151 Matching Annotations
  1. Last 7 days
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    Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain
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    1. scibot 19 Jul 2024
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      DOI: 10.1016/j.cell.2024.05.058

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    sciencedirect.com/science/article/pii/S0092867424006391
  3. Jul 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors
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    1. scibot 11 Jul 2024
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      DOI: 10.1016/j.celrep.2019.10.029

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    ncbi.nlm.nih.gov/pmc/articles/PMC6871768/
  5. Jun 2024
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    SMAD4 promotes somatic-germline contact during murine oocyte growth
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    1. scibot 04 Jun 2024
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      DOI: 10.7554/eLife.91798

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    ncbi.nlm.nih.gov/pmc/articles/PMC11142639/
  7. Apr 2024
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    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101528

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    sciencedirect.com/science/article/pii/S2666379124001976
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    Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells
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    1. scibot 26 Apr 2024
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    sciencedirect.com/science/article/pii/S2666379124001952
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    S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis
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    1. scibot 12 Apr 2024
      Promega, Walldorf, Germany, #W4011

      DOI: 10.1016/j.biopha.2024.116575

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    sciencedirect.com/science/article/pii/S0753332224004591
  11. Mar 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Doxorubicin‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways
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    1. scibot 27 Mar 2024
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      DOI: 10.3892/mmr.2024.13198

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    ncbi.nlm.nih.gov/pmc/articles/PMC10958136/
  13. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Regional modulation of toll-like receptor signaling pathway genes in acute epididymitis in mice
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    1. scibot 26 Mar 2024
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      DOI: 10.1111/andr.13630

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    onlinelibrary.wiley.com/doi/10.1111/andr.13630
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Depletion of SMN protein in mesenchymal progenitors impairs the development of bone and neuromuscular junction in spinal muscular atrophy
    1
    1. scibot 23 Mar 2024
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      DOI: 10.7554/eLife.92731

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    ncbi.nlm.nih.gov/pmc/articles/PMC10945524/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation
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    1. scibot 22 Mar 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10951985/
  16. 52.53.155.43 52.53.155.43
    TORC1 is an essential regulator of nutrient-controlled proliferation and differentiation in Leishmania
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    1. scibot 21 Mar 2024
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      DOI: 10.1038/s44319-024-00084-y

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      DOI: 10.1038/s44319-024-00084-y

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    3. scibot 16 Mar 2024
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      DOI: 10.1038/s44319-024-00084-y

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    52.53.155.43/7141871f0013a4bcb963eeace4dd2a37f4c5d4d5/myburgh-et-al-2024-torc1-is-an-essential-regulator-of-nutrient-controlled-proliferation-and-differentiation-in-html.html
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    PABPC1 mediates degradation of C9orf72-FTLD/ALS GGGGCC repeat RNA
    1
    1. scibot 08 Mar 2024
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    sciencedirect.com/science/article/pii/S2589004224005248
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    Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells
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    1. scibot 01 Mar 2024
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    sciencedirect.com/science/article/pii/S1535610824000485
  19. Feb 2024
  20. www.sciencedirect.com www.sciencedirect.com
    Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1
    1
    1. scibot 27 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113837

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    sciencedirect.com/science/article/pii/S2211124724001657
  21. Jan 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB
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    1. scibot 25 Jan 2024
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      DOI: 10.1016/j.cmet.2024.01.001

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    sciencedirect.com/science/article/pii/S1550413124000019
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    Recruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B
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    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.molcel.2023.12.011

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    sciencedirect.com/science/article/pii/S1097276523010304
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    Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology
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    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.isci.2023.108777

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    sciencedirect.com/science/article/pii/S2589004223028547
  25. Oct 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Transgenic mouse models support a protective role of type I IFN response in SARS-CoV-2 infection-related lung immunopathology and neuroinvasion
    1
    1. scibot 28 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113275

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    sciencedirect.com/science/article/pii/S2211124723012871
  27. Sep 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Identification of genes required for Plasmodium gametocyte-to-sporozoite development in the mosquito vector
    1
    1. scibot 16 Sep 2023
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      DOI: 10.1016/j.chom.2023.08.010

