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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Logic-based machine learning predicts how escitalopram attenuates cardiomyocyte hypertrophy

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1. scibot 06 Sep 2025
  
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  DOI: 10.1073/pnas.2420499122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11912418/
Aug 2025
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

Laser-Induced Graphene: A Promising Conductive Platform for Cell Culture

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1. scibot 20 Aug 2025
  
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  DOI: 10.1002/adhm.202502255
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202502255
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Zbtb16 determines the fate plasticity of cardiovascular progenitors through IGF2BP3-mediated mRNA stabilization

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116127
  
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sciencedirect.com/science/article/pii/S2211124725008988
Jul 2025
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Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia

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1. scibot 22 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.039
  
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sciencedirect.com/science/article/pii/S009286742500741X
elifesciences.org elifesciences.org

Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes

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1. scibot 16 Jul 2025
  
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  DOI: 10.7554/eLife.104048
  
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elifesciences.org/articles/104048
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BPS Publications

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1. scibot 11 Jul 2025
  
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  DOI: 10.1111/bph.70094
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70094
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Rbpms2 prevents major cardiac defects in cardiomyocyte-specific Rbpms-deficient mice

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1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.devcel.2025.06.013
  
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sciencedirect.com/science/article/pii/S1534580725003685
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Fatty acid metabolism suppresses neonatal cardiomyocyte proliferation by increasing PDK4 and HMGCS2 expression through PPARδ

1
1. scibot 21 May 2025
  
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  DOI: 10.1371/journal.pone.0318178
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12061097/
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Enhancing human pluripotent stem cell differentiation to cardiomyocytes through cardiac progenitor reseeding and cryopreservation

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112452
  
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sciencedirect.com/science/article/pii/S2589004225007138
Mar 2025
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Injectable hydrogel with miR-222-engineered extracellular vesicles ameliorates myocardial ischemic reperfusion injury via mechanotransduction

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.xcrm.2025.101987
  
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sciencedirect.com/science/article/pii/S2666379125000606
Feb 2025
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Sympathetic neurons can modify the intrinsic structural and functional properties of human pluripotent stem cell-derived cardiomyocytes

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1. scibot 27 Feb 2025
  
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  DOI: 10.1113/JP287569
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP287569
52.53.155.43 52.53.155.43

Maturation of human cardiac organoids enables complex disease modelling and drug discovery

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.05.611336
  
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52.53.155.43/2a3cc686934257c062697951b2a037bb697f8dd7/2024.09.05.611336v1.full-html.html
Dec 2024
elifesciences.org elifesciences.org

Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

1
1. scibot 20 Dec 2024
  
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  DOI: 10.7554/eLife.95597
  
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elifesciences.org/articles/95597
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Modulation of SNARE-dependent exocytosis in astrocytes improves neuropathology in Huntington's disease

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1. scibot 26 Nov 2024
  
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  DOI: 10.1242/dmm.052002
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11583919/
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CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity

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1. scibot 11 Nov 2024
  
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  DOI: 10.1016/j.stem.2024.10.007
  
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sciencedirect.com/science/article/pii/S1934590924003692
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CCRR regulate MYZAP-PKP2-Nav1.5 signaling pathway in atrial fibrillation following myocardial infarction

1
1. scibot 10 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111102
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11539591/
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Virtual drug screen reveals context-dependent inhibition of cardiomyocyte hypertrophy

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1. scibot 07 Nov 2024
  
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  DOI: 10.1111/bph.16163
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10592153/
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cardiovascular Complications of Pregnancy: Effects of maternal hypothyroidism on postnatal cardiomyocyte proliferation and cardiac disease responses of the progeny

1
1. scibot 03 Oct 2024
  
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  RRID:AB_476766
  
  DOI: 10.1152/ajpheart.00320.2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10659327/
Sep 2024
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Dynamic remodeling of Septin structures fine-tunes myogenic differentiation

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1. scibot 12 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110630
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11380178/
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Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids

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1. scibot 11 Sep 2024
  
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  DOI: 10.1016/j.stem.2024.08.008
  
