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  1. Mar 2023
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Psychological stress induces an increase in cholinergic enteric neuromuscular pathways mediated by glucocorticoid receptors
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      DOI: 10.3389/fnins.2023.1100473

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    Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity
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    sciencedirect.com/science/article/pii/S2211124723002164
  4. Feb 2023
  5. academic.oup.com academic.oup.com
    Genetic Val66Met BDNF Variant Increases Hyperphagia on Fat-rich Diets in Mice
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      DOI: 10.1210/endocr/bqad008

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    academic.oup.com/endo/article/164/3/bqad008/6984997
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    Prostaglandins limit nuclear actin to control nucleolar function during oogenesis
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    1. scibot 23 Feb 2023
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    frontiersin.org/articles/10.3389/fcell.2023.1072456/full
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
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    cd-22-0376-html.html
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    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
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    sciencedirect.com/science/article/pii/S1535610823000077
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    Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
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    1. scibot 10 Feb 2023
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      DOI: 10.1158/0008-5472.CAN-22-1533

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    aacrjournals.org/cancerres/article/83/2/219/715076/Plk1-Inhibitors-and-Abiraterone-Synergistically
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    Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis
    1
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    sciencedirect.com/science/article/pii/S0969996123000451
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    BPS Publications
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      DOI: 10.1111/bph.16014

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  13. Jan 2023
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    Elevated PAF1-RAD52 axis confers chemoresistance to human cancers
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    sciencedirect.com/science/article/pii/S2211124723000542
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    FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration
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    A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3
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  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts
    1
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      DOI: 10.3389/fcell.2022.1080626

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    Gasdermin D pore-forming activity is redox-sensitive
    1
    1. scibot 21 Jan 2023
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    Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system
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  20. www.nature.com www.nature.com
    Hippocampal dentate gyri proteomics reveals Wnt signaling involvement in the behavioral impairment in the THRSP-overexpressing ADHD mouse model
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      DOI: 10.1038/s42003-022-04387-5

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    Autotaxin facilitates selective LPA receptor signaling
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      DOI: 10.1016/j.chembiol.2022.12.006

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    sciencedirect.com/science/article/pii/S2451945622004561
  22. journals.lww.com journals.lww.com
    Transient neurogenesis in ischemic cortex from Sox2+... : Neural Regeneration Research
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    1. scibot 19 Jan 2023
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      DOI: 10.4103/1673-5374.357910

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  23. academic.oup.com academic.oup.com
    Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation
    1
    1. scibot 12 Jan 2023
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      DOI: 10.1093/hmg/ddac282

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    academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddac282/6825270
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours
    1
    1. scibot 12 Jan 2023
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      DOI: 10.1038/s41416-022-02100-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC9977765/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras–MAPK Signaling in Epithelioid Hemangioendothelioma
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    1. scibot 12 Jan 2023
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      DOI: 10.1158/1078-0432.CCR-22-0421

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    ncbi.nlm.nih.gov/pmc/articles/PMC9306355/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
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      DOI: 10.1158/0008-5472.CAN-21-4012

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    Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation
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  28. www.mdpi.com www.mdpi.com
    Remarkable Synergy When Combining EZH2 Inhibitors with YM155 Is H3K27me3-Independent
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      DOI: 10.3390/cancers15010208

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  29. Dec 2022
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-lasting BDNF signaling alterations in the amygdala of adolescent female rats exposed to the activity-based anorexia model
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    1. scibot 31 Dec 2022
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      DOI: 10.3389/fnbeh.2022.1087075

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  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality
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  32. www.mdpi.com www.mdpi.com
    Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice
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  33. www.sciencedirect.com www.sciencedirect.com
    Increased replication origin firing links replication stress to whole chromosomal instability in human cancer
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    sciencedirect.com/science/article/pii/S2211124722017284
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    The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response
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    VLDL-VLDLR axis facilitates brown fat thermogenesis through replenishment of lipid fuels and PPARβ/δ activation
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death
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      DOI: 10.7554/eLife.78609

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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage
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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PERIOD 2 Regulates Low Dose Radioprotection via PER2/pGSK3β/β-Catenin/Per2 Loop
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      DOI: 10.1016/j.isci.2022.105546

