Hypothesis

20 Matching Annotations

Oct 2025
www.sciencedirect.com www.sciencedirect.com

HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

1
1. scibot 11 Oct 2025
  
  in Public
  
  RRID:AB_470709
  
  DOI: 10.1016/j.celrep.2025.116382
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_470709
  
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  RRID:AB_470709
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RRID:AB_470709

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scibot

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sciencedirect.com/science/article/pii/S2211124725011532
Jan 2024
www.sciencedirect.com www.sciencedirect.com

Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease

1
1. scibot 11 Jan 2024
  
  in Public
  
  RRID:AB_470709
  
  DOI: 10.1016/j.jbc.2024.105641
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_470709
  
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  RRID:AB_470709
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RRID:AB_470709

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scibot

URL

sciencedirect.com/science/article/pii/S0021925824000176
Jul 2023
52.53.155.43 52.53.155.43

A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons

1
1. scibot 18 Jul 2023
  
  in Public
  
  RRID:AB_47070
  
  DOI: 10.1101/2023.05.29.542776
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @anisehay
  
  SciCrunch record: RRID:AB_470709
  
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  RRIDCUR:Unresolved RRID:AB_470709
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RRID:AB_470709

RRIDCUR:Unresolved

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scibot

URL

52.53.155.43/295724fe7577204c05a5e312c5e68d353e69e1f1/2023.05.29.542776v1.full-html.html
Jun 2023
www.sciencedirect.com www.sciencedirect.com

Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel

1
1. scibot 30 Jun 2023
  
  in Public
  
  RRID:AB_470709
  
  DOI: 10.1016/j.molcel.2023.06.004
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_470709
  
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  RRID:AB_470709
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RRID:AB_470709

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scibot

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sciencedirect.com/science/article/pii/S1097276523004264
Jul 2022
www.sciencedirect.com www.sciencedirect.com

Rapid macropinocytic transfer of α-synuclein to lysosomes

1
1. scibot 27 Jul 2022
  
  in Public
  
  AB_470709
  
  DOI: 10.1016/j.celrep.2022.111102
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_470709
  
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  RRID:AB_470709
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RRID:AB_470709

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scibot

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sciencedirect.com/science/article/pii/S2211124722009044
Jun 2022
www.sciencedirect.com www.sciencedirect.com

Supramolecular assembly of GSK3α as a cellular response to amino acid starvation

1
1. scibot 22 Jun 2022
  
  in Public
  
  RRID:AB_470709
  
  DOI: 10.1016/j.molcel.2022.05.025
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_470709
  
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  RRID:AB_470709
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RRID:AB_470709

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scibot

URL

sciencedirect.com/science/article/pii/S1097276522004920
Dec 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Association of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 With Angiotensin II Type 1 Receptor Impacts Mitochondrial Quality Control, Offering Promise for the Treatment of Vascular Senescence

1
1. scibot 04 Dec 2021
  
  in Public
  
  RRID:AB_470709
  
  DOI: 10.3389/fcvm.2021.788655
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_470709
  
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  RRID:AB_470709
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RRID:AB_470709

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8637926/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells

1
1. scibot 02 Dec 2021
  
  in Public
  
  RRID:AB_470709
  
  DOI: 10.1158/0008-5472.CAN-20-3371
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_470709
  
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  RRID:AB_470709
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RRID:AB_470709

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8178204/
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication

1
1. scibot 30 Jul 2021
  
  in Public
  
  RRID:AB_470709
  
  DOI: 10.1016/j.molcel.2018.09.007
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @Jmenke
  
  SciCrunch record: RRID:AB_470709
  
  What is this?
  
  RRIDCUR:Validated RRID:AB_470709
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RRID:AB_470709

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1097276518307548
www.sciencedirect.com www.sciencedirect.com

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

1
1. scibot 30 Jul 2021
  
  in Public
  
  RRID:AB_470709
  
  DOI: 10.1016/j.cell.2018.09.055
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @Jmenke
  
  SciCrunch record: RRID:AB_470709
  
  What is this?
  
  RRIDCUR:Validated RRID:AB_470709
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RRID:AB_470709

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S0092867418313060
www.sciencedirect.com www.sciencedirect.com

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

1
1. scibot 29 Jul 2021
  
  in Public
  
  RRID: AB_470709
  
  DOI: 10.1016/j.molcel.2019.10.016
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_470709
  
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  RRID:AB_470709
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RRID:AB_470709

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scibot

URL

sciencedirect.com/science/article/pii/S1097276519307944
Feb 2021
www.cell.com www.cell.com

Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation

1
1. scibot 25 Feb 2021
  
  in Public
  
  RRID:AB_470709
  
  DOI: 10.1016/j.molcel.2020.11.036
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_470709
  
  What is this?
  
  RRIDCUR:Validated RRID:AB_470709
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RRID:AB_470709

RRIDCUR:Validated

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scibot

URL

cell.com/molecular-cell/fulltext/S1097-2765(20)30836-4
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_470709
  
  DOI: 10.1016/j.chembiol.2019.05.009
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_470709
  
  What is this?
  
  RRID:AB_470709 RRIDCUR:Validated
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RRID:AB_470709

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2451945619301783
www.sciencedirect.com www.sciencedirect.com

MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_470709
  
  DOI: 10.1016/j.yexcr.2018.11.028
  
  Resource: (Abcam Cat# ab25631, RRID:AB_470709)
  
  Curator: @Jmenke
  
  SciCrunch record: RRID:AB_470709
  
  What is this?
  
  RRID:AB_470709 RRIDCUR:Validated
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RRID:AB_470709

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S0014482718311479
Nov 2018
bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_470709
  
  Curator: @evieth
  
  Resource used:
  
  (Abcam Cat# ab25631, RRID:AB_470709)
  
  SciCrunch record: RRID:AB_470709
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_470709 RRIDCUR:Validated
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RRID:AB_470709

RRIDCUR:Validated

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scibot

URL

bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0576-6
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 05 Nov 2018
  
  in Public
  
  AB_470709
  
  Resource used:
  
  (Abcam Cat# ab25631, RRID:AB_470709)
  
  SciCrunch record: RRID:AB_470709
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_470709
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RRID:AB_470709

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6075866/
www.sciencedirect.com www.sciencedirect.com

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_470709
  
  Resource used:
  
  (Abcam Cat# ab25631, RRID:AB_470709)
  
  SciCrunch record: RRID:AB_470709
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_470709
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RRID:AB_470709

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scibot

URL

sciencedirect.com/science/article/pii/S0092867418305865
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_470709
  
  Resource used:
  
  (Abcam Cat# ab25631, RRID:AB_470709)
  
  SciCrunch record: RRID:AB_470709
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_470709
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RRID:AB_470709

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC5791736/
www.sciencedirect.com www.sciencedirect.com

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_470709
  
  Curator: @evieth
  
  Resource used:
  
  (Abcam Cat# ab25631, RRID:AB_470709)
  
  SciCrunch record: RRID:AB_470709
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_470709 RRIDCUR:Validated
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RRID:AB_470709

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1534580717309851
Nov 2017
elifesciences.org elifesciences.org

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_470709
  
  Curator: @kaitlinsung
  
  Resource used:
  
  (Abcam Cat# ab25631, RRID:AB_470709)
  
  SciCrunch record: RRID:AB_470709
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_470709 RRIDCUR:Validated
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RRID:AB_470709

RRIDCUR:Validated

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scibot

URL

elifesciences.org/articles/23063