242 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress
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    1. scibot 14 Dec 2024
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    sciencedirect.com/science/article/pii/S2211124724014177
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    CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
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    sciencedirect.com/science/article/pii/S1097276524009493
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    Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuit
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    sciencedirect.com/science/article/pii/S2666379124006396
  5. Nov 2024
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    Localized release of muscle-generated BDNF regulates the initial formation of postsynaptic apparatus at neuromuscular synapses
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    nature.com/articles/s41418-024-01404-4
  7. Sep 2024
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    Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5
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    sciencedirect.com/science/article/pii/S0896627320300568
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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
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    sciencedirect.com/science/article/pii/S009286742400905X
  10. Aug 2024
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    Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
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    sciencedirect.com/science/article/pii/S1550413124002912
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    OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response
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    sciencedirect.com/science/article/pii/S109727652400618X
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    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S266637912400377X
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    Loss of Fbxw7 in Sertoli cells impairs testis development and causes infertility in mice
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    academic.oup.com/biolreprod/biolreprod/advance-article-abstract/doi/10.1093/biolre/ioz230/5688712
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    Variants in CAPZA2, a member of a F-actin capping complex, cause intellectual disability and developmental delay
    1
    1. scibot 02 Aug 2024
      mouse anti-α-tubulin

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  16. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Lithium improves cell viability in psychosine‐treated MO3.13 human oligodendrocyte cell line via autophagy activation
    2
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      DOI: 10.1002/jnr.23910

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    onlinelibrary.wiley.com/doi/10.1002/jnr.23910/full
  17. Jul 2024
  18. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Role of palmitoylation on the neuronal glycine transporter GlyT2
    1
    1. scibot 25 Jul 2024
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      DOI: 10.1111/jnc.16181

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16181
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    Efficient, specific, and combinatorial control of endogenous exon splicing with dCasRx-RBM25
    1
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      DOI: 10.1016/j.molcel.2024.05.028

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  20. 52.53.155.43 52.53.155.43
    PPAR_Interaction_with_UBR5_ATMIN_Promot-html.html
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      DOI: 10.1016/j.celrep.2019.01.013

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  21. www.cell.com www.cell.com
    Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance
    1
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      DOI: 10.1016/j.xcrm.2024.101611

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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00315-X
  22. Jun 2024
  23. www.sciencedirect.com www.sciencedirect.com
    Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.isci.2024.110199

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    sciencedirect.com/science/article/pii/S258900422401424X
  24. May 2024
  25. www.sciencedirect.com www.sciencedirect.com
    Direct interrogation of context-dependent GPCR activity with a universal biosensor platform
    1
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      DOI: 10.1016/j.cell.2024.01.028

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    sciencedirect.com/science/article/pii/S0092867424000655
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    Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
    1
    1. scibot 16 May 2024
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      DOI: 10.1016/j.celrep.2024.114205

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    sciencedirect.com/science/article/pii/S2211124724005333
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    The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation
    1
    1. scibot 14 May 2024
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      DOI: 10.1016/j.immuni.2024.04.016

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    sciencedirect.com/science/article/pii/S1074761324002218
  28. Apr 2024
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biochemical Fractionation of Human α-Synuclein in a Drosophila Model of Synucleinopathies
    1
    1. scibot 17 Apr 2024
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      DOI: 10.3390/ijms25073643

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    ncbi.nlm.nih.gov/pmc/articles/PMC11011978/
  30. www.biorxiv.org www.biorxiv.org
    Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG
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    1. scibot 12 Apr 2024
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      DOI: 10.1101/2024.04.01.587609

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    biorxiv.org/content/10.1101/2024.04.01.587609v1
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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    1. scibot 04 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114044

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    sciencedirect.com/science/article/pii/S2211124724003723
  32. Mar 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression
    1
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      DOI: 10.1158/2767-9764.CRC-23-0513

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    ncbi.nlm.nih.gov/pmc/articles/PMC10946310/
  34. www.sciencedirect.com www.sciencedirect.com
    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    2
    1. scibot 08 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001291
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer
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      DOI: 10.1158/2159-8290.CD-22-0874

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527600/
  36. Feb 2024
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biochemical fractionation of human α-Synuclein in a Drosophila model of synucleinopathies
    1
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      RRID:AB_477582

      DOI: 10.1101/2024.02.05.579034

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    ncbi.nlm.nih.gov/pmc/articles/PMC10871193/
  38. Jan 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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      DOI: 10.1126/science.adi3448

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    ncbi.nlm.nih.gov/pmc/articles/PMC10801813/
  40. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Glioblastoma and its treatment are associated with extensive accelerated brain aging
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      DOI: 10.1111/acel.14066

