69 Matching Annotations
  1. Dec 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidase
    1
    1. scibot 14 Dec 2024
      RRID:AB_398108

      DOI: 10.1038/s41531-024-00842-8

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    pmc.ncbi.nlm.nih.gov/articles/PMC11634889/
  3. Nov 2024
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual inhibition of aminoacyl-tRNA synthetase interacting multifunctional protein-2 and α-synuclein by steroid derivative is neuroprotective in Parkinson’s model
    1
    1. scibot 26 Nov 2024
      RRID:AB_398108

      DOI: 10.1016/j.isci.2024.111165

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    pmc.ncbi.nlm.nih.gov/articles/PMC11576395/
  5. Sep 2024
  6. www.biorxiv.org www.biorxiv.org
    Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson’s disease reveals unique and shared pathological features
    1
    1. scibot 28 Sep 2024
      RRID:AB_398108

      DOI: 10.1101/2024.09.20.613717

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    biorxiv.org/content/10.1101/2024.09.20.613717v1
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism
    1
    1. scibot 26 Sep 2024
      AB_398108

      DOI: 10.1101/2024.08.30.610586

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    ncbi.nlm.nih.gov/pmc/articles/PMC11384018/
  8. Jul 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions
    1
    1. scibot 30 Jul 2024
      AB_398108

      DOI: 10.1016/j.neuron.2024.06.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC11377155/
  10. Jun 2024
  11. www.sciencedirect.com www.sciencedirect.com
    Sex-specific biphasic alpha-synuclein response and alterations of interneurons in a COVID-19 hamster model
    1
    1. scibot 21 Jun 2024
      RRID:AB_398108

      DOI: 10.1016/j.ebiom.2024.105191

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    sciencedirect.com/science/article/pii/S2352396424002263
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    1. scibot 06 Jun 2024
      Figure S3Figure S3. List of the antibodies used in this study (related to Figures 1 to 9)A. Antibodies used for the detection of total aSyn.B. Antibodies used for the detection of α-syn phosphorylated at residue S129.C. Other antibodies used in the study.

      DOI: 10.1101/2022.03.30.486322

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  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha-synuclein aggregates are phosphatase resistant
    1
    1. scibot 04 Jun 2024
      RRID:AB_398108

      DOI: 10.1186/s40478-024-01785-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11141014/
  14. May 2024
  15. www.biorxiv.org www.biorxiv.org
    Sex-focused analyses of M83 A53T hemizygous mouse model with recombinant human alpha-synuclein preformed fibril injection identifies female resilience to disease progression: A combined magnetic resonance imaging and behavioural study
    1
    1. scibot 30 May 2024
      RRID:AB_398108

      DOI: 10.1101/2024.05.24.595642

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    biorxiv.org/content/10.1101/2024.05.24.595642v1
  16. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson’s disease in human dopaminergic neurons and a mouse model
    1
    1. scibot 16 May 2024
      RRID:AB_398108

      DOI: 10.1016/j.xcrm.2024.101570

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    sciencedirect.com/science/article/pii/S2666379124002623
  17. www.biorxiv.org www.biorxiv.org
    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
    1
    1. scibot 10 May 2024
      610787; BD Biosciences

      DOI: 10.1101/2024.01.25.577280

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    biorxiv.org/content/10.1101/2024.01.25.577280v1
  18. Apr 2024
  19. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis
    1
    1. scibot 25 Apr 2024
      RRID:AB_398108

      DOI: 10.1111/jnc.16114

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16114
  20. www.nature.com www.nature.com
    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
    1
    1. scibot 05 Apr 2024
      RRID:AB_398108

      DOI: 10.1038/s41419-024-06534-8

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    nature.com/articles/s41419-024-06534-8
  21. Dec 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
    1
    1. scibot 22 Dec 2023
      RRID:AB_398108

      DOI: 10.1016/j.neuron.2023.11.020

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    sciencedirect.com/science/article/pii/S0896627323008942
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
    1
    1. scibot 22 Dec 2023
      RRID:AB_398108

      DOI: 10.1038/s41467-023-44033-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10730909/
  24. Jul 2023
  25. 52.53.155.43 52.53.155.43
    NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62
    1
    1. scibot 19 Jul 2023
      RRID:AB_398108