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  40. Nov 2022
  41. www.sciencedirect.com www.sciencedirect.com
    Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation
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    sciencedirect.com/science/article/abs/pii/S1097276522010644
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    Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2
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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9672935/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer
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    CRABP2 is associated with thyroid cancer recurrence and promotes invasion via the integrin/FAK/AKT pathway
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    CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation
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    NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step
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    Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice
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    Brain Endothelial Cells in Contrary to the Aortic Do Not Transport but Degrade Low-Density Lipoproteins via Both LDLR and ALK1
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    GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
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    The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice
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    Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D
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    Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex
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    Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors
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    NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins
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    Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton
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    DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
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    Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1
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    Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle
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    LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease
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    Poziotinib for EGFR exon 20-mutant NSCLC: Clinical efficacy, resistance mechanisms, and impact of insertion location on drug sensitivity
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    Upregulation of FOXO1 contributes to lipopolysaccharide-induced pulmonary endothelial injury by induction of autophagy
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    BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1
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    Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth
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    Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response
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    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
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    Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
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    Mechanoreceptor Piezo1 Is Downregulated in Multiple Sclerosis Brain and Is Involved in the Maturation and Migration of Oligodendrocytes in vitro
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    Monocarboxylate transporter 1 deficiency impacts CD8+ T lymphocytes proliferation and recruitment to adipose tissue during obesity
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    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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    Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury
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    DDX41 is required for cGAS-STING activation against DNA virus infection
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    XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation
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    Increased microtubule growth triggered by microvesicle-mediated paracrine signaling is required for melanoma cancer cell invasion
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    A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling
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    NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition
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    Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML
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    Rational Combination of CRM1 Inhibitor Selinexor and Olaparib Shows Synergy in Ovarian Cancer Cell Lines and Mouse Models
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    CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair
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    DNA replication is highly resilient and persistent under the challenge of mild replication stress
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    Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial
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    Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
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    Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes
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    Brown adipose tissue involution associated with progressive restriction in progenitor competence
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    Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C
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  134. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MIRO2 regulates prostate cancer cell growth via GCN1-dependent stress signaling
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    Carbamazepine promotes surface expression of mutant Kir6.2-A28V ATP-sensitive potassium channels by modulating Golgi retention and autophagy
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    Inflammasome activation and pyroptosis via a lipid-regulated SIRT1-p53-ASC axis in macrophages from male mice and humans
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  137. aacrjournals.org aacrjournals.org
    δ-Tocotrienol is the most potent vitamin E form in inhibiting prostate cancer cell growth and inhibits prostate carcinogenesis in Ptenp-/- mice
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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies
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  139. Mar 2022
  140. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Acute inflammation down-regulates alpha-synuclein expression in enteric neurons
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    Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
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    Quantitative interaction proteomics reveals differences in the interactomes of amyloid precursor protein isoforms
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  144. www.embopress.org www.embopress.org
    Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission
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  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct and diverse chromatin proteomes of ageing mouse organs reveal protein signatures that correlate with physiological functions
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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle
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    Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ghrelin Regulates Expression of the Transcription Factor Pax6 in Hypoxic Brain Progenitor Cells and Neurons
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  149. www.sciencedirect.com www.sciencedirect.com
    Central dopaminergic control of cell proliferation in the colonic epithelium
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reducing host aldose reductase activity promotes neuronal differentiation of transplanted neural stem cells at spinal cord injury sites and facilitates locomotion recovery
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    Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord
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  152. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Alzheimer’s disease and cerebrovascular pathology alter brain endothelial inward rectifier potassium (KIR2.1) channels
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  153. Feb 2022
  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma
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  155. www.embopress.org www.embopress.org
    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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    Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces
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    Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans
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    Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  160. onlinelibrary.wiley.com onlinelibrary.wiley.com
    ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12
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  161. link.springer.com link.springer.com
    Targeting CCR2+ macrophages with BET inhibitor overcomes adaptive resistance to anti-VEGF therapy in ovarian cancer
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  162. Jan 2022
  163. www.nature.com www.nature.com
    Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes
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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
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  165. www.sciencedirect.com www.sciencedirect.com
    NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans
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    Sphingosine 1-phosphate receptor 4 promotes nonalcoholic steatohepatitis by activating NLRP3 inflammasome
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    Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity
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    The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TGFBR3L is an inhibin B co-receptor that regulates female fertility
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      DOI: 10.1126/sciadv.abl4391

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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defects in Emerin-nucleoskeleton binding disrupt nuclear structure and promote breast cancer cell motility and metastasis
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  172. Dec 2021
  173. www.science.org www.science.org
    Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
    1
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  174. www.science.org www.science.org
    TGFBR3L is an inhibin B co-receptor that regulates female fertility
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  175. www.sciencedirect.com www.sciencedirect.com
    Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells
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    Integrative proteo-transcriptomic and immunophenotyping signatures of HIV-1 elite control phenotype: A cross-talk between glycolysis and HIF signaling
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    Kaposi’s sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis
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  178. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway
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    Dynamic stem cell selection safeguards the genomic integrity of the epidermis
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  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease
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    YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis
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    lncRNA BORG:TRIM28 Complexes Drive Metastatic Progression by Inducing α6 Integrin/CD49f Expression in Breast Cancer Stem Cells
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    Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology
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    Methods to separate nuclear soluble fractions reflecting localizations in living cells
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    Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
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    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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  187. Nov 2021
  188. www.cell.com www.cell.com
    MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
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    Involvement of the miR-363-5p/P2RX4 Axis in Regulating Schwann Cell Phenotype after Nerve Injury
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      DOI: 10.3390/ijms222111601

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    TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis
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    Tpl2 contributes to IL-1β-induced IL-8 expression via ERK1/2 activation in canine dermal fibroblasts
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    Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency
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    FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
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    Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription
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    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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  198. Oct 2021
  199. academic.oup.com academic.oup.com
    Differentiation of human induced pluripotent stem cells into testosterone-producing Leydig-like cells
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    An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity
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    Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival
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    IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation
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    Effect of retinol dehydrogenase gene transfer in a novel rat model of Stargardt disease
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  204. Sep 2021
  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The TLR4–TRIF–type 1 IFN–IFN-γ pathway is crucial for gastric MALT lymphoma formation after Helicobacter suis infection
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    Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein
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    Immortalized striatal precursor neurons from Huntington’s disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics
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    Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
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    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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    Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging
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    A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth
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    Thiamine deficiency and recovery: impact of recurrent episodes and beneficial effect of treatment with Trolox and dimethyl sulfoxide
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    Comparison of Histone H3K4me3 between IVF and ICSI Technologies and between Boy and Girl Offspring
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      DOI: 10.3390/ijms22168574

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