109 Matching Annotations
  1. Jun 2024
  2. www.sciencedirect.com www.sciencedirect.com
    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.cmet.2024.05.015

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    sciencedirect.com/science/article/pii/S1550413124001918
  3. www.sciencedirect.com www.sciencedirect.com
    Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation
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    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.isci.2024.110199

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    sciencedirect.com/science/article/pii/S258900422401424X
  4. May 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell competition drives bronchiolization and pulmonary fibrosis
    1
    1. scibot 23 May 2024
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      DOI: 10.21203/rs.3.rs-4177351/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11092845/
  6. 52.53.155.43 52.53.155.43
    SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells
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    1. scibot 04 May 2024
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      DOI: 10.1101/2024.01.21.576539

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    52.53.155.43/696f49a3546de66e1af8cab87bfc89cda4bd0257/2024.01.21.576539v1.full-html.html
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
    1
    1. scibot 04 May 2024
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      DOI: 10.1158/0008-5472.CAN-23-2268

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    ncbi.nlm.nih.gov/pmc/articles/PMC11063763/
  8. Mar 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RhoA downregulation in the murine intestinal epithelium results in chronic Wnt activation and increased tumorigenesis
    1
    1. scibot 27 Mar 2024
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      DOI: 10.1016/j.isci.2024.109400

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    ncbi.nlm.nih.gov/pmc/articles/PMC10959657/
  10. Jan 2024
  11. www.science.org www.science.org
    An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate
    1
    1. scibot 18 Jan 2024
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      DOI: 10.1126/sciadv.adg4055

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    science.org/doi/10.1126/sciadv.adg4055
  12. Dec 2023
  13. www.sciencedirect.com www.sciencedirect.com
    Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1016/j.chembiol.2023.11.006

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    sciencedirect.com/science/article/pii/S245194562300421X
  14. Nov 2023
  15. www.sciencedirect.com www.sciencedirect.com
    Targeted perturbation of signaling-driven condensates
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.molcel.2023.10.023

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    sciencedirect.com/science/article/pii/S1097276523008602
  16. Jul 2023
  17. www.sciencedirect.com www.sciencedirect.com
    An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion
    1
    1. scibot 22 Jul 2023
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      DOI: 10.1016/j.devcel.2023.06.011

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    sciencedirect.com/science/article/abs/pii/S153458072300326X
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate
    1
    1. scibot 14 Jul 2023
      RRID:AB_397555

      DOI: 10.1126/sciadv.adg4055

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    ncbi.nlm.nih.gov/pmc/articles/PMC10337909/
  19. Jun 2023
  20. www.sciencedirect.com www.sciencedirect.com
    ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation
    1
    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.chembiol.2023.05.010

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    sciencedirect.com/science/article/pii/S2451945623001538
  21. May 2023
  22. www.sciencedirect.com www.sciencedirect.com
    A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma
    1
    1. scibot 25 May 2023
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      DOI: 10.1016/j.celrep.2023.112542

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    sciencedirect.com/science/article/pii/S2211124723005533
  23. www.sciencedirect.com www.sciencedirect.com
    Efficient and scalable generation of primordial germ cells in 2D culture using basement membrane extract overlay
    1
    1. scibot 24 May 2023
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      DOI: 10.1016/j.crmeth.2023.100488

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    sciencedirect.com/science/article/pii/S266723752300111X
  24. www.sciencedirect.com www.sciencedirect.com
    Modeling human ectopic pregnancies with trophoblast and vascular organoids
    1
    1. scibot 24 May 2023
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      DOI: 10.1016/j.celrep.2023.112546

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    sciencedirect.com/science/article/pii/S2211124723005570
  25. www.sciencedirect.com www.sciencedirect.com
    Multimodal characterization of murine gastruloid development
    1
    1. scibot 20 May 2023
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      DOI: 10.1016/j.stem.2023.04.018