      DOI: 10.1101/2023.06.05.543428

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    52.53.155.43/5185b06857919afc7fae38712332798a8a903a3a/2023.06.05.543428v1.full-html.html
  26. Jun 2023
  27. onlinelibrary.wiley.com onlinelibrary.wiley.com
    METTL14 is decreased and regulates m6A modification of α-synuclein in Parkinson's disease
    1
    1. scibot 15 Jun 2023
      RRID:AB_398108

      DOI: 10.1111/jnc.15882

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15882
  28. May 2023
  29. link.springer.com link.springer.com
    CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue
    1
    1. scibot 25 May 2023
      RRID:AB_398108

      DOI: 10.1186/s12915-023-01582-6

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    link.springer.com/article/10.1186/s12915-023-01582-6
  30. Oct 2022
  31. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous and a heterozygous SNCA gene knockout human-induced pluripotent stem cell line by CRISPR/Cas9 mediated allele-specific tuning of SNCA expression
    1
    1. scibot 22 Oct 2022
      RRID:AB_398108

      DOI: 10.1016/j.scr.2022.102952

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    sciencedirect.com/science/article/pii/S1873506122003014
  32. Sep 2022
  33. link.springer.com link.springer.com
    Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
    1
    1. scibot 20 Sep 2022
      RRID:AB_398108

      DOI: 10.1007/s00401-022-02491-8

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    link.springer.com/article/10.1007/s00401-022-02491-8
  34. Jul 2022
  35. elifesciences.org elifesciences.org
    Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala
    1
    1. scibot 27 Jul 2022
      RRID:AB_398108

      DOI: 10.7554/eLife.78055

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    elifesciences.org/articles/78055
  36. Jun 2022
  37. www.sciencedirect.com www.sciencedirect.com
    The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
    1
    1. scibot 10 Jun 2022
      RRID:AB_398108

      DOI: 10.1016/j.cell.2022.05.008

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    sciencedirect.com/science/article/pii/S009286742200592X
  38. May 2022
  39. link.springer.com link.springer.com
    Cocaine Modulates the Neuronal Endosomal System and Extracellular Vesicles in a Sex-Dependent Manner
    1
    1. scibot 03 May 2022
      RRID:AB_398108

      DOI: 10.1007/s11064-022-03612-1

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    link.springer.com/article/10.1007/s11064-022-03612-1
  40. Apr 2022
  41. www.sciencedirect.com www.sciencedirect.com
    Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
    1
    1. scibot 19 Apr 2022
      RRID:AB_398108

      DOI: 10.1016/j.celrep.2022.110675

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    sciencedirect.com/science/article/pii/S2211124722004272
  42. Mar 2022
  43. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Acute inflammation down-regulates alpha-synuclein expression in enteric neurons
    1
    1. scibot 31 Mar 2022
      RRID:AB_398108

      DOI: 10.1111/jnc.14656

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14656
  44. Oct 2021
  45. www.sciencedirect.com www.sciencedirect.com
    TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease
    1
    1. scibot 13 Oct 2021
      RRID:AB_398108

      DOI: 10.1016/j.neuron.2021.09.031

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    sciencedirect.com/science/article/pii/S0896627321007042
  46. Sep 2021
  47. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Overexpression of α-synuclein inhibits mitochondrial Ca2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction
    1
    1. scibot 14 Sep 2021
      RRID:AB_398108

      DOI: 10.1002/jnr.24952

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    onlinelibrary.wiley.com/doi/10.1002/jnr.24952
  48. Aug 2021
  49. www.nature.com www.nature.com
    Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation
    1
    1. scibot 21 Aug 2021
      RRID:AB_398108

      DOI: 10.1038/s41419-021-04046-3

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    nature.com/articles/s41419-021-04046-3
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity
    1
    1. scibot 17 Aug 2021
      RRID:AB_398108

      DOI: 10.1016/j.isci.2021.102878

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    ncbi.nlm.nih.gov/pmc/articles/PMC8350547/
  51. www.sciencedirect.com www.sciencedirect.com
    Methamphetamine persistently increases alpha-synuclein and suppresses gene promoter methylation within striatal neurons
    1
    1. scibot 14 Aug 2021
      AB_398108

      DOI: 10.1016/j.brainres.2019.05.035

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    sciencedirect.com/science/article/pii/S0006899319302902
  52. www.jneurosci.org www.jneurosci.org
    Untitled document
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    1. scibot 11 Aug 2021
      RRID:AB_398108

