27 Matching Annotations
  1. Oct 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of SMN Impairs Osteoblast–Osteoclast Coupling via IGF1–Akt–OPG Axis in Spinal Muscular Atrophy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12516799/
  3. Jul 2025
  4. www.science.org www.science.org
    M6A-dependent RNA condensation underlies FUS autoregulation and can be harnessed for ALS therapy development
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    science.org/doi/10.1126/sciadv.adx1357
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    M6A-dependent RNA condensation underlies FUS autoregulation and can be harnessed for ALS therapy development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12285722/
  6. Jan 2025
  7. www.sciencedirect.com www.sciencedirect.com
    Catecholaminergic dysfunction drives postural and locomotor deficits in a mouse model of spinal muscular atrophy
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    sciencedirect.com/science/article/pii/S2211124724014980
  8. Sep 2024
  9. www.sciencedirect.com www.sciencedirect.com
    C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology
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    sciencedirect.com/science/article/pii/S258900422402162X
  10. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Combined treatment with the histone deacetylase inhibitor LBH589 and a splice‐switch antisense oligonucleotide enhances SMN2 splicing and SMN expression in Spinal Muscular Atrophy cells
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14935
  11. Jul 2024
  12. www.cell.com www.cell.com
    Arginine methylation-enabled FUS phase separation with SMN contributes to neuronal granule formation
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    cell.com/cell-reports/abstract/S2211-1247(24)00866-0
  13. Mar 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Depletion of SMN protein in mesenchymal progenitors impairs the development of bone and neuromuscular junction in spinal muscular atrophy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10945524/
  15. Aug 2023
  16. www.science.org www.science.org
    Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
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    science.org/doi/10.1126/sciadv.adf6895
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10403219/
  18. Mar 2023
  19. www.sciencedirect.com www.sciencedirect.com
    A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses
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    sciencedirect.com/science/article/pii/S089662732300082X
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-Term SMN- and Ncald-ASO Combinatorial Therapy in SMA Mice and NCALD-ASO Treatment in hiPSC-Derived Motor Neurons Show Protective Effects
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    ncbi.nlm.nih.gov/pmc/articles/PMC9961752/
  21. Jan 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC9834662/
  23. Sep 2022
  24. www.sciencedirect.com www.sciencedirect.com
    SMN controls neuromuscular junction integrity through U7 snRNP
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    sciencedirect.com/science/article/pii/S221112472201230X
  25. Jun 2022
  26. www.sciencedirect.com www.sciencedirect.com
    Combinatorial ASO-mediated therapy with low dose SMN and the protective modifier Chp1 is not sufficient to ameliorate SMA pathology hallmarks
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    sciencedirect.com/science/article/pii/S0969996122001875
  27. www.sciencedirect.com www.sciencedirect.com
    Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy
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    sciencedirect.com/science/article/pii/S0092867422005293
  28. May 2022
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NOVA1 promotes SMN2 exon 7 splicing by binding the UCAC motif and increases SMN protein expression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9120702/
  30. Dec 2021
  31. academic.oup.com academic.oup.com
    A novel CARM1-HuR axis involved in muscle differentiation and plasticity misregulated in spinal muscular atrophy
    1
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    academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddab333/6428333
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models
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    ncbi.nlm.nih.gov/pmc/articles/PMC8605199/
  33. Nov 2021
  34. www.sciencedirect.com www.sciencedirect.com
    RNA promotes the formation of spatial compartments in the nucleus
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    sciencedirect.com/science/article/pii/S0092867421012307
  35. May 2021
  36. www.sciencedirect.com www.sciencedirect.com
    A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron protein
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    sciencedirect.com/science/article/pii/S2211124721004642
  37. Sep 2020
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases
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    ncbi.nlm.nih.gov/pmc/articles/PMC7181958/
  39. Jan 2020
  40. link.springer.com link.springer.com
    Motor Neurons Pathology After Chronic Exposure to MPTP in Mice
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    link.springer.com/article/10.1007/s12640-019-00121-y
  41. www.sciencedirect.com www.sciencedirect.com
    Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy
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    sciencedirect.com/science/article/pii/S2211124719315499
  42. www.sciencedirect.com www.sciencedirect.com
    The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA
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    sciencedirect.com/science/article/pii/S2211124719314846
  43. Nov 2017
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Perturbed MicroRNA Expression Pattern Characterizes Embryonic Neural Stem Cells Derived from a Severe Mouse Model of Spinal Muscular Atrophy (SMA)
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    ncbi.nlm.nih.gov/pmc/articles/PMC4581247/