502 Matching Annotations
  1. Feb 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Microglial pyroptosis drives neuropathic pain and targeting NLRP3 alleviates pain and neuroinflammation
    1
    1. scibot 20 Feb 2025
      RRID:AB_476743

      DOI: 10.1016/j.bbadis.2025.167737

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    sciencedirect.com/science/article/pii/S0925443925000821
  3. Jan 2025
  4. www.sciencedirect.com www.sciencedirect.com
    Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation
    1
    1. scibot 23 Jan 2025
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      DOI: 10.1016/j.cell.2024.12.009

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    sciencedirect.com/science/article/pii/S0092867424014223
  5. www.sciencedirect.com www.sciencedirect.com
    Lysosomal activity in response to the incubation of pristine and functionalized carbon nanodots
    1
    1. scibot 17 Jan 2025
      RRID:AB_476743

      DOI: 10.1016/j.isci.2024.111654

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    sciencedirect.com/science/article/pii/S2589004224028815
  6. www.jidonline.org www.jidonline.org
    5’-cap-dependent translation as a potent therapeutic target for lethal human squamous cell carcinoma
    1
    1. scibot 10 Jan 2025
      β-Actin

      DOI: 10.1016/j.jid.2020.08.021

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    jidonline.org/article/S0022-202X(20)32066-2/fulltext
  7. 52.53.155.43 52.53.155.43
    PDF-html.html
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    1. scibot 03 Jan 2025
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      DOI: 10.1074/mcp.m113.031591

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    52.53.155.43/3f93a1e6d9279abf85ecec7e26292c0f7687857c/1-s2.0-S2589004224028815-main-html.html
  8. 52.53.155.43 52.53.155.43
    1-s2.0-S2212877824002229-main-html.html
    1
    1. scibot 03 Jan 2025
      AB_476743

      DOI: 10.1016/j.molmet.2024.102091

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    52.53.155.43/ff53ca808409e557edfcd52846690258be8d728c/1-s2.0-S2212877824002229-main-html.html
  9. Dec 2024
  10. 52.53.155.43 52.53.155.43
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    1. scibot 29 Dec 2024
      RRID:AB_476743

      DOI: 10.1074/mcp.m113.031591

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    52.53.155.43/3f93a1e6d9279abf85ecec7e26292c0f7687857c/1-s2.0-S2589004224028815-main-html.html
  11. www.nature.com www.nature.com
    Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
    1
    1. scibot 21 Dec 2024
      RRID:AB_476743

      DOI: 10.1038/s41586-024-08348-2

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    nature.com/articles/s41586-024-08348-2
  12. www.nature.com www.nature.com
    Lithocholic acid phenocopies anti-ageing effects of calorie restriction
    1
    1. scibot 21 Dec 2024
      RRID:AB_476743

      DOI: 10.1038/s41586-024-08329-5

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    nature.com/articles/s41586-024-08329-5
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength
    1
    1. scibot 17 Dec 2024
      RRID:AB_476743

      DOI: 10.1016/j.neuron.2018.03.010

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    pmc.ncbi.nlm.nih.gov/articles/PMC5919779/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
    1
    1. scibot 13 Dec 2024
      RRID:AB_476743

      DOI: 10.1126/scisignal.adi9018

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    pmc.ncbi.nlm.nih.gov/articles/PMC10760916/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNA binding protein ZCCHC24 promotes tumorigenicity in triple-negative breast cancer
    1
    1. scibot 11 Dec 2024
      RRID:AB_476743

      DOI: 10.1038/s44319-024-00282-8

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    pmc.ncbi.nlm.nih.gov/articles/PMC11624195/
  16. Nov 2024
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modulation of SNARE-dependent exocytosis in astrocytes improves neuropathology in Huntington's disease
    1
    1. scibot 26 Nov 2024
      RRID:AB_476743

      DOI: 10.1242/dmm.052002

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    pmc.ncbi.nlm.nih.gov/articles/PMC11583919/
  18. elifesciences.org elifesciences.org
    Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model
    1
    1. scibot 07 Nov 2024
      RRID:AB_476743