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    sciencedirect.com/science/article/pii/S1931312823003359
  29. Aug 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection
    1
    1. scibot 31 Aug 2023
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      DOI: 10.1016/j.isci.2023.107552

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    ncbi.nlm.nih.gov/pmc/articles/PMC10460994/
  31. www.biorxiv.org www.biorxiv.org
    Acylation of MLKL impacts its function in necroptosis
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    1. scibot 28 Aug 2023
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      DOI: 10.1101/2023.08.19.553906

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    biorxiv.org/content/10.1101/2023.08.19.553906v1
  32. Jul 2023
  33. 52.53.155.43 52.53.155.43
    Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial organization
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      DOI: 10.1242/jcs.260745

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    52.53.155.43/84cf2b7dc60eecb18bb52883e6904f2535d498be/jcs260745supp-html.html
  34. Jun 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts
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    1. scibot 29 Jun 2023
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      DOI: 10.1016/j.isci.2023.107113

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    sciencedirect.com/science/article/pii/S2589004223011902
  36. www.sciencedirect.com www.sciencedirect.com
    An EZH2-NF-κB Regulatory Axis Drives Expression of Pro-Oncogenic Gene Signatures in Triple Negative Breast Cancer
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    1. scibot 27 Jun 2023
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      DOI: 10.1016/j.isci.2023.107115

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    sciencedirect.com/science/article/pii/S2589004223011926
  37. www.embopress.org www.embopress.org
    PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
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    1. scibot 23 Jun 2023
      RRID:AB_430833

      DOI: 10.15252/embr.202256399

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    embopress.org/doi/full/10.15252/embr.202256399
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TL-532, a novel specific Toll-like receptor 3 agonist rationally designed for targeting cancers: discovery process and biological characterization
    1
    1. scibot 07 Jun 2023
      RRID:AB_430833

      DOI: 10.15698/mic2023.06.797

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    ncbi.nlm.nih.gov/pmc/articles/PMC10236204/
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    Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α
    1
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      DOI: 10.1016/j.molcel.2023.05.008

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    sciencedirect.com/science/article/pii/S1097276523003325
  40. May 2023
  41. www.sciencedirect.com www.sciencedirect.com
    FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation
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      DOI: 10.1016/j.celrep.2023.112530

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    sciencedirect.com/science/article/pii/S2211124723005417
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    16p11.2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice
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      DOI: 10.1016/j.celrep.2023.112485

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    sciencedirect.com/science/article/pii/S2211124723004965
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    HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
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      DOI: 10.1016/j.celrep.2023.112496

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    sciencedirect.com/science/article/pii/S2211124723005077
  44. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Group IVE cytosolic phospholipase A2 limits psoriatic inflammation by mobilizing the anti-inflammatory lipid N-acylethanolamine
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      DOI: 10.1096/fj.202101958R

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    faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202101958R
  45. Apr 2023
  46. academic.oup.com academic.oup.com
    Neuronal blockade of thyroid hormone signaling increases sensitivity to diet-induced obesity in adult male mice
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      RRID:AB_430833

      DOI: 10.1210/endocr/bqad034

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    academic.oup.com/endo/article/164/4/bqad034/7045509
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical Evidence of Progesterone as a New Pharmacological Strategy in Human Adrenocortical Carcinoma Cell Lines
    1
    1. scibot 14 Apr 2023
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      DOI: 10.3390/ijms24076829

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    ncbi.nlm.nih.gov/pmc/articles/PMC10095539/
  48. www.biorxiv.org www.biorxiv.org
    Optineurin provides a mitophagy contact site for TBK1 activation
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    1. scibot 12 Apr 2023
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      DOI: 10.1101/2023.02.24.529790

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    biorxiv.org/content/10.1101/2023.02.24.529790v1
  49. Mar 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer
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    1. scibot 16 Mar 2023
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      DOI: 10.1158/1078-0432.CCR-21-3603

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    ncbi.nlm.nih.gov/pmc/articles/PMC9481728/
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    Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
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    1. scibot 03 Mar 2023
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      DOI: 10.1016/j.ccell.2023.02.004

