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  1. Last 7 days
  2. dx.doi.org dx.doi.org
    Age- and oxidative stress-induced centrosome amplification and renal stones in Drosophila Malpighian tubules
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  3. Dec 2024
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    H4K20me3-Mediated Repression of Inflammatory Genes is a Characteristic and Targetable Vulnerability of Persister Cancer Cells
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    Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11628624/
  6. Nov 2024
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    CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2
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  9. Sep 2024
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    CDK5RAP2 activates microtubule nucleator γTuRC by facilitating template formation and actin release
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    cell.com/developmental-cell/fulltext/S1534-5807(24)00529-X
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    Lamin chromatin binding is modulated by interactions of different LAP2α domains with lamins and chromatin
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    sciencedirect.com/science/article/pii/S2589004224020947
  12. Aug 2024
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    An actomyosin network organizes niche morphology and responds to feedback from recruited stem cells
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    Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes
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    GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy
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  16. Jul 2024
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    The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells
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    Wg/Wnt-signaling-induced nuclear translocation of β-catenin is attenuated by a β-catenin peptide through its interference with the IFT-A complex
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    cell.com/cell-reports/abstract/S2211-1247(24)00690-9
  19. Jun 2024
  20. www.sciencedirect.com www.sciencedirect.com
    TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons
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  21. May 2024
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    Centriolar satellites are sites of translation of centrosomal and ciliary proteins
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    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
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  24. elifesciences.org elifesciences.org
    Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes
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  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics
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      DOI: 10.7554/eLife.89100

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    ncbi.nlm.nih.gov/pmc/articles/PMC11060712/
  26. Apr 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response
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    Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy
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    Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery
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    sciencedirect.com/science/article/pii/S0960982224003075
  30. Mar 2024
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders
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    In vivo CRISPR screening directly targeting testicular cells
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    sciencedirect.com/science/article/pii/S2666979X24000375
  33. Feb 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of synaptopodin impairs mGluR5 and protein synthesis–dependent mGluR-LTD at CA3-CA1 synapses
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      DOI: 10.1093/pnasnexus/pgae062

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  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance
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    Dual roles of CCDC102A in governing centrosome duplication and cohesion
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    sciencedirect.com/science/article/pii/S221112472400024X
  37. Jan 2024
  38. www.sciencedirect.com www.sciencedirect.com
    Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo
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    sciencedirect.com/science/article/pii/S1934590923004332
  39. Nov 2023
  40. www.nature.com www.nature.com
    Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization
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    nature.com/articles/s41467-023-43180-8
  41. Oct 2023
  42. www.sciencedirect.com www.sciencedirect.com
    MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis
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    sciencedirect.com/science/article/pii/S1534580723005129
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    Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method
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    sciencedirect.com/science/article/pii/S1534580723004951
  44. Sep 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Centrins control chicken cone cell lipid droplet dynamics through lipid-droplet-localized SPDL1
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    sciencedirect.com/science/article/pii/S1534580723004082
  46. Aug 2023
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    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
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    sciencedirect.com/science/article/pii/S221112472300997X
  48. www.biorxiv.org www.biorxiv.org
    Loss of synaptopodin impairs mGluR5 and protein synthesis dependent mGluR-LTD at CA3-CA1 synapses
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      DOI: 10.1101/2023.08.02.551676

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    biorxiv.org/content/10.1101/2023.08.02.551676v1
  49. Jul 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation
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    sciencedirect.com/science/article/pii/S2211124723008616
  51. Jun 2023
  52. www.sciencedirect.com www.sciencedirect.com
    Spd-2 gene duplication reveals cell-type-specific pericentriolar material regulation
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    sciencedirect.com/science/article/pii/S0960982223007716
  53. www.embopress.org www.embopress.org
    A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans
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      DOI: 10.15252/embj.2023113616

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    embopress.org/doi/10.15252/embj.2023113616
  54. May 2023
  55. www.sciencedirect.com www.sciencedirect.com
    Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs
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    sciencedirect.com/science/article/pii/S258900422300932X
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    Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2
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    sciencedirect.com/science/article/pii/S2211124723005454
  57. Apr 2023
  58. www.sciencedirect.com www.sciencedirect.com
    Escape from oncogene-induced senescence is controlled by POU2F2 and memorized by chromatin scars
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      DOI: 10.1016/j.xgen.2023.100293