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sciencedirect.com/science/article/pii/S1934590924002947
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A broadly applicable method for quantifying cardiomyocyte cell division identifies proliferative events following myocardial infarction

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.crmeth.2024.100860
  
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sciencedirect.com/science/article/pii/S2667237524002388
Aug 2024
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Generation of a heterozygous Calsequestrin 2 F189L iPSC line (UMGi158-B) by CRISPR/Cas9 genome editing to investigate the cardiac pathophysiology of Takotsubo Syndrome and Catecholaminergic Polymorphic ventricular Tachycardia

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1. scibot 27 Aug 2024
  
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  DOI: 10.1016/j.scr.2024.103538
  
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sciencedirect.com/science/article/pii/S1873506124002368
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A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.stem.2024.07.006
  
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sciencedirect.com/science/article/pii/S193459092400256X
Jul 2024
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Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

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1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114448
  
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sciencedirect.com/science/article/pii/S2211124724007770
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Dystrophin deficiency impairs cell junction formation during embryonic myogenesis from pluripotent stem cells

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1. scibot 10 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110242
  
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sciencedirect.com/science/article/pii/S2589004224014676
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Substrate mechanics unveil early structural and functional pathology in iPSC micro-tissue models of hypertrophic cardiomyopathy

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1. scibot 08 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.109954
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11141149/
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Macrophages enhance contractile force in iPSC-derived human engineered cardiac tissue

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1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114302
  
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sciencedirect.com/science/article/pii/S2211124724006302
Apr 2024
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Dystrophin deficiency impairs cell junction formation during embryonic myogenesis

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1. scibot 28 Apr 2024
  
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  DOI: 10.1101/2023.12.05.569919
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10723310/
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Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development

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1. scibot 12 Apr 2024
  
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  DOI: 10.1016/j.stem.2024.03.011
  
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sciencedirect.com/science/article/pii/S1934590924000924
Mar 2024
www.cell.com www.cell.com

Myoglobin modulates the Hippo pathway to promote cardiomyocyte differentiation.

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1. scibot 07 Mar 2024
  
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  DOI: 10.1016/j.isci.2024.109146
  
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  DOI: 10.1016/j.isci.2024.109146
  
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  DOI: 10.1016/j.isci.2024.109146
  
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cell.com/iscience/abstract/S2589-0042(24)00367-5
Feb 2024
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The Mas agonist CGEN-856S prevents Ang II induced cardiomyocyte hypertrophy via nitric oxide production

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1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.peptides.2024.171182
  
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  DOI: 10.1016/j.peptides.2024.171182
  
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sciencedirect.com/science/article/pii/S0196978124000354
www.biorxiv.org www.biorxiv.org

Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

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1. scibot 15 Feb 2024
  
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  DOI: 10.1101/2024.02.01.578471
  
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biorxiv.org/content/10.1101/2024.02.01.578471v1
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Generation of CRISPR/Cas9 edited human induced pluripotent stem cell line carrying the heterozygous p.H695VfsX5 frameshift mutation in the exon 10 of the PKP2 gene

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1. scibot 15 Feb 2024
  
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  DOI: 10.1016/j.scr.2024.103341
  
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sciencedirect.com/science/article/pii/S1873506124000394
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Human iPSC-derived closed-loop cardiac tissue for drug assessment

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1. scibot 11 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108992
  
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Jan 2024
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Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization

1
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Dec 2023
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Generation of CRISPR-Cas9 edited human induced pluripotent stem cell line carrying BAG3 V468M mutation in its BAG domain

1
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Generation of a fluorescent oligodendrocyte reporter line in human induced pluripotent stem cells

1
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HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function

2
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Generation of Pelizaeus-Merzbacher disease (PMD) mutant (PLP1-C33Y) in induced pluripotent stem cell (iPSC) by CRISPR/Cas9 genome editing

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Multi-chamber cardioids unravel human heart development and cardiac defects

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Generation of heart and vascular system in rodents by blastocyst complementation

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Generation of induced pluripotent stem cell line (TMOi001-A-11) carrying a homozygous deletion in the synemin gene using CRISPR/Cas9

1
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Oct 2023
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Creation of an iPSC-Based Skeletal Muscle Model of McArdle Disease Harbouring the Mutation c.2392T>C (p.Trp798Arg) in the PYGM Gene