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    sciencedirect.com/science/article/pii/S1934590923001704
  26. Apr 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development
    1
    1. scibot 13 Apr 2023
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      DOI: 10.1016/j.devcel.2023.03.016

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    sciencedirect.com/science/article/pii/S1534580723001326
  28. Mar 2023
  29. www.sciencedirect.com www.sciencedirect.com
    A micropattern-based assay to study contact inhibition of locomotion and entosis of adherent human and canine cells in vitro
    1
    1. scibot 28 Mar 2023
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      DOI: 10.1016/j.xpro.2023.102186

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    sciencedirect.com/science/article/pii/S2666166723001442
  30. www.sciencedirect.com www.sciencedirect.com
    Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma
    1
    1. scibot 11 Mar 2023
      RRID:AB_397555

      DOI: 10.1016/j.celrep.2023.112212

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    sciencedirect.com/science/article/pii/S2211124723002231
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma
    1
    1. scibot 05 Mar 2023
      RRID:AB_397555

      DOI: 10.1158/1541-7786.MCR-22-0090

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    ncbi.nlm.nih.gov/pmc/articles/PMC9444924/
  32. Feb 2023
  33. www.mdpi.com www.mdpi.com
    CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2
    1
    1. scibot 15 Feb 2023
      RRID:AB_397555

      DOI: 10.3390/cells12040555

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    mdpi.com/2073-4409/12/4/555
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver
    1
    1. scibot 02 Feb 2023
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      DOI: 10.7554/eLife.82311

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    ncbi.nlm.nih.gov/pmc/articles/PMC9889086/
  35. Jan 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis
    1
    1. scibot 24 Jan 2023
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      DOI: 10.1016/j.devcel.2022.12.006

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    sciencedirect.com/science/article/pii/S1534580722008723
  37. www.sciencedirect.com www.sciencedirect.com
    Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin
    1
    1. scibot 11 Jan 2023
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      DOI: 10.1016/j.cell.2022.12.016

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    sciencedirect.com/science/article/pii/S009286742201529X
  38. Dec 2022
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/β-Catenin Signaling
    1
    1. scibot 31 Dec 2022
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      DOI: 10.3390/pharmaceutics14122774

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    ncbi.nlm.nih.gov/pmc/articles/PMC9781674/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Wnt antagonism without TGFβ induces rapid MSC chondrogenesis via increasing AJ interactions and restricting lineage commitment
    1
    1. scibot 30 Dec 2022
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      DOI: 10.1016/j.isci.2022.105713

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    ncbi.nlm.nih.gov/pmc/articles/PMC9792887/
  41. www.sciencedirect.com www.sciencedirect.com
    Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development
    1
    1. scibot 06 Dec 2022
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      DOI: 10.1016/j.immuni.2022.11.003

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    sciencedirect.com/science/article/pii/S1074761322005933
  42. Nov 2022
  43. www.nature.com www.nature.com
    mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity
    1
    1. scibot 29 Nov 2022
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      DOI: 10.1038/s41467-022-34763-y

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    nature.com/articles/s41467-022-34763-y
  44. Oct 2022
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfments
    1
    1. scibot 01 Oct 2022
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      DOI: 10.1016/j.isci.2022.105144

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    ncbi.nlm.nih.gov/pmc/articles/PMC9519618/
  46. Aug 2022
  47. journals.plos.org journals.plos.org
    Wnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions
    1
    1. scibot 31 Aug 2022
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      DOI: 10.1371/journal.pbio.3001759

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    journals.plos.org/plosbiology/article
  48. www.sciencedirect.com www.sciencedirect.com
    Vitamin D receptor activation is a feasible therapeutic target to impair adrenocortical tumorigenesis
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    1. scibot 30 Aug 2022
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      DOI: 10.1016/j.mce.2022.111757

