94 Matching Annotations
  1. Jun 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effects
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    pmc.ncbi.nlm.nih.gov/articles/PMC13238597/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13196427/
  4. May 2026
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systemic delivery of anti-sense oligonucleotide targeting α-synuclein for treatment in a mouse model of multiple system atrophy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13168115/
  6. Apr 2026
  7. www.sciencedirect.com www.sciencedirect.com
    Peptide-Mediated Delivery of α-Synuclein Targeting ASO: Pharmacokinetics, Safety, and CNS Efficacy in a Synucleinopathy Model
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    sciencedirect.com/science/article/pii/S0090955626000735
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13057073/
  9. Jan 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetic evidence for a functional association between Parkinson’s disease proteins leucine-rich repeat kinase 2 and α-synuclein during axonal transport
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12833220/
  11. www.nature.com www.nature.com
    Calcium overload induced mitochondrial and lysosomal dysfunction is regulated by Tousled-like kinase in a-synucleinopathy
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    nature.com/articles/s41419-025-08213-8
  12. Nov 2025
  13. link.springer.com link.springer.com
    Attenuating α-synuclein pathology in mice with in situ engineered astrocytes
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    link.springer.com/article/10.1186/s40035-025-00518-0
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12617525/
  15. www.science.org www.science.org
    CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
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    science.org/doi/10.1126/sciadv.adu0726
  16. Sep 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Low-density lipoprotein receptor–related protein 1 mediates α-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12407564/
  18. Jul 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12305205/
  20. www.eneuro.org www.eneuro.org
    SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures
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    eneuro.org/content/8/4/ENEURO.0166-21.2021
  21. May 2025
  22. www.sciencedirect.com www.sciencedirect.com
    Intravenous SARS-CoV-2 Spike protein induces neuroinflammation and alpha-synuclein accumulation in brain regions relevant to Parkinson’s disease
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    sciencedirect.com/science/article/pii/S0889159125001977
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chronic Vanadium Exposure Promotes Aggregation of Alpha‐Synuclein, Tau and Amyloid Beta in Mouse Brain
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12082766/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046008/
  25. link.springer.com link.springer.com
    Microglia-driven inflammation induces progressive tauopathies and synucleinopathies
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    link.springer.com/article/10.1038/s12276-025-01450-z
  26. Apr 2025
  27. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/d714363667c36879138a1281f0e5ba96fe4c1e37/PDF-html.html
  28. Mar 2025
  29. link.springer.com link.springer.com
    Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson’s disease
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    link.springer.com/article/10.1186/s40478-025-01958-5
  30. www.sciencedirect.com www.sciencedirect.com
    Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease
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    sciencedirect.com/science/article/pii/S2666379125000722
  31. Feb 2025
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils
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    pmc.ncbi.nlm.nih.gov/articles/PMC11846974/
  33. 52.53.155.43 52.53.155.43
    Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation
    1
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    52.53.155.43/01dd9728947fbe4affbd9309aaacf50825c24057/2024.10.14.618089.full-html.html
  34. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225001956-main-html.html
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  35. Jan 2025
  36. www.sciencedirect.com www.sciencedirect.com
    14–3-3θ phosphorylation exacerbates alpha-synuclein aggregation and toxicity
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    sciencedirect.com/science/article/pii/S0969996125000178
  37. www.sciencedirect.com www.sciencedirect.com
    G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis
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    sciencedirect.com/science/article/pii/S2211124724015298
  38. Dec 2024
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidase
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    pmc.ncbi.nlm.nih.gov/articles/PMC11634889/
  40. Nov 2024
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual inhibition of aminoacyl-tRNA synthetase interacting multifunctional protein-2 and α-synuclein by steroid derivative is neuroprotective in Parkinson’s model
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    pmc.ncbi.nlm.nih.gov/articles/PMC11576395/
  42. Sep 2024
  43. www.biorxiv.org www.biorxiv.org
    Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson’s disease reveals unique and shared pathological features
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    biorxiv.org/content/10.1101/2024.09.20.613717v1
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism
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    ncbi.nlm.nih.gov/pmc/articles/PMC11384018/
  45. Jul 2024
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions
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    ncbi.nlm.nih.gov/pmc/articles/PMC11377155/
  47. Jun 2024
  48. www.sciencedirect.com www.sciencedirect.com
    Sex-specific biphasic alpha-synuclein response and alterations of interneurons in a COVID-19 hamster model
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    sciencedirect.com/science/article/pii/S2352396424002263
  49. Local file Local file
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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha-synuclein aggregates are phosphatase resistant
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    ncbi.nlm.nih.gov/pmc/articles/PMC11141014/
  51. May 2024
  52. www.biorxiv.org www.biorxiv.org
    Sex-focused analyses of M83 A53T hemizygous mouse model with recombinant human alpha-synuclein preformed fibril injection identifies female resilience to disease progression: A combined magnetic resonance imaging and behavioural study
    1
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    biorxiv.org/content/10.1101/2024.05.24.595642v1
  53. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson’s disease in human dopaminergic neurons and a mouse model
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    sciencedirect.com/science/article/pii/S2666379124002623
  54. www.biorxiv.org www.biorxiv.org
    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
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    biorxiv.org/content/10.1101/2024.01.25.577280v1
  55. Apr 2024
  56. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16114
  57. www.nature.com www.nature.com
    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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    nature.com/articles/s41419-024-06534-8
  58. Dec 2023
  59. www.sciencedirect.com www.sciencedirect.com
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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    sciencedirect.com/science/article/pii/S0896627323008942
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10730909/
  61. Jul 2023
  62. 52.53.155.43 52.53.155.43
    NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62
    1
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    52.53.155.43/5185b06857919afc7fae38712332798a8a903a3a/2023.06.05.543428v1.full-html.html
  63. Jun 2023
  64. onlinelibrary.wiley.com onlinelibrary.wiley.com
    METTL14 is decreased and regulates m6A modification of α-synuclein in Parkinson's disease
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15882
  65. May 2023
  66. link.springer.com link.springer.com
    CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue
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    link.springer.com/article/10.1186/s12915-023-01582-6
  67. Oct 2022
  68. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous and a heterozygous SNCA gene knockout human-induced pluripotent stem cell line by CRISPR/Cas9 mediated allele-specific tuning of SNCA expression
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    sciencedirect.com/science/article/pii/S1873506122003014
  69. Sep 2022
  70. link.springer.com link.springer.com
    Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
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    link.springer.com/article/10.1007/s00401-022-02491-8
  71. Jul 2022
  72. elifesciences.org elifesciences.org
    Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala
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    elifesciences.org/articles/78055
  73. Jun 2022
  74. www.sciencedirect.com www.sciencedirect.com
    The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
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    sciencedirect.com/science/article/pii/S009286742200592X
  75. May 2022
  76. link.springer.com link.springer.com
    Cocaine Modulates the Neuronal Endosomal System and Extracellular Vesicles in a Sex-Dependent Manner
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    link.springer.com/article/10.1007/s11064-022-03612-1
  77. Apr 2022
  78. www.sciencedirect.com www.sciencedirect.com
    Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
    1
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    sciencedirect.com/science/article/pii/S2211124722004272
  79. Mar 2022
  80. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Acute inflammation down-regulates alpha-synuclein expression in enteric neurons
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14656
  81. Oct 2021
  82. www.sciencedirect.com www.sciencedirect.com
    TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease
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    sciencedirect.com/science/article/pii/S0896627321007042
  83. Sep 2021
  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Overexpression of α-synuclein inhibits mitochondrial Ca2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction
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    onlinelibrary.wiley.com/doi/10.1002/jnr.24952
  85. Aug 2021
  86. www.nature.com www.nature.com
    Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation
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    nature.com/articles/s41419-021-04046-3
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8350547/
  88. www.sciencedirect.com www.sciencedirect.com
    Methamphetamine persistently increases alpha-synuclein and suppresses gene promoter methylation within striatal neurons
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    sciencedirect.com/science/article/pii/S0006899319302902