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    sciencedirect.com/science/article/pii/S1535610823000326
  52. Feb 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Increased alcohol dehydrogenase 1 activity promotes longevity
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      DOI: 10.1016/j.cub.2023.01.059

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    CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis
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    Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability
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    Preclinical evidence of progesterone as a new pharmacological strategy in human adrenocortical carcinoma cell lines
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    Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence
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    Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ
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    FBXL6 depletion restrains clear cell renal cell carcinoma progression
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    Protocol for the generation of HIV-1 genomic RNA with altered levels of N6-methyladenosine
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    Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism
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    Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis
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    The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin
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    Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements
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    Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy
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    A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity
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    IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis
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  112. Jul 2021
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    Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas
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    PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts
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    A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity
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    CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity
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  118. Jun 2021
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    Ultracentrifugal separation, characterization, and functional study of extracellular vesicles derived from serum-free cell culture
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    Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment
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  122. May 2021
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    Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model
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    The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism
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    Disease-causing mutated ATLASTIN 3 is excluded from distal axons and reduces axonal autophagy
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    The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis
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    Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells
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    The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development
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    Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis
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    NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate
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    Low expression of the PPARγ-regulated gene thioredoxin-interacting protein accompanies human melanoma progression and promotes experimental lung metastases
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    The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming
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    Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis
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    In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions
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  138. Mar 2021
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    Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling
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  140. Feb 2021
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    Tissue‐specific deletion of mouse basolateral uniporter LAT4 (Slc43a2) reveals its crucial role in small intestine and kidney amino acid transport
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    Amelioration of elastase‐induced lung emphysema and reversal of pulmonary hypertension by pharmacological iNOS inhibition in mice
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    Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase
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    The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells
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  146. Jan 2021
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  148. Dec 2020
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    Rare Variant Burden Analysis within Enhancers Identifies CAV1 as an ALS Risk Gene
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  150. Nov 2020
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    PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage
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  152. Sep 2020
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    Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing
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    Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway
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    A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging
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    Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling
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    Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription
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  159. journals.plos.org journals.plos.org
    Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins
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      DOI: 10.1371/journal.pone.0233863

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    A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells
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      DOI: 10.1016/j.stem.2020.04.017

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  161. www.sciencedirect.com www.sciencedirect.com
    Liquidity Is a Critical Determinant for Selective Autophagy of Protein Condensates
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      Anti-Rabbit IgG HRP Conjugate

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  162. Jan 2020
  163. www.sciencedirect.com www.sciencedirect.com
    The Translational Landscape of the Human Heart
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      DOI: 10.1016/j.cell.2019.05.010

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  164. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Prothymosin alpha and its mimetic hexapeptide improve delayed tPA‐induced brain damage following cerebral ischemia
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      DOI: 10.1111/jnc.14858

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  165. www.sciencedirect.com www.sciencedirect.com
    Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb
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      DOI: 10.1016/j.immuni.2019.10.001

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    Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons
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      DOI: 10.1016/j.celrep.2019.05.051

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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors
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      DOI: 10.1016/j.celrep.2019.10.029

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    YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
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      DOI: 10.1016/j.celrep.2019.03.021

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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay
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      DOI: 10.7554/eLife.44199

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    MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes
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      DOI: 10.1016/j.molcel.2019.09.011

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  171. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.celrep.2018.12.017

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      DOI: 10.1016/j.devcel.2019.03.017

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  173. Nov 2018
  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  175. f1000research.com f1000research.com
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  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function
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  178. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages
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    Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells
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    APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway
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    Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics
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    Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis
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    sciencedirect.com/science/article/pii/S2451945617303240
  185. Nov 2017
  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors
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  187. www.sciencedirect.com www.sciencedirect.com
    Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles
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  188. www.sciencedirect.com www.sciencedirect.com
    ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation
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      Curator: @Zeljana_Babic

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  189. elifesciences.org elifesciences.org
    The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs
    2
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Granulin Knock Out Zebrafish Lack Frontotemporal Lobar Degeneration and Neuronal Ceroid Lipofuscinosis Pathology
    1
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