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    onlinelibrary.wiley.com/doi/10.1111/acel.14066
  41. Dec 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Age-dependent loss of cohesion protection in human oocytes
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      DOI: 10.1016/j.cub.2023.11.061

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    sciencedirect.com/science/article/pii/S0960982223016494
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    Systematic analysis of alternative exon-dependent interactome remodeling reveals multitasking functions of gene regulatory factors
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    sciencedirect.com/science/article/pii/S1097276523008717
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mir324 knockout regulates the structure of dendritic spines and impairs hippocampal long-term potentiation
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      DOI: 10.1038/s41598-023-49134-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC10713680/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MiR-138-5p Upregulation during Neuronal Maturation Parallels with an Increase in Neuronal Survival
    1
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      DOI: 10.3390/ijms242216509

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    ncbi.nlm.nih.gov/pmc/articles/PMC10671628/
  46. Nov 2023
  47. www.sciencedirect.com www.sciencedirect.com
    RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
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      DOI: 10.1016/j.molcel.2023.10.012

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    sciencedirect.com/science/article/pii/S1097276523008493
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    Aryl Hydrocarbon Receptor is a Tumor Promoter in MYCN-Amplified Neuroblastoma Cells Through Suppression of Differentiation
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      DOI: 10.1016/j.isci.2023.108303

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    sciencedirect.com/science/article/pii/S2589004223023805
  49. Oct 2023
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors
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      DOI: 10.1007/s00018-023-04983-6

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    pmc.ncbi.nlm.nih.gov/articles/PMC10613596/
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    KANK1 shapes focal adhesions by orchestrating protein binding, mechanical force sensing, and phase separation
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    sciencedirect.com/science/article/pii/S2211124723013335
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    Regulation of STING activity in DNA sensing by ISG15 modification
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      DOI: 10.1016/j.celrep.2023.113277

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    Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders
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  54. Sep 2023
  55. www.sciencedirect.com www.sciencedirect.com
    CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax
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  56. Aug 2023
  57. www.science.org www.science.org
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    A split-luciferase lysate-based approach to identify small-molecule modulators of phosphatase subunit interactions
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  59. Jul 2023
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage
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    Reduced histone gene copy number disrupts Drosophila Polycomb function
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  62. Jun 2023
  63. www.sciencedirect.com www.sciencedirect.com
    Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40
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    Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas
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  65. May 2023
  66. www.mdpi.com www.mdpi.com
    Evaluation of Poly(N-Ethyl Pyrrolidine Methacrylamide) (EPA) and Derivatives as Polymeric Vehicles for miRNA Delivery to Neural Cells
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  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A ubiquitin fusion reporter to monitor muscle proteostasis in C. elegans
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    Miniaturized and multiplexed high-content screening of drug and immune sensitivity in a multichambered microwell chip
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  70. Apr 2023
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    Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit
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    ZFP36-mediated mRNA decay regulates metabolism
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    Reduced histone gene copy number disrupts Drosophila Polycomb function
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    Lysine long-chain fatty acylation regulates the TEAD transcription factor
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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  76. Mar 2023
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    The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11
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  78. Jan 2023
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    Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats
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  80. Dec 2022
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    Autocleavage of separase suppresses its premature activation by promoting binding to cyclin B1
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  82. Nov 2022
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis
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    Dysregulated endolysosomal trafficking in cells arrested in the G1 phase of the host cell cycle impairs Salmonella vacuolar replication
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    Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice
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    Structural and functional basis of mammalian microRNA biogenesis by Dicer
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  87. Oct 2022
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolomic fingerprinting of renal disease progression in Bardet-Biedl syndrome reveals mitochondrial dysfunction in kidney tubular cells
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  89. Sep 2022
  90. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Aversive memory reactivation: A possible role for delta oscillations in the hippocampus–amygdala circuit
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    A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-β2 signaling
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  92. Aug 2022
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    A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing
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    Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis
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  95. Jun 2022
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    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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    Protein disulfide isomerase PDI-6 regulates Wnt secretion to coordinate inter-tissue UPRmt activation and lifespan extension in C. elegans
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    miR-182-5p Regulates Nogo-A Expression and Promotes Neurite Outgrowth of Hippocampal Neurons In Vitro
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  99. May 2022
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    The Taspase1/Myosin1f-axis regulates filopodia dynamics
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    Nde1 is required for heterochromatin compaction and stability in neocortical neurons
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  102. Mar 2022
  103. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sex hormones modulate pathogenic processes in experimental traumatic brain injury
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    SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones
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    BMI-1 regulates DNA end resection and homologous recombination repair
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    A coordinate-based co-localization index to quantify and visualize spatial associations in single-molecule localization microscopy
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    The ARM repeat domain of hemocyanin interacts with MKK4 to modulate antimicrobial peptides expression
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    PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo
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    Mutant Huntingtin Disrupts the Nuclear Pore Complex
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    Ankyrin-dependent Na+ channel clustering prevents neuromuscular synapse fatigue
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  157. Jun 2021
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    HER2-PI9 and HER2-I12: two novel and functionally active splice variants of the oncogene HER2 in breast cancer
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    Human iPSC lines from a Christianson syndrome patient with NHE6 W523X mutation, a biologically-related control, and CRISPR/Cas9 gene-corrected isogenic controls
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    C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation
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    Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells
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    XRCC1 prevents toxic PARP1 trapping during DNA base excision repair
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    Suppression of β-catenin signaling in colon carcinoma cells by a bacterial protein
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    Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program
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    O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses
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    The chromatin-remodeling protein BAF60/SWP73A regulates the plant immune receptor NLRs
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    Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation
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    Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring
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    Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning
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    CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition
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    Inhibition of p38 Mitogen–Activated Protein Kinase Ameliorates HAP40 Depletion–Induced Toxicity and Proteasomal Defect in Huntington’s Disease Model
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    A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN
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    RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions
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    Comparative Proteomics Unveils LRRFIP1 as a New Player in the DAPK1 Interactome of Neurons Exposed to Oxygen and Glucose Deprivation
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    Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner
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    Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
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    Site-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs
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    Genome-wide Survey of Ribosome Collision
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    FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells
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    Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche
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    Inhibition of the catalytic subunit of DNA‐dependent protein kinase (DNA‐PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses
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    Ensemble-Level Organization of Human Kinetochores and Evidence for Distinct Tension and Attachment Sensors
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    Functional Assessment In Vivo of the Mouse Homologue of the Human Ala-9-Ser NHE6 Variant
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    Cognitive Decline and Modulation of Alzheimer’s Disease-Related Genes After Inhibition of MicroRNA-101 in Mouse Hippocampal Neurons
    1
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      RRID:AB_477582