      DOI: 10.7554/eLife.93312

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    elifesciences.org/articles/93312
  19. Oct 2024
  20. aacrjournals.org aacrjournals.org
    Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein–coupled Receptor 68
    1
    1. scibot 02 Oct 2024
      RRID:AB_476743

      DOI: 10.1158/1535-7163.MCT-20-0150

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    aacrjournals.org/mct/article/20/6/1019/673256/Conophylline-Inhibits-Hepatocellular-Carcinoma-by
  21. Sep 2024
  22. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
    1. scibot 27 Sep 2024
      RRID:AB_476743

      DOI: 10.1111/bph.17320

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17320
  23. www.pnas.org www.pnas.org
    MDGAs perform activity-dependent synapse type-specific suppression via distinct extracellular mechanisms
    1
    1. scibot 26 Sep 2024
      RRID: AB_476743

      DOI: 10.1073/pnas.2322978121

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      Curator: @dhovakimyan1

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    pnas.org/doi/10.1073/pnas.2322978121
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
    1
    1. scibot 25 Sep 2024
      RRID:AB_476743

      DOI: 10.1038/s41467-024-52523-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC11410950/
  25. academic.oup.com academic.oup.com
    Changes in cardiac Aquaporin expression during aortic valve replacement surgery with cardiopulmonary bypass
    1
    1. scibot 25 Sep 2024
      RRID:AB_476692

      DOI: 10.1093/ejcts/ezz249

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    academic.oup.com/ejcts/advance-article/doi/10.1093/ejcts/ezz249/5571459
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice
    1
    1. scibot 06 Sep 2024
      RRID:AB_476743

      DOI: 10.1210/endocr/bqad133

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    ncbi.nlm.nih.gov/pmc/articles/PMC10502789/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes
    1
    1. scibot 05 Sep 2024
      RRID:AB_476743

      DOI: 10.1038/s41467-024-51676-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11362472/
  28. Aug 2024
  29. www.sciencedirect.com www.sciencedirect.com
    Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia
    1
    1. scibot 27 Aug 2024
      AB_476743

      DOI: 10.1016/j.freeradbiomed.2024.08.019

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    sciencedirect.com/science/article/pii/S0891584924006063
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer
    1
    1. scibot 22 Aug 2024
      RRID:AB_476743

      DOI: 10.1186/s13046-024-03124-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11321020/
  31. pubs.rsc.org pubs.rsc.org
    Hexane Insoluble Fraction from Purple Rice Extract Improves Steatohepatitis and Fibrosis via Inhibition of NF-κB and JNK Signaling
    1
    1. scibot 19 Aug 2024
      RRID:AB_476743

      DOI: 10.1039/D4FO00292J

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      Curator: @vtello

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    pubs.rsc.org/en/content/articlelanding/2024/fo/d4fo00292j
  32. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
    1
    1. scibot 02 Aug 2024
      RRID AB_476743

      DOI: 10.1152/ajpcell.00385.2020

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    journals.physiology.org/doi/full/10.1152/ajpcell.00385.2020
  33. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Executive function deficits and glutamatergic protein alterations in a progressive 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine mouse model of Parkinson's disease
    1
    1. scibot 02 Aug 2024
      AB_476743

      DOI: 10.1002/jnr.23638

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    onlinelibrary.wiley.com/doi/10.1002/jnr.23638/full
  34. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Association of N‐cadherin levels and downstream effectors of Rho GTPases with dendritic spine loss induced by chronic stress in rat hippocampal neurons
    1
    1. scibot 02 Aug 2024
      AB_476743

      DOI: 10.1002/jnr.23602

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    onlinelibrary.wiley.com/doi/10.1002/jnr.23602/full
  35. translationalneurodegeneration.biomedcentral.com translationalneurodegeneration.biomedcentral.com
    Ecto-GPR37: a potential biomarker for Parkinson’s disease
    1
    1. scibot 02 Aug 2024
      mouse anti-β-actin monoclonal