      DOI: 10.1523/JNEUROSCI.0930-14.2014

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    jneurosci.org/content/34/43/14304
  53. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    1. scibot 09 Aug 2021
      RRID:AB_398108

      DOI: 10.1016/j.celrep.2018.11.002

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    sciencedirect.com/science/article/pii/S2211124718317315
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology
    1
    1. scibot 08 Aug 2021
      AB_398108

      DOI: 10.1523/ENEURO.0004-17.2017

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    ncbi.nlm.nih.gov/pmc/articles/PMC5355896/
  55. Jul 2021
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets
    6
    1. scibot 30 Jul 2021
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      DOI: 10.1371/journal.pone.0132075

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    2. scibot 30 Jul 2021
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      DOI: 10.1371/journal.pone.0132075

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    3. scibot 30 Jul 2021
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      DOI: 10.1371/journal.pone.0132075

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    4. scibot 30 Jul 2021
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      DOI: 10.1371/journal.pone.0132075

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    5. scibot 30 Jul 2021
      AB_398108

      DOI: 10.1371/journal.pone.0132075

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    6. scibot 30 Jul 2021
      AB_398108

      DOI: 10.1371/journal.pone.0132075

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    ncbi.nlm.nih.gov/pmc/articles/PMC4489868/
  57. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Brain region‐dependent differential expression of alpha‐synuclein
    2
    1. scibot 30 Jul 2021
      AB_398108

      DOI: 10.1002/cne.23901

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    2. scibot 27 Jul 2021
      AB_398108

      DOI: 10.1002/cne.23901

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      RRIDCUR:Validated RRIDCUR:Duplicate RRID:AB_398108
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    onlinelibrary.wiley.com/doi/10.1002/cne.23901/full
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons
    1
    1. scibot 28 Jul 2021
      AB_398108

      DOI: 10.1523/ENEURO.0216-16.2017

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    ncbi.nlm.nih.gov/pmc/articles/PMC5409983/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology
    1
    1. scibot 27 Jul 2021
      AB_398108

      DOI: 10.1523/ENEURO.0004-17.2017

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    ncbi.nlm.nih.gov/pmc/articles/PMC5355896/
  60. link.springer.com link.springer.com
    Synuclein expression in the lizard Anolis carolinensis
    2
    1. scibot 27 Jul 2021
      610787

      DOI: 10.1007/s00359-016-1108-x

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      610787

      DOI: 10.1007/s00359-016-1108-x

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    link.springer.com/article/10.1007/s00359-016-1108-x
  61. May 2021
  62. www.sciencedirect.com www.sciencedirect.com
    α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology
    1
    1. scibot 12 May 2021
      RRID:AB_398108

      DOI: 10.1016/j.celrep.2021.109099

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    sciencedirect.com/science/article/pii/S2211124721004332
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ architecture of neuronal α-Synuclein inclusions
    1
    1. scibot 05 May 2021
      RRID:AB_398108

      DOI: 10.1038/s41467-021-22108-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC8046968/
  64. Apr 2021
  65. www.sciencedirect.com www.sciencedirect.com
    Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome
    1
    1. scibot 23 Apr 2021
      RRID:AB_398108

      DOI: 10.1016/j.cell.2021.03.048

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    sciencedirect.com/science/article/pii/S0092867421003792
  66. Mar 2021
  67. www.sciencedirect.com www.sciencedirect.com
    The AD tau core spontaneously self-assembles and recruits full-length tau to filaments
    1
    1. scibot 17 Mar 2021
      RRID:AB_398108

      DOI: 10.1016/j.celrep.2021.108843

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    sciencedirect.com/science/article/pii/S2211124721001571
  68. Feb 2021
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    α-synuclein strains that cause distinct pathologies differentially inhibit proteasome
    1
    1. scibot 26 Feb 2021
      RRID:AB_398108

      DOI: 10.7554/eLife.56825

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    ncbi.nlm.nih.gov/pmc/articles/PMC7406352/
  70. Oct 2020
  71. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a‐synuclein in mouse brain
    1
    1. scibot 22 Oct 2020
      RRID:AB_398108

      DOI: 10.1111/jnc.15199

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15199
  72. Sep 2020
  73. www.jbc.org www.jbc.org
    The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of alpha-synuclein
    1
    1. scibot 26 Sep 2020
      AB_398108