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    sciencedirect.com/science/article/pii/S2666979X23000599
  59. Feb 2023
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates
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  62. Dec 2022
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    CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors
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  67. Oct 2022
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    Increased microtubule growth triggered by microvesicle-mediated paracrine signaling is required for melanoma cancer cell invasion
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    The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling
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    Hotspot ESR1 mutations are multimodal and contextual modulators of breast cancer metastasis
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    Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD
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  87. Feb 2022
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    SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ
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    The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification
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    chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche
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    The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms
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    NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells
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    Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity
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    Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity
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    GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy
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  116. journals.plos.org journals.plos.org
    Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival
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  117. rupress.org rupress.org
    TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity
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  118. May 2021
  119. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rab34 is necessary for early stages of intracellular ciliogenesis
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  120. www.sciencedirect.com www.sciencedirect.com
    Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling
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    Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells
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    Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains
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    Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia
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    Acto-myosin network geometry defines centrosome position
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    Vertebrate cells differentially interpret ciliary and extraciliary cAMP
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  126. Mar 2021
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior
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  128. www.sciencedirect.com www.sciencedirect.com
    Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis
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  129. Feb 2021
  130. elifesciences.org elifesciences.org
    Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth
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      DOI: 10.7554/eLife.53618

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  131. academic.oup.com academic.oup.com
    Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling
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      DOI: 10.1093/cercor/bhz306

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    academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhz306/5673286
  132. Dec 2020
  133. www.sciencedirect.com www.sciencedirect.com
    Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions
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    Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage
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  135. www.cell.com www.cell.com
    The Aurora-A/TPX2 Axis Directs Spindle Orientation in Adherent Human Cells by Regulating NuMA and Microtubule Stability
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      DOI: 10.1016/j.cub.2020.10.096

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    WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin
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      DOI: 10.1016/j.celrep.2020.108469

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    Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated Cells
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  138. Nov 2020
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    The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina
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  140. Sep 2020
  141. www.sciencedirect.com www.sciencedirect.com
    CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression
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    Dynamic Buffering of Extracellular Chemokine by a Dedicated Scavenger Pathway Enables Robust Adaptation during Directed Tissue Migration
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    Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites
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    A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
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    Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila
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    The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress
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    Promiscuous Binding of Microprotein Mozart1 to γ-Tubulin Complex Mediates Specific Subcellular Targeting to Control Microtubule Array Formation
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    Microtubule Nucleation Properties of Single Human γTuRCs Explained by Their Cryo-EM Structure
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prickle isoforms determine handedness of helical morphogenesis
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  150. rupress.org rupress.org
    NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesisNCAM regulates temporal NPC specification
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      DOI: 10.1083/jcb.201902164

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  151. jcs.biologists.org jcs.biologists.org
    C3G localizes to mother centriole dependent on cenexin, and regulates centrosome duplication and primary cilia length
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      DOI: 10.1242/jcs.243113

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  152. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors
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      gamma-tubulin

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  153. Aug 2020
  154. link.springer.com link.springer.com
    Excess centrosomes disrupt vascular lumenization and endothelial cell adherens junctions
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      anti-γ-tubulin

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    MZT Proteins Form Multi-Faceted Structural Modules in the γ-Tubulin Ring Complex
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      Anti-γ-tubulin, mouse monoclonal, clone GTU-88

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  156. Jan 2020
  157. www.sciencedirect.com www.sciencedirect.com
    The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
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      RRID:AB_477584

      DOI: 10.1016/j.celrep.2019.11.012

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  158. elifesciences.org elifesciences.org
    Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration
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      DOI: 10.7554/eLife.45853

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    A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling
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      DOI: 10.1016/j.celrep.2019.07.025

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    The transcriptional repressor SNAI2 impairs neuroblastoma differentiation and inhibits response to retinoic acid therapy
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  163. elifesciences.org elifesciences.org
    Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis
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    Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex
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    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
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    Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia
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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    Reconstitution of Microtubule Nucleation In Vitro Reveals Novel Roles for Mzt1
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    Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication
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    Spindle-Length-Dependent HURP Localization Allows Centrosomes to Control Kinetochore-Fiber Plus-End Dynamics
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  173. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cordycepin improves behavioral‐LTP and dendritic structure in hippocampal CA1 area of rats
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    Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity
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    Chiral Cilia Orientation in the Left-Right Organizer
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    Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM
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      DOI: 10.1016/j.neuron.2019.02.009

