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  1. Last 7 days
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    Protocol for murine multi-tissue deep immunophenotyping using a 40-color full-spectrum flow cytometry panel
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    1. scibot 19 Dec 2024
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      DOI: 10.1016/j.xpro.2024.103492

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    sciencedirect.com/science/article/pii/S2666166724006579
  3. Dec 2024
  4. www.sciencedirect.com www.sciencedirect.com
    A double-edged sword role of IFN-γ producing iNKT cells in sepsis: persistent suppression of Treg cell formation in a Nr4a1 dependent manner
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    sciencedirect.com/science/article/pii/S2589004224026890
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    Prenatal antibiotics reduce breast milk IgA and induce dysbiosis in mouse offspring, increasing neonatal susceptibility to bacterial sepsis
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    sciencedirect.com/science/article/pii/S1931312824004074
  6. Nov 2024
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    Leader cells promote immunosuppression to drive ovarian cancer progression in vivo
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      DOI: 10.1016/j.celrep.2024.114979

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    sciencedirect.com/science/article/pii/S2211124724013305
  8. Sep 2024
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    Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.xpro.2021.100351

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    sciencedirect.com/science/article/pii/S2666166721000587
  10. Jul 2024
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    Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity
    1
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    sciencedirect.com/science/article/pii/S1535610824002393
  12. 52.53.155.43 52.53.155.43
    Lack of canonical thyroid hormone receptor α signaling changes regulatory T cell phenotype in female mice
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    Protection from environmental enteric dysfunction and growth improvement in malnourished newborns by amplification of secretory IgA
    1
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    sciencedirect.com/science/article/pii/S2666379124003525
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol to study the immune profile of syngeneic mouse tumor models
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      DOI: 10.1016/j.xpro.2024.103139

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    ncbi.nlm.nih.gov/pmc/articles/PMC11234017/
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    SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration
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    sciencedirect.com/science/article/pii/S2211124724007873
  16. Jun 2024
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    Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss
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      DOI: 10.1016/j.cell.2024.05.003

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    sciencedirect.com/science/article/pii/S0092867424004926
  18. May 2024
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    A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
    1
    1. scibot 24 May 2024
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    sciencedirect.com/science/article/pii/S1074761324002309
  20. Apr 2024
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    CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment
    1
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    sciencedirect.com/science/article/pii/S1074761324002085
  22. Mar 2024
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    Adipose stem cells control obesity-induced T cell infiltration into adipose tissue
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    sciencedirect.com/science/article/pii/S2211124724002912
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    NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment
    2
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      DOI: 10.1016/j.celrep.2024.113898

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    sciencedirect.com/science/article/pii/S2211124724002262
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FcγRIIB is an immune checkpoint limiting the activity of Treg-targeting antibodies in the tumor microenvironment
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      DOI: 10.1158/2326-6066.CIR-23-0389

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    ncbi.nlm.nih.gov/pmc/articles/PMC10911703/
  26. Feb 2024
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    Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells
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      DOI: 10.1016/j.immuni.2024.01.019

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    sciencedirect.com/science/article/pii/S1074761324000451
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    The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis
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      DOI: 10.1016/j.celrep.2024.113824

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    sciencedirect.com/science/article/pii/S2211124724001529
  29. Dec 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Oral tolerance to systemic vaccination remains intact without RORγt expression in regulatory T cells
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      DOI: 10.1016/j.isci.2023.108504

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    sciencedirect.com/science/article/pii/S2589004223025816
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    De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function
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      DOI: 10.1016/j.celrep.2023.113518

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    Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
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      DOI: 10.1016/j.celrep.2023.113560

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    sciencedirect.com/science/article/pii/S2211124723015723
  33. Nov 2023
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    An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2
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      DOI: 10.1016/j.xcrm.2023.101289

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    sciencedirect.com/science/article/pii/S2666379123004834
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An essential role for miR-15/16 in Treg suppression and restriction of proliferation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10664750/
  36. Oct 2023
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unedited allogeneic iNKT cells show extended persistence in MHC-mismatched canine recipients
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      DOI: 10.1016/j.xcrm.2023.101241

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    ncbi.nlm.nih.gov/pmc/articles/PMC10591065/
  38. Aug 2023
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    Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin
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    sciencedirect.com/science/article/pii/S0092867423008048
  40. 52.53.155.43 52.53.155.43
    CD39 inhibition and VISTA blockade may overcome radiotherapy resistance by targeting exhausted CD8+ T cells and immunosuppressive myeloid cells
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      DOI: 10.1016/j.xcrm.2023.101151