  89. www.jneurosci.org www.jneurosci.org
    Untitled document
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    jneurosci.org/content/34/43/14304
  90. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S2211124718317315
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology
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    ncbi.nlm.nih.gov/pmc/articles/PMC5355896/
  92. Jul 2021
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets
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    ncbi.nlm.nih.gov/pmc/articles/PMC4489868/
  94. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Brain region‐dependent differential expression of alpha‐synuclein
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    onlinelibrary.wiley.com/doi/10.1002/cne.23901/full
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC5409983/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology
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    ncbi.nlm.nih.gov/pmc/articles/PMC5355896/
  97. link.springer.com link.springer.com
    Synuclein expression in the lizard Anolis carolinensis
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    link.springer.com/article/10.1007/s00359-016-1108-x
  98. May 2021
  99. www.sciencedirect.com www.sciencedirect.com
    α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology
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    sciencedirect.com/science/article/pii/S2211124721004332
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ architecture of neuronal α-Synuclein inclusions
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    ncbi.nlm.nih.gov/pmc/articles/PMC8046968/
  101. Apr 2021
  102. www.sciencedirect.com www.sciencedirect.com
    Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome
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    sciencedirect.com/science/article/pii/S0092867421003792
  103. Mar 2021
  104. www.sciencedirect.com www.sciencedirect.com
    The AD tau core spontaneously self-assembles and recruits full-length tau to filaments
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    sciencedirect.com/science/article/pii/S2211124721001571
  105. Feb 2021
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    α-synuclein strains that cause distinct pathologies differentially inhibit proteasome
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC7406352/
  107. Oct 2020
  108. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a‐synuclein in mouse brain
    1
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15199
  109. Sep 2020
  110. www.jbc.org www.jbc.org
    The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of alpha-synuclein
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    jbc.org/content/295/23/8005/T1.expansion.html
  111. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Changes in the cellular fatty acid profile drive the proteasomal degradation of α‐synuclein and enhance neuronal survival
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001344R
  112. www.sciencedirect.com www.sciencedirect.com
    Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity
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    sciencedirect.com/science/article/pii/S2451945620301070
  113. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein
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    pubmed.ncbi.nlm.nih.gov/32900375/
  114. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
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    jneurosci.org/content/40/2/459
  115. Jan 2020
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkinson’s disease recovery by GM1 oligosaccharide treatment in the B4galnt1+/− mouse model
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC6920361/
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC6706297/
  118. link.springer.com link.springer.com
    Motor Neurons Pathology After Chronic Exposure to MPTP in Mice
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    link.springer.com/article/10.1007/s12640-019-00121-y
  119. www.sciencedirect.com www.sciencedirect.com
    Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies
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    sciencedirect.com/science/article/pii/S2211124719307673
  120. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14312
  121. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14656
  122. Nov 2017
  123. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity
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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-016-0403-7
  124. www.sciencedirect.com www.sciencedirect.com
    Proteasome Activation by Small Molecules
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    sciencedirect.com/science/article/pii/S2451945617301526
  125. www.sciencedirect.com www.sciencedirect.com
    Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
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    sciencedirect.com/science/article/pii/S0092867416315902
  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets
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    ncbi.nlm.nih.gov/pmc/articles/PMC4489868/
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    Loss of Mitochondrial Fission Depletes Axonal Mitochondria in Midbrain Dopamine Neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC4205554/
  128. www.jneurosci.org www.jneurosci.org
    Exogenous α-Synuclein Decreases Raft Partitioning of Cav2.2 Channels Inducing Dopamine Release
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    jneurosci.org/content/34/32/10603.long