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    sciencedirect.com/science/article/pii/S0303720722002052
  49. www.sciencedirect.com www.sciencedirect.com
    SOX transcription factors direct TCF-independent WNT/β-catenin responsive transcription to govern cell fate in human pluripotent stem cells
    1
    1. scibot 26 Aug 2022
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      DOI: 10.1016/j.celrep.2022.111247

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    sciencedirect.com/science/article/pii/S2211124722010658
  50. Jul 2022
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth
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    1. scibot 06 Jul 2022
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      DOI: 10.1158/0008-5472.CAN-20-4218

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    ncbi.nlm.nih.gov/pmc/articles/PMC9056178/
  52. May 2022
  53. www.sciencedirect.com www.sciencedirect.com
    An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling
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    1. scibot 25 May 2022
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      DOI: 10.1016/j.stem.2022.04.016

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    sciencedirect.com/science/article/pii/S1934590922001692
  54. www.sciencedirect.com www.sciencedirect.com
    5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis
    1
    1. scibot 13 May 2022
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      DOI: 10.1016/j.neuron.2022.04.024

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    sciencedirect.com/science/article/pii/S0896627322003695
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair
    1
    1. scibot 05 May 2022
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      DOI: 10.1096/fj.202200154R

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    ncbi.nlm.nih.gov/pmc/articles/PMC9044500/
  56. Apr 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Mechanical feedback defines organizing centers to drive digit emergence
    1
    1. scibot 13 Apr 2022
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      DOI: 10.1016/j.devcel.2022.03.004

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    sciencedirect.com/science/article/pii/S1534580722001642
  58. aacrjournals.org aacrjournals.org
    Hotspot ESR1 mutations are multimodal and contextual modulators of breast cancer metastasis
    1
    1. scibot 05 Apr 2022
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      DOI: 10.1158/0008-5472.CAN-21-2576

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    aacrjournals.org/cancerres/article/82/7/1321/694048/Hotspot-ESR1-Mutations-Are-Multimodal-and
  59. Mar 2022
  60. www.sciencedirect.com www.sciencedirect.com
    In vivo imaging of mammary epithelial cell dynamics in response to lineage-biased Wnt/β-catenin activation
    1
    1. scibot 09 Mar 2022
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      DOI: 10.1016/j.celrep.2022.110461

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    sciencedirect.com/science/article/pii/S2211124722001887
  61. www.nature.com www.nature.com
    Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop
    1
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  62. Jan 2022
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    Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development
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    Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
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    A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex
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    High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
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  89. May 2021
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    The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos
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    Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia
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    Cell Lineage Tracing Identifies Hormone-Regulated and Wnt-Responsive Vaginal Epithelial Stem Cells
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    Social Isolation in Male Rats During Adolescence Inhibits the Wnt/β-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood
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    Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites
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    Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin
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    Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells
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    The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer
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    Mechanical Ring Interfaces between Adherens Junction and Contractile Actomyosin to Coordinate Entotic Cell-in-Cell Formation
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    E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration
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    Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells
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    Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1
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    Maintenance of Primary Hepatocyte Functions In Vitro by Inhibiting Mechanical Tension-Induced YAP Activation
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    Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma
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    Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin–Independent Targets by Proteomics
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  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice
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    Endometrial Axin2+ Cells Drive Epithelial Homeostasis, Regeneration, and Cancer following Oncogenic Transformation
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    The Making of a Flight Feather: Bio-architectural Principles and Adaptation
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    Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells
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    Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
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    Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human
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    TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer
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    GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis
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    WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis
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    Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells
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    Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling
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    Growth hormone‐releasing hormone receptor antagonists modify molecular machinery in the progression of prostate cancer
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    The Polyploid State Plays a Tumor-Suppressive Role in the Liver
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  132. Nov 2017
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    Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover
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    Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles
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    Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors
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    Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells
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    Sam68 Allows Selective Targeting of Human Cancer Stem Cells
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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CaMKII Signaling Stimulates Mef2c Activity In Vitro but Only Minimally Affects Murine Long Bone Development in vivo
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
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    Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation
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