      DOI: 10.1074/jbc.RA120.013337

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    jbc.org/content/295/23/8005/T1.expansion.html
  74. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Changes in the cellular fatty acid profile drive the proteasomal degradation of α‐synuclein and enhance neuronal survival
    1
    1. scibot 23 Sep 2020
      RRID:AB_398108

      DOI: 10.1096/fj.202001344R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001344R
  75. www.sciencedirect.com www.sciencedirect.com
    Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity
    1
    1. scibot 16 Sep 2020
      RRID:AB_398108

      DOI: 10.1016/j.chembiol.2020.03.010

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    sciencedirect.com/science/article/pii/S2451945620301070
  76. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein
    1
    1. scibot 09 Sep 2020
      RRID:AB_398108

      DOI: 10.1186/s13024-020-00380-w

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    pubmed.ncbi.nlm.nih.gov/32900375/
  77. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
    1
    1. scibot 07 Sep 2020
      RRID:AB_398108

      DOI: 10.1523/JNEUROSCI.1076-19.2019

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    jneurosci.org/content/40/2/459
  78. Jan 2020
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkinson’s disease recovery by GM1 oligosaccharide treatment in the B4galnt1+/− mouse model
    1
    1. scibot 13 Jan 2020
      RRID:AB_398108

      DOI: 10.1038/s41598-019-55885-2

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      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC6920361/
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease
    1
    1. scibot 13 Jan 2020
      RRID:AB_398108

      DOI: 10.1016/j.neuron.2019.05.035

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    ncbi.nlm.nih.gov/pmc/articles/PMC6706297/
  81. link.springer.com link.springer.com
    Motor Neurons Pathology After Chronic Exposure to MPTP in Mice
    1
    1. scibot 13 Jan 2020
      AB_398108

      DOI: 10.1007/s12640-019-00121-y

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      RRID:AB_398108 RRIDCUR:Validated
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    link.springer.com/article/10.1007/s12640-019-00121-y
  82. www.sciencedirect.com www.sciencedirect.com
    Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies
    1
    1. scibot 13 Jan 2020
      RRID:AB_398108

      DOI: 10.1016/j.celrep.2019.06.009

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    sciencedirect.com/science/article/pii/S2211124719307673
  83. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Untitled document
    1
    1. scibot 13 Jan 2020
      RRID:AB_398108

      DOI: 10.1111/jnc.14312

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14312
  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Untitled document
    1
    1. scibot 12 Jan 2020
      RRID:AB_398108

      DOI: 10.1111/jnc.14656

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14656
  85. Nov 2017
  86. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity
    1
    1. scibot 08 Nov 2017
      mouse anti-aSyn (#610787, BD Biosciences

      Curator: @bandrow

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      RRID:AB_398108 RRIDCUR:Missing
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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-016-0403-7
  87. www.sciencedirect.com www.sciencedirect.com
    Proteasome Activation by Small Molecules
    1
    1. scibot 08 Nov 2017
      AB_398108

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S2451945617301526
  88. www.sciencedirect.com www.sciencedirect.com
    Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
    1
    1. scibot 08 Nov 2017
      AB_398108

      Curator: @chewbeccax

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      (BD Biosciences Cat# 610787, RRID:AB_398108)

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      RRID:AB_398108 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0092867416315902
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets
    2
    1. scibot 08 Nov 2017
      AB_398108

      Curator: @jcabotaj

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      (BD Biosciences Cat# 610787, RRID:AB_398108)

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      RRID:AB_398108
    2. scibot 08 Nov 2017
      AB_398108

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      (BD Biosciences Cat# 610787, RRID:AB_398108)

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    ncbi.nlm.nih.gov/pmc/articles/PMC4489868/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of Mitochondrial Fission Depletes Axonal Mitochondria in Midbrain Dopamine Neurons
    1
    1. scibot 08 Nov 2017
      AB_398108

      Curator: @gabimpine

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      (BD Biosciences Cat# 610787, RRID:AB_398108)

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    ncbi.nlm.nih.gov/pmc/articles/PMC4205554/
  91. www.jneurosci.org www.jneurosci.org
    Exogenous α-Synuclein Decreases Raft Partitioning of Cav2.2 Channels Inducing Dopamine Release
    1
    1. scibot 08 Nov 2017
      AB_398108

      Curator: @jcabotaj

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      (BD Biosciences Cat# 610787, RRID:AB_398108)

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      RRID:AB_398108 RRIDCUR:Validated
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    jneurosci.org/content/34/32/10603.long