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    52.53.155.43/75914c2645b295883453ae6f0848b8ff04ccb7e0/PIIS266637912300304X-html.html
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    SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine
    2
    1. scibot 17 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112940

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    52.53.155.43/746dceaaaecd8ad8008d9df523b985f7a77f181a/PIIS2211124723009518-html.html
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    Tumoral P2Y2 receptor modulates tumor growth and host anti-tumor immune responses in a syngeneic murine model of oral cancer
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      DOI: 10.1007/s11302-023-09960-z

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    link.springer.com/article/10.1007/s11302-023-09960-z
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
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      DOI: 10.1136/jitc-2022-006457

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    ncbi.nlm.nih.gov/pmc/articles/PMC10414095/
  44. 52.53.155.43 52.53.155.43
    crc-22-0293-html.html
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      DOI: 10.1158/2767-9764.crc-22-0293

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  45. Jun 2023
  46. www.sciencedirect.com www.sciencedirect.com
    Prolonged dysbiosis and altered immunity under nutritional intervention in a physiological mouse model of severe acute malnutrition
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      DOI: 10.1016/j.isci.2023.106910

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    sciencedirect.com/science/article/pii/S2589004223009872
  47. May 2023
  48. link.springer.com link.springer.com
    Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis
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      DOI: 10.1186/s12974-023-02784-z

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  49. Apr 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Gut dysbiosis promotes the breakdown of oral tolerance mediated through dysfunction of mucosal dendritic cells
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      DOI: 10.1016/j.celrep.2023.112431

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    The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries
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      DOI: 10.1016/j.immuni.2023.01.033

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    sciencedirect.com/science/article/pii/S1074761323000456
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    Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects
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      DOI: 10.1016/j.celrep.2023.112364

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    sciencedirect.com/science/article/pii/S2211124723003753
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    Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup
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      DOI: 10.1016/j.immuni.2023.03.008

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  54. Mar 2023
  55. www.sciencedirect.com www.sciencedirect.com
    Arresting microbiome development limits immune system maturation and resistance to infection in mice
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      DOI: 10.1016/j.chom.2023.03.006

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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model
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      DOI: 10.3389/fimmu.2023.1038689

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  57. www.sciencedirect.com www.sciencedirect.com
    Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions
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  58. Feb 2023
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    DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development
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      DOI: 10.1016/j.celrep.2023.112106

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  60. www.sciencedirect.com www.sciencedirect.com
    Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway
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  61. Nov 2022
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    Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection
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  63. Sep 2022
  64. www.sciencedirect.com www.sciencedirect.com
    The ketone body β-hydroxybutyrate mitigates ILC2-driven airway inflammation by regulating mast cell function
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  65. Aug 2022
  66. www.sciencedirect.com www.sciencedirect.com
    The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
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  67. Jun 2022
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    Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity
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    PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment
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  70. May 2022
  71. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial damage-associated molecular patterns trigger arginase-dependent lymphocyte immunoregulation
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    Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity
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  73. Mar 2022
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activating Mucosal-Associated Invariant T cells Induces a Broad Antitumor Response
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  76. Feb 2022
  77. www.sciencedirect.com www.sciencedirect.com
    Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity
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    Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
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  79. Jan 2022
  80. www.sciencedirect.com www.sciencedirect.com
    Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
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  81. www.nature.com www.nature.com
    Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization
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  82. Dec 2021
  83. www.nature.com www.nature.com
    GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
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  85. www.sciencedirect.com www.sciencedirect.com
    Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells
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  86. Nov 2021
  87. www.sciencedirect.com www.sciencedirect.com
    Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression
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    MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity
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    Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
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  91. Sep 2021
  92. www.sciencedirect.com www.sciencedirect.com
    Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
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  93. Aug 2021
  94. www.sciencedirect.com www.sciencedirect.com
    Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes
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    ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex and Gender in Renal Health and Function: Hypertensive female Sprague-Dawley rats require an intact nitric oxide synthase system for compensatory increases in renal regulatory T cells
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      DOI: 10.1152/ajprenal.00228.2020

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    The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression
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      DOI: 10.1016/j.immuni.2018.10.013

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    Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function
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  101. Jul 2021
  102. www.sciencedirect.com www.sciencedirect.com
    Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Response to Fungal Dysbiosis by Gut Resident CX3CR1+ Mononuclear Phagocytes Aggravates Allergic Airway Disease
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    A safe and effective mucosal RSV vaccine in mice consisting of RSV phosphoprotein and flagellin variant
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    Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity
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  107. Jun 2021
  108. www.sciencedirect.com www.sciencedirect.com
    Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop
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      DOI: 10.1016/j.cell.2021.05.027