      DOI: 10.1007/s12035-020-01957-8

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  203. www.nature.com www.nature.com
    C9orf72 in myeloid cells suppresses STING-induced inflammation
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      tubulin

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  204. link.springer.com link.springer.com
    Combining the lack of chromogranins with chronic L-DOPA treatment affects motor activity in mice
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      actin

      DOI: 10.1007/s00441-019-03159-8

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  205. Jan 2020
  206. www.sciencedirect.com www.sciencedirect.com
    Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity
    1
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      DOI: 10.1016/j.celrep.2019.06.078

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  207. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    Differential effect of glucose on ER-mitochondria Ca2+ exchange participates to insulin secretion and to glucotoxicity-mediated dysfunction of β cells.
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      DOI: 10.2337/db18-1112

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    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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    NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor
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      DOI: 10.1016/j.celrep.2019.09.087

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    Serial exposure to ethanol drinking and methamphetamine enhances glutamate excitotoxicity
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    Neutral Sphingomyelinase 2 (SMPD3)-Deficiency in Mice Causes Chondrodysplasia with Unimpaired Skeletal Mineralization
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    Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease
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    Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade
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    Properties of Individual Hippocampal Synapses Influencing NMDA-Receptor Activation by Spontaneous Neurotransmission
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      DOI: 10.1523/ENEURO.0419-18.2019

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    Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1
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    SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance
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    IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
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    Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease
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      DOI: 10.1016/j.molcel.2019.06.016

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    HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70
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      DOI: 10.1016/j.celrep.2019.09.023

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  220. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel CB1-ligands maintain homeostasis of the endocannabinoid-system in ω3- and ω6-long chain-PUFA deficiency
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      RRID:AB_477582

      DOI: 10.1194/jlr.M094664

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    Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5
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      RRID:AB_477582

      DOI: 10.1016/j.celrep.2019.08.102

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    Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction
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      RRID:AB_477582

      DOI: 10.1016/j.devcel.2019.11.001

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    Feedback-Driven Assembly of the Axon Initial Segment
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      RRID:AB_477582

      DOI: 10.1016/j.neuron.2019.07.029

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    Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia
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      RRID:AB_477582

      DOI: 10.1016/j.stem.2019.07.001

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      DOI: 10.1016/j.celrep.2019.01.013

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    Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan
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      RRID:AB_477582

      DOI: 10.1016/j.cub.2019.01.029

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    Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring
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      AB_477582

      DOI: 10.1016/j.molcel.2018.11.013

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  228. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Developmental Exposure to Psychostimulant Primes Activity‐dependent Gene Induction in Frontal Cortex
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      DOI: 10.1002/dneu.22660

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      DOI: 10.1038/s41467-019-08787-w

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    Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells
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      DOI: 10.1016/j.chembiol.2019.02.019

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  237. Nov 2018
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    NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus
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    A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression
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    A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network
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    Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
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