      DOI: 10.1186/s40035-021-00232-7

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    translationalneurodegeneration.biomedcentral.com/article/10.1186/s40035-021-00232-7
  36. www.mdpi.com www.mdpi.com
    Long Noncoding RNA HOXA11-AS and Transcription Factor HOXB13 Modulate the Expression of Bone Metastasis-Related Genes in Prostate Cancer
    1
    1. scibot 02 Aug 2024
      anti-ACTB

      DOI: 10.3390/genes12020182

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    mdpi.com/2073-4425/12/2/182/htm
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Purinergic receptor P2Y6 contributes to 1‐methyl‐4‐phenylpyridinium‐induced oxidative stress and cell death in neuronal SH‐SY5Y cells
    1
    1. scibot 02 Aug 2024
      RRID:AB_476743

      DOI: 10.1002/jnr.24119

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    onlinelibrary.wiley.com/doi/10.1002/jnr.24119/full
  38. Jul 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila
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    1. scibot 20 Jul 2024
      RRID:AB_476743

      DOI: 10.7554/eLife.53103

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    ncbi.nlm.nih.gov/pmc/articles/PMC7274782/
  40. www.cell.com www.cell.com
    The PP2A regulatory subunit PPP2R2A controls NAD+ biosynthesis to regulate T cell subset differentiation in systemic autoimmunity
    1
    1. scibot 18 Jul 2024
      RRID:AB_476743

      DOI: 10.1016/j.celrep.2024.114379

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    cell.com/cell-reports/fulltext/S2211-1247(24)00707-1
  41. www.sciencedirect.com www.sciencedirect.com
    Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress
    1
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      AB_476743

      DOI: 10.1016/j.molcel.2024.06.009

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    sciencedirect.com/science/article/pii/S1097276524005124
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism
    1
    1. scibot 02 Jul 2024
      RRID:AB_476743

      DOI: 10.7554/eLife.90278

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    ncbi.nlm.nih.gov/pmc/articles/PMC11213571/
  43. Jun 2024
  44. www.sciencedirect.com www.sciencedirect.com
    SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms
    1
    1. scibot 08 Jun 2024
      RRID:AB_476743

      DOI: 10.1016/j.isci.2024.109940

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    sciencedirect.com/science/article/pii/S2589004224011623
  45. www.sciencedirect.com www.sciencedirect.com
    Neurodegeneration and glial morphological changes are both prevented by TRPM2 inhibition during the progression of a Parkinson's disease mouse model
    1
    1. scibot 07 Jun 2024
      RRID:AB_476743

      DOI: 10.1016/j.expneurol.2024.114780

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    sciencedirect.com/science/article/pii/S0014488624001067
  46. www.sciencedirect.com www.sciencedirect.com
    De novo and salvage purine synthesis pathways across tissues and tumors
    1
    1. scibot 04 Jun 2024
      RRID:AB_476743

      DOI: 10.1016/j.cell.2024.05.011

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    sciencedirect.com/science/article/pii/S0092867424005208
  47. May 2024
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Contrasting consequences of podocyte IGF1R inhibition
    1
    1. scibot 09 May 2024
      RRID:AB_476743

      DOI: 10.1016/j.isci.2024.109749

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    ncbi.nlm.nih.gov/pmc/articles/PMC11068853/
  49. www.mdpi.com www.mdpi.com
    IL17A Suppresses IGFBP1 in Human Endometrial Stromal Cells
    1
    1. scibot 03 May 2024
      RRID:AB_476743