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  109. May 2021
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology
    1
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      17-5773-82

      DOI: 10.1126/sciadv.abe4601

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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist
    1
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      Anti-mouse Foxp3 APC (FJK-16S) rat monoclonal

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  112. www.sciencedirect.com www.sciencedirect.com
    Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke
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    In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma
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  114. www.sciencedirect.com www.sciencedirect.com
    The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation
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    T Cell Receptor Is Required for Differentiation, but Not Maintenance, of Intestinal CD4+ Intraepithelial Lymphocytes
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  116. Apr 2021
  117. www.sciencedirect.com www.sciencedirect.com
    Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells
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    Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome
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    The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis
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      DOI: 10.1016/j.cell.2020.05.048

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    Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells
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  121. Feb 2021
  122. elifesciences.org elifesciences.org
    The kinase PDK1 is critical for promoting T follicular helper cell differentiation
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  123. www.cell.com www.cell.com
    Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies
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  124. Jan 2021
  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Booster Dose Enhances Immunogenicity of the COVID-19 Vaccine Candidate ChAdOx1 nCoV-19 in Aged Mice
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      DOI: 10.1016/j.medj.2020.12.006

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  126. www.sciencedirect.com www.sciencedirect.com
    Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma
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  127. Sep 2020
  128. www.sciencedirect.com www.sciencedirect.com
    Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells
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  129. www.sciencedirect.com www.sciencedirect.com
    Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function
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      RRID:AB_469457

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    Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation
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      DOI: 10.1016/j.celrep.2020.107892

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  131. www.sciencedirect.com www.sciencedirect.com
    An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint
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      DOI: 10.1016/j.cell.2020.04.030

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  132. elifesciences.org elifesciences.org
    Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo
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  133. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Heparin affects the induction of regulatory T cells independent of anticoagulant activity and suppresses the allogeneic immune responses
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      RRID: AB_469457

      DOI: 10.1111/cei.13480

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  134. journals.physiology.org journals.physiology.org
    Hypertensive female Sprague-Dawley rats require an intact nitric oxide synthase system for compensatory increases in renal regulatory T cells | American Journal of Physiology-Renal Physiology
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      RRID: AB_469457

      DOI: 10.1152/ajprenal.00228.2020

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  135. Jan 2020
  136. www.sciencedirect.com www.sciencedirect.com
    Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis
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      RRID:AB_469457

      DOI: 10.1016/j.cmet.2019.10.006

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  137. www.sciencedirect.com www.sciencedirect.com
    miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival
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      RRID:AB_469457

      DOI: 10.1016/j.celrep.2019.07.064

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  138. www.sciencedirect.com www.sciencedirect.com
    Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells
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      RRID:AB_469457

      DOI: 10.1016/j.celrep.2019.10.018

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  139. www.cell.com www.cell.com
    Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells
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      DOI: 10.1016/j.cmet.2019.05.016

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    cell.com/cell-metabolism/fulltext/S1550-4131(19)30256-6
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    The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells
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    Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation
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  142. www.sciencedirect.com www.sciencedirect.com
    Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity
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      RRID:AB_469457

      DOI: 10.1016/j.cmet.2019.10.015

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  143. www.sciencedirect.com www.sciencedirect.com
    TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases
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      DOI: 10.1016/j.celrep.2019.05.061

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  144. www.sciencedirect.com www.sciencedirect.com
    Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection
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      RRID:AB_469457

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  145. www.cell.com www.cell.com
    Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies
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      DOI: 10.1016/j.celrep.2019.04.091

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  146. Nov 2018
  147. www.sciencedirect.com www.sciencedirect.com
    Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  149. www.sciencedirect.com www.sciencedirect.com
    IKZF1 Enhances Immune Infiltrate Recruitment in Solid Tumors and Susceptibility to Immunotherapy
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    Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis
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    CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine
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    KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity
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    White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection
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  154. Nov 2017
  155. www.sciencedirect.com www.sciencedirect.com
    Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells
    1
    1. scibot 08 Nov 2017
      RRID:AB_469457

      Curator: @Jmenke

      Resource used:

      (Thermo Fisher Scientific Cat# 17-5773-82, RRID:AB_469457)

      SciCrunch record: RRID:AB_469457

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_469457 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1074761317303151