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    CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1
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  181. Nov 2018
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    WDR5 Stabilizes Actin Architecture to Promote Multiciliated Cell Formation
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    Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination
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    Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis
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    Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown
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    Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
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    Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages
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    Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Control of endothelial cell polarity and sprouting angiogenesis by non-centrosomal microtubules
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  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture
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      T6557

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    Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7
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    A Method for the Acute and Rapid Degradation of Endogenous Proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC5733393/
  196. europepmc.org europepmc.org
    Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells.
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  197. academic.oup.com academic.oup.com
    Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response
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  198. Nov 2017
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    An RNAi Screen in a Novel Model of Oriented Divisions Identifies the Actin-Capping Protein Z β as an Essential Regulator of Spindle Orientation
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    Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis
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    Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression
    1
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      Anti-gamma-tubulin, mouse monoclonalSigma-AldrichClone: T6557

      Curator: @Jmenke

      Resource used:

      (Sigma-Aldrich Cat# T6557, RRID:AB_477584)

      SciCrunch record: RRID:AB_477584

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_477584 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S1931312817302494
  202. link.springer.com link.springer.com
    IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents
    1
    1. scibot 08 Nov 2017
      RRID:AB_477584

      Curator: @chewbeccax

      Resource used:

      (Sigma-Aldrich Cat# T6557, RRID:AB_477584)

      SciCrunch record: RRID:AB_477584

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_477584 RRIDCUR:Validated
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    link.springer.com/article/10.1007/s00125-017-4345-9
  203. www.sciencedirect.com www.sciencedirect.com
    Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy
    1
    1. scibot 08 Nov 2017
      AB_477584

      Curator: @chewbeccax

      Resource used:

      (Sigma-Aldrich Cat# T6557, RRID:AB_477584)

      SciCrunch record: RRID:AB_477584

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_477584 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0960982217307236
  204. www.sciencedirect.com www.sciencedirect.com
    Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding
    1
    1. scibot 08 Nov 2017
      AB_477584

      Curator: @chewbeccax

      Resource used:

      (Sigma-Aldrich Cat# T6557, RRID:AB_477584)

      SciCrunch record: RRID:AB_477584

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_477584 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0896627317300934
  205. www.sciencedirect.com www.sciencedirect.com
    NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres
    1
    1. scibot 08 Nov 2017
      AB_477584

      Curator: @Zeljana_Babic

      Resource used:

      (Sigma-Aldrich Cat# T6557, RRID:AB_477584)

      SciCrunch record: RRID:AB_477584

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_477584 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276517300424
  206. www.sciencedirect.com www.sciencedirect.com
    Differential Routing of Mindbomb1 via Centriolar Satellites Regulates Asymmetric Divisions of Neural Progenitors
    1
    1. scibot 08 Nov 2017
      AB_477584

      Curator: @gabimpine

      Resource used:

      (Sigma-Aldrich Cat# T6557, RRID:AB_477584)

      SciCrunch record: RRID:AB_477584

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_477584 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0896627316310418
  207. www.sciencedirect.com www.sciencedirect.com
    Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision
    1
    1. scibot 08 Nov 2017
      AB_477584

      Curator: @gabimpine

      Resource used:

      (Sigma-Aldrich Cat# T6557, RRID:AB_477584)

      SciCrunch record: RRID:AB_477584

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_477584 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0092867416317482
  208. www.cell.com www.cell.com
    GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy
    1
    1. scibot 08 Nov 2017
      AB_477584

      Resource used:

      (Sigma-Aldrich Cat# T6557, RRID:AB_477584)

      SciCrunch record: RRID:AB_477584

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_477584
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    cell.com/action/showExperimentalProcedures
  209. elifesciences.org elifesciences.org
    Registered report: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis
    1
    1. scibot 08 Nov 2017
      Mouse anti-γ-tubulin (clone GTU-88)

      Curator: @jcabotaj

      Resource used:

      (Sigma-Aldrich Cat# T6557, RRID:AB_477584)

      SciCrunch record: RRID:AB_477584

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_477584 RRIDCUR:Missing
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    URL

    elifesciences.org/content/4/e04796