1
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Aug 2023
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Generation of a homozygous CRYAB p.Arg120Gly mutant (UKEi001-A-1) from a human iPSC line

1
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Jul 2023
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Generation of vascularized human cardiac organoids for 3D in vitro modeling

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Jun 2023
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High-throughput longitudinal electrophysiology screening of mature chamber-specific hiPSC-CMs using optical mapping

1
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Restored autophagy is protective against PAK3-induced cardiac dysfunction

1
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May 2023
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Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs

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  DOI: 10.1038/s41536-023-00302-6
  
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FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis

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Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V

1
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Apr 2023
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Vascular cells improve functionality of human cardiac organoids

1
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Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells

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Multimodal charting of molecular and functional cell states via in situ electro-sequencing

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Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

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Mar 2023
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Activation of β-catenin in mesenchymal progenitors leads to muscle mass loss

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Nov 2022
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Generation of human induced pluripotent stem cell line encoding for a genetically encoded voltage indicator Arclight A242

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SENP7 deSUMOylase-governed transcriptional program coordinates sarcomere assembly and is targeted in muscle atrophy

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Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models

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Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros

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Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2

1
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Oct 2022
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Chemotherapeutic drug screening in 3D-Bioengineered human myobundles provides insight into taxane-induced myotoxicities

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ncbi.nlm.nih.gov/pmc/articles/PMC9579017/
Sep 2022
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STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells

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  DOI: 10.1016/j.crmeth.2022.100300
  
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Aug 2022
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Generation of self-assembling cardiac organoids using hiPSC-derived cardiomyocytes

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  DOI: 10.1016/j.heliyon.2022.e10365
  
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Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1

1
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  DOI: 10.1152/ajpcell.00415.2021
  
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52.53.155.43/57680dead6bbad05523888b70e4064b19b2b12f9/ajpcell.00415.2021-html.html
journals.physiology.org journals.physiology.org

Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1

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Septin7 is indispensable for proper skeletal muscle architecture and function

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  DOI: 10.7554/eLife.75863
  
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Jun 2022
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The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load

1
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May 2022
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Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15

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  DOI: 10.1016/j.isci.2022.104337
  
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Apr 2022
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RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development

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Generation of heterozygous (MRli003-A-5) and homozygous (MRli003-A-6) voltage-sensing knock-in human iPSC lines by CRISPR/Cas9 editing of the AAVS1 locus

1
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Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons

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Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy

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Engineering of thick human functional myocardium via static stretching and electrical stimulation

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Generation of heterozygous (MRli003-A-3) and homozygous (MRli003-A-4) TRPM4 knockout human iPSC lines

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MBNL1 drives dynamic transitions between fibroblasts and myofibroblasts in cardiac wound healing

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Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability

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Generation of human induced pluripotent stem cell lines encoding for genetically encoded calcium indicators RCaMP1h and GCaMP6f

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Generation of SCN5A heterozygous knock-out human induced pluripotent stem cell line by CRISPR/Cas9-mediated genome editing

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Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome

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Generation of a human induced pluripotent stem cell line YCMi004-A from a patient with dilated cardiomyopathy carrying a protein-truncating mutation of the Titin gene and its differentiation towards cardiomyocytes

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Nov 2021
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Generation of heterozygous (MRli003-A-1) and homozygous (MRli003-A-2) MYH10 knockout human iPSC lines

1
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Generation and characterization of three induced pluripotent stem cell lines (NUIGi046-A, NUIGi046-B, NUIGi046-C) from a 51-year-old healthy individual

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Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction

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Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

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Oct 2021
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MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis

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Sep 2021
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Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species

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RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy

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Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2

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Generation of the human induced pluripotent stem cell (hiPSC) line PSMi006-A from a patient affected by an autosomal recessive form of Long QT Syndrome type 1

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Untitled document

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BPS Publications

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  mouse anti‐α‐actinin
  
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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo

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Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation

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Generation of a NKX2.1 – p63 double transgenic knock-in reporter cell line from human induced pluripotent stem cells (MHHi006-A-4)

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Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes

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Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

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Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome

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Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion

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Prestin amplifies cardiac motor functions

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Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

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Apr 2021
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A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature

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Mar 2021
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Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells

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  DOI: 10.1038/s41596-021-00497-2
  
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Isolated downregulation of HCN2 in ventricles of rats with streptozotocin-induced diabetic cardiomyopathy

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  DOI: 10.1186/s12872-021-01929-3
  
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link.springer.com/article/10.1186/s12872-021-01929-3
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Human iPSC-Derived Cardiomyocytes , are Susceptible to SARS-CoV-2 Infection

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Generation and cardiac differentiation of an induced pluripotent stem cell line from a patient with arrhythmia-induced cardiomyopathy

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Generation of the human induced pluripotent stem cell (hiPSC) line PSMi006-A from a patient affected by an autosomal recessive form of Long QT Syndrome type 1

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Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

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Establishment of MHHi001-A-5, a GCaMP6f and RedStar dual reporter human iPSC line for in vitro and in vivo characterization and in situ-tracing of iPSC-derivatives

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Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle

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Generation of two human ISG15 knockout iPSC clones using CRISPR/Cas9 editing

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Generation of a Human iPSC Line GIBHi002-A-2 with Dual-Reporter for NKX2-5 Using TALENs

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Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour

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Myosin-18B Regulates Higher-Order Organization of the Cardiac Sarcomere through Thin Filament Cross-Linking and Thick Filament Dynamics

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Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration

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Direct Comparison of Mononucleated and Binucleated Cardiomyocytes Reveals Molecular Mechanisms Underlying Distinct Proliferative Competencies

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Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

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Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes

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Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

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Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes

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Human STAT1 gain-of-function iPSC line from a patient suffering from chronic mucocutaneous candidiasis

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Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation

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An Optimized Protocol for Human Direct Cardiac Reprogramming

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F1000Research Article: Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the <i>AAVS1</i> locus as not an entirely safe harbour.

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Generation of pluripotent stem cell lines and CRISPR/Cas9 modified isogenic controls from a patient with dilated cardiomyopathy harboring a RBM20 p.R634W mutation

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Transcriptional landscape of myogenesis from human pluripotent stem cells reveals a key role of TWIST1 in maintenance of skeletal muscle progenitors

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Rational Reprogramming of Cellular States by Combinatorial Perturbation

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Conversion of Astrocytes and Fibroblasts into Functional Noradrenergic Neurons

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Endogenous IGF Signaling Directs Heterogeneous Mesoderm Differentiation in Human Embryonic Stem Cells

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Generation and characterization of a human induced pluripotent stem cell line UOWi005-A from dermal fibroblasts derived from a CCNFS621G familial amyotrophic lateral sclerosis patient using mRNA reprogramming

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Mechanical Forces Regulate Cardiomyocyte Myofilament Maturation via the VCL-SSH1-CFL Axis

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Generation of the human induced pluripotent stem cell (hiPSC) line PSMi006-A from a patient affected by an autosomal recessive form of Long QT Syndrome type 1

1
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Untitled document

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In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors

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Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia

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Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway

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Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming

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  DOI: 10.7554/eLife.40532
  
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  DOI: 10.1016/j.stem.2019.01.013
  
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Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification

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Generation of the human induced pluripotent stem cell (hiPSC) line PSMi003-A from a patient affected by an autosomal recessive form of Long QT Syndrome type 1

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Generation of the human induced pluripotent stem cell (hiPSC) line PSMi002-A from a patient affected by the Jervell and Lange-Nielsen syndrome and carrier of two compound heterozygous mutations on the KCNQ1 gene

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Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions

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Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction

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Quaking RNA-Binding Proteins Control Early Myofibril Formation by Modulating Tropomyosin

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Endothelin-1 promotes hypertrophic remodelling of cardiac myocytes by activating sustained signalling and transcription downstream of endothelin type A receptors

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Variants in the Oxidoreductase PYROXD1 Cause Early-Onset Myopathy with Internalized Nuclei and Myofibrillar Disorganization

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1. scibot 08 Nov 2017
  
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  α-actinin2 (Sigma clone A7811, 1:100)
  
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