      DOI: 10.3390/reprodmed5020006

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  50. Apr 2024
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    Targeting PDGF signaling of cancer-associated fibroblasts blocks feedback activation of HIF-1α and tumor progression of clear cell ovarian cancer
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    Modulating PCGF4 stability is an efficient metastasis-regulatory strategy utilized by distinct subtypes of Cancer-Associated Fibroblasts in intrahepatic cholangiocarcinoma
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    ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis
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    KSCBi005-A-10(hiPSC-HIF1αKO), a HIF1α knockout human induced pluripotent stem cell line, for demonstrating the role of cellular response to hypoxia
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    Microtubule-associated protein MAP7 promotes tubulin posttranslational modifications and cargo transport to enable osmotic adaptation
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    Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells
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    Caldendrin is a repressor of PIEZO2 channels and touch sensation in mice
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    OPA1 mediates muscle differentiation by promoting a metabolic switch via the supercomplex assembly factor SCAF1
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    MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance
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  64. Feb 2024
  65. 52.53.155.43 52.53.155.43
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    Sound-evoked adenosine release in cooperation with neuromodulatory circuits permits auditory cortical plasticity and perceptual learning
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    SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination
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    EBAG9-deficient mice display decreased bone mineral density with suppressed autophagy
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    Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells
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    Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma
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    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
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  86. Nov 2023
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    Transcriptomic analysis of sorted lung cells revealed a proviral activity of the NF-κB pathway toward SARS-CoV-2
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    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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    CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative, and non-associative learning
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    Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritis
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    DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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  95. Sep 2023
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    A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants
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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.
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    Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores
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  99. Aug 2023
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    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
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    The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr
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  102. 52.53.155.43 52.53.155.43
    MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC
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    Hypothalamic astrocytic-BMAL1 regulates energy homeostasis in a sex-dependent manner
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  104. 52.53.155.43 52.53.155.43
    Promoter Gene Methylation Regulates Clooxygenase-2 Expression in Androgen-Dependent and Independent Prostate Cancer Cells
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    Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern
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    The ATR inhibitor VE-821 increases the sensitivity of gastric cancer cells to cisplatin
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    Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging
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    Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations
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    NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62
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    2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience
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    Inhibition of Monoacylglycerol Lipase Decreases Angiogenic Features of Endothelial Cells via Release of Tissue Inhibitor of Metalloproteinase-1 from Lung Cancer Cells
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    xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity
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  121. aacrjournals.org aacrjournals.org
    Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer
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    CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue
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    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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    Promoter Gene Methylation Regulates Clooxygenase-2 Expression in Androgen-Dependent and Independent Prostate Cancer Cells
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    Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation
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  133. academic.oup.com academic.oup.com
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    Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells
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    Fast and efficient synaptosome isolation and post-synaptic density enrichment from hiPSC-motor neurons by biochemical sub-cellular fractionation
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    OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis
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    Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis
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  180. Sep 2022
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    Virological features and pathogenicity of SARS-CoV-2 Omicron BA.2
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    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
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    Restoration of mitochondria axonal transport by adaptor Disc1 supplementation prevents neurodegeneration and rescues visual function
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    Na/K-ATPase Suppresses LPS-Induced Pro-Inflammatory Signaling Through Lyn
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    Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
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  187. Aug 2022
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    Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2
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    The BASP1 transcriptional corepressor modifies chromatin through lipid-dependent and lipid-independent mechanisms
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    The redox cycling of STAT2 maintains innate immune homeostasis
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    APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation
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    Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons
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    Mitotane Targets Lipid Droplets to Induce Lipolysis in Adrenocortical Carcinoma
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    Calpain-Independent Intracellular Protease Activity Is Elevated in Excitotoxic Cortical Neurons Prior to Delayed Calcium Deregulation and Mitochondrial Dysfunction
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    Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells
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    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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    Receptor editing constrains development of phosphatidyl choline-specific B cells in VH12-transgenic mice
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    CPEB3-dependent increase in GluA2 subunits impairs excitatory transmission onto inhibitory interneurons in a mouse model of fragile X
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    HIV-1 exploits the Fanconi anemia pathway for viral DNA integration
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    Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition
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    A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
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  210. Apr 2022
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    Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer
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    Manipulation of the miR-378a/mt-ATP6 regulatory axis rescues ATP synthase in the diabetic heart and offers a novel role for lncRNA Kcnq1ot1
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    Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes
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    Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli
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      DOI: 10.15252/emmm.202114876

      Resource: (Sigma-Aldrich Cat# A5316, RRID:AB_476743)

      Curator: @scibot

      SciCrunch record: RRID:AB_476743

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      RRID:AB_476743
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    embopress.org/doi/abs/10.15252/emmm.202114876