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Aug 2025
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A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.08.001
  
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sciencedirect.com/science/article/pii/S1097276525006513
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Doxorubicin Induces a Senescent Phenotype in Murine and Human Astrocytes

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1. scibot 07 Aug 2025
  
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  DOI: 10.1111/jnc.70177
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12322803/
Jul 2025
www.biorxiv.org www.biorxiv.org

Mitotic slippage causes nuclear instability in polyploid cells

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1. scibot 25 Jul 2025
  
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  DOI: 10.1101/2025.07.21.665898
  
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biorxiv.org/content/10.1101/2025.07.21.665898v1
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Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3

1
1. scibot 02 Jul 2025
  
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  DOI: 10.1126/sciadv.adu8422
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12189954/
Jun 2025
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Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3

1
1. scibot 28 Jun 2025
  
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  DOI: 10.1126/sciadv.adu8422
  
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science.org/doi/10.1126/sciadv.adu8422
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Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

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1. scibot 24 Jun 2025
  
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  DOI: 10.1038/s41418-025-01532-5
  
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nature.com/articles/s41418-025-01532-5
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Senescence-resistant human mesenchymal progenitor cells counter aging in primates

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.05.021
  
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sciencedirect.com/science/article/pii/S0092867425005719
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Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS

1
1. scibot 03 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.05.008
  
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sciencedirect.com/science/article/pii/S0092867425005562
May 2025
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YTHDF1 differentiates the contributing roles of mTORC1 in aging

1
1. scibot 29 May 2025
  
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  DOI: 10.1016/j.molcel.2025.05.003
  
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sciencedirect.com/science/article/pii/S1097276525004083
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Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.nbd.2025.106939
  
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sciencedirect.com/science/article/pii/S096999612500155X
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Mitochondrial CCN1 drives ferroptosis via fatty acid β-oxidation

1
1. scibot 17 May 2025
  
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  DOI: 10.1016/j.devcel.2025.04.004
  
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sciencedirect.com/science/article/pii/S1534580725002060
Apr 2025
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ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition

1
1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.04.004
  
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sciencedirect.com/science/article/pii/S1097276525003077
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A CRISPR mis-insertion in the Zic3 5′UTR inhibits in vivo translation and is predicted to result in formation of an mRNA stem-loop hairpin

1
1. scibot 02 Apr 2025
  
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  RRID:AB_443298
  
  DOI: 10.1242/bio.061677
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11957448/
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Homeostatic regulation of nucleoporins is a central driver of nuclear pore biogenesis

1
1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115468
  
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sciencedirect.com/science/article/pii/S2211124725002396
Mar 2025
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Mechanical Loading Induces NRF2 Nuclear Translocation to Epigenetically Remodel Oxidative Stress Defense in Osteocytes

1
1. scibot 28 Mar 2025
  
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  DOI: 10.3390/antiox14030346
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11939503/
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YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks

1
1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.02.003
  
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sciencedirect.com/science/article/pii/S109727652500108X
Feb 2025
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Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.molcel.2025.01.031
  
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sciencedirect.com/science/article/pii/S109727652500098X
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Protocols for the application of human embryonic stem cell-derived neurons for aging modeling and gene manipulation

1
1. scibot 21 Feb 2025
  
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  RRID:AB_10107828
  
  DOI: 10.1016/j.xpro.2025.103633
  
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sciencedirect.com/science/article/pii/S2666166725000395
Dec 2024
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Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles

1
1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.015
  
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sciencedirect.com/science/article/pii/S1097276524009201
Nov 2024
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Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging

1
1. scibot 16 Nov 2024
  
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  DOI: 10.1016/j.cell.2024.10.019
  
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sciencedirect.com/science/article/pii/S0092867424012017
Sep 2024
onlinelibrary.wiley.com onlinelibrary.wiley.com

Linking activation of synaptic NMDA receptors-induced CREB signaling to brief exposure of cortical neurons to oligomeric amyloid-beta peptide

1
1. scibot 27 Sep 2024
  
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  DOI: 10.1111/jnc.16222
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16222
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Metformin decelerates aging clock in male monkeys

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1. scibot 13 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.021
  
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sciencedirect.com/science/article/pii/S0092867424009140
Aug 2024
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MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation

1
1. scibot 29 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114682
  
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sciencedirect.com/science/article/pii/S2211124724010337
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Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice

1
1. scibot 27 Aug 2024
  
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  DOI: 10.1038/s41467-024-51030-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11344041/
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Epitranscriptomic reader YTHDF2 regulates SEK1(MAP2K4)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress

1
1. scibot 23 Aug 2024
  
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  DOI: 10.1016/j.isci.2024.110619
  
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sciencedirect.com/science/article/pii/S2589004224018443
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Protocol for machine-learning-based 3D image analysis of nuclear envelope tubules in cultured cells

1
1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.xpro.2024.103214
  
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sciencedirect.com/science/article/pii/S2666166724003794
Jul 2024
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The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway

1
1. scibot 23 Jul 2024
  
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  RRID:AB_443298
  
  DOI: 10.1111/acel.14258
  
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onlinelibrary.wiley.com/doi/10.1111/acel.14258
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SHP2 mutations promote glycolysis and inhibit apoptosis via PKM2/hnRNPK signaling in colorectal cancer

1
1. scibot 18 Jul 2024
  
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  AB_16048
  
  DOI: 10.1016/j.isci.2024.110462
  
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sciencedirect.com/science/article/pii/S2589004224016870
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Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus

1
1. scibot 17 Jul 2024
  
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  RRID:AB_443298
  
  DOI: 10.1016/j.xcrm.2024.101647
  
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sciencedirect.com/science/article/pii/S2666379124003616
Jun 2024
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Impaired Tryptophan Metabolism by Type 2 Inflammation in Epithelium Worsening Asthma

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1. scibot 08 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.109923
  
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sciencedirect.com/science/article/pii/S2589004224011453
May 2024
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Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite

2
1. scibot 31 May 2024
  
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  RRID:AB_443298
  
  DOI: 10.1016/j.ccell.2024.05.006
  
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2. scibot 31 May 2024
  
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  RRID:AB_443298
  
  DOI: 10.1016/j.ccell.2024.05.006
  
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sciencedirect.com/science/article/pii/S1535610824001697
52.53.155.43 52.53.155.43

TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis

2
1. scibot 17 May 2024
  
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  DOI: 10.20944/preprints202402.1027.v1
  
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2. scibot 17 May 2024
  
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  RRID:AB_443298
  
  DOI: 10.20944/preprints202402.1027.v1
  
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52.53.155.43/86d6d1effc82110b06a7585d839c944adff76cc8/preprints202402.1027.v1-html.html
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cav3.2 channel regulates cerebral ischemia/reperfusion injury: a promising target for intervention

1
1. scibot 15 May 2024
  
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  DOI: 10.4103/1673-5374.390966
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11090426/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis

1
1. scibot 03 Apr 2024
  
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  RRID:AB_443298
  
  DOI: 10.3390/ijms25063343
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10970352/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Non-random spatial organization of telomere varies during the cell cycle and requires LAP2 and BAF

1
1. scibot 22 Mar 2024
  
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The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA

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Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide

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AurkA/TPX2 co-overexpression in nontransformed cells promotes genome instability through induction of chromosome mis-segregation and attenuation of the p53 signalling pathway

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ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression.

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Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer

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Intermittent Hypobaric Hypoxia Ameliorates Autistic-Like Phenotypes in Mice

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Cullin-RING E3 ubiquitin ligase 4 regulates neurite morphogenesis during neurodevelopment

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JNEUROSCI.1665-23.2023.full-html.html

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Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres

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Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk

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Disparate macrophage responses are linked to infection outcome of Hantan virus in humans or rodents

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CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise

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A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope

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Dec 2023
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A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling

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TRPC4 deletion elicits behavioral defects in sociability by dysregulating expression of microRNA-138-2

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The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection

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Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

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Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53

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Endonucleosis mediates internalization of cytoplasm into the nucleus in senescent cells

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Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation

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Deep learning enables STORM-like superresolution image reconstruction from conventional microscopy

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Antiangiogenic Action of JZL184 on Endothelial Cells via Inhibition of VEGF Expression in Hypoxic Lung Cancer Cells

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Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial Cells

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Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

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DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C

