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Aug 2025
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Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.stem.2025.07.014
  
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EGTA-induced disruption of adherens junctions in zebrafish embryonic epidermis

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  DOI: 10.1002/1873-3468.70142
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70142
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Protocol for vibratome sectioning, immunofluorescence, and S-phase labeling of inner ear organoids

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  DOI: 10.1016/j.xpro.2025.104032
  
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HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes

1
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cell.com/cell-metabolism/fulltext/S1550-4131(25)00334-1
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Desmosomal cadherin tension loss in pemphigus vulgaris mediated by the inhibition of active RhoA at cell-cell adhesions

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pmc.ncbi.nlm.nih.gov/articles/PMC12307676/
Jul 2025
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FGF-induced phospholipase Cγ signaling regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism

1
1. scibot 30 Jul 2025
  
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cell.com/cell-reports/abstract/S2211-1247(25)00817-4
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A spatiotemporal atlas of mouse gastrulation and early organogenesis to explore axial patterning and project in vitro models onto in vivo space

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Identification of a Specific Granular Marker of Zebrafish Eosinophils Enables Development of New Tools for Their Study

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academic.oup.com/jimmunol/article/213/12/1893/7960519
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Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection

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1. scibot 17 Jul 2025
  
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ars.els-cdn.com/content/image/1-s2.0-S1074761316303831-mmc1.pdf
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Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication

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1-s2.0-S2589004225013422-main-html.html

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Integrated protocol for single-cell RNA sequencing, organoid culture, and RNA-protein spatial analysis in gastroesophageal tissues

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1. scibot 08 Jul 2025
  
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  DOI: 10.1186/s44330-025-00035-6
  
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link.springer.com/article/10.1186/s44330-025-00035-6
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Generation of germinal-vesicle oocytes from mouse embryonic stem cells under an ovarian soma-free condition

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1. scibot 01 Jul 2025
  
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  DOI: 10.1016/j.devcel.2025.06.008
  
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Jun 2025
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MET pathway inhibition increases chemo-immunotherapy efficacy in small cell lung cancer

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  DOI: 10.1016/j.xcrm.2025.102194
  
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FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development

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  DOI: 10.1158/0008-5472.CAN-24-4576
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12169444/
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BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways

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  DOI: 10.1016/j.celrep.2025.115779
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00550-9
May 2025
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Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development

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1. scibot 21 May 2025
  
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  DOI: 10.7554/eLife.103615
  
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TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells

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1. scibot 20 May 2025
  
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1-s2.0-S2589004225009472-main-html.html

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Integrating collecting systems in human kidney organoids through fusion of distal nephron to ureteric bud

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ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion

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Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling

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Apr 2025
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A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection

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PDF-html.html

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52.53.155.43/d82b50f0340a265ea39586fdf6016ce1aa48cfa1/PDF-html.html
Feb 2025
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PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors

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  DOI: 10.1038/s41593-024-01865-3
  
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Thyroid Hormone Regulates Postnatal Development of the Rete Testis in Mice

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  DOI: 10.1210/endocr/bqae125
  
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The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells

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Novel Pannexin 1 isoform is increased in cancer

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A developmental atlas of mouse vestibular-like inner ear organoids

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Accelerated production of human epithelial organoids in a miniaturized spinning bioreactor

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  DOI: 10.1016/j.crmeth.2024.100903
  
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Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome

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  DOI: 10.1016/j.stem.2024.12.007
  
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Dec 2024
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Personalized Medicine in Acromegaly: The ACROFAST Study

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  DOI: 10.1210/clinem/dgae444
  
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ZEB2 drives intra-tumor heterogeneity and skin squamous cell carcinoma formation with distinct EMP transition states.

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  DOI: 10.1016/j.isci.2024.111169
  
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IFRD1 is required for maintenance of bladder epithelial homeostasis

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  DOI: 10.1016/j.isci.2024.111282
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11613175/
Sep 2024
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Metabolic Reprogramming Promotes Neural Crest Migration via Yap/Tead Signaling

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  DOI: 10.1016/j.devcel.2020.03.005
  
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Disruption of DNA methylation–mediated cranial neural crest proliferation and differentiation causes orofacial clefts in mice

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Microgravity Induces Transient EMT in Human Keratinocytes by Early Down-Regulation of E-Cadherin and Cell-Adhesion Remodeling

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Table 3 Antibodies/Staining substrates used in studies

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ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells

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MicroRNA-7 regulates endocrine progenitor delamination and endocrine cell mass in developing pancreatic islets

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Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions

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The evolutionarily ancient FOXA transcription factors shape the murine gut microbiome via control of epithelial glycosylation

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Patterning and folding of intestinal villi by active mesenchymal dewetting

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Estrogen promotes the progression of adenomyosis by inhibiting CITED2 through miR-145

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TATA-binding associated factors have distinct roles during early mammalian development

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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo

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Oct4 controls basement membrane development during human embryogenesis

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RhoA downregulation in the murine intestinal epithelium results in chronic Wnt activation and increased tumorigenesis

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An early cell shape transition drives evolutionary expansion of the human forebrain

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DDX3 regulates cancer immune surveillance via 3′ UTR-mediated cell-surface expression of PD-L1

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Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines

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PTBP3/IGF2BP3/HMGA1 axis promotes renal cancer growth and metastasis

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Identification of a core transcriptional program driving the human renal mesenchymal-to-epithelial transition

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Exercise enhances placental labyrinth trophoblast development by activation of PGC-1α and FNDC5/irisin

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Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk

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Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition

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D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder

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β-adrenergic receptor regulates embryonic epithelial extensibility through actomyosin inhibition

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Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas

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Endonucleosis mediates internalization of cytoplasm into the nucleus in senescent cells

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Syndecan-1 shedding destroys epithelial adherens junctions through STAT3 after renal ischemia/reperfusion injury

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Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids

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Highly-parallel production of designer organoids by mosaic patterning of progenitors

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The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery

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Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses

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Molecular Oncology - 2023 - Horie-html.html

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Chemoproteomic strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration

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Integrative analysis of single-cell RNA-seq and ATAC-seq reveals heterogeneity of induced pluripotent stem cell derived hepatic organoids

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British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html

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Length limitation of astral microtubules orients cell divisions in murine intestinal crypts

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Oncogenic K-Ras suppresses global miRNA function

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Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial organization

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Targeting 14-3-3ζ by a small-molecule compound AI-34 maintains epithelial barrier integrity and alleviates colitis in mice via stabilizing β-catenin

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The Loss of the E3 ubiquitin ligase TRIP12 inhibits Pancreatic Acinar Cell Plasticity and Tumor Cell Metastatic Capacity

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Multimodal characterization of murine gastruloid development

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Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cells

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Major depression-related factor NEGR1 controls salivary secretion in mouse submandibular glands

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Loss of fibroblast growth factor receptor 2 (FGFR2) leads to defective bladder urothelial regeneration after Cyclophosphamide injury

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Blastopore gating mechanism to regulate extracellular fluid excretion

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Whole-mount staining of mouse colorectal cancer organoids and fibroblast-organoid co-cultures

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CCR7 Mediates Cell Invasion and Migration in Extrahepatic Cholangiocarcinoma by Inducing Epithelial–Mesenchymal Transition

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Formation and function of the meningeal arachnoid barrier around the developing mouse brain

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CAMSAP2 localizes to the Golgi in islet β-cells and facilitates Golgi-ER trafficking

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Expanding the prostate cancer cell line repertoire with ACRJ-PC28, an AR-negative neuroendocrine cell line derived from an African-Caribbean patient

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Epidermal stratification requires retromer-mediated desmoglein-1 recycling

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TWIK-related acid-sensitive K+ channel 2 promotes renal fibrosis by inducing cell cycle arrest

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Physical confinement promotes mesenchymal trans-differentiation of invading transformed cells in vivo

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RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation

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Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity

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Tissue imaging reveals disruption of epithelial mitochondrial networks and loss of mitochondria-associated cytochrome-C in inflamed human and murine colon

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Protocol for the setup and use of a human choroid plexus endothelial-epithelial two-cell-type in vitro model

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Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation

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TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex

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CDON contributes to Hedgehog-dependent patterning and growth of the developing limb

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Opposing roles of ZEB1 in the cytoplasm and nucleus control cytoskeletal assembly and YAP1 activity

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Pressure and curvature control of the cell cycle in epithelia growing under spherical confinement

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Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis

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Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster

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Infecting kidney organoids with a cDNA reporter clone of SARS-CoV-2

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Role of ERK signaling in bladder urothelium in response to cyclophosphamide injury

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Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization

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Genomic erosion and horizontal gene transfer shape functional differences of the ExlA toxin in Pseudomonas spp.

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Ym1+ macrophages orchestrate fibrosis, lesion growth and progression during development of murine pancreatic cancer

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NR2F1 is a barrier to dissemination of early stage breast cancer cells.

