A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair

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Mechanical feedback defines organizing centers to drive digit emergence

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Hotspot ESR1 mutations are multimodal and contextual modulators of breast cancer metastasis

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In vivo imaging of mammary epithelial cell dynamics in response to lineage-biased Wnt/β-catenin activation

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Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop

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Jan 2022
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Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development

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Adaptive differentiation promotes intestinal villus recovery

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Pharmacological targeting of Sam68 functions in colorectal cancer stem cells

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Enteric glial cell heterogeneity regulates intestinal stem cell niches

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A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

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Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis

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Diurnal regulation of oxidative phosphorylation restricts hepatocyte proliferation and inflammation

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Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

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RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia

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Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function

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TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer

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Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

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Untitled document

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A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex

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KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis

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Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

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High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

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The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos

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Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells

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High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

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Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

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Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

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Cell Lineage Tracing Identifies Hormone-Regulated and Wnt-Responsive Vaginal Epithelial Stem Cells

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Social Isolation in Male Rats During Adolescence Inhibits the Wnt/β-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood

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Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites

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Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

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Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells

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The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

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Mechanical Ring Interfaces between Adherens Junction and Contractile Actomyosin to Coordinate Entotic Cell-in-Cell Formation

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Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

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Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self‐renewal of colonic stem and progenitor cells

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E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration

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Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

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Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1

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Maintenance of Primary Hepatocyte Functions In Vitro by Inhibiting Mechanical Tension-Induced YAP Activation

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Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma

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Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin–Independent Targets by Proteomics

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PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice

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Endometrial Axin2+ Cells Drive Epithelial Homeostasis, Regeneration, and Cancer following Oncogenic Transformation

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The Making of a Flight Feather: Bio-architectural Principles and Adaptation

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Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells

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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

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Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

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TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer

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GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis

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WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis

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Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells

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Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

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Growth hormone‐releasing hormone receptor antagonists modify molecular machinery in the progression of prostate cancer

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The Polyploid State Plays a Tumor-Suppressive Role in the Liver

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Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover

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Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles

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Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors

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Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells

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Sam68 Allows Selective Targeting of Human Cancer Stem Cells

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CaMKII Signaling Stimulates Mef2c Activity In Vitro but Only Minimally Affects Murine Long Bone Development in vivo

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Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

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Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

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