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Perturbations in 3D genome organization can promote acquired drug resistance

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Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration

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Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis

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DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype

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Jul 2023
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The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina

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Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells

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Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

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Jun 2023
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Ex vivo immunocapture and functional characterization of cell-type-specific mitochondria using MitoTag mice

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Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation

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5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling

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Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging

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Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2

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Annexins A2 and A5 are potential early biomarkers of hepatocarcinogenesis

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Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System

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High-resolution confocal and light-sheet imaging of collagen 3D network architecture in very large samples

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Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System

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Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate

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hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung’s disease

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Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery

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GEN1 promotes common fragile site expression

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Connections between sister and non-sister telomeres of segregating chromatids maintain euploidy

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Cystatin B deficiency results in sustained histone H3 tail cleavage in postnatal mouse brain mediated by increased chromatin-associated cathepsin L activity

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Dynamic chromosomal interactions and control of heterochromatin positioning by Ki‐67

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Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling

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TissUExM enables quantitative ultrastructural analysis in whole vertebrate embryos by expansion microscopy

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De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

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Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors

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The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth

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EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression

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Processing and Subcellular Localization of the Hepatitis E Virus Replicase: Identification of Candidate Viral Factories

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Measurement of autophagy via LC3 western blotting following DNA-damage-induced senescence

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Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

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The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

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Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging

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Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate

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An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling

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Nde1 is required for heterochromatin compaction and stability in neocortical neurons

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Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis

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A puromycin-dependent activity-based sensing probe for histochemical staining of hydrogen peroxide in cells and animal tissues

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Apr 2022
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Long-term Hyperandrogenemia and/or Western-style Diet in Rhesus Macaque Females Impairs Preimplantation Embryogenesis

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Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function

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Processing and Subcellular Localization of the Hepatitis E Virus Replicase: Identification of Candidate Viral Factories

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Feb 2022
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EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells

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Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration

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Mapping the invisible chromatin transactions of prophase chromosome remodeling

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Vitamin D receptor, STAT3, and TET2 cooperate to establish tolerogenesis

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Contribution of Brain Processes to Tissue Loss After Spinal Cord Injury: Does a Pain-Induced Rise in Blood Pressure Fuel Hemorrhage?

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Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity

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The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair

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Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males

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The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress

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RNF8 is not required for histone-to-protamine exchange in spermiogenesis

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Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm

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New insights into the ORF2 capsid protein, a key player of the hepatitis E virus lifecycle

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Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer

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TIMELESS mutation alters phase responsiveness and causes advanced sleep phase

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Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium

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HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

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Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation

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MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages

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The SUN1-SPDYA interaction plays an essential role in meiosis prophase I

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In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration

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Parental genome unification is highly error-prone in mammalian embryos

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Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes

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Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

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MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism

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Mutant p53 suppresses innate immune signaling to promote tumorigenesis

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Huntingtin-mediated axonal transport requires arginine methylation by PRMT6

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ER-directed TREX1 limits cGAS activation at micronuclei

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Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration

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Metoclopramide treatment blocks CD93-signaling-mediated self-renewal of chronic myeloid leukemia stem cells

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Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1

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DDX56 Binds to Chikungunya Virus RNA To Control Infection

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Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner

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Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication

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PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin

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Depatuxizumab mafodotin (ABT-414)-induced glioblastoma cell death requires EGFR overexpression, but not EGFRY1068 phosphorylation

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The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function

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Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration

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FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism

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Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome

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N 6 -methyladenosine regulates the stability of RNA:DNA hybrids in human cells

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Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability

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Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation

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HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70

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The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair

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Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors

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Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

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Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs

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Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

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The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis

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Proteostasis network alteration in lysosomal storage disorders: Insights from the mouse model of Krabbe disease

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MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

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Engaging pain fibers after a spinal cord injury fosters hemorrhage and expands the area of secondary injury

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NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

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Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness

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Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown

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Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer

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Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

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A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response

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HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types

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Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport

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Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice

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Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells

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Nov 2017
elifesciences.org elifesciences.org

Efficient protein targeting to the inner nuclear membrane requires Atlastin-dependent maintenance of ER topology

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The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines

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Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation

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KChIP2 is a core transcriptional regulator of cardiac excitability

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Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

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