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Protocol for the generation and expansion of human iPS cell-derived ureteric bud organoids

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Generation of functional chimeric kidney containing exogenous progenitor-derived stroma and nephron via a conditional empty niche

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R-SPONDIN2+ mesenchymal cells form the bud tip progenitor niche during human lung development

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Immortalized human choroid plexus endothelial cells enable an advanced endothelial-epithelial two-cell type in vitro model of the choroid plexus

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A mechanism for exocyst-mediated tethering via Arf6 and PIP5K1C-driven phosphoinositide conversion

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Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception

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Ym1+ macrophages orchestrate fibrosis, lesion growth and progression during development of murine pancreatic cancer

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A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

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A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair

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Table 2 Primary antibodies

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Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells

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Tumorigenic transformation of human prostatic epithelial cell line RWPE-1 by growth hormone-releasing hormone (GHRH)

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Nutritional control of thyroid morphogenesis through gastrointestinal hormones

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Human iPSC-derived renal organoids engineered to report oxidative stress can predict drug-induced toxicity

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Suspension culture promotes serosal mesothelial development in human intestinal organoids

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Attenuation of SARS-CoV-2 Infection by Losartan in Human Kidney Organoids

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ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12

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GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis

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β-catenin links cell seeding density to global gene expression during mouse embryonic stem cell differentiation

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Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

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The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment

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DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation

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WW, PH and C-Terminal Domains Cooperate to Direct the Subcellular Localizations of PLEKHA5, PLEKHA6 and PLEKHA7

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Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation

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Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease

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A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation

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Oestrogen signalling drives ciliogenesis in human endometrial organoids

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Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion

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Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States

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Urothelial organoids originating from Cd49f high mouse stem cells display Notch-dependent differentiation capacity

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KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis

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T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

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PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism

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SARNP, a participant in mRNA splicing and export, negatively regulates E‐cadherin expression via interaction with pinin

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Regulation of Glucose-Dependent Golgi-Derived Microtubules by cAMP/EPAC2 Promotes Secretory Vesicle Biogenesis in Pancreatic β Cells

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Heparan Sulfate Proteoglycan Sulfation Regulates Uterine Differentiation and Signaling During Embryo Implantation

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Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX‐2 involvement

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HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model

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Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

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The pattern of nodal morphogen signaling is shaped by co-receptor expression

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Neonatal susceptibility to meningitis results from the immaturity of epithelial barriers and gut microbiota

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Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy

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ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation

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Charting human development using a multi-endodermal organ atlas and organoid models

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Prostate-specific deletion of Cdh1 induces murine prostatic inflammation and bladder overactivity

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Mapping Development of the Human Intestinal Niche at Single-Cell Resolution

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Differentiation of Human Intestinal Organoids with Endogenous Vascular Endothelial Cells

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Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function

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The Mammalian Crumbs Complex Defines a Distinct Polarity Domain Apical of Epithelial Tight Junctions

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Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells

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A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization

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PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression

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Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

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Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target?

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A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature

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An early cell shape transition drives evolutionary expansion of the human forebrain

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TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells

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Buckling of an Epithelium Growing under Spherical Confinement

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In vivo regeneration of neo-nephrons in rodents by renal progenitor cell transplantation

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Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells

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Inhibition of breast cancer stem-like cells by a triterpenoid, ursolic acid, via activation of Wnt antagonist, sFRP4 and suppression of miRNA-499a-5p

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TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance

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In utero exposure to maternal diabetes impairs nephron progenitor differentiation

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Schistosoma mansoni Eggs Modulate the Timing of Granuloma Formation to Promote Transmission

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Integrin-Mediated Focal Anchorage Drives Epithelial Zippering during Mouse Neural Tube Closure

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BPS Publications

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Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors

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Generation of Human Renal Vesicles in Mouse Organ Niche Using Nephron Progenitor Cell Replacement System

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The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells

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In Vitro and In Vivo Development of the Human Airway at Single-Cell Resolution

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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

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A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells

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Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential

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Grading TESI: Crypt and villus formation in tissue-engineered small intestine alters with stem/progenitor cell source | American Journal of Physiology-Gastrointestinal and Liver Physiology

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Mechanical Ring Interfaces between Adherens Junction and Contractile Actomyosin to Coordinate Entotic Cell-in-Cell Formation

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PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism

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Generation of integration free human iPSC line SORMi002-A from neonatal foreskin fibroblasts

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Dkk1 Controls Cell-Cell Interaction through Regulation of Non-nuclear β-Catenin Pools

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Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis

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Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization

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AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration

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Leukocyte receptor tyrosine kinase interacts with secreted midkine to promote survival of migrating neural crest cells

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